STRINGSTRING
BATF BATF CD40LG CD40LG Mpzl2 Mpzl2 ATF2 ATF2 LYL1 LYL1 FAS FAS TCIRG1 TCIRG1 SHH SHH CDK6 CDK6 BTK BTK TNFSF13B TNFSF13B LOC100717234 LOC100717234 ENTPD7 ENTPD7 Il4 Il4 BRAF BRAF LOC100726990 LOC100726990 TSHR TSHR Spib Spib BAX BAX GPS2 GPS2 CLCF1 CLCF1 FUT7 FUT7 LOC100722203 LOC100722203 CD79B CD79B FNIP1 FNIP1 WNT4 WNT4 RC3H2 RC3H2 XRCC4 XRCC4 RORC RORC CTNNB1 CTNNB1 CCR7 CCR7 CLEC4D CLEC4D CD28 CD28 BAK1 BAK1 TMEM98 TMEM98 LOC100730084 LOC100730084 KDELR1 KDELR1 H0UU10_CAVPO H0UU10_CAVPO PTGER4 PTGER4 NCOR1 NCOR1 MERTK MERTK TGFB1 TGFB1 SASH3 SASH3 CD3E CD3E APC APC IL12B IL12B BLM BLM KAT7 KAT7 CD19 CD19 PLCG2 PLCG2 DCLRE1C DCLRE1C PAX1 PAX1 TESPA1 TESPA1 Slamf1 Slamf1 SP3 SP3 LMBR1L LMBR1L GBA GBA NTRK1 NTRK1 IRF4 IRF4 EZH2 EZH2 CARD11 CARD11 NFATC1 NFATC1 PRR7 PRR7 LRRC8A LRRC8A RC3H1 RC3H1 EOMES EOMES TSC1 TSC1 ZAP70 ZAP70 Gon4l Gon4l EP300 EP300 DOCK10 DOCK10 ABL1 ABL1 DOCK11 DOCK11 PBX1 PBX1 HDAC7 HDAC7 ADA ADA DCAF1 DCAF1 RIPK2 RIPK2 CDH17 CDH17 SOX13 SOX13 H0V8X3_CAVPO H0V8X3_CAVPO FOXP3 FOXP3 PTPN2 PTPN2 RBPJ RBPJ FLT3 FLT3 PIK3R1 PIK3R1 PPP3CB PPP3CB AXL AXL RSAD2 RSAD2 IL15 IL15 H0VC92_CAVPO H0VC92_CAVPO PLCL2 PLCL2 JAG2 JAG2 RORA RORA THEMIS THEMIS DNAJA3 DNAJA3 GATA3 GATA3 GPR18 GPR18 PLA2G2D PLA2G2D SLC25A5 SLC25A5 CTSV CTSV RABL3 RABL3 Ifnb1 Ifnb1 NKX2-3 NKX2-3 FOXN1 FOXN1 TYRO3 TYRO3 CYLD CYLD ARMC5 ARMC5 ITK ITK SYK SYK PATZ1 PATZ1 TOX TOX H0VHS7_CAVPO H0VHS7_CAVPO ATM ATM FADD FADD ADAM17 ADAM17 DLL4 DLL4 KIT KIT MTOR MTOR CD79A CD79A LOC100716811 LOC100716811 Cd4 Cd4 MS4A1 MS4A1 IL21 IL21 MALT1 MALT1 TRAF3IP2 TRAF3IP2 STAT6 STAT6 CMTM7 CMTM7 CD3D CD3D CLEC4G CLEC4G ABL2 ABL2 CHD7 CHD7 ITPKB ITPKB MR1 MR1 CD1D CD1D PRKDC PRKDC ATG5 ATG5 LIG4 LIG4 MSH2 MSH2 FBXO7 FBXO7 TXK TXK ANXA1 ANXA1 MYB MYB POLM POLM LEPR LEPR ENPP1 ENPP1 BCL3 BCL3 NOTCH2 NOTCH2 IL9R IL9R ONECUT1 ONECUT1 GPR183 GPR183 H0VWA6_CAVPO H0VWA6_CAVPO SPI1 SPI1 GIMAP1 GIMAP1 WNT1 WNT1 CCR9 CCR9 MFNG MFNG H0VXJ3_CAVPO H0VXJ3_CAVPO Stat5b Stat5b SRF SRF Rpl22 Rpl22 FZD7 FZD7 LOC100734449 LOC100734449 ID2 ID2 NFAM1 NFAM1 BCL2 BCL2 IL18R1 IL18R1 LOC100725529 LOC100725529 DLL1 DLL1 Yy1 Yy1 AIRE AIRE LOC100730587 LOC100730587 ZFP36L2 ZFP36L2 ATP7A ATP7A RIPK3 RIPK3 TBX21 TBX21 H0W510_CAVPO H0W510_CAVPO NCAPH2 NCAPH2 IL9 IL9 CD3G CD3G RAG2 RAG2 Sox4 Sox4 NHEJ1 NHEJ1 PSMB11 PSMB11 RAG1 RAG1 LY6D LY6D EGR1 EGR1 FLT3LG FLT3LG TCF7 TCF7 HLX HLX SYVN1 SYVN1 H0WDY0_CAVPO H0WDY0_CAVPO ZBTB7B ZBTB7B POU2F2 POU2F2 CLEC4E CLEC4E LOC100735600 LOC100735600 IL6R IL6R ADGRG3 ADGRG3 LOC100714884 LOC100714884 POU1F1 POU1F1 POU2AF1 POU2AF1 ZBTB7A ZBTB7A MAFB MAFB OTUD5 OTUD5 ITFG2 ITFG2 CD8A CD8A ZBTB1 ZBTB1 Hhex Hhex NFATC3 NFATC3 IKZF1 IKZF1 LOC100725261 LOC100725261 LEF1 LEF1 B2M B2M ZNF683 ZNF683 Foxp1 Foxp1 RELB RELB DNAJB9 DNAJB9 HECTD1 HECTD1 PTPRJ PTPRJ TNFSF8 TNFSF8 LOC100716684 LOC100716684 HLA-DQB1 HLA-DQB1 STAT3 STAT3 BCL11A BCL11A GLI3 GLI3 CD74 CD74 STK11 STK11 CRACR2A CRACR2A TUSC2 TUSC2 SEMA4A SEMA4A CR2 CR2 HLA-DMA HLA-DMA JAK3 JAK3 FZD9 FZD9 CCR6 CCR6 RUNX2 RUNX2 RHOH RHOH DPP4 DPP4 IKZF3 IKZF3 IFN-alpha10 IFN-alpha10 SLAMF8 SLAMF8 IL7R IL7R JMJD6 JMJD6 IRF1 IRF1 BCL6 BCL6 PKNOX1 PKNOX1 ATP11C ATP11C WNT10B WNT10B PTPRC PTPRC ZFP36L1 ZFP36L1 LEP LEP TPD52 TPD52 TCF3 TCF3 BCL11B BCL11B ST3GAL1 ST3GAL1 TP53 TP53 DOCK2 DOCK2 IL7 IL7 FZD5 FZD5 LOC100724988 LOC100724988 MINK1 MINK1 LGALS1 LGALS1 PTK2B PTK2B LOC100722772 LOC100722772
