STRINGSTRING
PAX6 PAX6 HOXD13 HOXD13 FGFR1 FGFR1 PAX3 PAX3 CUL3 CUL3 BTRC BTRC IGF1R IGF1R PDGFB PDGFB PLXND1 PLXND1 CAPN1 CAPN1 TBX3 TBX3 NFIB NFIB SEMA3A SEMA3A LRRC1 LRRC1 ETV4 ETV4 ESRP2 ESRP2 FRS2 FRS2 PTCH1 PTCH1 TNF TNF BSX BSX PML PML TGFB1 TGFB1 FGL1 FGL1 EGFR EGFR WNT4 WNT4 TWSG1 TWSG1 BAX BAX CDC42 CDC42 MSN MSN SHH SHH VDR VDR EPHA2 EPHA2 TET2 TET2 EDA EDA MED1 MED1 MSX2 MSX2 PTHLH PTHLH HOXA13 HOXA13 BMP7 BMP7 SOSTDC1 SOSTDC1 ELF3 ELF3 LRP6 LRP6 CAV1 CAV1 SCRIB SCRIB TP63 TP63 FGFR2 FGFR2 TGFB3 TGFB3 SFRP1 SFRP1 FGF7 FGF7 TGFBR2 TGFBR2 TBX2 TBX2 DAG1 DAG1 SLC9A3R1 SLC9A3R1 IGFBP5 IGFBP5 AREG AREG GLI3 GLI3 CYP7B1 CYP7B1 GLI2 GLI2 CCL11 CCL11 Pgr Pgr Selenoh Selenoh WNT5A WNT5A SLIT2 SLIT2 CTNND1 CTNND1 ESRP1 ESRP1 RPS6KA1 RPS6KA1 NOG NOG FGF10 FGF10 NKX3-1 NKX3-1 Csf1 Csf1 FEM1B FEM1B ENSCPOP00000022082 ENSCPOP00000022082 DDR1 DDR1 ARG1 ARG1 MMP2 MMP2 PHB2 PHB2 ESR2 ESR2 CEBPB CEBPB BCL2 BCL2 TNC TNC PROP1 PROP1 TGM2 TGM2 AR AR FGF8 FGF8 TFAP2C TFAP2C NR3C1 NR3C1 NOTCH2 NOTCH2 Rxfp1 Rxfp1 CSMD1 CSMD1 RARG RARG PLXNA1 PLXNA1 SLC12A2 SLC12A2 Serpinb5 Serpinb5 HOXB13 HOXB13 SEMA3C SEMA3C LAMA1 LAMA1 STAT6 STAT6 NRG3 NRG3 CDH1 CDH1 PROX1 PROX1 EDAR EDAR MST1 MST1 KDM5B KDM5B POLB POLB ROBO1 ROBO1 NKX2-3 NKX2-3 TGFA TGFA LAMA5 LAMA5 NRP1 NRP1 LRP5 LRP5 NCOA3 NCOA3 TGFB2 TGFB2 CSMD2 CSMD2 DUOX2 DUOX2 BMP4 BMP4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PAX6Paired box 6. (436 aa)
HOXD13Homeobox D13. (313 aa)
FGFR1Fibroblast growth factor receptor. (822 aa)
PAX3Paired box 3. (484 aa)
CUL3Cullin 3; Belongs to the cullin family. (765 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (582 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
PLXND1Plexin D1. (1600 aa)
CAPN1Calpain 1; Belongs to the peptidase C2 family. (714 aa)
TBX3T-box transcription factor 3. (739 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (494 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (772 aa)
LRRC1Leucine rich repeat containing 1. (458 aa)
ETV4ETS variant 4. (464 aa)
ESRP2Epithelial splicing regulatory protein 2. (719 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
PTCH1Patched 1. (1379 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
BSXBrain specific homeobox. (232 aa)
PMLPromyelocytic leukemia. (849 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
FGL1Fibrinogen like 1. (219 aa)
EGFRReceptor protein-tyrosine kinase. (1214 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
CDC42Cell division cycle 42. (191 aa)
MSNMoesin. (577 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (447 aa)
VDRVitamin D receptor. (424 aa)
EPHA2EPH receptor A2. (976 aa)
TET2Tet methylcytosine dioxygenase 2. (1863 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (390 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1584 aa)
MSX2Msh homeobox 2. (267 aa)
PTHLHParathyroid hormone like hormone. (176 aa)
HOXA13Homeobox A13. (203 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
SOSTDC1Sclerostin domain containing 1. (206 aa)
ELF3E74 like ETS transcription factor 3. (372 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
SCRIBScribble planar cell polarity protein. (1653 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
