STRINGSTRING
EP300 EP300 Gdf1 Gdf1 ENSCPOP00000024428 ENSCPOP00000024428 IMPACT IMPACT Cops9 Cops9 C9orf116 C9orf116 OPN3 OPN3 ZBTB1 ZBTB1 MMP3 MMP3 TP53INP1 TP53INP1 MDM2 MDM2 POLD1 POLD1 HYAL3 HYAL3 MMP2 MMP2 MFAP4 MFAP4 RUVBL2 RUVBL2 N4BP1 N4BP1 Chek1 Chek1 TREX1 TREX1 Parp1 Parp1 SDE2 SDE2 MAPK13 MAPK13 NFATC4 NFATC4 TMEM161A TMEM161A DDB2 DDB2 TIMP1 TIMP1 DDIAS DDIAS CASP9 CASP9 ACTR5 ACTR5 Aqp1 Aqp1 INO80 INO80 PTPRK PTPRK PBK PBK OPN1SW OPN1SW PCNA PCNA MME MME PIK3R1 PIK3R1 DHX36 DHX36 MMP9 MMP9 EI24 EI24 Pold3 Pold3 ATR ATR XPC XPC MMP1 MMP1 USP47 USP47 OPN5 OPN5 HYAL2 HYAL2 ERCC4 ERCC4 METTL3 METTL3 SMPD1 SMPD1 USP28 USP28 XPA XPA PPID PPID POLK POLK SIRT1 SIRT1 RHBDD1 RHBDD1 NEDD4 NEDD4 BAK1 BAK1 Yy1 Yy1 Crip1 Crip1 MC1R MC1R TP53 TP53 BMF BMF KDM1A KDM1A DDB1 DDB1 EIF2S1 EIF2S1 EIF2AK4 EIF2AK4 PRKCD PRKCD CDKN1A CDKN1A STK11 STK11 CUL4B CUL4B ENSCPOP00000025455 ENSCPOP00000025455 POLH POLH MYC MYC RHNO1 RHNO1 RNF168 RNF168 MAPK9 MAPK9 POLI POLI ERCC1 ERCC1 BAX BAX CREBBP CREBBP TRIAP1 TRIAP1 NOC2L NOC2L
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EP300E1A binding protein p300. (2425 aa)
Gdf1TGF_BETA_2 domain-containing protein. (367 aa)
ENSCPOP00000024428PARP-type domain-containing protein. (104 aa)
IMPACTImpact RWD domain protein. (318 aa)
Cops9Uncharacterized protein. (57 aa)
C9orf116Chromosome 9 open reading frame 116. (136 aa)
OPN3Opsin 3; Belongs to the G-protein coupled receptor 1 family. (399 aa)
ZBTB1Zinc finger and BTB domain containing 1. (712 aa)
MMP3Matrix metallopeptidase 3. (479 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (240 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
POLD1DNA polymerase. (1134 aa)
HYAL3Hyaluronidase. (412 aa)
MMP2Matrix metallopeptidase 2. (662 aa)
MFAP4Microfibril associated protein 4. (257 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (486 aa)
N4BP1NEDD4 binding protein 1. (886 aa)
Chek1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (439 aa)
TREX1Three prime repair exonuclease 1. (314 aa)
Parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa)
SDE2SDE2 telomere maintenance homolog. (453 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
NFATC4Nuclear factor of activated T cells 4. (901 aa)
TMEM161ATransmembrane protein 161A. (474 aa)
DDB2Damage specific DNA binding protein 2. (289 aa)
TIMP1TIMP metallopeptidase inhibitor 1. (207 aa)
DDIASDNA damage induced apoptosis suppressor. (897 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (447 aa)
ACTR5Actin related protein 5; Belongs to the actin family. (602 aa)
Aqp1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
INO80INO80 complex ATPase subunit. (1558 aa)
PTPRKProtein tyrosine phosphatase receptor type K. (1455 aa)
PBKPDZ binding kinase. (324 aa)
OPN1SWG_PROTEIN_RECEP_F1_2 domain-containing protein. (346 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
MMEMembrane metalloendopeptidase. (718 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
DHX36DEAH-box helicase 36. (916 aa)
MMP9Matrix metallopeptidase 9. (715 aa)
EI24EI24 autophagy associated transmembrane protein. (349 aa)
Pold3Uncharacterized protein. (466 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2539 aa)
XPCXPC complex subunit, DNA damage recognition and repair factor. (923 aa)
MMP1Matrix metallopeptidase 1. (472 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1375 aa)
OPN5Opsin 5; Belongs to the G-protein coupled receptor 1 family. (333 aa)
HYAL2Hyaluronidase. (471 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (553 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (627 aa)
USP28Ubiquitin specific peptidase 28; Belongs to the peptidase C19 family. (1051 aa)
XPAXPA, DNA damage recognition and repair factor. (263 aa)
PPIDPeptidylprolyl isomerase D. (370 aa)
POLKDNA polymerase kappa. (540 aa)
SIRT1Sirtuin 1. (717 aa)
RHBDD1Rhomboid domain containing 1. (309 aa)
NEDD4E3 ubiquitin-protein ligase. (896 aa)
BAK1BCL2 antagonist/killer 1. (214 aa)
Yy1Uncharacterized protein. (195 aa)
Crip1LIM zinc-binding domain-containing protein. (77 aa)
MC1RMelanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (316 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (423 aa)
BMFBcl2 modifying factor. (236 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (865 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1651 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (169 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (435 aa)
CUL4BCullin 4B; Belongs to the cullin family. (936 aa)
ENSCPOP00000025455Protein kinase domain-containing protein. (360 aa)
POLHDNA polymerase eta. (712 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
RHNO1RAD9-HUS1-RAD1 interacting nuclear orphan 1. (233 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (573 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
POLIDNA polymerase iota. (662 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (300 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
CREBBPCREB binding protein. (2441 aa)
TRIAP1TP53 regulated inhibitor of apoptosis 1. (76 aa)
NOC2LNOC2 like nucleolar associated transcriptional repressor. (799 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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