STRINGSTRING
CD274 CD274 Il12a Il12a FUT4 FUT4 AP3B1 AP3B1 AGER AGER KIF26B KIF26B TGFB1 TGFB1 SASH3 SASH3 H0UW27_CAVPO H0UW27_CAVPO CD3E CD3E IL12B IL12B BLM BLM IL1B IL1B AIF1 AIF1 MAGI1 MAGI1 ZMIZ1 ZMIZ1 Dhps Dhps TNF TNF PAWR PAWR CCL19 CCL19 LOC100716469 LOC100716469 TESPA1 TESPA1 Slamf1 Slamf1 PIK3R6 PIK3R6 RASAL3 RASAL3 Vsir Vsir IL18 IL18 H0V0Q7_CAVPO H0V0Q7_CAVPO CITED2 CITED2 FGA FGA H0V169_CAVPO H0V169_CAVPO CARD11 CARD11 CAPN1 CAPN1 BTNL2 BTNL2 AP3D1 AP3D1 TYK2 TYK2 ADK ADK TRAF6 TRAF6 ZAP70 ZAP70 IL4I1 IL4I1 EPHB6 EPHB6 MMRN1 MMRN1 SLC7A1 SLC7A1 Bad Bad IL2RA IL2RA ABL1 ABL1 ST3GAL4 ST3GAL4 JAK1 JAK1 ADA ADA DMTN DMTN RIPK2 RIPK2 H0V7S4_CAVPO H0V7S4_CAVPO PCK1 PCK1 SOX13 SOX13 VCAM1 VCAM1 SELP SELP FOXP3 FOXP3 ITGAL ITGAL MDK MDK FSTL3 FSTL3 ADAM19 ADAM19 XBP1 XBP1 FGG FGG IL15 IL15 MEX3B MEX3B IL2 IL2 DNAJA3 DNAJA3 GATA3 GATA3 NCKAP1L NCKAP1L FGB FGB Tnfrsf14 Tnfrsf14 ITGA4 ITGA4 NFKBIZ NFKBIZ PPP3CA PPP3CA CYLD CYLD Kifap3 Kifap3 CD81 CD81 SYK SYK FCHO1 FCHO1 CARMIL2 CARMIL2 H0VHS7_CAVPO H0VHS7_CAVPO TJP1 TJP1 PLAUR PLAUR Ccr2 Ccr2 FADD FADD CDH1 CDH1 VNN1 VNN1 LOC100716811 LOC100716811 THY1 THY1 HLA-DRA HLA-DRA Cd4 Cd4 LOC100733338 LOC100733338 SELE SELE NFAT5 NFAT5 IL21 IL21 MALT1 MALT1 HLA-DOA HLA-DOA ABL2 ABL2 DUSP10 DUSP10 IL6ST IL6ST ITPKB ITPKB IL27RA IL27RA NFKBID NFKBID CD1D CD1D ANXA1 ANXA1 MYB MYB JAK2 JAK2 IL23A IL23A FLOT2 FLOT2 ADAM8 ADAM8 GPAM GPAM NODAL NODAL NCK2 NCK2 SART1 SART1 Stat5b Stat5b CD5 CD5 SLC4A1 SLC4A1 RELA RELA F11R F11R HSPD1 HSPD1 IGFBP2 IGFBP2 Shb Shb LOC100714501 LOC100714501 EFNB3 EFNB3 CHST4 CHST4 LOC100719905 LOC100719905 Foxo3 Foxo3 SPTA1 SPTA1 GCNT1 GCNT1 CCDC88B CCDC88B Sox4 Sox4 SOCS1 SOCS1 MFSD2B MFSD2B RAG1 RAG1 Zp3 Zp3 SKAP1 SKAP1 Ceacam1 Ceacam1 Plpp3 Plpp3 CHST2 CHST2 PTPN23 PTPN23 HLX HLX IL12RB1 IL12RB1 ZBTB7B ZBTB7B RUNX1 RUNX1 LOC100730653 LOC100730653 SOX12 SOX12 HAS2 HAS2 PDE4D PDE4D ENSCPOP00000021738 ENSCPOP00000021738 L1CAM L1CAM HES1 HES1 ZBTB16 ZBTB16 ALOX5 ALOX5 TBX18 TBX18 LOC100734419 LOC100734419 LOC100713671 LOC100713671 Pdpn Pdpn LOC100720894 LOC100720894 KAT5 KAT5 LOC101788125 LOC101788125 NCK1 NCK1 LOC100718520 LOC100718520 LOC100714756 LOC100714756 LOC100714780 LOC100714780 ZBTB1 ZBTB1 ENSCPOP00000023262 ENSCPOP00000023262 WNT5A WNT5A ENSCPOP00000023466 ENSCPOP00000023466 CD83 CD83 PYCARD PYCARD LEF1 LEF1 FLOT1 FLOT1 WNT3A WNT3A SMAD7 SMAD7 HLA-DQB1 HLA-DQB1 GLI3 GLI3 RAP1GAP RAP1GAP CD74 CD74 LOC100712719 LOC100712719 HLA-DMA HLA-DMA ITGA6 ITGA6 GCNT2 GCNT2 JAK3 JAK3 TGFBR2 TGFBR2 RHOH RHOH CD6 CD6 LOC100719246 LOC100719246 DENND6A DENND6A PRKCQ PRKCQ DPP4 DPP4 TFRC TFRC CD276 CD276 KITLG KITLG RARA RARA CAV1 CAV1 RNASE10 RNASE10 MYO10 MYO10 ENSCPOP00000027720 ENSCPOP00000027720 IL7R IL7R IGF2 IGF2 IL4R IL4R NR4A3 NR4A3 BCL6 BCL6 CX3CL1 CX3CL1 ENSCPOP00000028310 ENSCPOP00000028310 AFDN AFDN LOC100715615 LOC100715615 WNT10B WNT10B PTPRC PTPRC Rps3 Rps3 EFNB1 EFNB1 BMP7 BMP7 CD86 CD86 ETS1 ETS1 AMBRA1 AMBRA1 RASGRP1 RASGRP1 SOCS5 SOCS5 LEP LEP CD47 CD47 HLA-DOB HLA-DOB Il2rg Il2rg LOC100735392 LOC100735392 ENSCPOP00000029431 ENSCPOP00000029431 Sirpa Sirpa CORO1A CORO1A Selenok Selenok EGR3 EGR3 DOCK8 DOCK8 TNFSF4 TNFSF4 IL7 IL7 MEGF10 MEGF10 Ank3 Ank3 LGALS1 LGALS1 RUNX3 RUNX3 CD40LG CD40LG IHH IHH EPHB4 EPHB4 SHH SHH IL1RL2 IL1RL2 TNFSF14 TNFSF14 TNFSF13B TNFSF13B PTPRU PTPRU CD27 CD27 LOC100716672 LOC100716672 BCL10 BCL10 Cd244 Cd244 Il4 Il4 TNFSF11 TNFSF11 IGF1 IGF1 FUT7 FUT7 IRAK1 IRAK1 VTCN1 VTCN1 EMILIN2 EMILIN2 FAM49B FAM49B ICOS ICOS CCR7 CCR7 CD28 CD28 EFNB2 EFNB2 TNFRSF13C TNFRSF13C
