STRINGSTRING
DLG3 DLG3 EIF6 EIF6 IFT20 IFT20 Lmnb2 Lmnb2 SEH1L SEH1L STX3 STX3 ENSCPOP00000028975 ENSCPOP00000028975 LOC100716703 LOC100716703 SYNJ2BP SYNJ2BP LGI1 LGI1 SNAPIN SNAPIN NACC2 NACC2 ARL3 ARL3 Vamp2 Vamp2 TERF2 TERF2 WDR34 WDR34 ENSCPOP00000031404 ENSCPOP00000031404 WDR60 WDR60 EXOC3L4 EXOC3L4 RELN RELN RAB8A RAB8A LMNB1 LMNB1 Fcgr4 Fcgr4 PCM1 PCM1 DLG1 DLG1 EZR EZR MAPK10 MAPK10 ENSCPOP00000033061 ENSCPOP00000033061 STX1B STX1B SSNA1 SSNA1 IFT172 IFT172 ADAM22 ADAM22 CACNG3 CACNG3 ENSCPOP00000023134 ENSCPOP00000023134 NSG1 NSG1 AP2M1 AP2M1 AKIRIN2 AKIRIN2 XPO1 XPO1 TTC21B TTC21B IFT43 IFT43 SYNJ1 SYNJ1 RAB11A RAB11A ENSCPOP00000021311 ENSCPOP00000021311 NPTXR NPTXR DLG4 DLG4 GRIP2 GRIP2 EXOC3L2 EXOC3L2 CNIH3 CNIH3 RRS1 RRS1 BBS12 BBS12 LCA5L LCA5L HASPIN HASPIN H0W649_CAVPO H0W649_CAVPO Rpgr Rpgr KIF5C KIF5C IFT52 IFT52 CACNG4 CACNG4 NLGN1 NLGN1 KIF17 KIF17 LMNA LMNA IFT27 IFT27 KIF3B KIF3B STX4 STX4 ARHGAP44 ARHGAP44 CACNG7 CACNG7 ANKS1B ANKS1B STAU2 STAU2 IFT81 IFT81 NOP9 NOP9 Myo5b Myo5b TTC21A TTC21A Ltv1 Ltv1 GRIP1 GRIP1 GRIPAP1 GRIPAP1 GPHN GPHN IFT74 IFT74 SLC1A1 SLC1A1 KIF5A KIF5A KALRN KALRN CALY CALY SSX2IP SSX2IP HNRNPU HNRNPU MIOS MIOS SPAG17 SPAG17 SHISA4 SHISA4 DNM3 DNM3 MAK MAK RCC2 RCC2 FKBP4 FKBP4 CACNG2 CACNG2 H0UYX0_CAVPO H0UYX0_CAVPO SNAP25 SNAP25 FCGR2 FCGR2 WASL WASL IFT140 IFT140 LRRC1 LRRC1 SNAP23 SNAP23 NUP88 NUP88 SGCD SGCD VPS35 VPS35 H0V208_CAVPO H0V208_CAVPO NME7 NME7 WDR19 WDR19 AP3D1 AP3D1 AKAP9 AKAP9 IFT122 IFT122 TRAF3IP1 TRAF3IP1 LCA5 LCA5 STAU1 STAU1 TNFAIP2 TNFAIP2 GIT1 GIT1 NMD3 NMD3 EXOC3 EXOC3 IFT46 IFT46 CAMK2A CAMK2A AKAP6 AKAP6 WDR35 WDR35 ABCE1 ABCE1 WASHC5 WASHC5 ZNF365 ZNF365 TTC26 TTC26 IFT57 IFT57 KIF5B KIF5B KLHL21 KLHL21 SNAP47 SNAP47 Sdad1 Sdad1 HSPB11 HSPB11 CEP72 CEP72 IFT88 IFT88 CEP131 CEP131 NETO1 NETO1 LRRC7 LRRC7 H0VF00_CAVPO H0VF00_CAVPO Ap2b1 Ap2b1 EXOC3L1 EXOC3L1 DLG2 DLG2 DYNC2LI1 DYNC2LI1 LOC100721103 LOC100721103 NDC1 NDC1 ICK ICK IPO9 IPO9 MYO6 MYO6 SMAD7 SMAD7 DYNLL1 DYNLL1 CLSTN1 CLSTN1 MZT1 MZT1 CPLX1 CPLX1 ENSCPOP00000026253 ENSCPOP00000026253 SCRIB SCRIB NPTX1 NPTX1 ENSCPOP00000027747 ENSCPOP00000027747 DYNC2H1 DYNC2H1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DLG3Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (850 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (246 aa)
IFT20Intraflagellar transport 20. (132 aa)
Lmnb2Uncharacterized protein; Belongs to the intermediate filament family. (617 aa)
SEH1LSEH1 like nucleoporin; Belongs to the WD repeat SEC13 family. (418 aa)
STX3Syntaxin 3; Belongs to the syntaxin family. (288 aa)
ENSCPOP00000028975Uncharacterized protein. (138 aa)
LOC100716703Uncharacterized protein. (157 aa)
SYNJ2BPSynaptojanin 2 binding protein. (145 aa)
LGI1Leucine rich glioma inactivated 1. (557 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
NACC2NACC family member 2. (791 aa)
ARL3ADP ribosylation factor like GTPase 3; Belongs to the small GTPase superfamily. Arf family. (189 aa)
Vamp2V-SNARE coiled-coil homology domain-containing protein. (164 aa)
TERF2Telomeric repeat binding factor 2. (542 aa)
WDR34WD repeat domain 34. (534 aa)
ENSCPOP00000031404Uncharacterized protein. (448 aa)
WDR60WD repeat domain 60. (986 aa)
EXOC3L4Exocyst complex component 3 like 4. (699 aa)
RELNReelin. (3423 aa)
RAB8ARAB8A, member RAS oncogene family. (207 aa)
LMNB1Lamin B1; Belongs to the intermediate filament family. (496 aa)
