(39 nodes) Ion gated channel activity network (Cavia porcellus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TRPC3	ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (849 aa)
	ANO5	Anoctamin. (886 aa)
	CALHM1	Calcium homeostasis modulator 1. (344 aa)
	PKD2L1	Polycystin 2 like 1, transient receptor potential cation channel. (760 aa)
	TRPM5	Transient receptor potential cation channel subfamily M member 5. (1159 aa)
	Nmur2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (403 aa)
	ANO8	Anoctamin. (1034 aa)
	ANO9	Anoctamin. (746 aa)
	KCNK18	Potassium two pore domain channel subfamily K member 18; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (384 aa)
	KCNT2	Potassium sodium-activated channel subfamily T member 2. (1010 aa)
	LOC100727546	VWFA domain-containing protein. (923 aa)
	KCNN4	Intermediate-conductance calcium-activated potassium channel. (427 aa)
	ANO2	Anoctamin. (1003 aa)
	KCNN2	Potassium calcium-activated channel subfamily N member 2. (842 aa)
	ASIC1	Acid sensing ion channel subunit 1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (526 aa)
	TMEM63B	Transmembrane protein 63B. (832 aa)
	TMEM63A	Transmembrane protein 63A. (809 aa)
	Ttyh3	Protein tweety homolog; Probable chloride channel; Belongs to the tweety family. (524 aa)
	ANO6	Anoctamin. (922 aa)
	ANO1	Anoctamin. (1011 aa)
	TTYH1	Protein tweety homolog; Probable chloride channel; Belongs to the tweety family. (380 aa)
	KCNMA1	Potassium calcium-activated channel subfamily M alpha 1. (1133 aa)
	ENSCPOP00000025593	Uncharacterized protein. (180 aa)
	TMEM63C	Transmembrane protein 63C. (804 aa)
	KCNMB1	Potassium calcium-activated channel subfamily M regulatory beta subunit 1. (191 aa)
	ASIC2	Acid sensing ion channel subunit 2; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (493 aa)
	TRPM4	Transient receptor potential cation channel subfamily M member 4. (1138 aa)
	ANO10	Anoctamin. (661 aa)
	KCNN1	Potassium calcium-activated channel subfamily N member 1. (558 aa)
	H0W682_CAVPO	Protein tweety homolog; Probable chloride channel. (108 aa)
	TTYH2	Protein tweety homolog; Probable chloride channel. (533 aa)
	KCNT1	Potassium sodium-activated channel subfamily T member 1. (1229 aa)
	KCNMB3	Potassium calcium-activated channel subfamily M regulatory beta subunit 3. (270 aa)
	KCNN3	Potassium calcium-activated channel subfamily N member 3. (720 aa)
	LOC100726159	VWFA domain-containing protein. (911 aa)
	LOC100727821	VWFA domain-containing protein. (923 aa)
	CLCA1	Chloride channel accessory 1. (913 aa)
	CLCA2	Chloride channel accessory 2. (861 aa)
	Kcnmb2	KcnmB2_inactiv domain-containing protein. (235 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANO1	CLCA2	ENSCPOP00000028034	ENSCPOP00000013467	Anoctamin.	Chloride channel accessory 2.	0.648
ANO1	KCNN3	ENSCPOP00000028034	ENSCPOP00000014172	Anoctamin.	Potassium calcium-activated channel subfamily N member 3.	0.407
ANO2	CLCA2	ENSCPOP00000000819	ENSCPOP00000013467	Anoctamin.	Chloride channel accessory 2.	0.577
ANO9	KCNMA1	ENSCPOP00000003330	ENSCPOP00000027309	Anoctamin.	Potassium calcium-activated channel subfamily M alpha 1.	0.552
ASIC1	ASIC2	ENSCPOP00000000364	ENSCPOP00000020959	Acid sensing ion channel subunit 1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	Acid sensing ion channel subunit 2; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	0.913
ASIC2	ASIC1	ENSCPOP00000020959	ENSCPOP00000000364	Acid sensing ion channel subunit 2; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	Acid sensing ion channel subunit 1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	0.913
CALHM1	PKD2L1	ENSCPOP00000009856	ENSCPOP00000009799	Calcium homeostasis modulator 1.	Polycystin 2 like 1, transient receptor potential cation channel.	0.442
CALHM1	TRPM4	ENSCPOP00000009856	ENSCPOP00000020440	Calcium homeostasis modulator 1.	Transient receptor potential cation channel subfamily M member 4.	0.687
CALHM1	TRPM5	ENSCPOP00000009856	ENSCPOP00000009206	Calcium homeostasis modulator 1.	Transient receptor potential cation channel subfamily M member 5.	0.748
CLCA1	CLCA2	ENSCPOP00000013470	ENSCPOP00000013467	Chloride channel accessory 1.	Chloride channel accessory 2.	0.695
CLCA1	LOC100726159	ENSCPOP00000013470	ENSCPOP00000013747	Chloride channel accessory 1.	VWFA domain-containing protein.	0.688
CLCA2	ANO1	ENSCPOP00000013467	ENSCPOP00000028034	Chloride channel accessory 2.	Anoctamin.	0.648
CLCA2	ANO2	ENSCPOP00000013467	ENSCPOP00000000819	Chloride channel accessory 2.	Anoctamin.	0.577
CLCA2	CLCA1	ENSCPOP00000013467	ENSCPOP00000013470	Chloride channel accessory 2.	Chloride channel accessory 1.	0.695
CLCA2	ENSCPOP00000025593	ENSCPOP00000013467	ENSCPOP00000025593	Chloride channel accessory 2.	Uncharacterized protein.	0.584
CLCA2	LOC100726159	ENSCPOP00000013467	ENSCPOP00000013747	Chloride channel accessory 2.	VWFA domain-containing protein.	0.690
CLCA2	LOC100727546	ENSCPOP00000013467	ENSCPOP00000000993	Chloride channel accessory 2.	VWFA domain-containing protein.	0.585
CLCA2	LOC100727821	ENSCPOP00000013467	ENSCPOP00000013473	Chloride channel accessory 2.	VWFA domain-containing protein.	0.584
ENSCPOP00000025593	CLCA2	ENSCPOP00000025593	ENSCPOP00000013467	Uncharacterized protein.	Chloride channel accessory 2.	0.584
KCNK18	KCNN1	ENSCPOP00000003245	ENSCPOP00000018896	Potassium two pore domain channel subfamily K member 18; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.	Potassium calcium-activated channel subfamily N member 1.	0.454