STRINGSTRING
ENSCPOP00000023576 ENSCPOP00000023576 GPER1 GPER1 ERGIC3 ERGIC3 Pmaip1 Pmaip1 CHP1 CHP1 CIB1 CIB1 RAPGEF3 RAPGEF3 PSEN1 PSEN1 ENSCPOP00000024929 ENSCPOP00000024929 PRR5L PRR5L EDEM2 EDEM2 BORCS5 BORCS5 FYN FYN GLI3 GLI3 STK11 STK11 ZPR1 ZPR1 PRKCD PRKCD FBXW7 FBXW7 PRKCQ PRKCQ Tmem30a Tmem30a FLNA FLNA Map2 Map2 TRIM46 TRIM46 HPCA HPCA KCNB1 KCNB1 TNFRSF1A TNFRSF1A ENSCPOP00000029129 ENSCPOP00000029129 DHX9 DHX9 LEP LEP STOM STOM Ywhae Ywhae TCAF1 TCAF1 ARPC2 ARPC2 TARDBP TARDBP MIEF2 MIEF2 ENSCPOP00000029968 ENSCPOP00000029968 Ank3 Ank3 LOC100721198 LOC100721198 HPCAL1 HPCAL1 Vamp2 Vamp2 BCAS3 BCAS3 ENSCPOP00000030763 ENSCPOP00000030763 ENSCPOP00000030850 ENSCPOP00000030850 ENSCPOP00000030888 ENSCPOP00000030888 PRNP PRNP SHH SHH MSN MSN LDLRAP1 LDLRAP1 PDCD10 PDCD10 SFN SFN JUP JUP MYO1C MYO1C HDAC3 HDAC3 H0VQ71_CAVPO H0VQ71_CAVPO AKT2 AKT2 CDC42 CDC42 MFF MFF MIEF1 MIEF1 LOC100725073 LOC100725073 PCM1 PCM1 CDK5 CDK5 ACTR3 ACTR3 CEP290 CEP290 UACA UACA SH3GLB1 SH3GLB1 STX18 STX18 CPSF6 CPSF6 Prkaca Prkaca EZR EZR CEMIP CEMIP RIPOR1 RIPOR1 DYNC1H1 DYNC1H1 HSP90AB1 HSP90AB1 OAZ3 OAZ3 KIF20B KIF20B CACNB3 CACNB3 PGAP1 PGAP1 FEZ1 FEZ1 NCBP2 NCBP2 Spag5 Spag5 C2CD5 C2CD5 PPM1A PPM1A NRDE2 NRDE2 PLK3 PLK3 COMMD1 COMMD1 Hsp90aa1 Hsp90aa1 OAZ2 OAZ2 RBM22 RBM22 XPO4 XPO4 TGFB1 TGFB1 NEDD4 NEDD4 PAK1 PAK1 EHD2 EHD2 Trim28 Trim28 ERBB2 ERBB2 ABCA12 ABCA12 TM9SF4 TM9SF4 HCLS1 HCLS1 Anxa2 Anxa2 VPS11 VPS11 RUFY3 RUFY3 FBXW9 FBXW9 CAMK4 CAMK4 GAS6 GAS6 ASPH ASPH BAG3 BAG3 PIK3R1 PIK3R1 MLC1 MLC1 H0W027_CAVPO H0W027_CAVPO CDK5R1 CDK5R1 EFCAB7 EFCAB7 SORL1 SORL1 CHP2 CHP2 JAK2 JAK2 GSK3B GSK3B H0VBD1_CAVPO H0VBD1_CAVPO EHD1 EHD1 TOMM7 TOMM7 KIF5B KIF5B MTMR2 MTMR2 BCAP31 BCAP31 Dab2 Dab2 CAMK1 CAMK1 NUMA1 NUMA1 CEP131 CEP131 UBR5 UBR5 TEK TEK CD81 CD81 ITGB1BP1 ITGB1BP1 RIOK2 RIOK2 ZC3H12A ZC3H12A KIF3A KIF3A PTPN5 PTPN5 CDH1 CDH1 CALY CALY MAVS MAVS CAPN10 CAPN10 MECP2 MECP2 Dctn1 Dctn1 SMO SMO PLA2G4E PLA2G4E Brca1 Brca1 ACTN2 ACTN2 DMAP1 DMAP1 ANP32B ANP32B CTDSPL2 CTDSPL2 B3GAT3 B3GAT3 TMEM30B TMEM30B TENM1 TENM1 FIS1 FIS1 SLC51B SLC51B CHRM1 CHRM1 SLC35D3 SLC35D3 PCNT PCNT TPR TPR GSK3A GSK3A PTPN23 PTPN23 LOC100725322 LOC100725322 MAPK14 MAPK14 RDX RDX ENSCPOP00000022046 ENSCPOP00000022046 MTCL1 MTCL1 SAR1B SAR1B MDM2 MDM2 PDCD5 PDCD5 KHDRBS1 KHDRBS1 EIPR1 EIPR1 TBC1D20 TBC1D20 PRKAA1 PRKAA1 Cdk1 Cdk1 PDZK1 PDZK1 H0V597_CAVPO H0V597_CAVPO HYAL2 HYAL2 ZDHHC2 ZDHHC2 H0V4A5_CAVPO H0V4A5_CAVPO PRKD1 PRKD1 Ipo5 Ipo5 ECT2 ECT2 RAB21 RAB21 OAZ1 OAZ1 LOC100725052 LOC100725052 TCF7L2 TCF7L2 RAB29 RAB29 LOC100725824 LOC100725824 SAR1A SAR1A EDEM1 EDEM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSCPOP00000023576Uncharacterized protein. (201 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
ERGIC3ERGIC and golgi 3. (383 aa)
Pmaip1Uncharacterized protein. (102 aa)
CHP1Calcineurin like EF-hand protein 1. (195 aa)
CIB1Calcium and integrin binding 1. (191 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (926 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
ENSCPOP00000024929SCP2 domain-containing protein. (143 aa)
PRR5LProline rich 5 like. (368 aa)
EDEM2alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (574 aa)
BORCS5BLOC-1 related complex subunit 5. (196 aa)
FYNTyrosine-protein kinase. (537 aa)
GLI3GLI family zinc finger 3. (1580 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (435 aa)
ZPR1ZPR1 zinc finger. (459 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
FBXW7F-box and WD repeat domain containing 7. (711 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (705 aa)
Tmem30aCell cycle control protein; Belongs to the CDC50/LEM3 family. (364 aa)
FLNAFilamin A. (2645 aa)
Map2Microtubule-associated protein. (559 aa)
TRIM46Tripartite motif containing 46. (672 aa)
HPCAHippocalcin. (193 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (855 aa)
TNFRSF1ATNF receptor superfamily member 1A. (469 aa)
ENSCPOP00000029129Protein kinase domain-containing protein. (254 aa)
DHX9DExH-box helicase 9. (1373 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (165 aa)
STOMStomatin. (284 aa)
Ywhae14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa)
