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AADAC AADAC LPL LPL PNPLA1 PNPLA1 LIPC LIPC SMPD2 SMPD2 PNLIPRP2 PNLIPRP2 CEL CEL PLCG2 PLCG2 SMPD1 SMPD1 PLAAT2 PLAAT2 ABHD3 ABHD3 GPLD1 GPLD1 NAPEPLD NAPEPLD LIPA LIPA ABHD4 ABHD4 PLCD1 PLCD1 PNPLA7 PNPLA7 PNPLA4 PNPLA4 PLA2G2A PLA2G2A LOC100730472 LOC100730472 PLA2G1B PLA2G1B PLA2G5 PLA2G5 PITPNM3 PITPNM3 PRDX6 PRDX6 SMPD3 SMPD3 LOC100721835 LOC100721835 LYPLA2 LYPLA2 ENSCPOP00000029947 ENSCPOP00000029947 PLA2G2F PLA2G2F SMPD4 SMPD4 PLCB2 PLCB2 PLCB4 PLCB4 ENSCPOP00000028852 ENSCPOP00000028852 LIPI LIPI ENPP2 ENPP2 PLBD2 PLBD2 PLCH2 PLCH2 MGLL MGLL DDHD1 DDHD1 ENSCPOP00000024925 ENSCPOP00000024925 PROCA1 PROCA1 PLA2G7 PLA2G7 ABHD2 ABHD2 PLD6 PLD6 ABHD6 ABHD6 LOC100716398 LOC100716398 PLCB1 PLCB1 TM7SF3 TM7SF3 ABHD12B ABHD12B DDHD2 DDHD2 ABHD16B ABHD16B LIPH LIPH PLA2G4E PLA2G4E PNLIP PNLIP DAGLA DAGLA LDAH LDAH NOTUM NOTUM PLA2G3 PLA2G3 PLCL1 PLCL1 FAAH FAAH PNPLA6 PNPLA6 PLB1 PLB1 ABHD16A ABHD16A Ces1d Ces1d PLD1 PLD1 PLA2G2E PLA2G2E PLCE1 PLCE1 OC90 OC90 PNPLA5 PNPLA5 LIPG LIPG PLAAT1 PLAAT1 PLA2G2D PLA2G2D SMPDL3B SMPDL3B DAGLB DAGLB PLCL2 PLCL2 H0V9U3_CAVPO H0V9U3_CAVPO H0V9I2_CAVPO H0V9I2_CAVPO PLCD3 PLCD3 PLA1A PLA1A PLCZ1 PLCZ1 PLA2G4F PLA2G4F PLA2G4D PLA2G4D PLD2 PLD2 PNPLA2 PNPLA2 SEC23IP SEC23IP LOC100717473 LOC100717473 PNPLA8 PNPLA8 PLBD1 PLBD1 PLA2G4A PLA2G4A GDPD1 GDPD1 GDE1 GDE1 LIPE LIPE ABHD1 ABHD1 PLA2G2C PLA2G2C PLA2G6 PLA2G6 PLCB3 PLCB3 PLCH1 PLCH1 PLAAT3 PLAAT3 LOC100714893 LOC100714893 GDPD3 GDPD3 HMOX1 HMOX1 H0W8W0_CAVPO H0W8W0_CAVPO PLA2G15 PLA2G15 LCAT LCAT LYPLA1 LYPLA1 ABHD15 ABHD15 Tmem8b Tmem8b ASPG ASPG PNPLA3 PNPLA3 PLCG1 PLCG1 PLA2G10 PLA2G10 H0VU94_CAVPO H0VU94_CAVPO PLA2G12B PLA2G12B LOC106024982 LOC106024982 PLCD4 PLCD4 PLA2G12A PLA2G12A ABHD12 ABHD12
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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AADACArylacetamide deacetylase. (353 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (495 aa)
PNPLA1Patatin like phospholipase domain containing 1. (554 aa)
LIPCLipase C, hepatic type. (497 aa)
SMPD2Sphingomyelin phosphodiesterase 2. (430 aa)
PNLIPRP2Pancreatic lipase-related protein 2; Lipase with broad substrate specificity. Can hydrolyze both phospholipids and galactolipids. Acts preferentially on monoglycerides, phospholipids and galactolipids. Contributes to milk fat hydrolysis (By similarity); Belongs to the AB hydrolase superfamily. Lipase family. (451 aa)
CELCarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (594 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1270 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (627 aa)
PLAAT2Phospholipase A and acyltransferase 2. (167 aa)
ABHD3Abhydrolase domain containing 3. (438 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (839 aa)
NAPEPLDN-acyl phosphatidylethanolamine phospholipase D. (395 aa)
LIPALipase; Belongs to the AB hydrolase superfamily. Lipase family. (399 aa)
ABHD4Abhydrolase domain containing 4. (335 aa)
PLCD1Phosphoinositide phospholipase C. (755 aa)
PNPLA7Patatin like phospholipase domain containing 7. (1341 aa)
