(13 nodes) Seh1-associated complex network (Cavia porcellus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SESN1	Sestrin 1. (564 aa)
	NPRL2	NPR2 like, GATOR1 complex subunit. (380 aa)
	Depdc5	DEP domain-containing protein. (1576 aa)
	SZT2	SZT2 subunit of KICSTOR complex. (3427 aa)
	MIOS	Meiosis regulator for oocyte development. (875 aa)
	BMT2	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (381 aa)
	CASTOR1	Cytosolic arginine sensor for mTORC1 subunit 1. (329 aa)
	WDR24	WD repeat domain 24. (790 aa)
	SEC13	SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (322 aa)
	RRAGA	Ras related GTP binding A. (313 aa)
	NPRL3	NPR3 like, GATOR1 complex subunit. (582 aa)
	WDR59	WD repeat domain 59. (983 aa)
	SEH1L	SEH1 like nucleoporin; Belongs to the WD repeat SEC13 family. (418 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMT2	Depdc5	ENSCPOP00000012731	ENSCPOP00000005408	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	DEP domain-containing protein.	0.953
BMT2	NPRL2	ENSCPOP00000012731	ENSCPOP00000002517	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	NPR2 like, GATOR1 complex subunit.	0.939
BMT2	NPRL3	ENSCPOP00000012731	ENSCPOP00000024916	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	NPR3 like, GATOR1 complex subunit.	0.923
BMT2	RRAGA	ENSCPOP00000012731	ENSCPOP00000014910	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Ras related GTP binding A.	0.741
BMT2	SEH1L	ENSCPOP00000012731	ENSCPOP00000028736	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	SEH1 like nucleoporin; Belongs to the WD repeat SEC13 family.	0.410
BMT2	SESN1	ENSCPOP00000012731	ENSCPOP00000012427	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Sestrin 1.	0.432
BMT2	SZT2	ENSCPOP00000012731	ENSCPOP00000005507	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	SZT2 subunit of KICSTOR complex.	0.921
BMT2	WDR24	ENSCPOP00000012731	ENSCPOP00000013766	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	WD repeat domain 24.	0.429
BMT2	WDR59	ENSCPOP00000012731	ENSCPOP00000028724	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	WD repeat domain 59.	0.426
CASTOR1	Depdc5	ENSCPOP00000013137	ENSCPOP00000005408	Cytosolic arginine sensor for mTORC1 subunit 1.	DEP domain-containing protein.	0.745
CASTOR1	MIOS	ENSCPOP00000013137	ENSCPOP00000010559	Cytosolic arginine sensor for mTORC1 subunit 1.	Meiosis regulator for oocyte development.	0.965
CASTOR1	NPRL2	ENSCPOP00000013137	ENSCPOP00000002517	Cytosolic arginine sensor for mTORC1 subunit 1.	NPR2 like, GATOR1 complex subunit.	0.724
CASTOR1	NPRL3	ENSCPOP00000013137	ENSCPOP00000024916	Cytosolic arginine sensor for mTORC1 subunit 1.	NPR3 like, GATOR1 complex subunit.	0.741
CASTOR1	RRAGA	ENSCPOP00000013137	ENSCPOP00000014910	Cytosolic arginine sensor for mTORC1 subunit 1.	Ras related GTP binding A.	0.644
CASTOR1	SEC13	ENSCPOP00000013137	ENSCPOP00000014162	Cytosolic arginine sensor for mTORC1 subunit 1.	SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family.	0.942
CASTOR1	SEH1L	ENSCPOP00000013137	ENSCPOP00000028736	Cytosolic arginine sensor for mTORC1 subunit 1.	SEH1 like nucleoporin; Belongs to the WD repeat SEC13 family.	0.956
CASTOR1	SZT2	ENSCPOP00000013137	ENSCPOP00000005507	Cytosolic arginine sensor for mTORC1 subunit 1.	SZT2 subunit of KICSTOR complex.	0.652
CASTOR1	WDR24	ENSCPOP00000013137	ENSCPOP00000013766	Cytosolic arginine sensor for mTORC1 subunit 1.	WD repeat domain 24.	0.956
CASTOR1	WDR59	ENSCPOP00000013137	ENSCPOP00000028724	Cytosolic arginine sensor for mTORC1 subunit 1.	WD repeat domain 59.	0.960
Depdc5	BMT2	ENSCPOP00000005408	ENSCPOP00000012731	DEP domain-containing protein.	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	0.953