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BATFBasic leucine zipper ATF-like transcription factor. (126 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (260 aa)
Mpzl2Ig-like domain-containing protein. (352 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
LYL1LYL1 basic helix-loop-helix family member. (266 aa)
FASFas cell surface death receptor. (334 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (447 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
BTKTyrosine-protein kinase. (659 aa)
TNFSF13BTNF superfamily member 13b; Belongs to the tumor necrosis factor family. (272 aa)
LOC100717234Uncharacterized protein. (187 aa)
ENTPD7Ectonucleoside triphosphate diphosphohydrolase 7; Belongs to the GDA1/CD39 NTPase family. (604 aa)
Il4Interleukin-4. (144 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (738 aa)
LOC100726990Uncharacterized protein. (187 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (763 aa)
SpibETS domain-containing protein. (263 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
GPS2G protein pathway suppressor 2. (327 aa)
CLCF1Cardiotrophin like cytokine factor 1. (223 aa)
FUT7Fucosyltransferase 7. (342 aa)
LOC100722203BZIP domain-containing protein. (150 aa)
CD79BCD79b molecule. (285 aa)
FNIP1Folliculin interacting protein 1. (1164 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa)
RC3H2Ring finger and CCCH-type domains 2. (1188 aa)
XRCC4X-ray repair cross complementing 4. (333 aa)
RORCRAR related orphan receptor C. (518 aa)
CTNNB1Catenin beta 1. (781 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (375 aa)
CLEC4DC-type lectin domain family 4 member D. (196 aa)
CD28CD28 molecule. (222 aa)
BAK1BCL2 antagonist/killer 1. (214 aa)
TMEM98Transmembrane protein 98. (226 aa)
LOC100730084Beta-1,3-N-acetylglucosaminyltransferase. (373 aa)
KDELR1ER lumen protein-retaining receptor. (212 aa)
H0UU10_CAVPOUncharacterized protein. (245 aa)
PTGER4Prostaglandin E2 receptor 4; Belongs to the G-protein coupled receptor 1 family. (487 aa)
NCOR1Nuclear receptor corepressor 1. (2389 aa)
MERTKMER proto-oncogene, tyrosine kinase. (852 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
SASH3SAM and SH3 domain containing 3. (380 aa)
CD3ECD3e molecule. (194 aa)
APCAPC regulator of WNT signaling pathway. (2842 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (332 aa)
BLMBLM RecQ like helicase. (1405 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (612 aa)
CD19B-lymphocyte antigen CD19; Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (By similarity). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. Required for normal B cell differentiation and proliferation in [...] (536 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1270 aa)
DCLRE1CDNA cross-link repair 1C. (688 aa)
PAX1Paired box 1. (401 aa)
TESPA1Thymocyte expressed, positive selection associated 1. (508 aa)
Slamf1Ig-like domain-containing protein. (293 aa)
SP3Sp3 transcription factor. (690 aa)
LMBR1LLimb development membrane protein 1 like; Belongs to the LIMR family. (488 aa)
GBAGlucosylceramidase. (516 aa)
NTRK1Tyrosine-protein kinase receptor. (798 aa)
IRF4Interferon regulatory factor 4. (452 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (747 aa)
CARD11Caspase recruitment domain family member 11. (1158 aa)
NFATC1Nuclear factor of activated T cells 1. (928 aa)