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
CD274CD274 molecule. (289 aa)
Il12aInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (221 aa)
FUT4Fucosyltransferase 4. (519 aa)
AP3B1Adaptor related protein complex 3 subunit beta 1. (1276 aa)
AGERAdvanced glycosylation end-product specific receptor. (377 aa)
KIF26BKinesin family member 26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2100 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
SASH3SAM and SH3 domain containing 3. (380 aa)
H0UW27_CAVPOSCY domain-containing protein. (109 aa)
CD3ECD3e molecule. (194 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (332 aa)
BLMBLM RecQ like helicase. (1405 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
MAGI1Membrane associated guanylate kinase, WW and PDZ domain containing 1. (1181 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1068 aa)
DhpsUncharacterized protein. (369 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
PAWRPro-apoptotic WT1 regulator. (307 aa)
CCL19C-C motif chemokine. (107 aa)
LOC100716469Ig-like domain-containing protein. (259 aa)
TESPA1Thymocyte expressed, positive selection associated 1. (508 aa)
Slamf1Ig-like domain-containing protein. (293 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (763 aa)
RASAL3RAS protein activator like 3. (1024 aa)
VsirIg-like domain-containing protein. (312 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (189 aa)
H0V0Q7_CAVPOAIG1-type G domain-containing protein. (309 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (269 aa)
FGAFibrinogen alpha chain. (775 aa)
H0V169_CAVPOIg-like domain-containing protein. (224 aa)
CARD11Caspase recruitment domain family member 11. (1158 aa)
CAPN1Calpain 1; Belongs to the peptidase C2 family. (714 aa)
BTNL2Butyrophilin like 2. (484 aa)
AP3D1AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane. (1161 aa)
TYK2Tyrosine-protein kinase. (1174 aa)
ADKAdenosine kinase. (362 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (543 aa)
ZAP70Tyrosine-protein kinase. (551 aa)
IL4I1Amine oxidase. (546 aa)
EPHB6EPH receptor B6. (1015 aa)
MMRN1Multimerin 1. (1215 aa)
SLC7A1Solute carrier family 7 member 1. (629 aa)
BadUncharacterized protein. (166 aa)
IL2RAInterleukin 2 receptor subunit alpha. (268 aa)
ABL1Tyrosine-protein kinase. (1145 aa)
ST3GAL4ST3 beta-galactoside alpha-2,3-sialyltransferase 4; Belongs to the glycosyltransferase 29 family. (441 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
ADAAdenosine deaminase. (365 aa)
DMTNDematin actin binding protein. (371 aa)
RIPK2Receptor interacting serine/threonine kinase 2. (442 aa)
H0V7S4_CAVPOIg-like domain-containing protein. (205 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
SOX13SRY-box transcription factor 13. (617 aa)
VCAM1Vascular cell adhesion molecule 1. (732 aa)
SELPSelectin P. (768 aa)
FOXP3Forkhead box P3. (432 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1170 aa)
MDKMidkine. (143 aa)
FSTL3Follistatin like 3. (258 aa)
ADAM19ADAM metallopeptidase domain 19. (907 aa)
XBP1X-box binding protein 1. (268 aa)
FGGFibrinogen gamma chain. (445 aa)
