STRINGSTRING
CD109 CD109 SBNO2 SBNO2 CALCR CALCR Anxa2 Anxa2 NF1 NF1 ATP6AP1 ATP6AP1 IL20 IL20 TRAF6 TRAF6 TREM2 TREM2 NFATC1 NFATC1 TNF TNF GPC3 GPC3 TGFB1 TGFB1 CD300LF CD300LF GLO1 GLO1 TNFSF11 TNFSF11 CHUK CHUK CTNNB1 CTNNB1 GPR68 GPR68 TCIRG1 TCIRG1 EPHA2 EPHA2 TCTA TCTA TMEM64 TMEM64 SNX10 SNX10 SFRP1 SFRP1 TFRC TFRC SH3PXD2A SH3PXD2A Foxp1 Foxp1 CCN4 CCN4 TOB2 TOB2 Csf1 Csf1 MAPK14 MAPK14 PAFAH1B1 PAFAH1B1 FAM20C FAM20C FOS FOS TYROBP TYROBP EFNA2 EFNA2 DCSTAMP DCSTAMP GPR183 GPR183 CSF1R CSF1R JUNB JUNB TNFRSF11A TNFRSF11A ENPP1 ENPP1 MITF MITF IREB2 IREB2 FARP2 FARP2 GAB2 GAB2 OCSTAMP OCSTAMP CD81 CD81 OSTM1 OSTM1 IAPP IAPP LRRK1 LRRK1 PIK3R1 PIK3R1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD109CD109 molecule. (1402 aa)
SBNO2Strawberry notch homolog 2. (1326 aa)
CALCRCalcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. (474 aa)
Anxa2Annexin. (339 aa)
NF1Neurofibromin 1. (2750 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (469 aa)
IL20Interleukin 20. (176 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (543 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (229 aa)
NFATC1Nuclear factor of activated T cells 1. (928 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (529 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
CD300LFCD300 molecule like family member f. (320 aa)
GLO1Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (185 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (315 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (749 aa)
CTNNB1Catenin beta 1. (781 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (363 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
EPHA2EPH receptor A2. (976 aa)
TCTAT-cell leukemia translocation-altered gene protein homolog; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family. (109 aa)
TMEM64Transmembrane protein 64. (376 aa)
SNX10Sorting nexin 10. (201 aa)
SFRP1Secreted frizzled related protein 1. (307 aa)
TFRCTransferrin receptor protein 1. (765 aa)
SH3PXD2ASH3 and PX domains 2A. (1129 aa)
Foxp1Fork-head domain-containing protein. (687 aa)
CCN4Cellular communication network factor 4. (367 aa)
TOB2Transducer of ERBB2, 2. (340 aa)
Csf1Uncharacterized protein. (257 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
FAM20CFAM20C golgi associated secretory pathway kinase. (508 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
TYROBPTYRO protein tyrosine kinase binding protein. (115 aa)
EFNA2Ephrin A2; Belongs to the ephrin family. (190 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (470 aa)
GPR183G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (357 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (979 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
TNFRSF11ATNF receptor superfamily member 11a. (515 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (900 aa)
MITFMelanocyte inducing transcription factor. (526 aa)
IREB2Iron responsive element binding protein 2. (839 aa)
FARP2FERM, ARH/RhoGEF and pleckstrin domain protein 2. (1052 aa)
GAB2GRB2 associated binding protein 2. (635 aa)
OCSTAMPOsteoclast stimulatory transmembrane protein. (468 aa)
CD81Tetraspanin. (236 aa)
OSTM1Osteoclastogenesis associated transmembrane protein 1. (334 aa)
IAPPIslet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism; Belongs to the calcitonin family. (92 aa)
LRRK1Leucine rich repeat kinase 1. (2015 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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