PRR7Proline rich 7, synaptic. (272 aa)
LRRC8ALeucine rich repeat containing 8 VRAC subunit A. (810 aa)
RC3H1Ring finger and CCCH-type domains 1. (1116 aa)
EOMESEomesodermin. (697 aa)
TSC1TSC complex subunit 1. (1166 aa)
ZAP70Tyrosine-protein kinase. (551 aa)
Gon4lUncharacterized protein. (2144 aa)
EP300E1A binding protein p300. (2425 aa)
DOCK10Dedicator of cytokinesis 10; Belongs to the DOCK family. (2198 aa)
ABL1Tyrosine-protein kinase. (1145 aa)
DOCK11Dedicator of cytokinesis 11; Belongs to the DOCK family. (2074 aa)
PBX1PBX homeobox 1. (430 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (997 aa)
ADAAdenosine deaminase. (365 aa)
DCAF1DDB1 and CUL4 associated factor 1. (1451 aa)
RIPK2Receptor interacting serine/threonine kinase 2. (442 aa)
CDH17Cadherin 17. (831 aa)
SOX13SRY-box transcription factor 13. (617 aa)
H0V8X3_CAVPOIg-like domain-containing protein. (327 aa)
FOXP3Forkhead box P3. (432 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (364 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (518 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (987 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PPP3CBSerine/threonine-protein phosphatase. (531 aa)
AXLAXL receptor tyrosine kinase. (888 aa)
RSAD2Radical S-adenosyl methionine domain containing 2. (358 aa)
IL15Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family. (162 aa)
H0VC92_CAVPOUncharacterized protein. (384 aa)
PLCL2Phosphoinositide phospholipase C. (1009 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1095 aa)
RORARAR related orphan receptor A. (467 aa)
THEMISThymocyte selection associated. (635 aa)
DNAJA3DnaJ heat shock protein family (Hsp40) member A3. (479 aa)
GATA3GATA binding protein 3. (443 aa)
GPR18G protein-coupled receptor 18. (335 aa)
PLA2G2DPhospholipase A(2). (159 aa)
SLC25A5Solute carrier family 25 member 5; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
CTSVCathepsin V; Belongs to the peptidase C1 family. (333 aa)
RABL3RAB, member of RAS oncogene family like 3. (236 aa)
Ifnb1Uncharacterized protein. (189 aa)
NKX2-3NK2 homeobox 3. (358 aa)
FOXN1Forkhead box N1. (649 aa)
TYRO3TYRO3 protein tyrosine kinase. (880 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
ARMC5Armadillo repeat containing 5. (905 aa)
ITKTyrosine-protein kinase. (626 aa)
SYKTyrosine-protein kinase. (579 aa)
PATZ1POZ/BTB and AT hook containing zinc finger 1. (687 aa)
TOXThymocyte selection associated high mobility group box. (526 aa)
H0VHS7_CAVPOUncharacterized protein. (85 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3031 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (206 aa)
ADAM17ADAM metallopeptidase domain 17. (826 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (970 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
CD79ACD79a molecule. (224 aa)
LOC100716811Signal transducer and activator of transcription. (795 aa)
Cd4Uncharacterized protein. (523 aa)
MS4A1Membrane spanning 4-domains A1. (298 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (146 aa)
MALT1MALT1 paracaspase. (780 aa)
TRAF3IP2TRAF3 interacting protein 2. (561 aa)
STAT6Signal transducer and activator of transcription. (838 aa)
CMTM7CKLF like MARVEL transmembrane domain containing 7. (171 aa)
CD3DCD3d molecule. (171 aa)
CLEC4GC-type lectin domain family 4 member G. (298 aa)
