STRINGSTRING
SCOC SCOC HDAC6 HDAC6 CHMP4B CHMP4B WAC WAC FEZ2 FEZ2 MAP3K7 MAP3K7 RALB RALB Gdf1 Gdf1 TMEM39B TMEM39B SCFD1 SCFD1 PIK3R4 PIK3R4 BAG3 BAG3 PIP4K2A PIP4K2A OPTN OPTN FYCO1 FYCO1 RAB3GAP2 RAB3GAP2 ATG2A ATG2A SLC25A5 SLC25A5 SNX4 SNX4 SMCR8 SMCR8 C9orf72 C9orf72 TIGAR TIGAR PRKAA2 PRKAA2 KDR KDR VPS13D VPS13D USP36 USP36 TBK1 TBK1 ATP6V0A1 ATP6V0A1 GNAI3 GNAI3 MTOR MTOR SNX30 SNX30 Nrbp2 Nrbp2 SMG1 SMG1 USP30 USP30 UBQLN2 UBQLN2 SESN1 SESN1 ATG5 ATG5 WIPI1 WIPI1 EHMT2 EHMT2 SPTLC1 SPTLC1 WDR24 WDR24 PINK1 PINK1 PIP4K2C PIP4K2C LOC100728392 LOC100728392 GPSM1 GPSM1 TRIM13 TRIM13 H0VXJ2_CAVPO H0VXJ2_CAVPO Rnf31 Rnf31 SESN3 SESN3 CALCOCO2 CALCOCO2 ADRB2 ADRB2 RAB12 RAB12 HMOX1 HMOX1 TLR2 TLR2 IKBKG IKBKG TMEM39A TMEM39A PHF23 PHF23 ATG12 ATG12 RAB3GAP1 RAB3GAP1 RNF41 RNF41 SUPT5H SUPT5H Pafah1b2 Pafah1b2 NOD1 NOD1 HTT HTT NUPR1 NUPR1 ENSCPOP00000023749 ENSCPOP00000023749 TECPR1 TECPR1 BNIP3L BNIP3L SH3GLB1 SH3GLB1 SNX7 SNX7 EPM2A EPM2A DCN DCN ATP13A2 ATP13A2 LZTS1 LZTS1 NOD2 NOD2 VPS13C VPS13C SESN2 SESN2 SIRT1 SIRT1 ATG14 ATG14 SPTLC2 SPTLC2 RUBCN RUBCN QSOX1 QSOX1 UBQLN4 UBQLN4 POLDIP2 POLDIP2 FEZ1 FEZ1 TSC2 TSC2 LARP1 LARP1 TBC1D25 TBC1D25 PIK3C3 PIK3C3 TSC1 TSC1 SLC25A4 SLC25A4 HIF1A HIF1A PIP4K2B PIP4K2B PIM2 PIM2 NPC1 NPC1 RIPK2 RIPK2 MTM1 MTM1 BECN1 BECN1 Il4 Il4 CLEC16A CLEC16A Wdr45 Wdr45 STING1 STING1 HSPB8 HSPB8 KIAA1324 KIAA1324 TP53 TP53 BNIP3 BNIP3 ENSCPOP00000029147 ENSCPOP00000029147 AMBRA1 AMBRA1 Vdac1 Vdac1 SNX18 SNX18 ULK1 ULK1 LOC100729512 LOC100729512 ENSCPOP00000027535 ENSCPOP00000027535 LRSAM1 LRSAM1 SEC22B SEC22B Cln3 Cln3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCOCShort coiled-coil protein. (82 aa)
HDAC6Histone deacetylase 6. (1196 aa)
CHMP4BCharged multivesicular body protein 4B. (224 aa)
WACWW domain containing adaptor with coiled-coil. (632 aa)
FEZ2Fasciculation and elongation protein zeta 2. (318 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
RALBRAS like proto-oncogene B. (206 aa)
Gdf1TGF_BETA_2 domain-containing protein. (367 aa)
TMEM39BTransmembrane protein 39B. (495 aa)
SCFD1Sec1 family domain containing 1; Belongs to the STXBP/unc-18/SEC1 family. (664 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1354 aa)
BAG3BCL2 associated athanogene 3. (572 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (398 aa)
OPTNOptineurin. (576 aa)
FYCO1FYVE and coiled-coil domain containing 1. (1440 aa)
RAB3GAP2RAB3 GTPase activating non-catalytic protein subunit 2. (1314 aa)
ATG2AAutophagy related 2A. (1904 aa)
SLC25A5Solute carrier family 25 member 5; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
SNX4Sorting nexin 4. (403 aa)
SMCR8SMCR8-C9orf72 complex subunit. (936 aa)
C9orf72C9orf72-SMCR8 complex subunit. (481 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (265 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1345 aa)
VPS13DVacuolar protein sorting 13 homolog D. (4228 aa)
USP36Ubiquitin specific peptidase 36; Belongs to the peptidase C19 family. (1102 aa)
TBK1TANK binding kinase 1. (729 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (832 aa)
GNAI3Guanine nucleotide-binding protein G(i) subunit alpha; Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modul [...] (354 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
SNX30Sorting nexin family member 30. (493 aa)
Nrbp2Uncharacterized protein. (258 aa)
SMG1SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3632 aa)
USP30Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (517 aa)
UBQLN2Ubiquilin 2. (624 aa)
SESN1Sestrin 1. (564 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (446 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1188 aa)
SPTLC1Serine palmitoyltransferase long chain base subunit 1. (461 aa)
WDR24WD repeat domain 24. (790 aa)
PINK1PTEN induced kinase 1. (574 aa)
PIP4K2CPhosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (419 aa)
