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NRP1 NRP1 PLXNA3 PLXNA3 ECE1 ECE1 ILK ILK TBX1 TBX1 COL25A1 COL25A1 EXT1 EXT1 LOC100730761 LOC100730761 CHD7 CHD7 PLXNA4 PLXNA4 RET RET ACKR3 ACKR3 H0VQQ2_CAVPO H0VQQ2_CAVPO PHOX2A PHOX2A ERBB3 ERBB3 GABRB2 GABRB2 UNC13A UNC13A PHOX2B PHOX2B NTF4 NTF4 NAV2 NAV2 Mnx1 Mnx1 NTF3 NTF3 ADARB1 ADARB1 HOXB1 HOXB1 H0W5D5_CAVPO H0W5D5_CAVPO POU4F3 POU4F3 NEUROG1 NEUROG1 H0WDW8_CAVPO H0WDW8_CAVPO PAX2 PAX2 HES1 HES1 HOXA1 HOXA1 UNC13B UNC13B SIX4 SIX4 MAFB MAFB NRTN NRTN LPAR1 LPAR1 PRKCG PRKCG SULF2 SULF2 NRP2 NRP2 SERPINE2 SERPINE2 HOXD3 HOXD3 EGR2 EGR2 GLI3 GLI3 SULF1 SULF1 FGFR3 FGFR3 DAG1 DAG1 ENSCPOP00000026472 ENSCPOP00000026472 HOXB2 HOXB2 HOXA3 HOXA3 AFG3L2 AFG3L2 SIX1 SIX1 NPTX1 NPTX1 KCNA2 KCNA2 EDN1 EDN1 RPL24 RPL24 Chrnb2 Chrnb2 TCIRG1 TCIRG1 TMEM126A TMEM126A ENSCPOP00000032677 ENSCPOP00000032677 FBXO45 FBXO45 CTNNB1 CTNNB1 RNF165 RNF165 CTSV CTSV DMD DMD EPHB2 EPHB2 SEMA3F SEMA3F SLC1A3 SLC1A3 LRIG2 LRIG2 VCAM1 VCAM1 SALL1 SALL1 ATP8B1 ATP8B1 ISL1 ISL1 GABRB3 GABRB3 EDNRA EDNRA DICER1 DICER1 GABRA5 GABRA5 SEMA3A SEMA3A CITED2 CITED2 NTRK1 NTRK1 LRIG1 LRIG1 EPHB1 EPHB1 VAX1 VAX1 SLC25A46 SLC25A46 TFAP2A TFAP2A ITGA4 ITGA4 SLC24A4 SLC24A4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NRP1Neuropilin; Belongs to the neuropilin family. (925 aa)
PLXNA3Plexin A3. (1872 aa)
ECE1Endothelin-converting enzyme 1; Converts big endothelin-1 to endothelin-1; Belongs to the peptidase M13 family. (771 aa)
ILKIntegrin-linked protein kinase; Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. (452 aa)
TBX1T-box transcription factor 1. (360 aa)
COL25A1Collagen type XXV alpha 1 chain. (664 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
LOC100730761Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (418 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2996 aa)
PLXNA4Plexin A4. (1893 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1114 aa)
ACKR3Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (362 aa)
H0VQQ2_CAVPOCyclic nucleotide-binding domain-containing protein. (852 aa)
PHOX2APaired like homeobox 2A. (285 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1336 aa)
GABRB2Gamma-aminobutyric acid type A receptor beta2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (512 aa)
UNC13AUnc-13 homolog A. (1650 aa)
PHOX2BPaired like homeobox 2B. (284 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (215 aa)
NAV2Neuron navigator 2. (2385 aa)
Mnx1Homeobox domain-containing protein. (233 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
ADARB1Adenosine deaminase RNA specific B1. (603 aa)
HOXB1Homeobox B1. (301 aa)
H0W5D5_CAVPODUF4074 domain-containing protein. (324 aa)
POU4F3POU domain protein. (338 aa)
NEUROG1Neurogenin 1. (241 aa)
H0WDW8_CAVPOTRASH domain-containing protein. (156 aa)
PAX2Paired box 2. (393 aa)
HES1Hes family bHLH transcription factor 1. (279 aa)
HOXA1Homeobox A1. (333 aa)
UNC13BUnc-13 homolog B. (1959 aa)
SIX4SIX homeobox 4. (766 aa)
MAFBMAF bZIP transcription factor B. (326 aa)
NRTNNeurturin. (197 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa)
SULF2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (872 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (926 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (397 aa)
HOXD3Homeobox D3. (432 aa)
EGR2Early growth response 2. (473 aa)
GLI3GLI family zinc finger 3. (1580 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (869 aa)
FGFR3Fibroblast growth factor receptor. (801 aa)
DAG1Dystroglycan 1. (891 aa)
ENSCPOP00000026472Uncharacterized protein. (286 aa)
HOXB2Homeobox B2. (360 aa)
HOXA3Homeobox A3. (444 aa)
AFG3L2AFG3 like matrix AAA peptidase subunit 2. (809 aa)
SIX1SIX homeobox 1. (284 aa)
NPTX1Neuronal pentraxin 1. (432 aa)
KCNA2Potassium voltage-gated channel subfamily A member 2; Belongs to the potassium channel family. (499 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (208 aa)
RPL24TRASH domain-containing protein. (157 aa)
Chrnb2Uncharacterized protein. (499 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
TMEM126ATransmembrane protein 126A. (195 aa)
ENSCPOP00000032677Eph LBD domain-containing protein. (286 aa)
FBXO45F-box protein 45. (283 aa)
CTNNB1Catenin beta 1. (781 aa)
RNF165Ring finger protein 165. (336 aa)
CTSVCathepsin V; Belongs to the peptidase C1 family. (333 aa)
DMDDystrophin. (3613 aa)
EPHB2EPH receptor B2. (949 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (785 aa)
SLC1A3Amino acid transporter. (542 aa)
LRIG2Leucine rich repeats and immunoglobulin like domains 2. (1063 aa)
VCAM1Vascular cell adhesion molecule 1. (732 aa)
SALL1Spalt like transcription factor 1. (1287 aa)
ATP8B1Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1146 aa)
ISL1ISL LIM homeobox 1. (349 aa)
GABRB3Gamma-aminobutyric acid type A receptor beta3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (441 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (399 aa)
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1903 aa)
GABRA5Gamma-aminobutyric acid type A receptor alpha5 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (462 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (772 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (269 aa)
NTRK1Tyrosine-protein kinase receptor. (798 aa)
LRIG1Leucine rich repeats and immunoglobulin like domains 1. (1089 aa)
EPHB1EPH receptor B1. (736 aa)
VAX1Ventral anterior homeobox 1. (321 aa)
SLC25A46Solute carrier family 25 member 46; Belongs to the mitochondrial carrier (TC 2.A.29) family. (382 aa)
TFAP2ATranscription factor AP-2 alpha. (437 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1021 aa)
SLC24A4Solute carrier family 24 member 4; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (605 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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