STRINGSTRING
MRE11 MRE11 NUCKS1 NUCKS1 SAMHD1 SAMHD1 ATRX ATRX LOC100736130 LOC100736130 ATR ATR BRCA2 BRCA2 DDX11 DDX11 DNA2 DNA2 MMS22L MMS22L GEN1 GEN1 Cenpx Cenpx ENSCPOP00000025543 ENSCPOP00000025543 CENPS CENPS ALYREF ALYREF EME2 EME2 FAM111A FAM111A TONSL TONSL TRAIP TRAIP WRN WRN PRIMPOL PRIMPOL RFWD3 RFWD3 THOC1 THOC1 FANCM FANCM BLM BLM PCNA PCNA H0VDT0_CAVPO H0VDT0_CAVPO MUS81 MUS81 MAML1 MAML1 EXD2 EXD2 Cdk9 Cdk9 H0VGS2_CAVPO H0VGS2_CAVPO FBH1 FBH1 SMARCAL1 SMARCAL1 ETAA1 ETAA1 RAD51 RAD51 Rtel1 Rtel1 EME1 EME1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (706 aa)
NUCKS1Nuclear casein kinase and cyclin dependent kinase substrate 1. (243 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (526 aa)
ATRXATRX chromatin remodeler. (2481 aa)
LOC100736130Uncharacterized protein. (287 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2539 aa)
BRCA2BRCA2 DNA repair associated. (3151 aa)
DDX11DEAD/H-box helicase 11. (878 aa)
DNA2DNA replication helicase/nuclease 2. (1021 aa)
MMS22LMMS22 like, DNA repair protein. (1237 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (916 aa)
CenpxUncharacterized protein. (79 aa)
ENSCPOP00000025543AAA_12 domain-containing protein. (243 aa)
CENPSCentromere protein S. (135 aa)
ALYREFAly/REF export factor. (256 aa)
EME2Essential meiotic structure-specific endonuclease subunit 2. (371 aa)
FAM111AFamily with sequence similarity 111 member A. (597 aa)
TONSLTonsoku like, DNA repair protein. (1395 aa)
TRAIPTRAF interacting protein. (469 aa)
WRNWRN RecQ like helicase. (1462 aa)
PRIMPOLPrimase and DNA directed polymerase. (547 aa)
RFWD3Ring finger and WD repeat domain 3. (764 aa)
THOC1THO complex 1. (657 aa)
FANCMFA complementation group M. (1971 aa)
BLMBLM RecQ like helicase. (1405 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
H0VDT0_CAVPOProtein kinase domain-containing protein. (337 aa)
MUS81MUS81 structure-specific endonuclease subunit. (562 aa)
MAML1Mastermind like transcriptional coactivator 1. (794 aa)
EXD2Exonuclease 3'-5' domain containing 2. (619 aa)
Cdk9Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (372 aa)
H0VGS2_CAVPOUncharacterized protein. (611 aa)
FBH1F-box DNA helicase 1. (1012 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (938 aa)
ETAA1ETAA1 activator of ATR kinase. (866 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
Rtel1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1246 aa)
EME1Essential meiotic structure-specific endonuclease 1. (578 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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