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WDR12 WDR12 PES1-2 PES1-2 MRTO4 MRTO4 EIF6 EIF6 CASP8 CASP8 ENSCPOP00000033053 ENSCPOP00000033053 RRS1 RRS1 LOC100716855 LOC100716855 PES1 PES1 CASP10 CASP10 MDN1 MDN1 RPF1 RPF1 LAS1L LAS1L FTSJ3 FTSJ3 RRP1B RRP1B WDR74 WDR74 RRP15 RRP15 BOP1 BOP1 EBNA1BP2 EBNA1BP2 NIP7 NIP7 Pes1 Pes1 ZNF622 ZNF622 NOC2L NOC2L NSA2 NSA2 RRP1 RRP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WDR12Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (423 aa)
PES1-2Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family. (563 aa)
MRTO4Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (241 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (246 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (481 aa)
ENSCPOP00000033053Protein MAK16 homolog; Belongs to the MAK16 family. (256 aa)
RRS1Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (357 aa)
LOC100716855Brix domain-containing protein. (368 aa)
PES1Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family. (549 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (474 aa)
MDN1Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. (5563 aa)
RPF1Ribosome production factor 1 homolog. (349 aa)
LAS1LLAS1 like, ribosome biogenesis factor. (698 aa)
FTSJ3pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (838 aa)
RRP1BRibosomal RNA processing 1B. (719 aa)
WDR74WD repeat domain 74. (384 aa)
RRP15Ribosomal RNA processing 15 homolog. (281 aa)
BOP1Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (734 aa)
EBNA1BP2EBNA1 binding protein 2. (305 aa)
NIP760S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (180 aa)
Pes1Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family. (590 aa)
ZNF622Zinc finger protein 622. (478 aa)
NOC2LNOC2 like nucleolar associated transcriptional repressor. (799 aa)
NSA2NSA2 ribosome biogenesis factor. (260 aa)
RRP1Ribosomal RNA processing 1. (448 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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