STRINGSTRING
ARRB2 ARRB2 IGF1 IGF1 STK4 STK4 LRP6 LRP6 E2F3 E2F3 PDCD4 PDCD4 ARRB1 ARRB1 SOD2 SOD2 CCDC142 CCDC142 DNMT1 DNMT1 CDKN2A CDKN2A GSK3B GSK3B MAP2K4 MAP2K4 Il12a Il12a SIRT1 SIRT1 GRIA4 GRIA4 IL12B IL12B PPARG PPARG LYPD3 LYPD3 RBM10 RBM10 SLC7A5 SLC7A5 DIPK2A DIPK2A APOH APOH ATF4 ATF4 MFN2 MFN2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARRB2Arrestin beta 2. (417 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (153 aa)
STK4Serine/threonine kinase 4. (487 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
E2F3E2F transcription factor 3. (457 aa)
PDCD4Programmed cell death 4. (469 aa)
ARRB1Arrestin beta 1. (430 aa)
SOD2Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
CCDC142Coiled-coil domain containing 142. (761 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1600 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (134 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (423 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (386 aa)
Il12aInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (221 aa)
SIRT1Sirtuin 1. (717 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (819 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (332 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (504 aa)
LYPD3LY6/PLAUR domain containing 3. (349 aa)
RBM10RNA binding motif protein 10. (931 aa)
SLC7A5Solute carrier family 7 member 5. (477 aa)
DIPK2ADivergent protein kinase domain 2A. (430 aa)
APOHApolipoprotein H. (235 aa)
ATF4Activating transcription factor 4. (354 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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