STRINGSTRING
ANK2 ANK2 NRAP NRAP PDE4B PDE4B NEBL NEBL S100A1 S100A1 FLNA FLNA KRT19 KRT19 FKBP1B FKBP1B NEB NEB RYR2 RYR2 RYR3 RYR3 ENSCPOP00000028064 ENSCPOP00000028064 ACTN1 ACTN1 PARVA PARVA ENSCPOP00000028528 ENSCPOP00000028528 MYL12A MYL12A FLNC FLNC MYOZ3 MYOZ3 PDLIM5 PDLIM5 CHORDC1 CHORDC1 FHL2 FHL2 ENSCPOP00000029567 ENSCPOP00000029567 CRYAB CRYAB ANK1 ANK1 CFL2 CFL2 ITGB1BP2 ITGB1BP2 Ank3 Ank3 SYNPO SYNPO VCL VCL CSRP1 CSRP1 Smn1 Smn1 PPP1R12B PPP1R12B JUP JUP HOMER1 HOMER1 MYH6 MYH6 CASQ2 CASQ2 CASQ1 CASQ1 SCN5A SCN5A TCAP TCAP HSPB1 HSPB1 SYNE2 SYNE2 ENSCPOP00000026034 ENSCPOP00000026034 MYO18B MYO18B Fkbp1a Fkbp1a SCN3B SCN3B ENSCPOP00000024842 ENSCPOP00000024842 PSEN1 PSEN1 ACTN4 ACTN4 CSRP3 CSRP3 ENSCPOP00000024015 ENSCPOP00000024015 GGPS1 GGPS1 CSRP2 CSRP2 ATP2B4 ATP2B4 PPP2R5A PPP2R5A ENSCPOP00000023061 ENSCPOP00000023061 CACNA1C CACNA1C ANXA5 ANXA5 FHL5 FHL5 KY KY BMP10 BMP10 LDB3 LDB3 SYNPO2 SYNPO2 PDLIM4 PDLIM4 FHL3 FHL3 BIN1 BIN1 KCNA5 KCNA5 C7orf57 C7orf57 C10orf71 C10orf71 STUB1 STUB1 Pdlim2 Pdlim2 CTNNB1 CTNNB1 PDLIM3 PDLIM3 TRIM63 TRIM63 LOC100713869 LOC100713869 CAPN3 CAPN3 PGM1 PGM1 Prickle4 Prickle4 SLC4A1 SLC4A1 SYNPO2L SYNPO2L RYR1 RYR1 SCN8A SCN8A SYNC SYNC PGM5 PGM5 MYL9 MYL9 ACTN2 ACTN2 H0VP65_CAVPO H0VP65_CAVPO XIRP2 XIRP2 HDAC4 HDAC4 RTN2 RTN2 LOC100727533 LOC100727533 SRI SRI FBXO32 FBXO32 SPHKAP SPHKAP PPP3CA PPP3CA GRK3 GRK3 SPTAN1 SPTAN1 Myzap Myzap DMD DMD AKAP4 AKAP4 NOS1AP NOS1AP PPP3CB PPP3CB PALLD PALLD MYPN MYPN BAG3 BAG3 FBP2 FBP2 MYOZ2 MYOZ2 MYH7 MYH7 GRIN2B GRIN2B CAVIN4 CAVIN4 PPP1R12A PPP1R12A TRIM54 TRIM54 HRC HRC MYOZ1 MYOZ1 ACTN3 ACTN3 PDLIM1 PDLIM1 Glrx3 Glrx3 NEXN NEXN SCN1A SCN1A Krt8 Krt8 PDLIM7 PDLIM7 SLC8A1 SLC8A1 ASB2 ASB2 PSEN2 PSEN2 MYOT MYOT KCNN2 KCNN2 SLC2A1 SLC2A1 PAK1 PAK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ANK2Ankyrin 2. (3876 aa)
NRAPNebulin related anchoring protein. (1730 aa)
PDE4BPhosphodiesterase. (736 aa)
NEBLNebulette. (1000 aa)
S100A1Protein S100; Belongs to the S-100 family. (94 aa)
FLNAFilamin A. (2645 aa)
KRT19Keratin 19; Belongs to the intermediate filament family. (397 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
NEBNebulin. (7032 aa)
RYR2Ryanodine receptor 2. (4910 aa)
RYR3Ryanodine receptor 3. (4843 aa)
ENSCPOP00000028064IF rod domain-containing protein; Belongs to the intermediate filament family. (393 aa)
ACTN1Actinin alpha 1. (914 aa)
PARVAParvin alpha. (347 aa)
ENSCPOP00000028528IF rod domain-containing protein; Belongs to the intermediate filament family. (253 aa)
MYL12AMyosin light chain 12A. (178 aa)
FLNCFilamin C. (2726 aa)
MYOZ3Myozenin 3. (252 aa)
PDLIM5PDZ and LIM domain 5. (614 aa)
CHORDC1Cysteine and histidine rich domain containing 1. (332 aa)
FHL2Four and a half LIM domains 2. (279 aa)
ENSCPOP00000029567IF rod domain-containing protein; Belongs to the intermediate filament family. (456 aa)
CRYABAlphaB-crystallin; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
ANK1Ankyrin 1. (1911 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
ITGB1BP2Integrin subunit beta 1 binding protein 2. (346 aa)
Ank3Uncharacterized protein. (1948 aa)
SYNPOSynaptopodin. (937 aa)
VCLVinculin. (1134 aa)
CSRP1Cysteine and glycine rich protein 1. (193 aa)
Smn1Tudor domain-containing protein. (302 aa)
PPP1R12BProtein phosphatase 1 regulatory subunit. (1053 aa)
JUPJunction plakoglobin. (745 aa)
HOMER1Homer scaffold protein 1. (329 aa)
MYH6Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1938 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (408 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (399 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2015 aa)
TCAPTitin-cap. (167 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (200 aa)
SYNE2Spectrin repeat containing nuclear envelope protein 2. (6922 aa)
ENSCPOP00000026034Tudor domain-containing protein. (290 aa)
MYO18BMyosin XVIIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2559 aa)
Fkbp1aPeptidylprolyl isomerase. (108 aa)
SCN3BSodium voltage-gated channel beta subunit 3. (215 aa)
ENSCPOP00000024842Uncharacterized protein. (173 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
