STRINGSTRING
BMP5 BMP5 CTNNB1 CTNNB1 WNT4 WNT4 Irx2 Irx2 TCAP TCAP PHACTR4 PHACTR4 STK4 STK4 Sall4 Sall4 SFRP2 SFRP2 BCL10 BCL10 SHH SHH BCAS3 BCAS3 IRX3 IRX3 PLXNB2 PLXNB2 BCL2L11 BCL2L11 GREM1 GREM1 ENSCPOP00000030467 ENSCPOP00000030467 PAX8 PAX8 OVOL2 OVOL2 CASP8 CASP8 EDA EDA PTK7 PTK7 FZD2 FZD2 GATAD2A GATAD2A PFN1 PFN1 BMP7 BMP7 SUFU SUFU TEAD2 TEAD2 DAB2IP DAB2IP CECR2 CECR2 RGMA RGMA RALA RALA WNT6 WNT6 SPINT1 SPINT1 LRP6 LRP6 RARA RARA KDM2B KDM2B SCRIB SCRIB SIX1 SIX1 FGFR2 FGFR2 SFRP1 SFRP1 GDNF GDNF SDC4 SDC4 Vegfa Vegfa PRKACB PRKACB COBL COBL Tgif1 Tgif1 LMO4 LMO4 RAB23 RAB23 MAP3K7 MAP3K7 YWHAZ YWHAZ HECTD1 HECTD1 IFT172 IFT172 HES5 HES5 KAT2A KAT2A Specc1l Specc1l ENSCPOP00000024297 ENSCPOP00000024297 SEC24B SEC24B WNT5A WNT5A BRD2 BRD2 DVL3 DVL3 NOG NOG FGF10 FGF10 ADM ADM HOXA1 HOXA1 PAX2 PAX2 SFRP5 SFRP5 Sox4 Sox4 DVL2 DVL2 FZD1 FZD1 ZIC2 ZIC2 H0W3X9_CAVPO H0W3X9_CAVPO LHX2 LHX2 IFT52 IFT52 SOX11 SOX11 TGM2 TGM2 SHANK3 SHANK3 FGF8 FGF8 IRX1 IRX1 NCKAP1 NCKAP1 HAND1 HAND1 CASP10 CASP10 NODAL NODAL SDCCAG8 SDCCAG8 APAF1 APAF1 RARG RARG KDM6A KDM6A RET RET SEMA4C SEMA4C CELSR1 CELSR1 ARHGAP35 ARHGAP35 ABL2 ABL2 MTHFD1 MTHFD1 HESX1 HESX1 DLC1 DLC1 ROCK2 ROCK2 FOLR1 FOLR1 CTHRC1 CTHRC1 FZD6 FZD6 CDH1 CDH1 EDAR EDAR ST14 ST14 LUZP1 LUZP1 COQ7 COQ7 STK3 STK3 ARID1A ARID1A ITGB1BP1 ITGB1BP1 VASP VASP VANGL2 VANGL2 MTHFD1L MTHFD1L CC2D2A CC2D2A FZD3 FZD3 RPS7 RPS7 WNT9B WNT9B SPINT2 SPINT2 GRHL3 GRHL3 BRPF1 BRPF1 GATA3 GATA3 CDK20 CDK20 SETD2 SETD2 IFT57 IFT57 TGFB2 TGFB2 FGF3 FGF3 GLMN GLMN KDM2A KDM2A ENAH ENAH BMP4 BMP4 DVL1 DVL1 SALL1 SALL1 ATOH8 ATOH8 PAX3 PAX3 SKI SKI DEAF1 DEAF1 OPA1 OPA1 ABL1 ABL1 GRHL2 GRHL2 PRICKLE1 PRICKLE1 MIB1 MIB1 HIF1A HIF1A FUZ FUZ LOC100716676 LOC100716676 Hs2st1 Hs2st1 IFT122 IFT122 TULP3 TULP3 LIAS LIAS TRAF6 TRAF6 TRIM71 TRIM71 TSC1 TSC1 ZEB2 ZEB2 NFIB NFIB STIL STIL TMED2 TMED2 LRRC1 LRRC1 CITED2 CITED2 KIF20B KIF20B TSC2 TSC2 MTHFR MTHFR SOX8 SOX8 PTCH1 PTCH1 OSR1 OSR1 CLUAP1 CLUAP1 TBXT TBXT HNF1B HNF1B TGFB1 TGFB1 TCTN1 TCTN1 MED12 MED12 MKS1 MKS1 IPMK IPMK TFAP2A TFAP2A Prkaca Prkaca
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMP5Bone morphogenetic protein 5. (454 aa)
CTNNB1Catenin beta 1. (781 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa)
Irx2Iroquois homeobox 2. (471 aa)
TCAPTitin-cap. (167 aa)
PHACTR4Phosphatase and actin regulator. (713 aa)
STK4Serine/threonine kinase 4. (487 aa)
Sall4Uncharacterized protein. (272 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
BCL10BCL10 immune signaling adaptor. (234 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (447 aa)
BCAS3BCAS3 microtubule associated cell migration factor. (943 aa)
IRX3Iroquois homeobox 3. (484 aa)
PLXNB2Plexin B2. (1845 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (196 aa)
GREM1Gremlin. (184 aa)
ENSCPOP00000030467Uncharacterized protein. (127 aa)
PAX8Paired box 8. (457 aa)
OVOL2Ovo like zinc finger 2. (269 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (481 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (390 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1063 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (551 aa)
GATAD2AGATA zinc finger domain containing 2A. (640 aa)
PFN1Profilin; Belongs to the profilin family. (140 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (484 aa)
TEAD2TEA domain transcription factor 2. (452 aa)
DAB2IPDAB2 interacting protein. (1193 aa)
CECR2CECR2 histone acetyl-lysine reader. (1413 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (445 aa)