ABL2Tyrosine-protein kinase. (1157 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2996 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (890 aa)
MR1Major histocompatibility complex, class I-related; Belongs to the MHC class I family. (337 aa)
CD1DIg-like domain-containing protein. (335 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4043 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
LIG4DNA ligase. (911 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
FBXO7F-box protein 7. (524 aa)
TXKTyrosine-protein kinase. (507 aa)
ANXA1Annexin. (346 aa)
MYBMYB proto-oncogene, transcription factor. (743 aa)
POLMDNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (485 aa)
LEPRLeptin receptor. (1174 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (900 aa)
BCL3BCL3 transcription coactivator. (424 aa)
NOTCH2Notch receptor 2. (2455 aa)
IL9RInterleukin 9 receptor. (443 aa)
ONECUT1One cut domain family member. (465 aa)
GPR183G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (357 aa)
H0VWA6_CAVPOIRF tryptophan pentad repeat domain-containing protein. (158 aa)
SPI1Spi-1 proto-oncogene. (258 aa)
GIMAP1GTPase, IMAP family member 1. (306 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
CCR9C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family. (366 aa)
MFNGMFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (199 aa)
H0VXJ3_CAVPOUncharacterized protein. (345 aa)
Stat5bSignal transducer and activator of transcription. (786 aa)
SRFSerum response factor. (461 aa)
Rpl22Uncharacterized protein. (129 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (569 aa)
LOC100734449Uncharacterized protein. (183 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
NFAM1NFAT activating protein with ITAM motif 1. (263 aa)
BCL2BCL2 apoptosis regulator. (183 aa)
IL18R1Interleukin 18 receptor 1. (481 aa)
LOC100725529Uncharacterized protein. (200 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (607 aa)
Yy1Uncharacterized protein. (195 aa)
AIREAutoimmune regulator. (540 aa)
LOC100730587Uncharacterized protein. (191 aa)
ZFP36L2ZFP36 ring finger protein like 2. (403 aa)
ATP7AATPase copper transporting alpha. (1433 aa)
RIPK3Receptor interacting serine/threonine kinase 3; Belongs to the protein kinase superfamily. (482 aa)
TBX21T-box transcription factor 21. (388 aa)
H0W510_CAVPOUncharacterized protein. (203 aa)
NCAPH2Non-SMC condensin II complex subunit H2. (608 aa)
IL9Interleukin 9. (130 aa)
CD3GCD3g molecule. (181 aa)
RAG2Recombination activating 2. (527 aa)
Sox4HMG box domain-containing protein. (227 aa)
NHEJ1Non-homologous end joining factor 1. (299 aa)
PSMB11Proteasome subunit beta. (297 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
LY6DLymphocyte antigen 6 family member D. (122 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (535 aa)
FLT3LGFms related tyrosine kinase 3 ligand. (179 aa)
TCF7Transcription factor 7. (262 aa)
HLXH2.0 like homeobox. (442 aa)
SYVN1Synoviolin 1. (605 aa)
H0WDY0_CAVPOUncharacterized protein. (158 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (543 aa)
POU2F2POU domain protein. (576 aa)
CLEC4EC-type lectin domain family 4 member E. (210 aa)
LOC100735600Uncharacterized protein. (187 aa)
IL6RInterleukin 6 receptor. (450 aa)
ADGRG3Adhesion G protein-coupled receptor G3; Belongs to the G-protein coupled receptor 2 family. (600 aa)
LOC100714884Uncharacterized protein. (187 aa)
POU1F1POU domain protein. (316 aa)
