STRINGSTRING
SHANK2 SHANK2 NR2E1 NR2E1 GRPR GRPR NPAS4 NPAS4 NRXN2 NRXN2 OXT OXT CHD8 CHD8 TSC2 TSC2 FMR1 FMR1 TREM2 TREM2 GAD1 GAD1 LOC100716676 LOC100716676 GABRB3 GABRB3 BRINP1 BRINP1 VPS13A VPS13A DVL1 DVL1 GRID1 GRID1 SLC6A4 SLC6A4 MTOR MTOR KALRN KALRN TBX1 TBX1 MECP2 MECP2 TH TH EXT1 EXT1 LOC100730761 LOC100730761 EN1 EN1 H0VSR6_CAVPO H0VSR6_CAVPO GNB1L GNB1L KCNQ1 KCNQ1 SHANK3 SHANK3 PTCHD4 PTCHD4 PTEN PTEN SHANK1 SHANK1 ATXN1 ATXN1 DLG4 DLG4 NLGN2 NLGN2 ENSCPOP00000022553 ENSCPOP00000022553 NLGN3 NLGN3 HTT HTT DRD1 DRD1 GRIN1 GRIN1 CIC CIC CX3CR1 CX3CR1 GNG8 GNG8 ENSCPOP00000027747 ENSCPOP00000027747 MKKS MKKS OXTR OXTR Chrnb2 Chrnb2 MAPK8IP2 MAPK8IP2 Septin5 Septin5 AVPR1A AVPR1A PTCHD1 PTCHD1 RPTOR RPTOR ATXN1L ATXN1L Cln8 Cln8 PCM1 PCM1 NRXN3 NRXN3 EIF4EBP2 EIF4EBP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SHANK2SH3 and multiple ankyrin repeat domains 2. (1839 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (389 aa)
GRPRGastrin releasing peptide receptor; Belongs to the G-protein coupled receptor 1 family. (383 aa)
NPAS4Neuronal PAS domain protein 4. (802 aa)
NRXN2Neurexin 2. (1613 aa)
OXTOxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (125 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2583 aa)
TSC2TSC complex subunit 2. (1745 aa)
FMR1Fragile X mental retardation 1. (612 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (229 aa)
GAD1Glutamate decarboxylase 1. (594 aa)
LOC100716676TPR_REGION domain-containing protein. (567 aa)
GABRB3Gamma-aminobutyric acid type A receptor beta3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (441 aa)
BRINP1BMP/retinoic acid inducible neural specific 1. (761 aa)
VPS13AVacuolar protein sorting 13 homolog A. (3051 aa)
DVL1Dishevelled segment polarity protein 1. (698 aa)
GRID1Glutamate ionotropic receptor delta type subunit 1. (930 aa)
SLC6A4Sodium-dependent serotonin transporter; Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner (By similarity); Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily. (612 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
KALRNKalirin RhoGEF kinase. (2964 aa)
TBX1T-box transcription factor 1. (360 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (504 aa)
THTyrosine hydroxylase. (498 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
LOC100730761Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (418 aa)
EN1Homeobox protein engrailed-like. (292 aa)
H0VSR6_CAVPOUncharacterized protein. (327 aa)
GNB1LG protein subunit beta 1 like. (327 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1; Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity). Associates with KCNE beta subunits that modulates current kinetics (By similarity). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac r [...] (671 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1694 aa)
PTCHD4Patched domain containing 4. (895 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (355 aa)
SHANK1SH3 and multiple ankyrin repeat domains 1. (1749 aa)
ATXN1Ataxin 1. (790 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (754 aa)
NLGN2Neuroligin 2. (662 aa)
ENSCPOP00000022553Protein kinase domain-containing protein. (86 aa)
NLGN3Neuroligin 3. (846 aa)
HTTHuntingtin. (3133 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (444 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (943 aa)
CICCapicua transcriptional repressor. (2524 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (356 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
ENSCPOP00000027747LAM_G_DOMAIN domain-containing protein. (151 aa)
MKKSMcKusick-Kaufman syndrome. (575 aa)
OXTROxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (390 aa)
Chrnb2Uncharacterized protein. (499 aa)
MAPK8IP2Mitogen-activated protein kinase 8 interacting protein 2. (951 aa)
Septin5Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (378 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (418 aa)
PTCHD1Patched domain containing 1. (888 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
ATXN1LAtaxin 1 like. (689 aa)
Cln8CLN8 transmembrane ER and ERGIC protein. (288 aa)
PCM1Pericentriolar material 1. (2080 aa)
NRXN3Neurexin 3. (1571 aa)
EIF4EBP2Eukaryotic translation initiation factor 4E binding protein 2. (121 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.