91 items (Cavia porcellus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PAX6	Paired box 6. (436 aa)
	RXRA	Retinoid X receptor alpha. (459 aa)
	MACROH2A1	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (371 aa)
	H0V021_CAVPO	HMG box domain-containing protein. (565 aa)
	BAP1	Ubiquitin carboxyl-terminal hydrolase. (729 aa)
	HR	HR lysine demethylase and nuclear receptor corepressor. (1208 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (747 aa)
	EOMES	Eomesodermin. (697 aa)
	KDM6B	Lysine demethylase 6B. (1467 aa)
	EP300	E1A binding protein p300. (2425 aa)
	GRHL2	Grainyhead like transcription factor 2. (620 aa)
	H0V6I7_CAVPO	Uncharacterized protein. (231 aa)
	KDM4D	Lysine demethylase 4D. (512 aa)
	SBNO2	Strawberry notch homolog 2. (1326 aa)
	GATA1	GATA binding protein 1. (401 aa)
	XBP1	X-box binding protein 1. (268 aa)
	ATRX	ATRX chromatin remodeler. (2481 aa)
	LEMD2	LEM domain containing 2. (494 aa)
	H0VCZ7_CAVPO	Fork-head domain-containing protein. (548 aa)
	GRHL3	Grainyhead like transcription factor 3. (603 aa)
	TOP1	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (768 aa)
	TOX2	TOX high mobility group box family member 2. (535 aa)
	CTCF	CCCTC-binding factor. (711 aa)
	GRHL1	Grainyhead like transcription factor 1. (611 aa)
	TOX	Thymocyte selection associated high mobility group box. (526 aa)
	H1-0	H1 histone family member 0. (194 aa)
	HNRNPU	Heterogeneous nuclear ribonucleoprotein U. (822 aa)
	MECP2	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (504 aa)
	WBP2	WW domain binding protein 2. (261 aa)
	H0VN16_CAVPO	Uncharacterized protein. (71 aa)
	PER1	Period circadian regulator 1. (1286 aa)
	KDM5A	Lysine demethylase 5A. (1527 aa)
	RXRB	Retinoid X receptor beta. (414 aa)
	JMJD1C	Jumonji domain containing 1C. (2536 aa)
	HDAC3	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
	HDAC2	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
	KDM6A	Lysine demethylase 6A. (1164 aa)
	OGT	O-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
	NUP50	Nucleoporin 50. (457 aa)
	SRF	Serum response factor. (461 aa)
	PRDM14	PR/SET domain 14. (515 aa)
	Cebpa	Uncharacterized protein. (158 aa)
	SUZ12	SUZ12 polycomb repressive complex 2 subunit. (737 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (549 aa)
	LOC106027455	H15 domain-containing protein. (211 aa)
	CEBPB	CCAAT enhancer binding protein beta. (216 aa)
	TOX4	TOX high mobility group box family member 4. (619 aa)
	ZIC2	Zic family member 2. (523 aa)
	Foxo3	Forkhead box O3. (660 aa)
	WBP2NL	WBP2 N-terminal like. (336 aa)
	VAX2	Ventral anterior homeobox 2. (291 aa)
	H1-1	Histone cluster 1 H1 family member a. (215 aa)
	MYOG	Myogenin. (249 aa)
	H0W7U6_CAVPO	H15 domain-containing protein. (269 aa)
	Pou5f1	POU domain protein. (361 aa)
	RUVBL2	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (486 aa)
	H1-2	Histone cluster 1 H1 family member c. (213 aa)
	MYOD1	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (318 aa)
	LOC101788961	H15 domain-containing protein. (278 aa)
	H1-10	H1 histone family member X. (185 aa)
	KDM3A	Lysine demethylase 3A. (1258 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (796 aa)
	RCC1	Regulator of chromosome condensation 1. (549 aa)
	POLE3	DNA polymerase epsilon 3, accessory subunit. (147 aa)
	Pitx2	Homeobox protein. (325 aa)
	ACTN4	Actinin alpha 4. (911 aa)
	NR1H3	Nuclear receptor subfamily 1 group H member 3. (443 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	MACROH2A2	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
	RUNX2	RUNX family transcription factor 2. (541 aa)
	RARA	Retinoic acid receptor alpha. (462 aa)