POU2AF1POU class 2 homeobox associating factor 1. (263 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (564 aa)
MAFBMAF bZIP transcription factor B. (326 aa)
OTUD5OTU deubiquitinase 5. (571 aa)
ITFG2Integrin alpha FG-GAP repeat containing 2. (444 aa)
CD8ACD8 alpha. (237 aa)
ZBTB1Zinc finger and BTB domain containing 1. (712 aa)
HhexHomeobox domain-containing protein. (98 aa)
NFATC3Nuclear factor of activated T cells 3. (1060 aa)
IKZF1IKAROS family zinc finger 1. (511 aa)
LOC100725261Interferon alpha 1. (187 aa)
LEF1Lymphoid enhancer binding factor 1. (396 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (125 aa)
ZNF683Zinc finger protein 683. (436 aa)
Foxp1Fork-head domain-containing protein. (687 aa)
RELBRELB proto-oncogene, NF-kB subunit. (554 aa)
DNAJB9DnaJ heat shock protein family (Hsp40) member B9. (222 aa)
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2505 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1311 aa)
TNFSF8Tumor necrosis factor ligand 3A; Belongs to the tumor necrosis factor family. (234 aa)
LOC100716684Uncharacterized protein. (187 aa)
HLA-DQB1Ig-like domain-containing protein. (270 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
BCL11ABAF chromatin remodeling complex subunit BCL11A. (825 aa)
GLI3GLI family zinc finger 3. (1580 aa)
CD74CD74 molecule. (280 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (435 aa)
CRACR2ACalcium release activated channel regulator 2A. (717 aa)
TUSC2Tumor suppressor 2, mitochondrial calcium regulator. (110 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (761 aa)
CR2Complement C3d receptor 2. (874 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (264 aa)
JAK3Tyrosine-protein kinase. (1078 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (596 aa)
CCR6C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (376 aa)
RUNX2RUNX family transcription factor 2. (541 aa)
RHOHRas homolog family member H. (191 aa)
DPP4Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (764 aa)
IKZF3IKAROS family zinc finger 3. (510 aa)
IFN-alpha10Interferon-alpha10. (187 aa)
SLAMF8SLAM family member 8. (279 aa)
IL7RInterleukin 7 receptor. (461 aa)
JMJD6Jumonji domain containing 6, arginine demethylase and lysine hydroxylase. (414 aa)
IRF1Interferon regulatory factor. (326 aa)
BCL6BCL6 transcription repressor. (705 aa)
PKNOX1PBX/knotted 1 homeobox 1. (436 aa)
ATP11CPhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1085 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (390 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1307 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (165 aa)
TPD52Uncharacterized protein. (246 aa)
TCF3Transcription factor 3. (648 aa)
BCL11BBAF chromatin remodeling complex subunit BCL11B. (898 aa)
ST3GAL1ST3 beta-galactoside alpha-2,3-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (339 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (423 aa)
DOCK2Dedicator of cytokinesis 2; Belongs to the DOCK family. (1843 aa)
IL7Interleukin 7. (152 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
LOC100724988Uncharacterized protein. (182 aa)
MINK1Misshapen like kinase 1. (1342 aa)
LGALS1Galectin. (135 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
LOC100722772Uncharacterized protein. (187 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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