IL15Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family. (162 aa)
MEX3BMex-3 RNA binding family member B. (534 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (152 aa)
DNAJA3DnaJ heat shock protein family (Hsp40) member A3. (479 aa)
GATA3GATA binding protein 3. (443 aa)
NCKAP1LNCK associated protein 1 like. (1111 aa)
FGBFibrinogen beta chain. (479 aa)
Tnfrsf14HVEM. (286 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1021 aa)
NFKBIZNFKB inhibitor zeta. (720 aa)
PPP3CASerine/threonine-protein phosphatase. (518 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
Kifap3Uncharacterized protein. (671 aa)
CD81Tetraspanin. (236 aa)
SYKTyrosine-protein kinase. (579 aa)
FCHO1FCH domain only 1. (892 aa)
CARMIL2Capping protein regulator and myosin 1 linker 2. (1372 aa)
H0VHS7_CAVPOUncharacterized protein. (85 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1754 aa)
PLAURPlasminogen activator, urokinase receptor. (309 aa)
Ccr2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (371 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (206 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (891 aa)
VNN1Vanin 1. (513 aa)
LOC100716811Signal transducer and activator of transcription. (795 aa)
THY1Thy-1 protein. (161 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
Cd4Uncharacterized protein. (523 aa)
LOC100733338Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (278 aa)
SELESelectin E. (586 aa)
NFAT5Nuclear factor of activated T cells 5. (1485 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (146 aa)
MALT1MALT1 paracaspase. (780 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (310 aa)
ABL2Tyrosine-protein kinase. (1157 aa)
DUSP10Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
IL6STInterleukin 6 signal transducer. (903 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (890 aa)
IL27RAInterleukin 27 receptor subunit alpha. (641 aa)
NFKBIDNFKB inhibitor delta. (327 aa)
CD1DIg-like domain-containing protein. (335 aa)
ANXA1Annexin. (346 aa)
MYBMYB proto-oncogene, transcription factor. (743 aa)
JAK2Tyrosine-protein kinase. (1035 aa)
IL23AInterleukin-23 subunit alpha; Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tu [...] (189 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
ADAM8ADAM metallopeptidase domain 8. (824 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (828 aa)
NODALNodal growth differentiation factor. (351 aa)
NCK2Cytoplasmic protein. (377 aa)
SART1Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (689 aa)
Stat5bSignal transducer and activator of transcription. (786 aa)
CD5CD5 molecule. (483 aa)
SLC4A1Anion exchange protein. (901 aa)
RELARELA proto-oncogene, NF-kB subunit. (549 aa)
F11RF11 receptor. (299 aa)
HSPD1Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (574 aa)
IGFBP2Insulin like growth factor binding protein 2. (262 aa)
ShbSH2 domain-containing protein. (479 aa)
LOC100714501Ig-like domain-containing protein. (257 aa)
EFNB3Ephrin B3; Belongs to the ephrin family. (340 aa)
CHST4Sulfotransferase; Belongs to the sulfotransferase 1 family. (383 aa)
LOC100719905Uncharacterized protein. (469 aa)
Foxo3Forkhead box O3. (660 aa)
SPTA1Spectrin alpha, erythrocytic 1. (2415 aa)
GCNT1Glucosaminyl (N-acetyl) transferase 1. (427 aa)
CCDC88BCoiled-coil domain containing 88B. (1503 aa)