ACTN4Actinin alpha 4. (911 aa)
CSRP3Cysteine and glycine rich protein 3. (194 aa)
ENSCPOP00000024015Uncharacterized protein. (5460 aa)
GGPS1Geranylgeranyl diphosphate synthase 1; Belongs to the FPP/GGPP synthase family. (299 aa)
CSRP2Cysteine and glycine rich protein 2. (193 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1207 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (487 aa)
ENSCPOP00000023061Uncharacterized protein. (184 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2089 aa)
ANXA5Annexin. (318 aa)
FHL5Four and a half LIM domains 5. (283 aa)
KYKyphoscoliosis peptidase. (661 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
LDB3LIM domain binding 3. (709 aa)
SYNPO2Synaptopodin 2. (1270 aa)
PDLIM4PDZ and LIM domain 4. (290 aa)
FHL3Four and a half LIM domains 3. (280 aa)
BIN1Bridging integrator 1. (577 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (609 aa)
C7orf57Chromosome 7 open reading frame 57. (291 aa)
C10orf71Chromosome 10 open reading frame 71. (1409 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
Pdlim2LIM zinc-binding domain-containing protein. (129 aa)
CTNNB1Catenin beta 1. (781 aa)
PDLIM3PDZ and LIM domain 3. (362 aa)
TRIM63Tripartite motif containing 63. (329 aa)
LOC100713869BTB domain-containing protein. (458 aa)
CAPN3Calpain 3; Belongs to the peptidase C2 family. (779 aa)
PGM1Phosphoglucomutase 1; Belongs to the phosphohexose mutase family. (580 aa)
Prickle4Uncharacterized protein. (316 aa)
SLC4A1Anion exchange protein. (901 aa)
SYNPO2LSynaptopodin 2 like. (975 aa)
RYR1Ryanodine receptor 1. (4554 aa)
SCN8ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1876 aa)
SYNCSyncoilin, intermediate filament protein; Belongs to the intermediate filament family. (470 aa)
PGM5Phosphoglucomutase 5; Belongs to the phosphohexose mutase family. (567 aa)
MYL9Myosin light chain 9. (172 aa)
ACTN2Actinin alpha 2. (894 aa)
H0VP65_CAVPOIF rod domain-containing protein; Belongs to the intermediate filament family. (403 aa)
XIRP2Xin actin binding repeat containing 2. (3296 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1078 aa)
RTN2Reticulon. (475 aa)
LOC100727533BTB domain-containing protein. (458 aa)
SRISorcin. (198 aa)
FBXO32F-box protein 32. (355 aa)
SPHKAPSPHK1 interactor, AKAP domain containing. (1700 aa)
PPP3CASerine/threonine-protein phosphatase. (518 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (673 aa)
SPTAN1Spectrin alpha, non-erythrocytic 1. (2418 aa)
MyzapUncharacterized protein. (441 aa)
DMDDystrophin. (3613 aa)
AKAP4A-kinase anchoring protein 4. (804 aa)
NOS1APNitric oxide synthase 1 adaptor protein. (448 aa)
PPP3CBSerine/threonine-protein phosphatase. (531 aa)
PALLDPalladin, cytoskeletal associated protein. (1108 aa)
MYPNMyopalladin. (1321 aa)
BAG3BCL2 associated athanogene 3. (572 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (339 aa)
MYOZ2Myozenin 2. (264 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1949 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1381 aa)
CAVIN4Caveolae associated protein 4. (365 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1069 aa)
TRIM54Tripartite motif containing 54. (364 aa)
HRCHistidine rich calcium binding protein. (674 aa)
MYOZ1Myozenin 1. (298 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (889 aa)
PDLIM1PDZ and LIM domain 1. (328 aa)
Glrx3Uncharacterized protein. (171 aa)
NEXNNexilin F-actin binding protein. (674 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1997 aa)
Krt8IF rod domain-containing protein; Belongs to the intermediate filament family. (474 aa)
PDLIM7PDZ and LIM domain 7. (456 aa)
SLC8A1Sodium/calcium exchanger 1; Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage- gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels r [...] (970 aa)
ASB2Ankyrin repeat and SOCS box containing 2. (640 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
MYOTMyotilin. (484 aa)
KCNN2Potassium calcium-activated channel subfamily N member 2. (842 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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