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Cxcr1 Cxcr1 LRRTM1 LRRTM1 CACNG4 CACNG4 SCYL2 SCYL2 CACNG7 CACNG7 LMBRD1 LMBRD1 ACKR3 ACKR3 SAG SAG RAMP3 RAMP3 Grk4 Grk4 CALY CALY CNTN2 CNTN2 SYK SYK CD81 CD81 Ap2b1 Ap2b1 GRK3 GRK3 DRD2 DRD2 PLD2 PLD2 CLTC CLTC RAB5A RAB5A GRIA1 GRIA1 SNAP25 SNAP25 DRD3 DRD3 CACNG2 CACNG2 Cxcr2 Cxcr2 DNM3 DNM3 NEDD4 NEDD4 HTR2B HTR2B GRIA2 GRIA2 SNX1 SNX1 ENSCPOP00000027062 ENSCPOP00000027062 ADM ADM CAV1 CAV1 CALCRL CALCRL FCER1G FCER1G ULK1 ULK1 RAMP2 RAMP2 RAB31 RAB31 CD9 CD9 CAV3 CAV3 LDLRAP1 LDLRAP1 GRB2 GRB2 ITGB1 ITGB1 ARRB2 ARRB2 EZR EZR ENSCPOP00000033061 ENSCPOP00000033061 AP2M1 AP2M1 PICALM PICALM CACNG3 CACNG3 MYO6 MYO6 ARRB1 ARRB1 CLTCL1 CLTCL1 LRP1 LRP1 CD36 CD36 ACHE ACHE SNCA SNCA PTGER3 PTGER3 DNM2 DNM2 DNM1 DNM1 TFRC TFRC CXCL8 CXCL8 SYNJ1 SYNJ1 HTR1B HTR1B Ceacam1 Ceacam1 RAMP1 RAMP1 HGS HGS H0W649_CAVPO H0W649_CAVPO
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Cxcr1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (355 aa)
LRRTM1Leucine rich repeat transmembrane neuronal 1. (522 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (325 aa)
SCYL2SCY1 like pseudokinase 2. (888 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
LMBRD1LMBR1 domain containing 1. (537 aa)
ACKR3Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (362 aa)
SAGS-antigen. (404 aa)
RAMP3Receptor activity-modifying protein 3; Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL (By similarity). (192 aa)
Grk4G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (432 aa)
CALYCalcyon neuron specific vesicular protein. (220 aa)
CNTN2Contactin 2. (1041 aa)
SYKTyrosine-protein kinase. (579 aa)
CD81Tetraspanin. (236 aa)
Ap2b1AP complex subunit beta. (951 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (673 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (446 aa)
PLD2Phospholipase. (936 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1682 aa)
RAB5ARAB5A, member RAS oncogene family. (214 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (861 aa)
SNAP25Synaptosomal-associated protein; Belongs to the SNAP-25 family. (205 aa)
DRD3Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (364 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
Cxcr2Interleukin-8 receptor CXCR2; Belongs to the G-protein coupled receptor 1 family. (352 aa)
DNM3Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (811 aa)
NEDD4E3 ubiquitin-protein ligase. (896 aa)
HTR2B5-hydroxytryptamine receptor 2B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide- binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity [...] (480 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
SNX1Sorting nexin 1. (521 aa)
ENSCPOP00000027062RGS domain-containing protein. (146 aa)
ADMAdrenomedullin. (182 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
CALCRLCalcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (464 aa)
FCER1GHigh affinity immunoglobulin epsilon receptor subunit gamma; Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functi [...] (86 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1037 aa)
RAMP2Receptor activity-modifying protein 2; Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL (By similarity). (157 aa)
RAB31RAB31, member RAS oncogene family. (196 aa)
CD9Tetraspanin. (227 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (308 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
ARRB2Arrestin beta 2. (417 aa)
EZREzrin. (586 aa)
ENSCPOP00000033061AP complex subunit beta. (889 aa)
AP2M1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (435 aa)
PICALMPhosphatidylinositol binding clathrin assembly protein. (660 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
MYO6Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1294 aa)
ARRB1Arrestin beta 1. (430 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1676 aa)
LRP1LDL receptor related protein 1. (4508 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
ACHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (613 aa)
SNCAAlpha-synuclein; Belongs to the synuclein family. (140 aa)
PTGER3Prostaglandin E receptor 3. (363 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (878 aa)
DNM1Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (864 aa)
TFRCTransferrin receptor protein 1. (765 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity). (101 aa)
SYNJ1Synaptojanin 1. (1607 aa)
HTR1B5-hydroxytryptamine receptor 1B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopami [...] (389 aa)
Ceacam1Uncharacterized protein. (518 aa)
RAMP1Receptor activity-modifying protein 1; Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL (By similarity). (148 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (778 aa)
H0W649_CAVPOVoltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (280 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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