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PARK7 PARK7 H0V8N6_CAVPO H0V8N6_CAVPO ACPP ACPP DHRS9 DHRS9 PNPLA2 PNPLA2 DGAT1 DGAT1 DGAT2 DGAT2 ALDH1A2 ALDH1A2 LOC100724620 LOC100724620 LOC100717492 LOC100717492 ALDH16A1 ALDH16A1 Rdh11 Rdh11 CEL CEL RBP4 RBP4 DHRS3 DHRS3 NAPEPLD NAPEPLD DHRS7 DHRS7 AKR1B1 AKR1B1 CYP1A2 CYP1A2 LOC100734190 LOC100734190 LOC100735818 LOC100735818 ALDH3B1 ALDH3B1 RDH5 RDH5 TKTL2 TKTL2 ABHD4 ABHD4 GDPD3 GDPD3 RETSAT RETSAT H0WCC9_CAVPO H0WCC9_CAVPO TPK1 TPK1 RDH16 RDH16 SDR9C7 SDR9C7 ALDH3A2 ALDH3A2 LIPE LIPE GDE1 GDE1 GDPD1 GDPD1 AKR1E2 AKR1E2 Aldh2 Aldh2 LOC100727028 LOC100727028 CYP1B1 CYP1B1 ADH5 ADH5 ENSCPOP00000029971 ENSCPOP00000029971 LOC100732581 LOC100732581 CBR4 CBR4 LOC100723118 LOC100723118 ENSCPOP00000032185 ENSCPOP00000032185 LOC100732853 LOC100732853 RBP1 RBP1 CHKA CHKA H0W0J6_CAVPO H0W0J6_CAVPO LOC100725498 LOC100725498 RDH8 RDH8 H0VW66_CAVPO H0VW66_CAVPO CYP1A1 CYP1A1 EDNRB EDNRB BCO1 BCO1 RPE65 RPE65 Scnn1b Scnn1b PNLIP PNLIP SULT1E1 SULT1E1 TTR TTR AKR1A1 AKR1A1 CACNA1H CACNA1H RDH13 RDH13 TKTL1 TKTL1 AWAT2 AWAT2 HAO1 HAO1 PNPLA4 PNPLA4 SDR16C5 SDR16C5 THTPA THTPA Rdh10 Rdh10 RDH12 RDH12 PECR PECR HSD11B2 HSD11B2 NAAA NAAA DHRS13 DHRS13 LOC100732008 LOC100732008
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PARK7Parkinsonism associated deglycase. (189 aa)
H0V8N6_CAVPOUncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (191 aa)
ACPPAcid phosphatase, prostate; Belongs to the histidine acid phosphatase family. (340 aa)
DHRS9Dehydrogenase/reductase 9; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (319 aa)
PNPLA2Patatin like phospholipase domain containing 2. (486 aa)
DGAT1O-acyltransferase. (493 aa)
DGAT2Diacylglycerol O-acyltransferase 2. (388 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (512 aa)
LOC100724620Aldo-keto reductase family 1 member C3. (323 aa)
LOC100717492Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa)
ALDH16A1Aldehyde dehydrogenase family 16 member A1. (804 aa)
Rdh11Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (316 aa)
CELCarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (594 aa)
RBP4Apolipoprotein D. (173 aa)
DHRS3Dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (304 aa)
NAPEPLDN-acyl phosphatidylethanolamine phospholipase D. (395 aa)
DHRS7Dehydrogenase/reductase 7; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (450 aa)
AKR1B1Aldo-keto reductase family 1 member B. (316 aa)
CYP1A2Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] (515 aa)
LOC100734190Uncharacterized protein. (369 aa)
LOC100735818Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (315 aa)
ALDH3B1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (468 aa)
RDH5Retinol dehydrogenase 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (318 aa)
TKTL2Transketolase like 2. (627 aa)
ABHD4Abhydrolase domain containing 4. (335 aa)
GDPD3Glycerophosphodiester phosphodiesterase domain containing 3. (303 aa)
RETSATRetinol saturase. (610 aa)
H0WCC9_CAVPOUncharacterized protein. (384 aa)
TPK1Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family. (243 aa)
RDH16Retinol dehydrogenase 16; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (318 aa)
SDR9C7Short chain dehydrogenase/reductase family 9C member 7; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (313 aa)
ALDH3A2Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (507 aa)
LIPELipase E, hormone sensitive type. (802 aa)
GDE1Glycerophosphodiester phosphodiesterase 1. (331 aa)
GDPD1Glycerophosphodiester phosphodiesterase domain containing 1. (314 aa)
AKR1E2Aldo-keto reductase family 1 member E2. (330 aa)
Aldh2Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (521 aa)
LOC100727028PKS_ER domain-containing protein. (382 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (540 aa)
ADH5S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (367 aa)
ENSCPOP00000029971Aldedh domain-containing protein. (216 aa)
LOC100732581Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (501 aa)
CBR4Carbonyl reductase 4. (237 aa)
LOC100723118Aldo_ket_red domain-containing protein. (316 aa)
ENSCPOP00000032185Aldedh domain-containing protein. (166 aa)
LOC100732853Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (500 aa)
RBP1Retinol binding protein 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
CHKACholine kinase alpha. (413 aa)
H0W0J6_CAVPOUncharacterized protein. (384 aa)
LOC100725498Aldo_ket_red domain-containing protein. (315 aa)
RDH8Retinol dehydrogenase 8; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (314 aa)
H0VW66_CAVPOUncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (306 aa)
CYP1A1Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] (516 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (415 aa)
BCO1Beta-carotene oxygenase 1. (557 aa)
RPE65Retinoid isomerohydrolase RPE65. (490 aa)
Scnn1bUncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (640 aa)
PNLIPPancreatic triacylglycerol lipase. (428 aa)
SULT1E1Sulfotransferase 1E1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesteroland xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency. Does not sulfonate cortisol, testosterone and dopamine (By similarity). (296 aa)
TTRTransthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. (131 aa)
AKR1A1Aldo-keto reductase family 1 member A1. (325 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2337 aa)
RDH13Retinol dehydrogenase 13; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (334 aa)
TKTL1Transketolase like 1. (597 aa)
AWAT2Acyl-CoA wax alcohol acyltransferase 2. (303 aa)
HAO1Hydroxyacid oxidase 1. (370 aa)
PNPLA4Patatin like phospholipase domain containing 4. (253 aa)
SDR16C5Short chain dehydrogenase/reductase family 16C member 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (361 aa)
THTPAThiamine triphosphatase. (231 aa)
Rdh10Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (285 aa)
RDH12Retinol dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (316 aa)
PECRPeroxisomal trans-2-enoyl-CoA reductase; Participates in chain elongation of fatty acids. Has no 2,4- dienoyl-CoA reductase activity. (302 aa)
HSD11B2Hydroxysteroid 11-beta dehydrogenase 2. (395 aa)
NAAAN-acylethanolamine-hydrolyzing acid amidase subunit alpha; Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N- myristoylethanolamine > N-stearoylethanolamine > N-oleoylethanolamine > N-linoleoylethanolamine > N-arachidonoylethanolamine. (347 aa)
DHRS13Dehydrogenase/reductase 13. (378 aa)
LOC100732008PKS_ER domain-containing protein. (375 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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