STRINGSTRING
H0V3F2_CAVPO H0V3F2_CAVPO NR2E1 NR2E1 TFAP2A TFAP2A GBA2 GBA2 DCX DCX LHX8 LHX8 PTK2 PTK2 EPHB3 EPHB3 TCTN1 TCTN1 Hsp90aa1 Hsp90aa1 DCC DCC EPHB1 EPHB1 LINGO1 LINGO1 ZMIZ1 ZMIZ1 HPRT1 HPRT1 FGF8 FGF8 ARX ARX GBX2 GBX2 PHOX2B PHOX2B SCYL2 SCYL2 SECISBP2 SECISBP2 DRAXIN DRAXIN AGBL4 AGBL4 RAC3 RAC3 LRRC45 LRRC45 PLXNA4 PLXNA4 B4GALT5 B4GALT5 ARHGAP35 ARHGAP35 DISC1 DISC1 LOC100730761 LOC100730761 NDEL1 NDEL1 SLC4A10 SLC4A10 TAOK1 TAOK1 SEMA3E SEMA3E CNTN2 CNTN2 PLXNA3 PLXNA3 EPHA4 EPHA4 EPHB2 EPHB2 LHX6 LHX6 GATA2 GATA2 NDNF NDNF DRD2 DRD2 SPTBN4 SPTBN4 NRP1 NRP1 NR4A2 NR4A2 FGFR1 FGFR1 NIN NIN SZT2 SZT2 EPHB6 EPHB6 DCLK1 DCLK1 H0V3A7_CAVPO H0V3A7_CAVPO ZEB2 ZEB2 NFIB NFIB HSP90AB1 HSP90AB1 SEMA3A SEMA3A MPP5 MPP5 MYCBP2 MYCBP2 PRDM8 PRDM8 ADARB1 ADARB1 NHLH2 NHLH2 UQCRQ UQCRQ ATP7A ATP7A NPY NPY AGTPBP1 AGTPBP1 LOC100725331 LOC100725331 PTEN PTEN H0W837_CAVPO H0W837_CAVPO H0UZN0_CAVPO H0UZN0_CAVPO ASCL1 ASCL1 Cdh11 Cdh11 TTC36 TTC36 LOC100716924 LOC100716924 SCN1B SCN1B C12orf57 C12orf57 NTRK2 NTRK2 GABRB1 GABRB1 PAFAH1B1 PAFAH1B1 RAC1 RAC1 LOC100725824 LOC100725824 SLIT2 SLIT2 BTG2 BTG2 ATG7 ATG7 TSKU TSKU B4GALT6 B4GALT6 GLI2 GLI2 NRP2 NRP2 DRD1 DRD1 DCLK2 DCLK2 FGFR2 FGFR2 Map2 Map2 FEZF2 FEZF2 LEP LEP ARHGEF28 ARHGEF28 UBB UBB Chrnb2 Chrnb2 Rapgef2 Rapgef2 KIFBP KIFBP CDK5 CDK5 ENSCPOP00000032677 ENSCPOP00000032677 FBXO45 FBXO45
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
H0V3F2_CAVPOUncharacterized protein. (1365 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (389 aa)
TFAP2ATranscription factor AP-2 alpha. (437 aa)
GBA2Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (908 aa)
DCXDoublecortin. (366 aa)
LHX8LIM homeobox 8. (337 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1084 aa)
EPHB3EPH receptor B3. (1011 aa)
TCTN1Tectonic family member 1. (590 aa)
Hsp90aa1Heat shock protein 90 alpha family class A member 1. (733 aa)
DCCDCC netrin 1 receptor. (991 aa)
EPHB1EPH receptor B1. (736 aa)
LINGO1Leucine rich repeat and Ig domain containing 1. (620 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1068 aa)
HPRT1Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (218 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (308 aa)
ARXAristaless related homeobox. (418 aa)
GBX2Gastrulation brain homeobox 2. (338 aa)
PHOX2BPaired like homeobox 2B. (284 aa)
SCYL2SCY1 like pseudokinase 2. (888 aa)
SECISBP2SECIS binding protein 2. (854 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (335 aa)
AGBL4ATP/GTP binding protein like 4. (540 aa)
RAC3Rac family small GTPase 3. (192 aa)
LRRC45Leucine rich repeat containing 45. (669 aa)
PLXNA4Plexin A4. (1893 aa)
B4GALT5Beta-1,4-galactosyltransferase 5. (349 aa)
ARHGAP35Rho GTPase activating protein 35. (1500 aa)
DISC1DISC1 scaffold protein. (775 aa)
LOC100730761Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (418 aa)
NDEL1NudE neurodevelopment protein 1 like 1. (345 aa)
SLC4A10Anion exchange protein. (1118 aa)
TAOK1TAO kinase 1. (963 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (648 aa)
CNTN2Contactin 2. (1041 aa)
PLXNA3Plexin A3. (1872 aa)
EPHA4EPH receptor A4. (986 aa)
EPHB2EPH receptor B2. (949 aa)
LHX6LIM homeobox 6. (364 aa)
GATA2GATA binding protein 2. (374 aa)