Sox4HMG box domain-containing protein. (227 aa)
SOCS1Suppressor of cytokine signaling 1. (217 aa)
MFSD2BMajor facilitator superfamily domain containing 2B. (429 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
Zp3ZP domain-containing protein. (412 aa)
SKAP1Src kinase associated phosphoprotein 1. (365 aa)
Ceacam1Uncharacterized protein. (518 aa)
Plpp3acidPPc domain-containing protein. (312 aa)
CHST2Sulfotransferase; Belongs to the sulfotransferase 1 family. (531 aa)
PTPN23Protein tyrosine phosphatase non-receptor type 23. (1623 aa)
HLXH2.0 like homeobox. (442 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (714 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (543 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (465 aa)
LOC100730653Ig-like domain-containing protein. (300 aa)
SOX12Transcription factor SOX. (310 aa)
HAS2Hyaluronan synthase 2. (552 aa)
PDE4DPhosphodiesterase. (782 aa)
ENSCPOP00000021738RING-type domain-containing protein. (326 aa)
L1CAML1 cell adhesion molecule. (1255 aa)
HES1Hes family bHLH transcription factor 1. (279 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
TBX18T-box transcription factor 18. (606 aa)
LOC100734419Interleukin-1. (150 aa)
LOC100713671Ig-like domain-containing protein; Belongs to the MHC class II family. (306 aa)
PdpnUncharacterized protein. (158 aa)
LOC100720894Ig-like domain-containing protein. (264 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (541 aa)
LOC101788125Ig-like domain-containing protein. (178 aa)
NCK1Cytoplasmic protein. (377 aa)
LOC100718520Uncharacterized protein. (295 aa)
LOC100714756SCY domain-containing protein. (114 aa)
LOC100714780Ig-like domain-containing protein. (257 aa)
ZBTB1Zinc finger and BTB domain containing 1. (712 aa)
ENSCPOP00000023262Interleukin-1. (137 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ENSCPOP00000023466Ig-like domain-containing protein. (301 aa)
CD83CD83 molecule. (206 aa)
PYCARDPYD and CARD domain containing. (195 aa)
LEF1Lymphoid enhancer binding factor 1. (396 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (328 aa)
SMAD7SMAD family member 7. (221 aa)
HLA-DQB1Ig-like domain-containing protein. (270 aa)
GLI3GLI family zinc finger 3. (1580 aa)
RAP1GAPRAP1 GTPase activating protein. (744 aa)
CD74CD74 molecule. (280 aa)
LOC100712719Interleukin-1. (163 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (264 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1158 aa)
GCNT2Glucosaminyl (N-acetyl) transferase 2 (I blood group). (401 aa)
JAK3Tyrosine-protein kinase. (1078 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
RHOHRas homolog family member H. (191 aa)
CD6CD6 molecule. (670 aa)
LOC100719246Ig-like domain-containing protein. (267 aa)
DENND6ADENN domain containing 6A. (608 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (705 aa)
DPP4Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (764 aa)
TFRCTransferrin receptor protein 1. (765 aa)
CD276Uncharacterized protein. (628 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (271 aa)
RARARetinoic acid receptor alpha. (462 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
RNASE10Ribonuclease A family member 10 (inactive); Belongs to the pancreatic ribonuclease family. (256 aa)
MYO10Myosin X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2051 aa)
ENSCPOP00000027720Uncharacterized protein. (119 aa)
