STRINGSTRING
NPFF NPFF TMEM98 TMEM98 HGF HGF IGSF9B IGSF9B KLK8 KLK8 GRIN2C GRIN2C OXT OXT ATPSCKMT ATPSCKMT PAWR PAWR CACNG2 CACNG2 GBA GBA IGSF11 IGSF11 CACNB3 CACNB3 STX1A STX1A FMR1 FMR1 DICER1 DICER1 NOS3 NOS3 COMT COMT NCAM1 NCAM1 JAM2 JAM2 AKAP9 AKAP9 GRIN2B GRIN2B FGFR1 FGFR1 ACPP ACPP DVL1 DVL1 RIMS2 RIMS2 TNR TNR CST7 CST7 MTMR2 MTMR2 NMU NMU PCLO PCLO NETO1 NETO1 H0VF00_CAVPO H0VF00_CAVPO Nmur2 Nmur2 SLC8A2 SLC8A2 WASF3 WASF3 TNFRSF21 TNFRSF21 CHRNA4 CHRNA4 RAPGEF4 RAPGEF4 CTSS CTSS MTNR1B MTNR1B TMEM130 TMEM130 Trpa1 Trpa1 MTOR MTOR MAG MAG RNF10 RNF10 CHRNA5 CHRNA5 ROCK2 ROCK2 KCNC4 KCNC4 TAFA4 TAFA4 GRIN2A GRIN2A MYRF MYRF LPIN1 LPIN1 EIF2AK3 EIF2AK3 GLRA1 GLRA1 GHSR GHSR GSK3B GSK3B SPX SPX SLC25A12 SLC25A12 CTSC CTSC TLR4 TLR4 EDNRB EDNRB LOC100735416 LOC100735416 PARD3 PARD3 ITGA2 ITGA2 P2RX3 P2RX3 CUX2 CUX2 ZFHX2 ZFHX2 SHANK3 SHANK3 CCKBR CCKBR TMEM108 TMEM108 NLGN1 NLGN1 CACNG4 CACNG4 ADRB2 ADRB2 TNFRSF1B TNFRSF1B PTEN PTEN SHANK1 SHANK1 DBN1 DBN1 SH3GL1 SH3GL1 DLGAP3 DLGAP3 NPTX2 NPTX2 GHRL GHRL ZNF488 ZNF488 CHRNB4 CHRNB4 GRIP2 GRIP2 DLG4 DLG4 NPTXR NPTXR NLGN2 NLGN2 APP APP CARTPT CARTPT TYMP TYMP Drd4 Drd4 AGT AGT CBLN1 CBLN1 CCK CCK CCN3 CCN3 SCN11A SCN11A SOX10 SOX10 UNC13B UNC13B Tbc1d24 Tbc1d24 NLGN3 NLGN3 NCMAP NCMAP TENM4 TENM4 SHISA9 SHISA9 DLGAP2 DLGAP2 F2R F2R Rtn4 Rtn4 DLGAP1 DLGAP1 EGR2 EGR2 ABAT ABAT DLGAP4 DLGAP4 SHISA7 SHISA7 FABP5 FABP5 GPR35 GPR35 MGLL MGLL DAG1 DAG1 ZMYND8 ZMYND8 KCNJ10 KCNJ10 GRIN1 GRIN1 RGS4 RGS4 S100B S100B Rims1 Rims1 GRIN2D GRIN2D TPPP TPPP Tac4 Tac4 NPTX1 NPTX1 ENSCPOP00000027747 ENSCPOP00000027747 SLC9A1 SLC9A1 TMEM25 TMEM25 SSH1 SSH1 AFDN AFDN CNIH2 CNIH2 FGF12 FGF12 OPRD1 OPRD1 SLC8A3 SLC8A3 Chrna7 Chrna7 ADORA1 ADORA1 EIF4A3 EIF4A3 HTR2C HTR2C PTK2B PTK2B LOC100735187 LOC100735187 ENSCPOP00000031025 ENSCPOP00000031025 AVPR1A AVPR1A HOMER1 HOMER1 RELN RELN HCRT HCRT BAIAP2 BAIAP2 GPR171 GPR171 IL33 IL33 STX1B STX1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NPFFNeuropeptide FF-amide peptide precursor. (109 aa)
TMEM98Transmembrane protein 98. (226 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
IGSF9BImmunoglobulin superfamily member 9B. (1369 aa)
KLK8Kallikrein related peptidase 8; Belongs to the peptidase S1 family. (258 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1209 aa)
OXTOxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (125 aa)
ATPSCKMTATP synthase c subunit lysine N-methyltransferase. (210 aa)
PAWRPro-apoptotic WT1 regulator. (307 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
GBAGlucosylceramidase. (516 aa)
IGSF11Immunoglobulin superfamily member 11. (420 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (484 aa)
STX1ASyntaxin 1A; Belongs to the syntaxin family. (288 aa)
FMR1Fragile X mental retardation 1. (612 aa)
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1903 aa)
NOS3Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity); Belongs to the NOS family. (1206 aa)
COMTCatechol-O-methyltransferase. (292 aa)
NCAM1Neural cell adhesion molecule 1. (848 aa)
JAM2Junctional adhesion molecule 2. (260 aa)
AKAP9A-kinase anchoring protein 9. (3887 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1381 aa)
FGFR1Fibroblast growth factor receptor. (822 aa)
ACPPAcid phosphatase, prostate; Belongs to the histidine acid phosphatase family. (340 aa)