LOC100728392Interferon-gamma-inducible GTPase IFGGD1 protein. (398 aa)
GPSM1G protein signaling modulator 1. (706 aa)
TRIM13Tripartite motif containing 13. (407 aa)
H0VXJ2_CAVPOUncharacterized protein. (240 aa)
Rnf31Uncharacterized protein. (1072 aa)
SESN3Sestrin 3. (414 aa)
CALCOCO2Calcium binding and coiled-coil domain 2. (443 aa)
ADRB2Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. (418 aa)
RAB12RAB12, member RAS oncogene family. (210 aa)
HMOX1Heme oxygenase 1. (297 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (782 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (416 aa)
TMEM39ATransmembrane protein 39A. (488 aa)
PHF23PHD finger protein 23. (350 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (987 aa)
RNF41Ring finger protein 41. (317 aa)
SUPT5HTranscription elongation factor SPT5. (1087 aa)
Pafah1b2SGNH_hydro domain-containing protein. (202 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (873 aa)
HTTHuntingtin. (3133 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (90 aa)
ENSCPOP00000023749Uncharacterized protein. (244 aa)
TECPR1Tectonin beta-propeller repeat containing 1. (1166 aa)
BNIP3LBCL2 interacting protein 3 like. (214 aa)
SH3GLB1SH3 domain containing GRB2 like, endophilin B1. (394 aa)
SNX7Sorting nexin 7. (470 aa)
EPM2AEPM2A glucan phosphatase, laforin. (193 aa)
DCNDecorin; May affect the rate of fibrils formation. (361 aa)
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1173 aa)
LZTS1Leucine zipper tumor suppressor 1. (606 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1018 aa)
VPS13CVacuolar protein sorting 13 homolog C. (2875 aa)
SESN2Sestrin 2. (480 aa)
SIRT1Sirtuin 1. (717 aa)
ATG14Autophagy related 14. (492 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (562 aa)
RUBCNRubicon autophagy regulator. (954 aa)
QSOX1Sulfhydryl oxidase 1; Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. Plays a role in disulfide bond formation in a variety of extracellular proteins. In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration. (613 aa)
UBQLN4Ubiquilin 4. (593 aa)
POLDIP2DNA polymerase delta interacting protein 2. (368 aa)
FEZ1Fasciculation and elongation protein zeta 1. (403 aa)
TSC2TSC complex subunit 2. (1745 aa)
LARP1La ribonucleoprotein domain family member 1. (954 aa)
TBC1D25TBC1 domain family member 25. (716 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
TSC1TSC complex subunit 1. (1166 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (828 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (362 aa)
PIM2Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (370 aa)
NPC1NPC intracellular cholesterol transporter 1. (1277 aa)
RIPK2Receptor interacting serine/threonine kinase 2. (442 aa)
MTM1Myotubularin 1. (599 aa)
BECN1Beclin 1. (448 aa)
Il4Interleukin-4. (144 aa)
CLEC16AC-type lectin domain containing 16A. (1049 aa)
Wdr45Uncharacterized protein. (360 aa)
STING1Transmembrane protein 173. (379 aa)
HSPB8Heat shock protein family B (small) member 8; Belongs to the small heat shock protein (HSP20) family. (196 aa)
KIAA1324KIAA1324. (1014 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (423 aa)
BNIP3BCL2 interacting protein 3. (194 aa)
ENSCPOP00000029147Uncharacterized protein. (272 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1291 aa)
Vdac1Uncharacterized protein. (283 aa)
SNX18Sorting nexin. (607 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1037 aa)
LOC100729512IRG-type G domain-containing protein. (418 aa)
ENSCPOP00000027535Uncharacterized protein. (148 aa)
LRSAM1Leucine rich repeat and sterile alpha motif containing 1. (727 aa)
SEC22BSEC22 homolog B, vesicle trafficking protein (gene/pseudogene); Belongs to the synaptobrevin family. (215 aa)
Cln3Battenin. (438 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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