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ARPC2 ARPC2 CDK5R1 CDK5R1 CACNG4 CACNG4 ATP2B2 ATP2B2 PTEN PTEN H0W649_CAVPO H0W649_CAVPO SHANK1 SHANK1 H0W6Z4_CAVPO H0W6Z4_CAVPO MAP1A MAP1A GRIP2 GRIP2 DLG4 DLG4 LOC100732158 LOC100732158 CACNG3 CACNG3 SQSTM1 SQSTM1 FLOT1 FLOT1 FYN FYN SHISA7 SHISA7 SLC9A3R1 SLC9A3R1 RAB4A RAB4A GRIN1 GRIN1 Nsf Nsf SNX27 SNX27 DLG3 DLG3 FUS FUS RAPSN RAPSN SHANK3 SHANK3 Cabp1 Cabp1 IL1R1 IL1R1 OPHN1 OPHN1 PRNP PRNP LOC100732436 LOC100732436 HOMER1 HOMER1 PTPN4 PTPN4 CTNNB1 CTNNB1 GRIA2 GRIA2 NEDD4 NEDD4 DNM3 DNM3 CACNG2 CACNG2 IGSF11 IGSF11 CANX CANX GRIA1 GRIA1 SYNDIG1 SYNDIG1 GRIN2B GRIN2B NECAB2 NECAB2 CAMK2A CAMK2A H0VE70_CAVPO H0VE70_CAVPO DRD2 DRD2 NETO1 NETO1 H0VF00_CAVPO H0VF00_CAVPO SHANK2 SHANK2 PICK1 PICK1 C16orf70 C16orf70 PTPN5 PTPN5 NETO2 NETO2 GRIN2A GRIN2A Myo5b Myo5b GSK3B GSK3B HOMER2 HOMER2 FLOT2 FLOT2 ND2 ND2 PLCG1 PLCG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (325 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1296 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (355 aa)
H0W649_CAVPOVoltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (280 aa)
SHANK1SH3 and multiple ankyrin repeat domains 1. (1749 aa)
H0W6Z4_CAVPOUncharacterized protein. (750 aa)
MAP1AMicrotubule associated protein 1A. (2915 aa)
GRIP2Glutamate receptor interacting protein 2. (1004 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (754 aa)
LOC100732158Uncharacterized protein. (246 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
SQSTM1Sequestosome 1. (415 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
FYNTyrosine-protein kinase. (537 aa)
SHISA7Shisa family member 7. (377 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (358 aa)
RAB4ARAB4A, member RAS oncogene family. (218 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (943 aa)
NsfUncharacterized protein. (748 aa)
SNX27Sorting nexin 27. (541 aa)
DLG3Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (850 aa)
FUSFUS RNA binding protein. (490 aa)
RAPSNReceptor associated protein of the synapse. (412 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1694 aa)
Cabp1Uncharacterized protein. (227 aa)
IL1R1Interleukin 1 receptor type 1. (572 aa)
OPHN1Uncharacterized protein. (802 aa)
PRNPMajor prion protein; Belongs to the prion family. (244 aa)
LOC100732436Uncharacterized protein. (327 aa)
HOMER1Homer scaffold protein 1. (329 aa)
PTPN4Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (914 aa)
CTNNB1Catenin beta 1. (781 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
NEDD4E3 ubiquitin-protein ligase. (896 aa)
DNM3Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (811 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
IGSF11Immunoglobulin superfamily member 11. (420 aa)
CANXCalnexin. (593 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (861 aa)
SYNDIG1Synapse differentiation inducing 1. (250 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1381 aa)
NECAB2N-terminal EF-hand calcium binding protein 2. (320 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
H0VE70_CAVPOUncharacterized protein. (796 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (446 aa)
NETO1Neuropilin and tolloid like 1. (450 aa)
H0VF00_CAVPOUncharacterized protein. (323 aa)
SHANK2SH3 and multiple ankyrin repeat domains 2. (1839 aa)
PICK1Protein interacting with PRKCA 1. (415 aa)
C16orf70Chromosome 16 open reading frame 70. (422 aa)
PTPN5Protein tyrosine phosphatase non-receptor type 5. (541 aa)
NETO2Neuropilin and tolloid like 2. (520 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1462 aa)
Myo5bUncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1803 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (423 aa)
HOMER2Homer scaffold protein 2. (357 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
ND2NADH-ubiquinone oxidoreductase chain 2; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (347 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1235 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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