68 items (Cavia porcellus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CCDC22	Coiled-coil domain containing 22. (566 aa)
	PTPN23	Protein tyrosine phosphatase non-receptor type 23. (1623 aa)
	GRIP2	Glutamate receptor interacting protein 2. (1004 aa)
	Rab13	Uncharacterized protein. (203 aa)
	HGS	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (778 aa)
	EHD2	EH domain containing 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (543 aa)
	VPS51	VPS51 subunit of GARP complex. (781 aa)
	TRARG1	Trafficking regulator of GLUT4 (SLC2A4) 1. (175 aa)
	ANKRD63	Ankyrin repeat domain 63. (351 aa)
	ARHGAP44	Rho GTPase activating protein 44. (751 aa)
	EHD4	EH domain containing 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (512 aa)
	DENND1A	DENN domain containing 1A. (1005 aa)
	Myo5b	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1803 aa)
	GRIP1	Glutamate receptor interacting protein 1. (1127 aa)
	GRIPAP1	GRIP1 associated protein 1. (700 aa)
	VPS26C	VPS26 endosomal protein sorting factor C. (297 aa)
	ANKRD50	Ankyrin repeat domain 50. (1428 aa)
	EPG5	Ectopic P-granules autophagy protein 5 homolog. (2575 aa)
	SNX30	Sorting nexin family member 30. (493 aa)
	SNX12	Sorting nexin 12. (161 aa)
	RAB11FIP4	RAB11 family interacting protein 4. (598 aa)
	KIAA1109	KIAA1109. (4627 aa)
	DENND1B	DENN domain containing 1B. (766 aa)
	SNX4	Sorting nexin 4. (403 aa)
	RAB11FIP3	RAB11 family interacting protein 3. (446 aa)
	EHD1	EH domain containing 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (534 aa)
	STX6	Syntaxin 6; Belongs to the syntaxin family. (255 aa)
	ARF6	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
	SNX17	Sorting nexin 17. (470 aa)
	H0V9V8_CAVPO	WH2 domain-containing protein. (298 aa)
	ATP6AP1	ATPase H+ transporting accessory protein 1. (469 aa)
	EIPR1	EARP complex and GARP complex interacting protein 1. (387 aa)
	RAB8B	RAB8B, member RAS oncogene family. (201 aa)
	VPS35	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (797 aa)
	LRRC1	Leucine rich repeat containing 1. (458 aa)
	DENND1C	DENN domain containing 1C. (781 aa)
	FCGR2	Low affinity immunoglobulin gamma Fc region receptor II; Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. (341 aa)
	GGA3	Golgi associated, gamma adaptin ear containing, ARF binding protein 3. (714 aa)
	MICALL1	MICAL like 1. (846 aa)
	RAB35	RAB35, member RAS oncogene family. (186 aa)
	CCDC93	Coiled-coil domain containing 93. (635 aa)
	VPS26A	VPS26, retromer complex component A. (354 aa)
	VPS29	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. (209 aa)
	Washc1	WH2 domain-containing protein. (472 aa)
	ACAP2	ArfGAP with coiled-coil, ankyrin repeat and PH domains 2. (778 aa)
	VPS39	VPS39 subunit of HOPS complex. (875 aa)
	VPS53	VPS53 subunit of GARP complex. (832 aa)
	NSG1	Neuronal vesicle trafficking associated 1. (185 aa)
	VPS50	VPS50 subunit of EARP/GARPII complex. (936 aa)
	ANKRD27	Ankyrin repeat domain 27. (1067 aa)
	MICALL2	MICAL like 2. (975 aa)
	LMTK2	Lemur tyrosine kinase 2. (1493 aa)
	SCRIB	Scribble planar cell polarity protein. (1653 aa)
	SNX27	Sorting nexin 27. (541 aa)
	VPS35L	VPS35 endosomal protein sorting factor like. (964 aa)
	RAB14	RAB14, member RAS oncogene family. (215 aa)
	SNF8	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa)
	CMTM6	CKLF like MARVEL transmembrane domain containing 6. (182 aa)