RALARAS like proto-oncogene A. (206 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
SPINT1Serine peptidase inhibitor, Kunitz type 1. (500 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
RARARetinoic acid receptor alpha. (462 aa)
KDM2BLysine demethylase 2B. (1306 aa)
SCRIBScribble planar cell polarity protein. (1653 aa)
SIX1SIX homeobox 1. (284 aa)
FGFR2Fibroblast growth factor receptor. (801 aa)
SFRP1Secreted frizzled related protein 1. (307 aa)
GDNFGlial cell derived neurotrophic factor. (210 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (202 aa)
VegfaVascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (186 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
COBLCordon-bleu WH2 repeat protein. (1253 aa)
Tgif1Homeobox domain-containing protein. (99 aa)
LMO4LIM domain only 4. (165 aa)
RAB23RAB23, member RAS oncogene family. (236 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (245 aa)
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2505 aa)
IFT172Intraflagellar transport 172. (1749 aa)
HES5Hes family bHLH transcription factor 5. (164 aa)
KAT2ALysine acetyltransferase 2A. (753 aa)
Specc1lCalponin-homology (CH) domain-containing protein. (1129 aa)
ENSCPOP00000024297Uncharacterized protein. (406 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1224 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
BRD2Bromodomain containing 2. (804 aa)
DVL3Dishevelled segment polarity protein 3. (717 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (210 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
ADMAdrenomedullin. (182 aa)
HOXA1Homeobox A1. (333 aa)
PAX2Paired box 2. (393 aa)
SFRP5Secreted frizzled related protein 5. (296 aa)
Sox4HMG box domain-containing protein. (227 aa)
DVL2Dishevelled segment polarity protein 2. (737 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (634 aa)
ZIC2Zic family member 2. (523 aa)
H0W3X9_CAVPOUncharacterized protein. (2048 aa)
LHX2LIM homeobox 2. (406 aa)
IFT52Intraflagellar transport 52. (406 aa)
SOX11Transcription factor SOX. (377 aa)
TGM2TGc domain-containing protein. (735 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1694 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (308 aa)
IRX1Iroquois homeobox 1. (390 aa)
NCKAP1NCK associated protein 1. (1140 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (474 aa)
NODALNodal growth differentiation factor. (351 aa)
SDCCAG8Serologically defined colon cancer antigen 8. (714 aa)
APAF1Apoptotic peptidase activating factor 1. (1265 aa)
RARGRetinoic acid receptor gamma. (455 aa)
KDM6ALysine demethylase 6A. (1164 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1114 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (831 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (2909 aa)
ARHGAP35Rho GTPase activating protein 35. (1500 aa)
ABL2Tyrosine-protein kinase. (1157 aa)
MTHFD1Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (928 aa)
HESX1HESX homeobox 1. (185 aa)
DLC1DLC1 Rho GTPase activating protein. (1091 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1371 aa)
FOLR1Folate receptor alpha. (160 aa)
CTHRC1Collagen triple helix repeat containing 1. (247 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (644 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (891 aa)
EDAREctodysplasin A receptor. (446 aa)
ST14Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family. (830 aa)
LUZP1Leucine zipper protein 1. (1072 aa)
