node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BAG4 | TNF | ENSCPOP00000011328 | ENSCPOP00000002129 | BCL2 associated athanogene 4. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.612 |
CHP1 | FKBP1B | ENSCPOP00000024538 | ENSCPOP00000027333 | Calcineurin like EF-hand protein 1. | Peptidylprolyl isomerase. | 0.691 |
FKBP1B | CHP1 | ENSCPOP00000027333 | ENSCPOP00000024538 | Peptidylprolyl isomerase. | Calcineurin like EF-hand protein 1. | 0.691 |
IKBKB | TNF | ENSCPOP00000009478 | ENSCPOP00000002129 | Inhibitor of nuclear factor kappa B kinase subunit beta. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.996 |
LPIN1 | MGAT5 | ENSCPOP00000012195 | ENSCPOP00000004449 | Lipin 1. | Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase. | 0.432 |
MGAT5 | LPIN1 | ENSCPOP00000004449 | ENSCPOP00000012195 | Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase. | Lipin 1. | 0.432 |
Mprip | URI1 | ENSCPOP00000032657 | ENSCPOP00000003704 | Uncharacterized protein. | URI1 prefoldin like chaperone. | 0.405 |
PPP4R4 | PTPA | ENSCPOP00000012624 | ENSCPOP00000021528 | Protein phosphatase 4 regulatory subunit 4. | Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. | 0.802 |
PPP4R4 | TIPRL | ENSCPOP00000012624 | ENSCPOP00000028722 | Protein phosphatase 4 regulatory subunit 4. | TOR signaling pathway regulator. | 0.531 |
PTPA | PPP4R4 | ENSCPOP00000021528 | ENSCPOP00000012624 | Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. | Protein phosphatase 4 regulatory subunit 4. | 0.802 |
ROCK1 | ROCK2 | ENSCPOP00000009405 | ENSCPOP00000011391 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. | 0.942 |
ROCK1 | SEMA4D | ENSCPOP00000009405 | ENSCPOP00000031698 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. | Semaphorin 4D; Belongs to the semaphorin family. | 0.634 |
ROCK2 | ROCK1 | ENSCPOP00000011391 | ENSCPOP00000009405 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. | 0.942 |
ROCK2 | SEMA4D | ENSCPOP00000011391 | ENSCPOP00000031698 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. | Semaphorin 4D; Belongs to the semaphorin family. | 0.635 |
ROCK2 | TNF | ENSCPOP00000011391 | ENSCPOP00000002129 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.444 |
SEMA4D | ROCK1 | ENSCPOP00000031698 | ENSCPOP00000009405 | Semaphorin 4D; Belongs to the semaphorin family. | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. | 0.634 |
SEMA4D | ROCK2 | ENSCPOP00000031698 | ENSCPOP00000011391 | Semaphorin 4D; Belongs to the semaphorin family. | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. | 0.635 |
TIPRL | PPP4R4 | ENSCPOP00000028722 | ENSCPOP00000012624 | TOR signaling pathway regulator. | Protein phosphatase 4 regulatory subunit 4. | 0.531 |
TNF | BAG4 | ENSCPOP00000002129 | ENSCPOP00000011328 | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | BCL2 associated athanogene 4. | 0.612 |
TNF | IKBKB | ENSCPOP00000002129 | ENSCPOP00000009478 | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | Inhibitor of nuclear factor kappa B kinase subunit beta. | 0.996 |