TCAF1TRPM8 channel associated factor 1. (921 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
TARDBPTAR DNA binding protein. (413 aa)
MIEF2Mitochondrial elongation factor 2. (454 aa)
ENSCPOP00000029968Uncharacterized protein. (34 aa)
Ank3Uncharacterized protein. (1948 aa)
LOC100721198Cell cycle control protein; Belongs to the CDC50/LEM3 family. (364 aa)
HPCAL1Hippocalcin like 1. (193 aa)
Vamp2V-SNARE coiled-coil homology domain-containing protein. (164 aa)
BCAS3BCAS3 microtubule associated cell migration factor. (943 aa)
ENSCPOP00000030763Uncharacterized protein. (980 aa)
ENSCPOP00000030850WH2 domain-containing protein. (58 aa)
ENSCPOP00000030888Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (238 aa)
PRNPMajor prion protein; Belongs to the prion family. (244 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (447 aa)
MSNMoesin. (577 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (308 aa)
PDCD10Programmed cell death 10. (212 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
JUPJunction plakoglobin. (745 aa)
MYO1CMyosin IC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1078 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
H0VQ71_CAVPOUncharacterized protein. (117 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CDC42Cell division cycle 42. (191 aa)
MFFMitochondrial fission factor. (354 aa)
MIEF1Mitochondrial elongation factor 1. (463 aa)
LOC100725073PID domain-containing protein. (745 aa)
PCM1Pericentriolar material 1. (2080 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (411 aa)
CEP290Centrosomal protein 290. (2425 aa)
UACAUveal autoantigen with coiled-coil domains and ankyrin repeats. (1418 aa)
SH3GLB1SH3 domain containing GRB2 like, endophilin B1. (394 aa)
STX18Syntaxin 18. (335 aa)
CPSF6Cleavage and polyadenylation specific factor 6. (588 aa)
PrkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
EZREzrin. (586 aa)
CEMIPCell migration inducing hyaluronidase 1. (1363 aa)
RIPOR1RHO family interacting cell polarization regulator 1. (1209 aa)
DYNC1H1Dynein cytoplasmic 1 heavy chain 1. (4637 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (723 aa)
OAZ3Ornithine decarboxylase antizyme 3. (225 aa)
KIF20BKinesin family member 20B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1756 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (484 aa)
PGAP1GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI- anchored proteins from the endoplasmic reticulum to the Golgi. (872 aa)
FEZ1Fasciculation and elongation protein zeta 1. (403 aa)
NCBP2Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (156 aa)
Spag5Sperm associated antigen 5. (1196 aa)
C2CD5C2 calcium dependent domain containing 5. (1035 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (382 aa)
NRDE2NRDE-2, necessary for RNA interference, domain containing. (1165 aa)
PLK3Serine/threonine-protein kinase PLK. (646 aa)
COMMD1Copper metabolism domain containing 1. (188 aa)
Hsp90aa1Heat shock protein 90 alpha family class A member 1. (733 aa)
OAZ2Uncharacterized protein. (189 aa)
RBM22RNA binding motif protein 22. (420 aa)
XPO4Exportin 4. (1146 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
NEDD4E3 ubiquitin-protein ligase. (896 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
EHD2EH domain containing 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (543 aa)
Trim28Uncharacterized protein. (829 aa)
ERBB2Receptor protein-tyrosine kinase. (1256 aa)
ABCA12ATP binding cassette subfamily A member 12. (2597 aa)
TM9SF4Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (627 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (472 aa)
Anxa2Annexin. (339 aa)
VPS11Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (941 aa)
RUFY3RUN and FYVE domain containing 3. (628 aa)
FBXW9F-box and WD repeat domain containing 9. (457 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV. (418 aa)
GAS6Growth arrest specific 6. (678 aa)
ASPHAspartate beta-hydroxylase. (644 aa)
BAG3BCL2 associated athanogene 3. (572 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
MLC1Modulator of VRAC current 1. (388 aa)
H0W027_CAVPOUncharacterized protein. (722 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
EFCAB7EF-hand calcium binding domain 7. (629 aa)