Fcgr4Low affinity immunoglobulin gamma Fc region receptor IV; Receptor for the Fc region of immunoglobulin gamma. Also acts as a receptor for the Fc region of immunoglobulin epsilon (By similarity). Binds with intermediate affinity to both IgG2a and IgG2b (By similarity). Can bind to IgG2a and IgG2b monomers (By similarity). Does not display binding to IgG1 or IgG3 (By similarity). Mediates neutrophil activation by IgG complexes redundantly with Fcgr3 (By similarity). Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a (By similarity) [...] (250 aa)
PCM1Pericentriolar material 1. (2080 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (886 aa)
EZREzrin. (586 aa)
MAPK10Mitogen-activated protein kinase 10. (434 aa)
ENSCPOP00000033061AP complex subunit beta. (889 aa)
STX1BSyntaxin 1B; Belongs to the syntaxin family. (288 aa)
SSNA1SS nuclear autoantigen 1. (119 aa)
IFT172Intraflagellar transport 172. (1749 aa)
ADAM22ADAM metallopeptidase domain 22. (928 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
ENSCPOP00000023134DRBM domain-containing protein. (120 aa)
NSG1Neuronal vesicle trafficking associated 1. (185 aa)
AP2M1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (435 aa)
AKIRIN2Akirin 2. (163 aa)
XPO1Exportin 1. (1062 aa)
TTC21BTetratricopeptide repeat domain 21B. (1316 aa)
IFT43Intraflagellar transport 43. (205 aa)
SYNJ1Synaptojanin 1. (1607 aa)
RAB11AUncharacterized protein. (216 aa)
ENSCPOP00000021311Uncharacterized protein. (465 aa)
NPTXRNeuronal pentraxin receptor. (323 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (754 aa)
GRIP2Glutamate receptor interacting protein 2. (1004 aa)
EXOC3L2Exocyst complex component 3 like 2. (720 aa)
CNIH3Cornichon family AMPA receptor auxiliary protein 3. (129 aa)
RRS1Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (357 aa)
BBS12Bardet-Biedl syndrome 12. (704 aa)
LCA5LLebercilin LCA5 like. (684 aa)
HASPINHistone H3 associated protein kinase. (754 aa)
H0W649_CAVPOVoltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (280 aa)
RpgrUncharacterized protein. (645 aa)
KIF5CKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (957 aa)
IFT52Intraflagellar transport 52. (406 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (325 aa)
NLGN1Neuroligin 1. (843 aa)
KIF17Kinesin family member 17; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1011 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (624 aa)
IFT27Intraflagellar transport 27. (139 aa)
KIF3BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (748 aa)
STX4Syntaxin 4; Belongs to the syntaxin family. (298 aa)
ARHGAP44Rho GTPase activating protein 44. (751 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
ANKS1BAnkyrin repeat and sterile alpha motif domain containing 1B. (1260 aa)
STAU2Staufen double-stranded RNA binding protein 2. (570 aa)
IFT81Intraflagellar transport 81. (654 aa)
NOP9NOP9 nucleolar protein. (643 aa)
Myo5bUncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1803 aa)
TTC21ATetratricopeptide repeat domain 21A. (1305 aa)
Ltv1Uncharacterized protein. (481 aa)
GRIP1Glutamate receptor interacting protein 1. (1127 aa)
GRIPAP1GRIP1 associated protein 1. (700 aa)
GPHNMolybdopterin molybdenumtransferase; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. (709 aa)
IFT74Intraflagellar transport 74. (586 aa)
SLC1A1Amino acid transporter. (525 aa)
KIF5AKinesin family member 5A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1032 aa)
KALRNKalirin RhoGEF kinase. (2964 aa)
CALYCalcyon neuron specific vesicular protein. (220 aa)
SSX2IPSSX family member 2 interacting protein. (598 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (822 aa)
MIOSMeiosis regulator for oocyte development. (875 aa)
SPAG17Sperm associated antigen 17. (2283 aa)
