STRINGSTRING
TRPV5 TRPV5 TRPV6 TRPV6 TRPC3 TRPC3 GRIN2C GRIN2C ATP2A1 ATP2A1 SLC8A1 SLC8A1 CACNG2 CACNG2 TPCN2 TPCN2 TMC1 TMC1 TRPC1 TRPC1 PKD1 PKD1 CACNB3 CACNB3 STIM2 STIM2 GOLM1 GOLM1 P2rx4 P2rx4 CACNA1B CACNA1B SLC8B1 SLC8B1 CACNA2D4 CACNA2D4 TRPM7 TRPM7 TPCN1 TPCN1 Trpm8 Trpm8 Cacnb2 Cacnb2 GRIN2B GRIN2B Anxa2 Anxa2 GRIN3A GRIN3A MCOLN2 MCOLN2 ATP2A3 ATP2A3 RASA3 RASA3 ERC1 ERC1 CACNA2D3 CACNA2D3 MCOLN1 MCOLN1 SLC8A2 SLC8A2 TRPV1 TRPV1 TRPM5 TRPM5 SLC24A4 SLC24A4 SLC24A5 SLC24A5 PKD2L1 PKD2L1 CALHM1 CALHM1 TRPM6 TRPM6 LETM1 LETM1 Trpa1 Trpa1 CACHD1 CACHD1 Trpc4 Trpc4 TMEM165 TMEM165 CACNA1I CACNA1I SLC24A3 SLC24A3 CACNA1H CACNA1H ITPR2 ITPR2 CATSPER3 CATSPER3 TRPV2 TRPV2 PKD2L2 PKD2L2 TRPC5 TRPC5 GRIN2A GRIN2A SLC24A1 SLC24A1 TMCO1 TMCO1 PKD2 PKD2 CACNA1E CACNA1E TRPV3 TRPV3 CACNG7 CACNG7 TMC2 TMC2 ITGAV ITGAV MCU MCU RYR1 RYR1 TRPM2 TRPM2 H0VVJ6_CAVPO H0VVJ6_CAVPO OPRM1 OPRM1 GRM7 GRM7 CACNG4 CACNG4 HRH1 HRH1 ATP2C2 ATP2C2 ATP2B2 ATP2B2 CACNA1F CACNA1F P2rx7 P2rx7 PKDREJ PKDREJ H0W649_CAVPO H0W649_CAVPO ORAI1 ORAI1 CACNA2D2 CACNA2D2 ITPR3 ITPR3 CACNA1A CACNA1A CNR1 CNR1 TRPC6 TRPC6 TRPM4 TRPM4 CACNA1G CACNA1G CACNA1S CACNA1S ANXA6 ANXA6 CACNA2D1 CACNA2D1 CACNG6 CACNG6 ORAI3 ORAI3 ATP2B1 ATP2B1 PANX1 PANX1 ANXA5 ANXA5 CACNA1C CACNA1C CACNB1 CACNB1 CACNG1 CACNG1 MCOLN3 MCOLN3 CACNG3 CACNG3 ATP2B4 ATP2B4 ATP2A2 ATP2A2 PSEN1 PSEN1 LOC100714922 LOC100714922 TSPOAP1 TSPOAP1 STIM1 STIM1 Cacnb4 Cacnb4 GRIN1 GRIN1 TMEM37 TMEM37 TRPC7 TRPC7 GRIN2D GRIN2D TRPV4 TRPV4 RYR2 RYR2 RYR3 RYR3 GPM6A GPM6A CACFD1 CACFD1 SLC24A2 SLC24A2 MARCKSL1 MARCKSL1 SLC8A3 SLC8A3 ATP2C1 ATP2C1 ORAI2 ORAI2 ITPR1 ITPR1 ATP2B3 ATP2B3 Ncs1 Ncs1 ANXA9 ANXA9 CACNA1D CACNA1D CDK5 CDK5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRPV5Transient receptor potential cation channel subfamily V member 5; Belongs to the transient receptor (TC 1.A.4) family. (729 aa)
TRPV6Transient receptor potential cation channel subfamily V member 6; Belongs to the transient receptor (TC 1.A.4) family. (767 aa)
TRPC3ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (849 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1209 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1001 aa)
SLC8A1Sodium/calcium exchanger 1; Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage- gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels r [...] (970 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
TPCN2Two pore channel 2. (752 aa)
TMC1Transmembrane channel-like protein. (761 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (810 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4283 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (484 aa)
STIM2Stromal interaction molecule 2. (742 aa)
GOLM1Golgi membrane protein 1. (397 aa)
P2rx4Uncharacterized protein. (343 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2270 aa)
SLC8B1Solute carrier family 8 member B1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (580 aa)
CACNA2D4Calcium voltage-gated channel auxiliary subunit alpha2delta 4. (1101 aa)
TRPM7Transient receptor potential cation channel subfamily M member 7. (1754 aa)
TPCN1Two pore channel 1. (817 aa)
Trpm8Transient potential cation channel subfamily M member 8. (1104 aa)
Cacnb2SH3 domain-containing protein. (621 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1381 aa)
Anxa2Annexin. (339 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A. (1114 aa)
MCOLN2Mucolipin 2. (540 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1028 aa)
RASA3RAS p21 protein activator 3. (833 aa)
ERC1ELKS/RAB6-interacting/CAST family member 1. (1116 aa)
CACNA2D3Calcium voltage-gated channel auxiliary subunit alpha2delta 3. (991 aa)
MCOLN1Mucolipin 1. (582 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (840 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits [...] (839 aa)
TRPM5Transient receptor potential cation channel subfamily M member 5. (1159 aa)
SLC24A4Solute carrier family 24 member 4; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (605 aa)
SLC24A5Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (501 aa)
PKD2L1Polycystin 2 like 1, transient receptor potential cation channel. (760 aa)
CALHM1Calcium homeostasis modulator 1. (344 aa)
TRPM6Transient receptor potential cation channel subfamily M member 6. (1902 aa)
LETM1Leucine zipper and EF-hand containing transmembrane protein 1. (736 aa)
Trpa1ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (991 aa)
CACHD1Cache domain containing 1. (1272 aa)
Trpc4Transient receptor potential channel 4 alpha; Belongs to the transient receptor (TC 1.A.4) family. (977 aa)
TMEM165GDT1 family protein. (324 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2067 aa)