COQ75-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner. (217 aa)
STK3Serine/threonine kinase 3. (463 aa)
ARID1AAT-rich interaction domain 1A. (1903 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
VASPVasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (376 aa)
VANGL2Vang-like protein. (548 aa)
MTHFD1LMethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (901 aa)
CC2D2ACoiled-coil and C2 domain containing 2A. (1623 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
RPS740S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (194 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
SPINT2Serine peptidase inhibitor, Kunitz type 2. (252 aa)
GRHL3Grainyhead like transcription factor 3. (603 aa)
BRPF1Bromodomain and PHD finger containing 1. (1213 aa)
GATA3GATA binding protein 3. (443 aa)
CDK20Cyclin dependent kinase 20; Belongs to the protein kinase superfamily. (346 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2565 aa)
IFT57Intraflagellar transport 57. (429 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (440 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (235 aa)
GLMNGlomulin, FKBP associated protein. (562 aa)
KDM2ALysine demethylase 2A. (1161 aa)
ENAHENAH actin regulator. (768 aa)
BMP4Bone morphogenetic protein 4. (404 aa)
DVL1Dishevelled segment polarity protein 1. (698 aa)
SALL1Spalt like transcription factor 1. (1287 aa)
ATOH8Atonal bHLH transcription factor 8. (320 aa)
PAX3Paired box 3. (484 aa)
SKISKI proto-oncogene. (586 aa)
DEAF1DEAF1 transcription factor. (565 aa)
OPA1OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (942 aa)
ABL1Tyrosine-protein kinase. (1145 aa)
GRHL2Grainyhead like transcription factor 2. (620 aa)
PRICKLE1Prickle planar cell polarity protein 1. (832 aa)
MIB1Mindbomb E3 ubiquitin protein ligase 1. (963 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (828 aa)
FUZFuzzy planar cell polarity protein. (392 aa)
LOC100716676TPR_REGION domain-containing protein. (567 aa)
Hs2st1Uncharacterized protein. (356 aa)
IFT122Intraflagellar transport 122. (1218 aa)
TULP3Tubby-like protein; Belongs to the TUB family. (449 aa)
LIASLipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (371 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (543 aa)
TRIM71Tripartite motif containing 71. (866 aa)
TSC1TSC complex subunit 1. (1166 aa)
ZEB2Zinc finger E-box binding homeobox 2. (1253 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (494 aa)
STILSTIL centriolar assembly protein. (1049 aa)
TMED2Transmembrane p24 trafficking protein 2. (208 aa)
LRRC1Leucine rich repeat containing 1. (458 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (269 aa)
KIF20BKinesin family member 20B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1756 aa)
TSC2TSC complex subunit 2. (1745 aa)
MTHFRMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (671 aa)
SOX8SRY-box transcription factor 8. (462 aa)
PTCH1Patched 1. (1379 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
CLUAP1Clusterin associated protein 1. (432 aa)
TBXTT-box transcription factor T. (435 aa)
HNF1BHNF1 homeobox B. (558 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
TCTN1Tectonic family member 1. (590 aa)
MED12Mediator complex subunit 12. (1828 aa)
MKS1MKS transition zone complex subunit 1. (558 aa)
IPMKKinase; Belongs to the inositol phosphokinase (IPK) family. (377 aa)
TFAP2ATranscription factor AP-2 alpha. (437 aa)
PrkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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