	Hmgn2	Uncharacterized protein. (95 aa)
	SBNO1	Strawberry notch homolog 1. (1391 aa)
	THRB	Thyroid hormone receptor beta. (475 aa)
	KDM3B	Lysine demethylase 3B. (1723 aa)
	BCL6	BCL6 transcription repressor. (705 aa)
	HMGN1	High mobility group nucleosome binding domain 1. (130 aa)
	DHX9	DExH-box helicase 9. (1373 aa)
	ENSCPOP00000030006	H15 domain-containing protein. (273 aa)
	THRA	Thyroid hormone receptor alpha. (514 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1584 aa)
	LEMD3	LEM domain containing 3. (838 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	REPIN1	Replication initiator 1. (612 aa)
	HMGN3	High mobility group nucleosomal binding domain 3. (128 aa)
	CREBBP	CREB binding protein. (2441 aa)
	HSF1	Heat shock transcription factor 1. (555 aa)
	APEX1	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
	NR1H2	Nuclear receptor subfamily 1 group H member 2. (463 aa)
	ENSCPOP00000032800	HSF_DOMAIN domain-containing protein. (483 aa)
	ENSCPOP00000032936	H15 domain-containing protein. (272 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APEX1	CREBBP	ENSCPOP00000032125	ENSCPOP00000031881	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	CREB binding protein.	0.614
APEX1	EP300	ENSCPOP00000032125	ENSCPOP00000004894	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	E1A binding protein p300.	0.771
APEX1	HNRNPU	ENSCPOP00000032125	ENSCPOP00000010693	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Heterogeneous nuclear ribonucleoprotein U.	0.611
APEX1	MECP2	ENSCPOP00000032125	ENSCPOP00000011316	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).	0.413
APEX1	POLE3	ENSCPOP00000032125	ENSCPOP00000022384	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	DNA polymerase epsilon 3, accessory subunit.	0.709
ATRX	CREBBP	ENSCPOP00000007087	ENSCPOP00000031881	ATRX chromatin remodeler.	CREB binding protein.	0.622
ATRX	CTCF	ENSCPOP00000007087	ENSCPOP00000009600	ATRX chromatin remodeler.	CCCTC-binding factor.	0.473
ATRX	EP300	ENSCPOP00000007087	ENSCPOP00000004894	ATRX chromatin remodeler.	E1A binding protein p300.	0.557
ATRX	EZH2	ENSCPOP00000007087	ENSCPOP00000003350	ATRX chromatin remodeler.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.644
ATRX	HDAC2	ENSCPOP00000007087	ENSCPOP00000012920	ATRX chromatin remodeler.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.444
ATRX	HDAC3	ENSCPOP00000007087	ENSCPOP00000012861	ATRX chromatin remodeler.	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.441
ATRX	KDM5A	ENSCPOP00000007087	ENSCPOP00000012388	ATRX chromatin remodeler.	Lysine demethylase 5A.	0.412
ATRX	KDM6A	ENSCPOP00000007087	ENSCPOP00000013041	ATRX chromatin remodeler.	Lysine demethylase 6A.	0.517
ATRX	KDM6B	ENSCPOP00000007087	ENSCPOP00000003983	ATRX chromatin remodeler.	Lysine demethylase 6B.	0.469
ATRX	MACROH2A1	ENSCPOP00000007087	ENSCPOP00000000398	ATRX chromatin remodeler.	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.	0.665
ATRX	MACROH2A2	ENSCPOP00000007087	ENSCPOP00000025687	ATRX chromatin remodeler.	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.	0.626
ATRX	MECP2	ENSCPOP00000007087	ENSCPOP00000011316	ATRX chromatin remodeler.	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).	0.842
ATRX	POLE3	ENSCPOP00000007087	ENSCPOP00000022384	ATRX chromatin remodeler.	DNA polymerase epsilon 3, accessory subunit.	0.595
ATRX	PRDM14	ENSCPOP00000007087	ENSCPOP00000015743	ATRX chromatin remodeler.	PR/SET domain 14.	0.420
ATRX	RUVBL2	ENSCPOP00000007087	ENSCPOP00000019288	ATRX chromatin remodeler.	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.	0.614