96 items (Cavia porcellus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	PLS3	Plastin 3. (637 aa)
	STX1B	Syntaxin 1B; Belongs to the syntaxin family. (288 aa)
	Prkaca	Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
	DLG1	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (886 aa)
	CDK5	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (801 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
	Camk2d	Protein kinase domain-containing protein. (532 aa)
	LRP4	LDL receptor related protein 4. (1951 aa)
	Ank3	Uncharacterized protein. (1948 aa)
	SYNJ2BP	Synaptojanin 2 binding protein. (145 aa)
	RAPSN	Receptor associated protein of the synapse. (412 aa)
	CYTH1	Cytohesin 1. (400 aa)
	ENSCPOP00000029057	Synaptogyrin. (252 aa)
	SLC8A3	Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
	CHRNA1	Cholinergic receptor nicotinic alpha 1 subunit. (457 aa)
	ADORA3	Adenosine receptor A3; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (323 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (303 aa)
	ENSCPOP00000027747	LAM_G_DOMAIN domain-containing protein. (151 aa)
	SYP	Synaptophysin. (312 aa)
	Nefm	IF rod domain-containing protein; Belongs to the intermediate filament family. (866 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (705 aa)
	SYNGR3	Synaptogyrin. (229 aa)
	ACHE	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (613 aa)
	MYH10	Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1974 aa)
	SYNGR1	Synaptogyrin. (221 aa)
	DLGAP4	DLG associated protein 4. (992 aa)
	SERPINE2	Serpin family E member 2; Belongs to the serpin family. (397 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
	F2R	Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (426 aa)
	DNAJC5	DnaJ heat shock protein family (Hsp40) member C5. (198 aa)
	MUSK	Muscle associated receptor tyrosine kinase. (879 aa)
	Tbc1d24	Uncharacterized protein. (561 aa)
	UNC13B	Unc-13 homolog B. (1959 aa)
	LAMB1	Laminin subunit beta 1. (1792 aa)
	PDZRN3	PDZ domain containing ring finger 3. (785 aa)
	COLQ	Collagen like tail subunit of asymmetric acetylcholinesterase. (465 aa)
	APP	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (770 aa)
	DLG4	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (754 aa)
	NEFL	Neurofilament light; Belongs to the intermediate filament family. (545 aa)
	DLGAP3	DLG associated protein 3. (979 aa)
	CHRNE	Cholinergic receptor nicotinic epsilon subunit. (493 aa)
	KCNC3	Potassium voltage-gated channel subfamily C member 3; Belongs to the potassium channel family. (729 aa)
	SLC5A7	Solute carrier family 5 member 7; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (579 aa)
	FCHSD1	FCH and double SH3 domains 1. (690 aa)
	DOK7	Docking protein 7. (597 aa)
	EFNA2	Ephrin A2; Belongs to the ephrin family. (190 aa)
	SLC18A3	Solute carrier family 18 member A3. (533 aa)
	SYNGR4	Synaptogyrin. (234 aa)
	NLGN1	Neuroligin 1. (843 aa)
	SPOCK1	SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1. (379 aa)
	CDK5R1	Cyclin-dependent kinase 5 activator. (307 aa)
	APBB1	Amyloid beta precursor protein binding family B member 1. (709 aa)
	PRKCE	Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
	UNC13A	Unc-13 homolog A. (1650 aa)
	RPH3A	Rabphilin 3A. (667 aa)
	KCNN3	Potassium calcium-activated channel subfamily N member 3. (720 aa)
	SYNC	Syncoilin, intermediate filament protein; Belongs to the intermediate filament family. (470 aa)
	CHRNB1	Cholinergic receptor nicotinic beta 1 subunit. (502 aa)
	LAMA2	Laminin subunit alpha 2. (3113 aa)
	AKAP1	A-kinase anchoring protein 1. (860 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1078 aa)
	STXBP5	Syntaxin binding protein 5. (1067 aa)
	KCNC4	Potassium voltage-gated channel subfamily C member 4; Belongs to the potassium channel family. (594 aa)
	PPP1R9A	Protein phosphatase 1 regulatory subunit 9A. (1288 aa)
	FCHSD2	FCH and double SH3 domains 2. (764 aa)
	EPHA4	EPH receptor A4. (986 aa)
	DLG2	Discs large MAGUK scaffold protein 2. (870 aa)
	SV2A	Synaptic vesicle glycoprotein 2A. (742 aa)
	LAMB2	Laminin subunit beta 2. (1800 aa)
	LAMA5	Laminin subunit alpha 5. (3609 aa)