	RAB8A	RAB8A, member RAS oncogene family. (207 aa)
	VPS52	VPS52 subunit of GARP complex. (723 aa)
	RAB11B	RAB11B, member RAS oncogene family. (218 aa)
	EHD3	EH domain containing 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (535 aa)
	Arl4c	Uncharacterized protein. (98 aa)
	RAB11A	Uncharacterized protein. (216 aa)
	ENTR1	Endosome associated trafficking regulator 1. (429 aa)
	SNX7	Sorting nexin 7. (470 aa)
	RAB7A	RAB7A, member RAS oncogene family. (207 aa)
	SNX3	Sorting nexin 3. (104 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAP2	ARF6	ENSCPOP00000024094	ENSCPOP00000007317	ArfGAP with coiled-coil, ankyrin repeat and PH domains 2.	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	0.782
ACAP2	RAB11A	ENSCPOP00000024094	ENSCPOP00000021498	ArfGAP with coiled-coil, ankyrin repeat and PH domains 2.	Uncharacterized protein.	0.555
ACAP2	RAB11B	ENSCPOP00000024094	ENSCPOP00000022011	ArfGAP with coiled-coil, ankyrin repeat and PH domains 2.	RAB11B, member RAS oncogene family.	0.555
ACAP2	RAB11FIP3	ENSCPOP00000024094	ENSCPOP00000007655	ArfGAP with coiled-coil, ankyrin repeat and PH domains 2.	RAB11 family interacting protein 3.	0.596
ACAP2	RAB11FIP4	ENSCPOP00000024094	ENSCPOP00000010464	ArfGAP with coiled-coil, ankyrin repeat and PH domains 2.	RAB11 family interacting protein 4.	0.558
ACAP2	RAB35	ENSCPOP00000024094	ENSCPOP00000000355	ArfGAP with coiled-coil, ankyrin repeat and PH domains 2.	RAB35, member RAS oncogene family.	0.913
ANKRD27	GGA3	ENSCPOP00000026858	ENSCPOP00000001074	Ankyrin repeat domain 27.	Golgi associated, gamma adaptin ear containing, ARF binding protein 3.	0.408
ANKRD27	VPS29	ENSCPOP00000026858	ENSCPOP00000025190	Ankyrin repeat domain 27.	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.	0.928
ANKRD27	VPS35	ENSCPOP00000026858	ENSCPOP00000003407	Ankyrin repeat domain 27.	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	0.671
ANKRD50	CCDC22	ENSCPOP00000011560	ENSCPOP00000021146	Ankyrin repeat domain 50.	Coiled-coil domain containing 22.	0.545
ANKRD50	SNX27	ENSCPOP00000011560	ENSCPOP00000027560	Ankyrin repeat domain 50.	Sorting nexin 27.	0.479
ANKRD50	VPS29	ENSCPOP00000011560	ENSCPOP00000025190	Ankyrin repeat domain 50.	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.	0.614
ANKRD50	VPS35	ENSCPOP00000011560	ENSCPOP00000003407	Ankyrin repeat domain 50.	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	0.558
ANKRD63	CCDC22	ENSCPOP00000014585	ENSCPOP00000021146	Ankyrin repeat domain 63.	Coiled-coil domain containing 22.	0.545
ANKRD63	SNX27	ENSCPOP00000014585	ENSCPOP00000027560	Ankyrin repeat domain 63.	Sorting nexin 27.	0.420
ANKRD63	VPS29	ENSCPOP00000014585	ENSCPOP00000025190	Ankyrin repeat domain 63.	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.	0.614
ANKRD63	VPS35	ENSCPOP00000014585	ENSCPOP00000003407	Ankyrin repeat domain 63.	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	0.538
ARF6	ACAP2	ENSCPOP00000007317	ENSCPOP00000024094	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	ArfGAP with coiled-coil, ankyrin repeat and PH domains 2.	0.782
ARF6	Arl4c	ENSCPOP00000007317	ENSCPOP00000021549	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	Uncharacterized protein.	0.407
ARF6	GGA3	ENSCPOP00000007317	ENSCPOP00000001074	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	Golgi associated, gamma adaptin ear containing, ARF binding protein 3.	0.975