PNPLA4Patatin like phospholipase domain containing 4. (253 aa)
PLA2G2APhospholipase A2, membrane associated; Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Independent of its catalytic activity, acts as a ligand for integrins. Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1. Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1. Induces cell proliferat [...] (145 aa)
LOC100730472Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (559 aa)
PLA2G1BPhospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules; Belongs to the phospholipase A2 family. (146 aa)
PLA2G5Phospholipase A(2). (138 aa)
PITPNM3PITPNM family member 3. (1015 aa)
PRDX6Peroxiredoxin 6. (224 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (656 aa)
LOC100721835Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (565 aa)
LYPLA2Lysophospholipase 2. (231 aa)
ENSCPOP00000029947Phospholipase A(2). (146 aa)
PLA2G2FPhospholipase A(2). (214 aa)
SMPD4Sphingomyelin phosphodiesterase 4. (823 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
ENSCPOP00000028852Phospholipase A(2). (146 aa)
LIPILipase I. (474 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase 2. (857 aa)
PLBD2Phospholipase B-like; Putative phospholipase. (624 aa)
PLCH2Phosphoinositide phospholipase C. (1461 aa)
MGLLMonoglyceride lipase. (314 aa)
DDHD1DDHD domain containing 1. (826 aa)
ENSCPOP00000024925COesterase domain-containing protein. (295 aa)
PROCA1Protein interacting with cyclin A1. (384 aa)
PLA2G7Platelet-activating factor acetylhydrolase; Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids; Belongs to the AB hydrolase superfamily. Lipase family. (436 aa)
ABHD2Abhydrolase domain containing 2. (425 aa)
PLD6Phospholipase D family member 6. (225 aa)
ABHD6Abhydrolase domain containing 6. (337 aa)
LOC100716398G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (392 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1217 aa)
TM7SF3Transmembrane 7 superfamily member 3. (570 aa)
ABHD12BAbhydrolase domain containing 12B. (328 aa)
DDHD2DDHD domain containing 2. (668 aa)
ABHD16BAbhydrolase domain containing 16B. (466 aa)
LIPHLipase H. (497 aa)
PLA2G4EPhospholipase A2. (805 aa)
PNLIPPancreatic triacylglycerol lipase. (428 aa)
DAGLADiacylglycerol lipase alpha. (1037 aa)
LDAHLipid droplet associated hydrolase. (341 aa)
NOTUMNotum, palmitoleoyl-protein carboxylesterase. (500 aa)
PLA2G3Phospholipase A2 group III. (645 aa)
PLCL1Phosphoinositide phospholipase C. (1011 aa)
FAAHFatty acid amide hydrolase. (579 aa)
PNPLA6Patatin like phospholipase domain containing 6. (1334 aa)
PLB1Phospholipase B1, membrane-associated; Membrane-associated phospholipase. Exhibits a calcium- independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional specificity toward triacylglycerol. Exhibits also esterase activity toward p-nitrophenyl. May act on the brush border membrane to facilitate the absorption of digested lipids (By similarity). Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily. (1453 aa)
ABHD16AAbhydrolase domain containing 16A. (558 aa)
Ces1dCarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (565 aa)