SLC24A3Solute carrier family 24 member 3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (596 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2337 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2622 aa)
CATSPER3Cation channel sperm associated 3. (380 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (720 aa)
PKD2L2Polycystin 2 like 2, transient receptor potential cation channel. (621 aa)
TRPC5Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (974 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1462 aa)
SLC24A1Solute carrier family 24 member 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (1180 aa)
TMCO1Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling; Belongs to the TMCO1 family. (188 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (839 aa)
CACNA1EVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2313 aa)
TRPV3Transient receptor potential cation channel subfamily V member 3; Belongs to the transient receptor (TC 1.A.4) family. (789 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
TMC2Transmembrane channel-like protein. (868 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (963 aa)
MCUMitochondrial calcium uniporter. (344 aa)
RYR1Ryanodine receptor 1. (4554 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1502 aa)
H0VVJ6_CAVPOUncharacterized protein; Belongs to the transient receptor (TC 1.A.4) family. (1247 aa)
OPRM1Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP- bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell ty [...] (416 aa)
GRM7Glutamate metabotropic receptor 7. (922 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (325 aa)
HRH1Histamine H1 receptor; In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. (482 aa)
ATP2C2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (945 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1296 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1774 aa)
P2rx7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (594 aa)
PKDREJPolycystin family receptor for egg jelly. (2029 aa)
H0W649_CAVPOVoltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (280 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (302 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1129 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2663 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2105 aa)
CNR1Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] (472 aa)
TRPC6Uncharacterized protein; Belongs to the transient receptor (TC 1.A.4) family. (934 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1138 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2372 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1867 aa)
ANXA6Annexin. (753 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1078 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (257 aa)
ORAI3ORAI calcium release-activated calcium modulator 3. (297 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1249 aa)
PANX1Pannexin; Structural component of the gap junctions and the hemichannels. (427 aa)
ANXA5Annexin. (318 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2089 aa)
CACNB1Calcium voltage-gated channel auxiliary subunit beta 1. (641 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (224 aa)
MCOLN3Mucolipin 3. (553 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1207 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
LOC100714922Ion_trans domain-containing protein. (685 aa)
TSPOAP1TSPO associated protein 1. (1837 aa)
STIM1Stromal interaction molecule 1. (713 aa)
Cacnb4SH3 domain-containing protein. (519 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (943 aa)
TMEM37Transmembrane protein 37. (197 aa)
TRPC7Transient receptor potential cation channel subfamily C member 7; Belongs to the transient receptor (TC 1.A.4) family. (862 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (808 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
RYR2Ryanodine receptor 2. (4910 aa)
RYR3Ryanodine receptor 3. (4843 aa)
GPM6AGlycoprotein M6A. (278 aa)
CACFD1Calcium channel flower domain containing 1. (170 aa)
SLC24A2Solute carrier family 24 member 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (705 aa)
MARCKSL1MARCKS like 1. (238 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
ATP2C1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (977 aa)
ORAI2ORAI calcium release-activated calcium modulator 2. (307 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2738 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1226 aa)
Ncs1Uncharacterized protein. (168 aa)
ANXA9Annexin. (345 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2164 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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