86 items (Cavia porcellus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	OXT	Oxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (125 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (504 aa)
	COMMD1	Copper metabolism domain containing 1. (188 aa)
	PTCH1	Patched 1. (1379 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (229 aa)
	P2rx4	Uncharacterized protein. (343 aa)
	GAL	Galanin and GMAP prepropeptide. (123 aa)
	NFKBIA	NFKB inhibitor alpha. (314 aa)
	DENND5B	DENN domain containing 5B. (1231 aa)
	ABCA12	ATP binding cassette subfamily A member 12. (2597 aa)
	ACSL5	AMP-binding domain-containing protein. (682 aa)
	Anxa2	Annexin. (339 aa)
	ABCG4	ATP binding cassette subfamily G member 4. (646 aa)
	APOE	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (298 aa)
	SIRT1	Sirtuin 1. (717 aa)
	ZDHHC8	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (751 aa)
	Dbi	ACB domain-containing protein. (87 aa)
	GALR1	Galanin receptor 1; Belongs to the G-protein coupled receptor 1 family. (349 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	CRH	Corticotropin releasing hormone. (193 aa)
	LOC100721198	Cell cycle control protein; Belongs to the CDC50/LEM3 family. (364 aa)
	LOC100721835	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (565 aa)
	LDLRAP1	Low density lipoprotein receptor adaptor protein 1. (308 aa)
	Faslg	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (69 aa)
	ABCA3	ATP binding cassette subfamily A member 3. (1704 aa)
	AVPR1B	Vasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (422 aa)
	TNFSF11	Tumor necrosis factor ligand superfamily member. (315 aa)
	GPS2	G protein pathway suppressor 2. (327 aa)
	H0V9V8_CAVPO	WH2 domain-containing protein. (298 aa)
	PLA2R1	Phospholipase A2 receptor 1. (1394 aa)
	Dab2	PID domain-containing protein. (766 aa)
	LOC100725073	PID domain-containing protein. (745 aa)
	APOA1	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. (264 aa)
	TRIAP1	TP53 regulated inhibitor of apoptosis 1. (76 aa)
	NR1H2	Nuclear receptor subfamily 1 group H member 2. (463 aa)
	LOC100730472	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (559 aa)
	MFN2	Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
	LIPG	Lipase G, endothelial type. (498 aa)
	ABCA1	ATP binding cassette subfamily A member 1. (2200 aa)
	ABCA7	ATP binding cassette subfamily A member 7. (2108 aa)
	Ces1d	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (565 aa)
	PLA2G3	Phospholipase A2 group III. (645 aa)
	H0VM53_CAVPO	AMP-binding domain-containing protein. (696 aa)
	PLTP	Phospholipid transfer protein. (494 aa)
	TMF1	TATA element modulatory factor 1. (1092 aa)
	CYP19A1	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
	BMP6	Bone morphogenetic protein 6. (505 aa)
	SPP1	Secreted phosphoprotein 1. (263 aa)
	ABCG1	ATP binding cassette subfamily G member 1. (666 aa)
	TNFRSF11A	TNF receptor superfamily member 11a. (515 aa)
	H0VU94_CAVPO	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (520 aa)
	PLA2G10	Phospholipase A(2). (152 aa)
	NUCB2	Nucleobindin 2. (420 aa)
	ERFE	Erythroferrone. (337 aa)
	GHRL	Ghrelin and obestatin prepropeptide. (117 aa)
	LOC100734566	Uncharacterized protein. (558 aa)
	LOC100734845	Uncharacterized protein; Belongs to the cytochrome P450 family. (501 aa)
	H0WDU3_CAVPO	Uncharacterized protein. (147 aa)
	ENSCPOP00000021511	Uncharacterized protein. (72 aa)
	PLA2G6	Phospholipase A2 group VI. (803 aa)
	ENSCPOP00000022046	Thiolase_N domain-containing protein. (103 aa)
	MAP2K6	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
	NKX3-1	NK3 homeobox 1. (224 aa)
	PRELID1	PRELI domain containing 1. (219 aa)
	PLA2G4A	Phospholipase A2. (749 aa)
	ABCA5	ATP binding cassette subfamily A member 5. (1593 aa)
	LOC100717473	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (561 aa)
	PON1	Paraoxonase 1. (363 aa)
	ATP8A1	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1113 aa)
	PTGES	Prostaglandin E synthase. (153 aa)