FGFR2Fibroblast growth factor receptor. (801 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
SFRP1Secreted frizzled related protein 1. (307 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
TBX2T-box transcription factor 2. (686 aa)
DAG1Dystroglycan 1. (891 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (358 aa)
IGFBP5Insulin like growth factor binding protein 5. (271 aa)
AREGAmphiregulin. (241 aa)
GLI3GLI family zinc finger 3. (1580 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (493 aa)
GLI2GLI family zinc finger 2. (1570 aa)
CCL11Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. (96 aa)
PgrUncharacterized protein. (428 aa)
SelenohUncharacterized protein. (121 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
SLIT2Slit guidance ligand 2. (1391 aa)
CTNND1Catenin delta 1. (966 aa)
ESRP1Epithelial splicing regulatory protein 1. (681 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (210 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
NKX3-1NK3 homeobox 1. (224 aa)
Csf1Uncharacterized protein. (257 aa)
FEM1BFem-1 homolog B. (627 aa)
ENSCPOP00000022082SERPIN domain-containing protein; Belongs to the serpin family. (327 aa)
DDR1Tyrosine-protein kinase receptor. (915 aa)
ARG1Arginase. (322 aa)
MMP2Matrix metallopeptidase 2. (662 aa)
PHB2Prohibitin. (299 aa)
ESR2Estrogen receptor 2. (568 aa)
CEBPBCCAAT enhancer binding protein beta. (216 aa)
BCL2BCL2 apoptosis regulator. (183 aa)
TNCTenascin C. (2203 aa)
PROP1PROP paired-like homeobox 1. (227 aa)
TGM2TGc domain-containing protein. (735 aa)
ARAndrogen receptor. (926 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (308 aa)
TFAP2CTranscription factor AP-2 gamma. (473 aa)
NR3C1Glucocorticoid receptor; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP [...] (772 aa)
NOTCH2Notch receptor 2. (2455 aa)
Rxfp1Relaxin/insulin-like family peptide receptor 1. (755 aa)
CSMD1CUB and Sushi multiple domains 1. (3564 aa)
RARGRetinoic acid receptor gamma. (455 aa)
PLXNA1Plexin A1. (1911 aa)
SLC12A2Solute carrier family 12 member 2. (1136 aa)
Serpinb5SERPIN domain-containing protein; Belongs to the serpin family. (375 aa)
HOXB13Homeobox B13. (286 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (787 aa)
LAMA1Laminin subunit alpha 1. (3018 aa)
STAT6Signal transducer and activator of transcription. (838 aa)
NRG3Neuregulin 3. (600 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (891 aa)
PROX1Prospero homeobox 1. (737 aa)
EDAREctodysplasin A receptor. (446 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (712 aa)
KDM5BLysine demethylase 5B. (1529 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (340 aa)
ROBO1Roundabout guidance receptor 1. (1612 aa)
NKX2-3NK2 homeobox 3. (358 aa)
TGFATransforming growth factor alpha. (159 aa)
LAMA5Laminin subunit alpha 5. (3609 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (925 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1600 aa)
NCOA3Nuclear receptor coactivator. (1418 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (440 aa)
CSMD2CUB and Sushi multiple domains 2. (3545 aa)
DUOX2Dual oxidase 2. (1517 aa)
BMP4Bone morphogenetic protein 4. (404 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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