STRINGSTRING
PCNA PCNA GMNN GMNN BRCA2 BRCA2 GINS1 GINS1 MCM3 MCM3 POLA1 POLA1 MCM4 MCM4 Lig1 Lig1 MCM6 MCM6 DONSON DONSON ZNF830 ZNF830 CDC45 CDC45 RTF2 RTF2 GINS3 GINS3 DNA2 DNA2 CDT1 CDT1 UPF1 UPF1 H0VSI3_CAVPO H0VSI3_CAVPO Rtel1 Rtel1 RAD51 RAD51 ATAD5 ATAD5 MCM2 MCM2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
GMNNGeminin DNA replication inhibitor. (209 aa)
BRCA2BRCA2 DNA repair associated. (3151 aa)
GINS1GINS complex subunit 1. (196 aa)
MCM3DNA helicase; Belongs to the MCM family. (810 aa)
POLA1DNA polymerase. (1467 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
Lig1DNA ligase. (909 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
DONSONDownstream neighbor of SON. (553 aa)
ZNF830Zinc finger protein 830. (363 aa)
CDC45Cell division cycle 45. (566 aa)
RTF2Replication termination factor 2. (308 aa)
GINS3GINS complex subunit 3. (216 aa)
DNA2DNA replication helicase/nuclease 2. (1021 aa)
CDT1Chromatin licensing and DNA replication factor 1. (549 aa)
UPF1UPF1 RNA helicase and ATPase. (1109 aa)
H0VSI3_CAVPODNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. (677 aa)
Rtel1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1246 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
ATAD5ATPase family AAA domain containing 5. (1831 aa)
MCM2DNA helicase; Belongs to the MCM family. (898 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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