50 items (Cavia porcellus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	Guca1a	Uncharacterized protein. (200 aa)
	CACNA1D	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2164 aa)
	Ncs1	Uncharacterized protein. (168 aa)
	TSHR	Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (763 aa)
	LOC100732436	Uncharacterized protein. (327 aa)
	HPCAL1	Hippocalcin like 1. (193 aa)
	LOC100732736	Adenylyl cyclase-associated protein; Belongs to the CAP family. (429 aa)
	ENSCPOP00000028869	Uncharacterized protein. (609 aa)
	HPCA	Hippocalcin. (193 aa)
	P2RY13	Purinergic receptor P2Y13; Belongs to the G-protein coupled receptor 1 family. (339 aa)
	ENSCPOP00000027148	Uncharacterized protein. (278 aa)
	STIM1	Stromal interaction molecule 1. (713 aa)
	DRD1	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (444 aa)
	CAP2	Adenylyl cyclase-associated protein; Belongs to the CAP family. (476 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	ADORA2B	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (221 aa)
	CACNA1C	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2089 aa)
	GNG7	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	ENSCPOP00000022441	ANF_receptor domain-containing protein. (298 aa)
	GABBR1	Gamma-aminobutyric acid type B receptor subunit 1. (844 aa)
	RGS2	Regulator of G protein signaling 2. (211 aa)
	ORAI1	ORAI calcium release-activated calcium modulator 1. (302 aa)
	ADRB2	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. (418 aa)
	ADRB1	G_PROTEIN_RECEP_F1_2 domain-containing protein. (470 aa)
	GRM7	Glutamate metabotropic receptor 7. (922 aa)
	RD3	Retinal degeneration 3, GUCY2D regulator. (159 aa)
	GUCA2A	Guanylin; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins; Belongs to the guanylin family. (119 aa)
	GALR1	Galanin receptor 1; Belongs to the G-protein coupled receptor 1 family. (349 aa)
	DRD3	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (364 aa)
	GNAL	G protein subunit alpha L. (372 aa)
	H0V266_CAVPO	Uncharacterized protein. (2204 aa)
	NOS3	Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity); Belongs to the NOS family. (1206 aa)
	AKAP9	A-kinase anchoring protein 9. (3887 aa)
	H0V5P5_CAVPO	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (385 aa)
	Cap1	Adenylyl cyclase-associated protein; Belongs to the CAP family. (476 aa)
	NF1	Neurofibromin 1. (2750 aa)
	Vipr2	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (441 aa)
	GUCA2B	Guanylate cyclase activator 2B; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport; Belongs to the guanylin family. (113 aa)
	AKAP6	A-kinase anchoring protein 6. (2208 aa)
	ACR	Acrosin; Belongs to the peptidase S1 family. (447 aa)
	RXFP2	Relaxin family peptide receptor 2. (737 aa)
	GPR87	G protein-coupled receptor 87; Belongs to the G-protein coupled receptor 1 family. (358 aa)
	H0VE70_CAVPO	Uncharacterized protein. (796 aa)
	DRD2	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (446 aa)
	GUCA1B	Guanylate cyclase activator 1B. (200 aa)
	GHRHR	Growth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (422 aa)
	Rxfp1	Relaxin/insulin-like family peptide receptor 1. (755 aa)
	Lhcgr	Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (691 aa)
	PDZD3	PDZ domain containing 3. (495 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADORA2B	DRD1	ENSCPOP00000023685	ENSCPOP00000025180	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family.	0.586
ADORA2B	DRD2	ENSCPOP00000023685	ENSCPOP00000008318	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	0.692
ADORA2B	DRD3	ENSCPOP00000023685	ENSCPOP00000002322	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	0.564
ADORA2B	GNAL	ENSCPOP00000023685	ENSCPOP00000002727	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	G protein subunit alpha L.	0.904
ADORA2B	GNG7	ENSCPOP00000023685	ENSCPOP00000022986	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.593
ADORA2B	H0V5P5_CAVPO	ENSCPOP00000023685	ENSCPOP00000004985	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.422
ADORA2B	H0VE70_CAVPO	ENSCPOP00000023685	ENSCPOP00000008303	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.898
ADORA2B	LOC100732436	ENSCPOP00000023685	ENSCPOP00000031430	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.939
ADRB1	ADRB2	ENSCPOP00000017518	ENSCPOP00000018242	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.	0.931
ADRB1	DRD1	ENSCPOP00000017518	ENSCPOP00000025180	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family.	0.476
ADRB1	GNAL	ENSCPOP00000017518	ENSCPOP00000002727	G_PROTEIN_RECEP_F1_2 domain-containing protein.	G protein subunit alpha L.	0.931
ADRB1	GNG7	ENSCPOP00000017518	ENSCPOP00000022986	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.517
ADRB1	H0VE70_CAVPO	ENSCPOP00000017518	ENSCPOP00000008303	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Uncharacterized protein.	0.937
ADRB1	LOC100732436	ENSCPOP00000017518	ENSCPOP00000031430	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Uncharacterized protein.	0.985
ADRB1	Vipr2	ENSCPOP00000017518	ENSCPOP00000005540	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.539
ADRB2	ADRB1	ENSCPOP00000018242	ENSCPOP00000017518	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.931
ADRB2	CACNA1C	ENSCPOP00000018242	ENSCPOP00000023058	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	0.631
ADRB2	DRD1	ENSCPOP00000018242	ENSCPOP00000025180	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family.	0.476
ADRB2	GNAL	ENSCPOP00000018242	ENSCPOP00000002727	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.	G protein subunit alpha L.	0.932
ADRB2	GNG7	ENSCPOP00000018242	ENSCPOP00000022986	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.533