PLD1Phospholipase. (1064 aa)
PLA2G2EPhospholipase A(2). (152 aa)
PLCE1Phosphoinositide phospholipase C. (2282 aa)
OC90Otoconin-90; Major protein of the otoconia, a calcium carbonate structure in the saccule and utricle of the ear. Together with OTOL1, acts as a scaffold for otoconia biomineralization: sequesters calcium and forms interconnecting fibrils between otoconia that are incorporated into the calcium crystal structure. Together with OTOL1, modulates calcite crystal morphology and growth kinetics. It is unlikely that this protein has phospholipase A2 activity. (647 aa)
PNPLA5Patatin like phospholipase domain containing 5. (384 aa)
LIPGLipase G, endothelial type. (498 aa)
PLAAT1Phospholipase A and acyltransferase 1. (168 aa)
PLA2G2DPhospholipase A(2). (159 aa)
SMPDL3BAcid sphingomyelinase-like phosphodiesterase. (457 aa)
DAGLBDiacylglycerol lipase beta. (672 aa)
PLCL2Phosphoinositide phospholipase C. (1009 aa)
H0V9U3_CAVPOPhospholipase A(2). (146 aa)
H0V9I2_CAVPOUncharacterized protein. (238 aa)
PLCD3Phosphoinositide phospholipase C. (785 aa)
PLA1APhospholipase A1 member A. (457 aa)
PLCZ1Phosphoinositide phospholipase C. (601 aa)
PLA2G4FPhospholipase A2. (842 aa)
PLA2G4DPhospholipase A2. (790 aa)
PLD2Phospholipase. (936 aa)
PNPLA2Patatin like phospholipase domain containing 2. (486 aa)
SEC23IPSEC23 interacting protein. (994 aa)
LOC100717473Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (561 aa)
PNPLA8Patatin like phospholipase domain containing 8. (781 aa)
PLBD1Phospholipase B-like; Putative phospholipase. (559 aa)
PLA2G4APhospholipase A2. (749 aa)
GDPD1Glycerophosphodiester phosphodiesterase domain containing 1. (314 aa)
GDE1Glycerophosphodiester phosphodiesterase 1. (331 aa)
LIPELipase E, hormone sensitive type. (802 aa)
ABHD1Abhydrolase domain containing 1. (438 aa)
PLA2G2CPhospholipase A(2). (161 aa)
PLA2G6Phospholipase A2 group VI. (803 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1227 aa)
PLCH1Phosphoinositide phospholipase C. (1665 aa)
PLAAT3Phospholipase A and acyltransferase 3. (162 aa)
LOC100714893Uncharacterized protein. (302 aa)
GDPD3Glycerophosphodiester phosphodiesterase domain containing 3. (303 aa)
HMOX1Heme oxygenase 1. (297 aa)
H0W8W0_CAVPOG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (377 aa)
PLA2G15Phospholipase A2 group XV. (412 aa)
LCATLecithin-cholesterol acyltransferase. (441 aa)
LYPLA1Lysophospholipase 1. (196 aa)
ABHD15Abhydrolase domain containing 15. (462 aa)
Tmem8bUncharacterized protein. (890 aa)
ASPGAsparaginase. (565 aa)
PNPLA3Patatin like phospholipase domain containing 3. (405 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1235 aa)
PLA2G10Phospholipase A(2). (152 aa)
H0VU94_CAVPOCarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (520 aa)
PLA2G12BPhospholipase A2 group XIIB. (195 aa)
LOC106024982Phospholipase A2. (795 aa)
PLCD4Phosphoinositide phospholipase C. (762 aa)
PLA2G12APhospholipase A2 group XIIA. (195 aa)
ABHD12Abhydrolase domain containing 12. (397 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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