SHISA4Shisa family member 4. (192 aa)
DNM3Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (811 aa)
MAKMale germ cell associated kinase. (622 aa)
RCC2Regulator of chromosome condensation 2. (427 aa)
FKBP4Peptidylprolyl isomerase. (458 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
H0UYX0_CAVPOUncharacterized protein. (174 aa)
SNAP25Synaptosomal-associated protein; Belongs to the SNAP-25 family. (205 aa)
FCGR2Low affinity immunoglobulin gamma Fc region receptor II; Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. (341 aa)
WASLWASP like actin nucleation promoting factor. (505 aa)
IFT140Intraflagellar transport 140. (1463 aa)
LRRC1Leucine rich repeat containing 1. (458 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (222 aa)
NUP88Nucleoporin 88. (745 aa)
SGCDSarcoglycan delta. (289 aa)
VPS35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (797 aa)
H0V208_CAVPODUF4485 domain-containing protein. (182 aa)
NME7Nucleoside diphosphate kinase 7; Belongs to the NDK family. (376 aa)
WDR19WD repeat domain 19. (1341 aa)
AP3D1AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane. (1161 aa)
AKAP9A-kinase anchoring protein 9. (3887 aa)
IFT122Intraflagellar transport 122. (1218 aa)
TRAF3IP1TRAF3 interacting protein 1. (634 aa)
LCA5Lebercilin LCA5. (659 aa)
STAU1Staufen double-stranded RNA binding protein 1. (479 aa)
TNFAIP2TNF alpha induced protein 2. (691 aa)
GIT1GIT ArfGAP 1. (757 aa)
NMD360S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. (465 aa)
EXOC3Exocyst complex component 3. (755 aa)
IFT46Intraflagellar transport 46. (303 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
AKAP6A-kinase anchoring protein 6. (2208 aa)
WDR35WD repeat-containing protein 35; As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking. (1157 aa)
ABCE1ATP binding cassette subfamily E member 1. (599 aa)
WASHC5WASH complex subunit 5. (1154 aa)
ZNF365Zinc finger protein 365. (398 aa)
TTC26Tetratricopeptide repeat domain 26. (554 aa)
IFT57Intraflagellar transport 57. (429 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (929 aa)
KLHL21Kelch like family member 21. (596 aa)
SNAP47Synaptosome associated protein 47. (418 aa)
Sdad1Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (678 aa)
HSPB11Heat shock protein family B (small) member 11. (144 aa)
CEP72Centrosomal protein 72. (648 aa)
IFT88Intraflagellar transport 88. (825 aa)
CEP131Centrosomal protein 131. (1070 aa)
NETO1Neuropilin and tolloid like 1. (450 aa)
LRRC7Leucine rich repeat containing 7. (1504 aa)
H0VF00_CAVPOUncharacterized protein. (323 aa)
Ap2b1AP complex subunit beta. (951 aa)
EXOC3L1Exocyst complex component 3 like 1. (773 aa)
DLG2Discs large MAGUK scaffold protein 2. (870 aa)
DYNC2LI1Dynein cytoplasmic 2 light intermediate chain 1. (351 aa)
LOC100721103TPR_REGION domain-containing protein. (665 aa)
NDC1NDC1 transmembrane nucleoporin. (645 aa)
ICKIntestinal cell kinase. (632 aa)
IPO9Importin 9. (1034 aa)
MYO6Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1294 aa)
SMAD7SMAD family member 7. (221 aa)
DYNLL1Dynein light chain. (89 aa)
CLSTN1Calsyntenin 1. (989 aa)
MZT1Mitotic spindle organizing protein 1. (79 aa)
CPLX1Complexin 1. (134 aa)
ENSCPOP00000026253Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (565 aa)
SCRIBScribble planar cell polarity protein. (1653 aa)
NPTX1Neuronal pentraxin 1. (432 aa)
ENSCPOP00000027747LAM_G_DOMAIN domain-containing protein. (151 aa)
DYNC2H1Dynein cytoplasmic 2 heavy chain 1. (4253 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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