DVL1Dishevelled segment polarity protein 1. (698 aa)
RIMS2Regulating synaptic membrane exocytosis 2. (1410 aa)
TNRTenascin R. (1358 aa)
CST7Cystatin F. (143 aa)
MTMR2Myotubularin related protein 2. (643 aa)
NMUNeuromedin-U-9. (171 aa)
PCLOPiccolo presynaptic cytomatrix protein. (3548 aa)
NETO1Neuropilin and tolloid like 1. (450 aa)
H0VF00_CAVPOUncharacterized protein. (323 aa)
Nmur2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (403 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (840 aa)
WASF3WASP family member 3. (502 aa)
TNFRSF21TNF receptor superfamily member 21. (630 aa)
CHRNA4Cholinergic receptor nicotinic alpha 4 subunit. (620 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (989 aa)
CTSSCathepsin S; Belongs to the peptidase C1 family. (268 aa)
MTNR1BMelatonin receptor 1B; Belongs to the G-protein coupled receptor 1 family. (366 aa)
TMEM130Transmembrane protein 130. (345 aa)
Trpa1ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (991 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
MAGMyelin associated glycoprotein. (592 aa)
RNF10Ring finger protein 10. (797 aa)
CHRNA5Cholinergic receptor nicotinic alpha 5 subunit. (438 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1371 aa)
KCNC4Potassium voltage-gated channel subfamily C member 4; Belongs to the potassium channel family. (594 aa)
TAFA4TAFA chemokine like family member 4. (135 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1462 aa)
MYRFMyelin regulatory factor. (1053 aa)
LPIN1Lipin 1. (899 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1112 aa)
GLRA1Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (302 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (423 aa)
SPXSpexin hormone. (117 aa)
SLC25A12Solute carrier family 25 member 12; Belongs to the mitochondrial carrier (TC 2.A.29) family. (678 aa)
CTSCCathepsin C; Belongs to the peptidase C1 family. (463 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (837 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (415 aa)
LOC100735416VWFA domain-containing protein; Belongs to the integrin alpha chain family. (1159 aa)
PARD3Par-3 family cell polarity regulator. (1294 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1156 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (391 aa)
CUX2Homeobox protein cut-like. (1424 aa)
ZFHX2Zinc finger homeobox 2. (2554 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1694 aa)
CCKBRCholecystokinin B receptor; Belongs to the G-protein coupled receptor 1 family. (426 aa)
TMEM108Transmembrane protein 108. (566 aa)
NLGN1Neuroligin 1. (843 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (325 aa)
ADRB2Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. (418 aa)
TNFRSF1BTNF receptor superfamily member 1B. (482 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (355 aa)
SHANK1SH3 and multiple ankyrin repeat domains 1. (1749 aa)
DBN1Drebrin 1. (677 aa)
SH3GL1SH3 domain containing GRB2 like 1, endophilin A2. (359 aa)
DLGAP3DLG associated protein 3. (979 aa)
NPTX2Neuronal pentraxin-2; May be involved in binding, concentrating, and sorting soluble glycoproteins or glycolipids that are destined for the acrosome. (417 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
ZNF488Zinc finger protein 488. (318 aa)
CHRNB4Cholinergic receptor nicotinic beta 4 subunit. (489 aa)