	Washc1	WH2 domain-containing protein. (472 aa)
	RETN	Resistin. (112 aa)
	ENSCPOP00000024925	COesterase domain-containing protein. (295 aa)
	ENSCPOP00000024929	SCP2 domain-containing protein. (143 aa)
	LPCAT3	Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (487 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	LRP1	LDL receptor related protein 1. (4508 aa)
	NR1H3	Nuclear receptor subfamily 1 group H member 3. (443 aa)
	C1qtnf6	C1q domain-containing protein. (101 aa)
	PRKCD	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
	C1QTNF1	C1q and TNF related 1. (281 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (247 aa)
	P2RY2	Purinergic receptor P2Y2; Belongs to the G-protein coupled receptor 1 family. (376 aa)
	Tmem30a	Cell cycle control protein; Belongs to the CDC50/LEM3 family. (364 aa)
	EEPD1	Endonuclease/exonuclease/phosphatase family domain containing 1. (569 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA1	ABCA3	ENSCPOP00000008428	ENSCPOP00000031518	ATP binding cassette subfamily A member 1.	ATP binding cassette subfamily A member 3.	0.613
ABCA1	ABCG1	ENSCPOP00000008428	ENSCPOP00000013696	ATP binding cassette subfamily A member 1.	ATP binding cassette subfamily G member 1.	0.415
ABCA1	APOA1	ENSCPOP00000008428	ENSCPOP00000032306	ATP binding cassette subfamily A member 1.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family.	0.962
ABCA1	APOE	ENSCPOP00000008428	ENSCPOP00000006519	ATP binding cassette subfamily A member 1.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.773
ABCA1	CAV1	ENSCPOP00000008428	ENSCPOP00000027566	ATP binding cassette subfamily A member 1.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.433
ABCA1	NR1H2	ENSCPOP00000008428	ENSCPOP00000032644	ATP binding cassette subfamily A member 1.	Nuclear receptor subfamily 1 group H member 2.	0.921
ABCA1	NR1H3	ENSCPOP00000008428	ENSCPOP00000025335	ATP binding cassette subfamily A member 1.	Nuclear receptor subfamily 1 group H member 3.	0.904
ABCA1	PLTP	ENSCPOP00000008428	ENSCPOP00000011543	ATP binding cassette subfamily A member 1.	Phospholipid transfer protein.	0.536
ABCA1	PPARG	ENSCPOP00000008428	ENSCPOP00000001849	ATP binding cassette subfamily A member 1.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.627
ABCA12	ABCA5	ENSCPOP00000005396	ENSCPOP00000023053	ATP binding cassette subfamily A member 12.	ATP binding cassette subfamily A member 5.	0.441
ABCA12	APOA1	ENSCPOP00000005396	ENSCPOP00000032306	ATP binding cassette subfamily A member 12.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family.	0.598
ABCA12	NR1H2	ENSCPOP00000005396	ENSCPOP00000032644	ATP binding cassette subfamily A member 12.	Nuclear receptor subfamily 1 group H member 2.	0.610
ABCA12	NR1H3	ENSCPOP00000005396	ENSCPOP00000025335	ATP binding cassette subfamily A member 12.	Nuclear receptor subfamily 1 group H member 3.	0.560
ABCA12	ZDHHC8	ENSCPOP00000005396	ENSCPOP00000000509	ATP binding cassette subfamily A member 12.	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.	0.467
ABCA3	ABCA1	ENSCPOP00000031518	ENSCPOP00000008428	ATP binding cassette subfamily A member 3.	ATP binding cassette subfamily A member 1.	0.613
ABCA3	APOA1	ENSCPOP00000031518	ENSCPOP00000032306	ATP binding cassette subfamily A member 3.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family.	0.585
ABCA3	NR1H2	ENSCPOP00000031518	ENSCPOP00000032644	ATP binding cassette subfamily A member 3.	Nuclear receptor subfamily 1 group H member 2.	0.545
ABCA3	NR1H3	ENSCPOP00000031518	ENSCPOP00000025335	ATP binding cassette subfamily A member 3.	Nuclear receptor subfamily 1 group H member 3.	0.545
ABCA5	ABCA12	ENSCPOP00000023053	ENSCPOP00000005396	ATP binding cassette subfamily A member 5.	ATP binding cassette subfamily A member 12.	0.441
ABCA5	APOA1	ENSCPOP00000023053	ENSCPOP00000032306	ATP binding cassette subfamily A member 5.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family.	0.585