SORL1Sortilin related receptor 1. (2211 aa)
CHP2Calcineurin like EF-hand protein 2. (196 aa)
JAK2Tyrosine-protein kinase. (1035 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (423 aa)
H0VBD1_CAVPO14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (105 aa)
EHD1EH domain containing 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (534 aa)
TOMM7Translocase of outer mitochondrial membrane 7. (55 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (929 aa)
MTMR2Myotubularin related protein 2. (643 aa)
BCAP31B cell receptor associated protein 31. (246 aa)
Dab2PID domain-containing protein. (766 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (370 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2117 aa)
CEP131Centrosomal protein 131. (1070 aa)
UBR5Ubiquitin protein ligase E3 component n-recognin 5. (2649 aa)
TEKTEK receptor tyrosine kinase. (1029 aa)
CD81Tetraspanin. (236 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
RIOK2RIO kinase 2. (548 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (550 aa)
KIF3AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (728 aa)
PTPN5Protein tyrosine phosphatase non-receptor type 5. (541 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (891 aa)
CALYCalcyon neuron specific vesicular protein. (220 aa)
MAVSMitochondrial antiviral signaling protein. (533 aa)
CAPN10Calpain 10; Belongs to the peptidase C2 family. (667 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (504 aa)
Dctn1CAP-Gly domain-containing protein. (1281 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (789 aa)
PLA2G4EPhospholipase A2. (805 aa)
Brca1Uncharacterized protein. (79 aa)
ACTN2Actinin alpha 2. (894 aa)
DMAP1DNA methyltransferase 1 associated protein 1. (445 aa)
ANP32BAcidic nuclear phosphoprotein 32 family member B. (244 aa)
CTDSPL2CTD small phosphatase like 2. (403 aa)
B3GAT3Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family. (335 aa)
TMEM30BCell cycle control protein; Belongs to the CDC50/LEM3 family. (352 aa)
TENM1Teneurin transmembrane protein 1. (2732 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
SLC51BSolute carrier family 51 beta subunit. (120 aa)
CHRM1Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (460 aa)
SLC35D3Solute carrier family 35 member D3. (422 aa)
PCNTPericentrin. (2941 aa)
TPRTranslocated promoter region, nuclear basket protein. (2320 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (470 aa)
PTPN23Protein tyrosine phosphatase non-receptor type 23. (1623 aa)
LOC100725322Peptidase M60 domain-containing protein. (914 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
RDXRadixin. (604 aa)
ENSCPOP00000022046Thiolase_N domain-containing protein. (103 aa)
MTCL1Microtubule crosslinking factor 1. (1642 aa)
SAR1BSecretion associated Ras related GTPase 1B; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
PDCD5Programmed cell death 5. (125 aa)
KHDRBS1KH RNA binding domain containing, signal transduction associated 1. (471 aa)
EIPR1EARP complex and GARP complex interacting protein 1. (387 aa)
TBC1D20TBC1 domain family member 20. (403 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
Cdk1Protein kinase domain-containing protein. (240 aa)
PDZK1PDZ domain containing 1. (513 aa)
H0V597_CAVPOUncharacterized protein. (326 aa)
HYAL2Hyaluronidase. (471 aa)
ZDHHC2Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (323 aa)
H0V4A5_CAVPOUncharacterized protein. (830 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (845 aa)
Ipo5Importin N-terminal domain-containing protein. (1088 aa)
ECT2Epithelial cell transforming 2. (913 aa)
RAB21RAB21, member RAS oncogene family. (200 aa)
OAZ1Uncharacterized protein. (227 aa)
LOC100725052Peptidase M60 domain-containing protein. (919 aa)
TCF7L2Transcription factor 7 like 2. (350 aa)
RAB29RAB29, member RAS oncogene family. (204 aa)
LOC100725824HATPase_c domain-containing protein. (695 aa)
SAR1ASecretion associated Ras related GTPase 1A; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
EDEM1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (660 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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