IL7RInterleukin 7 receptor. (461 aa)
IGF2Insulin-like growth factor II; The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is r [...] (237 aa)
IL4RInterleukin 4 receptor. (829 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (633 aa)
BCL6BCL6 transcription repressor. (705 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (396 aa)
ENSCPOP00000028310Uncharacterized protein. (85 aa)
AFDNAfadin, adherens junction formation factor. (1794 aa)
LOC100715615Ig-like domain-containing protein; Belongs to the MHC class II family. (268 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (390 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1307 aa)
Rps3KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (345 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
CD86CD86 molecule. (320 aa)
ETS1ETS proto-oncogene 1, transcription factor. (441 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1291 aa)
RASGRP1RAS guanyl releasing protein 1. (796 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (165 aa)
CD47CD47 molecule. (321 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (270 aa)
Il2rgFibronectin type-III domain-containing protein. (362 aa)
LOC100735392Ig-like domain-containing protein; Belongs to the MHC class II family. (255 aa)
ENSCPOP00000029431Uncharacterized protein. (111 aa)
SirpaIg-like domain-containing protein. (292 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
SelenokUncharacterized protein. (91 aa)
EGR3Early growth response 3. (388 aa)
DOCK8Dedicator of cytokinesis 8; Belongs to the DOCK family. (2074 aa)
TNFSF4Tumor necrosis factor ligand 2B; Belongs to the tumor necrosis factor family. (185 aa)
IL7Interleukin 7. (152 aa)
MEGF10Multiple EGF like domains 10. (1148 aa)
Ank3Uncharacterized protein. (1948 aa)
LGALS1Galectin. (135 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (430 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (260 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (409 aa)
EPHB4EPH receptor B4. (1280 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (447 aa)
IL1RL2Interleukin 1 receptor like 2. (578 aa)
TNFSF14TNF superfamily member 14; Belongs to the tumor necrosis factor family. (241 aa)
TNFSF13BTNF superfamily member 13b; Belongs to the tumor necrosis factor family. (272 aa)
PTPRUProtein tyrosine phosphatase receptor type U. (1504 aa)
CD27CD27 molecule. (233 aa)
LOC100716672G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (353 aa)
BCL10BCL10 immune signaling adaptor. (234 aa)
Cd244Ig-like domain-containing protein. (345 aa)
Il4Interleukin-4. (144 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (315 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (153 aa)
FUT7Fucosyltransferase 7. (342 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (707 aa)
VTCN1V-set domain containing T cell activation inhibitor 1. (282 aa)
EMILIN2Elastin microfibril interfacer 2. (1042 aa)
FAM49BFamily with sequence similarity 49 member B. (324 aa)
ICOSInducible T cell costimulator. (199 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (375 aa)
CD28CD28 molecule. (222 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (295 aa)
TNFRSF13CTNF receptor superfamily member 13C. (186 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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