	PCLO	Piccolo presynaptic cytomatrix protein. (3548 aa)
	PTN	Pleiotrophin. (168 aa)
	DNAJA3	DnaJ heat shock protein family (Hsp40) member A3. (479 aa)
	STXBP5L	Syntaxin binding protein 5 like. (1098 aa)
	LAMC1	Laminin subunit gamma 1. (1557 aa)
	UNC13C	Unc-13 homolog C. (2198 aa)
	NRG1	Neuregulin 1. (700 aa)
	ERBIN	Erbb2 interacting protein. (1418 aa)
	ITGA7	Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1137 aa)
	TRIP4	Thyroid hormone receptor interactor 4. (577 aa)
	LAMA4	Laminin subunit alpha 4. (1810 aa)
	CHRND	Cholinergic receptor nicotinic delta subunit. (517 aa)
	SNTA1	Syntrophin alpha 1. (505 aa)
	THBS4	Thrombospondin 4. (958 aa)
	PRKAR1A	Protein kinase cAMP-dependent type I regulatory subunit alpha. (381 aa)
	GRIA1	Glutamate ionotropic receptor AMPA type subunit 1. (861 aa)
	EPHA7	EPH receptor A7. (969 aa)
	SYT2	Synaptotagmin 2. (421 aa)
	PSEN2	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
	ASCC1	Activating signal cointegrator 1 complex subunit 1. (335 aa)
	CIB2	Calcium and integrin binding family member 2. (187 aa)
	POSTN	Periostin. (759 aa)
	UTRN	Utrophin. (3432 aa)
	PDZRN4	PDZ domain containing ring finger 4. (777 aa)
	MYH9	Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1960 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACHE	APP	ENSCPOP00000026437	ENSCPOP00000020780	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.769
ACHE	COLQ	ENSCPOP00000026437	ENSCPOP00000021413	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Collagen like tail subunit of asymmetric acetylcholinesterase.	0.701
ACHE	DOK7	ENSCPOP00000026437	ENSCPOP00000017733	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Docking protein 7.	0.511
ACHE	ENSCPOP00000027747	ENSCPOP00000026437	ENSCPOP00000027747	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	LAM_G_DOMAIN domain-containing protein.	0.573
ACHE	MUSK	ENSCPOP00000026437	ENSCPOP00000022918	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Muscle associated receptor tyrosine kinase.	0.540
ACHE	NLGN1	ENSCPOP00000026437	ENSCPOP00000016648	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Neuroligin 1.	0.528
ACHE	SLC18A3	ENSCPOP00000026437	ENSCPOP00000016862	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Solute carrier family 18 member A3.	0.506
AKAP1	PRKAR1A	ENSCPOP00000011998	ENSCPOP00000003752	A-kinase anchoring protein 1.	Protein kinase cAMP-dependent type I regulatory subunit alpha.	0.879
AKAP1	Prkaca	ENSCPOP00000011998	ENSCPOP00000032930	A-kinase anchoring protein 1.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.920
AKAP1	SLC8A3	ENSCPOP00000011998	ENSCPOP00000029018	A-kinase anchoring protein 1.	Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.651
APBB1	APP	ENSCPOP00000014979	ENSCPOP00000020780	Amyloid beta precursor protein binding family B member 1.	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.999
APBB1	SNTA1	ENSCPOP00000014979	ENSCPOP00000004659	Amyloid beta precursor protein binding family B member 1.	Syntrophin alpha 1.	0.636
APP	ACHE	ENSCPOP00000020780	ENSCPOP00000026437	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	0.769
APP	APBB1	ENSCPOP00000020780	ENSCPOP00000014979	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Amyloid beta precursor protein binding family B member 1.	0.999
APP	CDK5	ENSCPOP00000020780	ENSCPOP00000032608	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.	0.594
APP	DLG4	ENSCPOP00000020780	ENSCPOP00000020709	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	0.499
APP	ITGA7	ENSCPOP00000020780	ENSCPOP00000006369	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Integrin subunit alpha 7; Belongs to the integrin alpha chain family.	0.439
APP	ITGB1	ENSCPOP00000020780	ENSCPOP00000031829	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Integrin beta; Belongs to the integrin beta chain family.	0.658
APP	LRP4	ENSCPOP00000020780	ENSCPOP00000030283	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	LDL receptor related protein 4.	0.597
APP	NEFL	ENSCPOP00000020780	ENSCPOP00000019685	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Neurofilament light; Belongs to the intermediate filament family.	0.594