NDNFNeuron derived neurotrophic factor. (568 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (446 aa)
SPTBN4Spectrin beta chain; Belongs to the spectrin family. (2530 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (925 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
FGFR1Fibroblast growth factor receptor. (822 aa)
NINNinein. (2132 aa)
SZT2SZT2 subunit of KICSTOR complex. (3427 aa)
EPHB6EPH receptor B6. (1015 aa)
DCLK1Doublecortin like kinase 1. (740 aa)
H0V3A7_CAVPOUncharacterized protein. (1320 aa)
ZEB2Zinc finger E-box binding homeobox 2. (1253 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (494 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (723 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (772 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (675 aa)
MYCBP2MYC binding protein 2. (4627 aa)
PRDM8PR/SET domain 8. (515 aa)
ADARB1Adenosine deaminase RNA specific B1. (603 aa)
NHLH2Nescient helix-loop-helix 2. (135 aa)
UQCRQUbiquinol-cytochrome c reductase complex III subunit VII. (82 aa)
ATP7AATPase copper transporting alpha. (1433 aa)
NPYNeuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. (97 aa)
AGTPBP1ATP/GTP binding protein 1. (1160 aa)
LOC100725331Uncharacterized protein. (1433 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (355 aa)
H0W837_CAVPOUncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (670 aa)
H0UZN0_CAVPOUncharacterized protein. (763 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (215 aa)
Cdh11Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (796 aa)
TTC36Tetratricopeptide repeat domain 36. (188 aa)
LOC100716924Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (796 aa)
SCN1BSodium voltage-gated channel beta subunit 1. (216 aa)
C12orf57Chromosome 12 open reading frame 57. (126 aa)
NTRK2Tyrosine-protein kinase receptor. (816 aa)
GABRB1Gamma-aminobutyric acid type A receptor beta1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (419 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (211 aa)
LOC100725824HATPase_c domain-containing protein. (695 aa)
SLIT2Slit guidance ligand 2. (1391 aa)
BTG2BTG anti-proliferation factor 2. (158 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (699 aa)
TSKUTsukushi, small leucine rich proteoglycan. (364 aa)
B4GALT6Beta-1,4-galactosyltransferase 6. (382 aa)
GLI2GLI family zinc finger 2. (1570 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (926 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (444 aa)
DCLK2Doublecortin like kinase 2. (756 aa)
FGFR2Fibroblast growth factor receptor. (801 aa)
Map2Microtubule-associated protein. (559 aa)
FEZF2FEZ family zinc finger 2. (461 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (165 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28. (1745 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
Chrnb2Uncharacterized protein. (499 aa)
Rapgef2Uncharacterized protein. (1640 aa)
KIFBPKIF1 binding protein. (621 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
ENSCPOP00000032677Eph LBD domain-containing protein. (286 aa)
FBXO45F-box protein 45. (283 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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