STRINGSTRING
OXT OXT IL1B IL1B PPARG PPARG COMMD1 COMMD1 PTCH1 PTCH1 TREM2 TREM2 P2rx4 P2rx4 GAL GAL NFKBIA NFKBIA DENND5B DENND5B ABCA12 ABCA12 ACSL5 ACSL5 Anxa2 Anxa2 ABCG4 ABCG4 APOE APOE SIRT1 SIRT1 ZDHHC8 ZDHHC8 Dbi Dbi GALR1 GALR1 CAV1 CAV1 CRH CRH LOC100721198 LOC100721198 LOC100721835 LOC100721835 LDLRAP1 LDLRAP1 Faslg Faslg ABCA3 ABCA3 AVPR1B AVPR1B TNFSF11 TNFSF11 GPS2 GPS2 H0V9V8_CAVPO H0V9V8_CAVPO PLA2R1 PLA2R1 Dab2 Dab2 LOC100725073 LOC100725073 APOA1 APOA1 TRIAP1 TRIAP1 NR1H2 NR1H2 LOC100730472 LOC100730472 MFN2 MFN2 LIPG LIPG ABCA1 ABCA1 ABCA7 ABCA7 Ces1d Ces1d PLA2G3 PLA2G3 H0VM53_CAVPO H0VM53_CAVPO PLTP PLTP TMF1 TMF1 CYP19A1 CYP19A1 BMP6 BMP6 SPP1 SPP1 ABCG1 ABCG1 TNFRSF11A TNFRSF11A H0VU94_CAVPO H0VU94_CAVPO PLA2G10 PLA2G10 NUCB2 NUCB2 ERFE ERFE GHRL GHRL LOC100734566 LOC100734566 LOC100734845 LOC100734845 H0WDU3_CAVPO H0WDU3_CAVPO ENSCPOP00000021511 ENSCPOP00000021511 PLA2G6 PLA2G6 ENSCPOP00000022046 ENSCPOP00000022046 MAP2K6 MAP2K6 NKX3-1 NKX3-1 PRELID1 PRELID1 PLA2G4A PLA2G4A ABCA5 ABCA5 LOC100717473 LOC100717473 PON1 PON1 ATP8A1 ATP8A1 PTGES PTGES Washc1 Washc1 RETN RETN ENSCPOP00000024925 ENSCPOP00000024925 ENSCPOP00000024929 ENSCPOP00000024929 LPCAT3 LPCAT3 MAPK9 MAPK9 LRP1 LRP1 NR1H3 NR1H3 C1qtnf6 C1qtnf6 PRKCD PRKCD C1QTNF1 C1QTNF1 ADIPOQ ADIPOQ P2RY2 P2RY2 Tmem30a Tmem30a EEPD1 EEPD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
OXTOxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (125 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (504 aa)
COMMD1Copper metabolism domain containing 1. (188 aa)
PTCH1Patched 1. (1379 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (229 aa)
P2rx4Uncharacterized protein. (343 aa)
GALGalanin and GMAP prepropeptide. (123 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
DENND5BDENN domain containing 5B. (1231 aa)
ABCA12ATP binding cassette subfamily A member 12. (2597 aa)
ACSL5AMP-binding domain-containing protein. (682 aa)
Anxa2Annexin. (339 aa)
ABCG4ATP binding cassette subfamily G member 4. (646 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (298 aa)
SIRT1Sirtuin 1. (717 aa)
ZDHHC8Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (751 aa)
DbiACB domain-containing protein. (87 aa)
GALR1Galanin receptor 1; Belongs to the G-protein coupled receptor 1 family. (349 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
CRHCorticotropin releasing hormone. (193 aa)
LOC100721198Cell cycle control protein; Belongs to the CDC50/LEM3 family. (364 aa)
LOC100721835Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (565 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (308 aa)
FaslgTNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (69 aa)
ABCA3ATP binding cassette subfamily A member 3. (1704 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (422 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (315 aa)
GPS2G protein pathway suppressor 2. (327 aa)
H0V9V8_CAVPOWH2 domain-containing protein. (298 aa)
PLA2R1Phospholipase A2 receptor 1. (1394 aa)
Dab2PID domain-containing protein. (766 aa)
LOC100725073PID domain-containing protein. (745 aa)
APOA1Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. (264 aa)
TRIAP1TP53 regulated inhibitor of apoptosis 1. (76 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (463 aa)
LOC100730472Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (559 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
LIPGLipase G, endothelial type. (498 aa)
ABCA1ATP binding cassette subfamily A member 1. (2200 aa)
ABCA7ATP binding cassette subfamily A member 7. (2108 aa)
Ces1dCarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (565 aa)
PLA2G3Phospholipase A2 group III. (645 aa)
H0VM53_CAVPOAMP-binding domain-containing protein. (696 aa)
PLTPPhospholipid transfer protein. (494 aa)
TMF1TATA element modulatory factor 1. (1092 aa)
CYP19A1Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
BMP6Bone morphogenetic protein 6. (505 aa)
SPP1Secreted phosphoprotein 1. (263 aa)
ABCG1ATP binding cassette subfamily G member 1. (666 aa)
TNFRSF11ATNF receptor superfamily member 11a. (515 aa)
H0VU94_CAVPOCarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (520 aa)
PLA2G10Phospholipase A(2). (152 aa)
NUCB2Nucleobindin 2. (420 aa)
ERFEErythroferrone. (337 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
LOC100734566Uncharacterized protein. (558 aa)
LOC100734845Uncharacterized protein; Belongs to the cytochrome P450 family. (501 aa)
H0WDU3_CAVPOUncharacterized protein. (147 aa)
ENSCPOP00000021511Uncharacterized protein. (72 aa)
PLA2G6Phospholipase A2 group VI. (803 aa)
ENSCPOP00000022046Thiolase_N domain-containing protein. (103 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
NKX3-1NK3 homeobox 1. (224 aa)
PRELID1PRELI domain containing 1. (219 aa)
PLA2G4APhospholipase A2. (749 aa)
ABCA5ATP binding cassette subfamily A member 5. (1593 aa)
LOC100717473Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (561 aa)
PON1Paraoxonase 1. (363 aa)
ATP8A1Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1113 aa)
PTGESProstaglandin E synthase. (153 aa)
Washc1WH2 domain-containing protein. (472 aa)
RETNResistin. (112 aa)
ENSCPOP00000024925COesterase domain-containing protein. (295 aa)
ENSCPOP00000024929SCP2 domain-containing protein. (143 aa)
LPCAT3Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (487 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
LRP1LDL receptor related protein 1. (4508 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (443 aa)
C1qtnf6C1q domain-containing protein. (101 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
C1QTNF1C1q and TNF related 1. (281 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (247 aa)
P2RY2Purinergic receptor P2Y2; Belongs to the G-protein coupled receptor 1 family. (376 aa)
Tmem30aCell cycle control protein; Belongs to the CDC50/LEM3 family. (364 aa)
EEPD1Endonuclease/exonuclease/phosphatase family domain containing 1. (569 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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