GRIP2Glutamate receptor interacting protein 2. (1004 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (754 aa)
NPTXRNeuronal pentraxin receptor. (323 aa)
NLGN2Neuroligin 2. (662 aa)
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (770 aa)
CARTPTCART prepropeptide. (129 aa)
TYMPThymidine phosphorylase; Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. (479 aa)
Drd4G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (341 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
CBLN1Cerebellin 1 precursor. (105 aa)
CCKCholecystokinin. (115 aa)
CCN3Cellular communication network factor 3. (356 aa)
SCN11ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1719 aa)
SOX10SRY-box transcription factor 10. (469 aa)
UNC13BUnc-13 homolog B. (1959 aa)
Tbc1d24Uncharacterized protein. (561 aa)
NLGN3Neuroligin 3. (846 aa)
NCMAPNon-compact myelin associated protein. (102 aa)
TENM4Teneurin transmembrane protein 4. (2890 aa)
SHISA9Shisa family member 9. (424 aa)
DLGAP2DLG associated protein 2. (1058 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (426 aa)
Rtn4Reticulon. (350 aa)
DLGAP1DLG associated protein 1. (989 aa)
EGR2Early growth response 2. (473 aa)
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa)
DLGAP4DLG associated protein 4. (992 aa)
SHISA7Shisa family member 7. (377 aa)
FABP5E-FABP; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
GPR35G protein-coupled receptor 35; Belongs to the G-protein coupled receptor 1 family. (327 aa)
MGLLMonoglyceride lipase. (314 aa)
DAG1Dystroglycan 1. (891 aa)
ZMYND8Zinc finger MYND-type containing 8. (1213 aa)
KCNJ10Potassium voltage-gated channel subfamily J member 10. (379 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (943 aa)
RGS4Regulator of G protein signaling 4. (205 aa)
S100BProtein S100; Belongs to the S-100 family. (92 aa)
Rims1C2 domain-containing protein. (219 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (808 aa)
TPPPTubulin polymerization promoting protein. (220 aa)
Tac4Uncharacterized protein. (90 aa)
NPTX1Neuronal pentraxin 1. (432 aa)
ENSCPOP00000027747LAM_G_DOMAIN domain-containing protein. (151 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (810 aa)
TMEM25Transmembrane protein 25. (365 aa)
SSH1Slingshot protein phosphatase 1. (1053 aa)
AFDNAfadin, adherens junction formation factor. (1794 aa)
CNIH2Cornichon family AMPA receptor auxiliary protein 2. (160 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
Chrna7Uncharacterized protein. (483 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. (326 aa)
EIF4A3Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family. (411 aa)
HTR2C5-hydroxytryptamine receptor 2C. (458 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
LOC100735187C-C motif chemokine. (93 aa)
ENSCPOP00000031025SAC domain-containing protein. (814 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (418 aa)
HOMER1Homer scaffold protein 1. (329 aa)
RELNReelin. (3423 aa)
HCRTHypocretin neuropeptide precursor. (110 aa)
BAIAP2BAI1 associated protein 2. (535 aa)
GPR171G protein-coupled receptor 171; Belongs to the G-protein coupled receptor 1 family. (319 aa)
IL33Interleukin 33. (280 aa)
STX1BSyntaxin 1B; Belongs to the syntaxin family. (288 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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