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STBD1 STBD1 AKAP7 AKAP7 CACNA1C CACNA1C CACNB1 CACNB1 EDNRA EDNRA CACNB3 CACNB3 SCN2A SCN2A SCN1A SCN1A SLC8A1 SLC8A1 PRKAR2A PRKAR2A KCNN2 KCNN2 CLTC CLTC Cacnb2 Cacnb2 AKAP6 AKAP6 PPP3CB PPP3CB IGF1R IGF1R H0V4J9_CAVPO H0V4J9_CAVPO SRI SRI DYSF DYSF RTN2 RTN2 KCND2 KCND2 FER1L5 FER1L5 SLC30A1 SLC30A1 ASB3 ASB3 CACNG7 CACNG7 RYR1 RYR1 PRKCE PRKCE Kcnj12 Kcnj12 CACNG1 CACNG1 AQP4 AQP4 ATP2B4 ATP2B4 SLC2A4 SLC2A4 ATP1A1 ATP1A1 ANK2 ANK2 KCNJ5 KCNJ5 TGFB3 TGFB3 CDH2 CDH2 SLC9A1 SLC9A1 ATP1B1 ATP1B1 ATP1A2 ATP1A2 Ank3 Ank3 Camk2d Camk2d CAV3 CAV3 ABCC9 ABCC9 VDR VDR MSN MSN CASQ1 CASQ1 SCN5A SCN5A GOT2 GOT2 EZR EZR Kcnj3 Kcnj3 STAC STAC ANKRD39 ANKRD39 CACNG4 CACNG4 CAPN3 CAPN3 H0W649_CAVPO H0W649_CAVPO BIN1 BIN1 KCNJ11 KCNJ11 ASB15 ASB15 FXYD1 FXYD1 SCN1B SCN1B CACNA1S CACNA1S CACNA2D1 CACNA2D1 CACNG6 CACNG6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STBD1Starch binding domain 1. (282 aa)
AKAP7A-kinase anchoring protein 7. (336 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2089 aa)
CACNB1Calcium voltage-gated channel auxiliary subunit beta 1. (641 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (399 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (484 aa)
SCN2ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1965 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1997 aa)
SLC8A1Sodium/calcium exchanger 1; Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage- gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels r [...] (970 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (395 aa)
KCNN2Potassium calcium-activated channel subfamily N member 2. (842 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1682 aa)
Cacnb2SH3 domain-containing protein. (621 aa)
AKAP6A-kinase anchoring protein 6. (2208 aa)
PPP3CBSerine/threonine-protein phosphatase. (531 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
H0V4J9_CAVPOUncharacterized protein. (291 aa)
SRISorcin. (198 aa)
DYSFDysferlin. (2103 aa)
RTN2Reticulon. (475 aa)
KCND2Potassium voltage-gated channel subfamily D member 2; Belongs to the potassium channel family. (630 aa)
FER1L5Fer-1 like family member 5. (2020 aa)
SLC30A1Solute carrier family 30 member 1. (448 aa)
ASB3Ankyrin repeat and SOCS box containing 3. (506 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
RYR1Ryanodine receptor 1. (4554 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
Kcnj12Uncharacterized protein. (535 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (224 aa)
AQP4Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (323 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1207 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1048 aa)
ANK2Ankyrin 2. (3876 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
CDH2Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (906 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (810 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity). (306 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
Ank3Uncharacterized protein. (1948 aa)
Camk2dProtein kinase domain-containing protein. (532 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
ABCC9ATP binding cassette subfamily C member 9. (1546 aa)
VDRVitamin D receptor. (424 aa)
MSNMoesin. (577 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (399 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2015 aa)
GOT2Aspartate aminotransferase. (430 aa)
EZREzrin. (586 aa)
Kcnj3IRK_C domain-containing protein. (194 aa)
STACSH3 and cysteine rich domain. (402 aa)
ANKRD39Ankyrin repeat domain 39. (183 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (325 aa)
CAPN3Calpain 3; Belongs to the peptidase C2 family. (779 aa)
H0W649_CAVPOVoltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (280 aa)
BIN1Bridging integrator 1. (577 aa)
KCNJ11ATP-sensitive inward rectifier potassium channel 11; This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Can form cardiac and smo [...] (390 aa)
ASB15Ankyrin repeat and SOCS box containing 15. (552 aa)
FXYD1FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (92 aa)
SCN1BSodium voltage-gated channel beta subunit 1. (216 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1867 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1078 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (257 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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