63 items (Cavia porcellus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	MTERF4	Mitochondrial transcription termination factor 4. (341 aa)
	MRPL20	Mitochondrial ribosomal protein L20; Belongs to the bacterial ribosomal protein bL20 family. (149 aa)
	ENSCPOP00000032575	Uncharacterized protein. (135 aa)
	MPV17L2	MPV17 mitochondrial inner membrane protein like 2; Belongs to the peroxisomal membrane protein PXMP2/4 family. (210 aa)
	ENSCPOP00000031834	Uncharacterized protein. (73 aa)
	RPL24	TRASH domain-containing protein. (157 aa)
	MRPS2	Mitochondrial ribosomal protein S2. (285 aa)
	RPS19	Ribosomal protein S19. (176 aa)
	SBDS	SBDS ribosome maturation factor. (250 aa)
	EIF6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (246 aa)
	RPL10	Ribosomal_L16 domain-containing protein. (214 aa)
	MRTO4	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (241 aa)
	ABT1	Activator of basal transcription 1. (269 aa)
	RPL5	Ribosomal_L18_c domain-containing protein. (297 aa)
	XRCC5	X-ray repair cross complementing 5. (739 aa)
	NGRN	Neugrin, neurite outgrowth associated. (294 aa)
	ENSCPOP00000023871	Ribosomal_L23eN domain-containing protein. (113 aa)
	RPL11	Ribosomal protein L11; Belongs to the universal ribosomal protein uL5 family. (178 aa)
	DHX29	ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily. (1334 aa)
	DHX30	DExH-box helicase 30. (1218 aa)
	RRP7A	Ribosomal RNA processing 7 homolog A. (280 aa)
	EFL1	Elongation factor like GTPase 1. (1126 aa)
	H0WDW8_CAVPO	TRASH domain-containing protein. (156 aa)
	RPS5	Ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family. (204 aa)
	BRIX1	Biogenesis of ribosomes BRX1. (346 aa)
	RRS1	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (357 aa)
	Nop2	SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (787 aa)
	CCDC105	Coiled-coil domain containing 105. (421 aa)
	LOC100716855	Brix domain-containing protein. (368 aa)
	H0W5N6_CAVPO	40S ribosomal protein S27. (84 aa)
	RPS14	Ribosomal protein S14; Belongs to the universal ribosomal protein uS11 family. (151 aa)
	FASTKD2	FAST kinase domains 2. (673 aa)
	BOP1	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (734 aa)
	NIP7	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (180 aa)
	C1QBP	Complement C1q binding protein. (281 aa)
	MTERF3	Mitochondrial transcription termination factor 3. (417 aa)
	Rpl23a	Ribosomal_L23eN domain-containing protein; Belongs to the universal ribosomal protein uL23 family. (156 aa)
	MRPS7	Mitochondrial ribosomal protein S7. (242 aa)
	Mrm2	Mitochondrial rRNA methyltransferase 2. (250 aa)
	RPS28	Ribosomal protein S28. (69 aa)
	H0W359_CAVPO	40S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family. (159 aa)
	RPLP0	60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (318 aa)
	LOC100716847	Uncharacterized protein. (80 aa)
	RPS27L	40S ribosomal protein S27. (105 aa)
	DHX37	DEAH-box helicase 37. (1161 aa)
	Pwp2	Uncharacterized protein. (924 aa)
	Rps27	40S ribosomal protein S27. (84 aa)
	NOP53	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (476 aa)
	MDN1	Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. (5563 aa)
	RPL10L	Ribosomal protein L10 like. (214 aa)
	MRPS11	Mitochondrial ribosomal protein S11; Belongs to the universal ribosomal protein uS11 family. (192 aa)
	PRKDC	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4043 aa)
	DDX28	DEAD-box helicase 28. (537 aa)
	RPL6	60S ribosomal protein L6; Belongs to the eukaryotic ribosomal protein eL6 family. (291 aa)
	RPS25	40S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family. (125 aa)
	NLE1	Notchless homolog 1. (485 aa)
	TRAF7	TNF receptor associated factor 7. (670 aa)
	ERAL1	Era like 12S mitochondrial rRNA chaperone 1. (437 aa)
	RPSA	40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteri [...] (295 aa)
	RPF2	Ribosome production factor 2 homolog. (306 aa)
	NSUN4	NOP2/Sun RNA methyltransferase 4; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (381 aa)
	MRPL22	Mitochondrial ribosomal protein L22; Belongs to the universal ribosomal protein uL22 family. (210 aa)
	EIF2A	Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. (534 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABT1	BRIX1	ENSCPOP00000026781	ENSCPOP00000020277	Activator of basal transcription 1.	Biogenesis of ribosomes BRX1.	0.743
ABT1	DDX28	ENSCPOP00000026781	ENSCPOP00000012383	Activator of basal transcription 1.	DEAD-box helicase 28.	0.779
ABT1	DHX29	ENSCPOP00000026781	ENSCPOP00000022582	Activator of basal transcription 1.	ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily.	0.444
ABT1	DHX30	ENSCPOP00000026781	ENSCPOP00000022391	Activator of basal transcription 1.	DExH-box helicase 30.	0.444
ABT1	DHX37	ENSCPOP00000026781	ENSCPOP00000015539	Activator of basal transcription 1.	DEAH-box helicase 37.	0.472
ABT1	Mrm2	ENSCPOP00000026781	ENSCPOP00000017430	Activator of basal transcription 1.	Mitochondrial rRNA methyltransferase 2.	0.664
ABT1	Pwp2	ENSCPOP00000026781	ENSCPOP00000015424	Activator of basal transcription 1.	Uncharacterized protein.	0.841
ABT1	RPF2	ENSCPOP00000026781	ENSCPOP00000006126	Activator of basal transcription 1.	Ribosome production factor 2 homolog.	0.644
ABT1	RRP7A	ENSCPOP00000026781	ENSCPOP00000022363	Activator of basal transcription 1.	Ribosomal RNA processing 7 homolog A.	0.415
ABT1	RRS1	ENSCPOP00000026781	ENSCPOP00000019555	Activator of basal transcription 1.	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.	0.726
BOP1	BRIX1	ENSCPOP00000004912	ENSCPOP00000020277	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Biogenesis of ribosomes BRX1.	0.999
BOP1	DDX28	ENSCPOP00000004912	ENSCPOP00000012383	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	DEAD-box helicase 28.	0.938
BOP1	DHX37	ENSCPOP00000004912	ENSCPOP00000015539	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	DEAH-box helicase 37.	0.413
BOP1	EIF6	ENSCPOP00000004912	ENSCPOP00000027926	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...]	0.993
BOP1	ENSCPOP00000023871	ENSCPOP00000004912	ENSCPOP00000023871	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Ribosomal_L23eN domain-containing protein.	0.943
BOP1	ENSCPOP00000032575	ENSCPOP00000004912	ENSCPOP00000032575	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Uncharacterized protein.	0.974
BOP1	H0WDW8_CAVPO	ENSCPOP00000004912	ENSCPOP00000021192	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	TRASH domain-containing protein.	0.433
BOP1	LOC100716855	ENSCPOP00000004912	ENSCPOP00000018358	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Brix domain-containing protein.	0.951
BOP1	MDN1	ENSCPOP00000004912	ENSCPOP00000014095	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family.	0.649
BOP1	MRPL22	ENSCPOP00000004912	ENSCPOP00000006098	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Mitochondrial ribosomal protein L22; Belongs to the universal ribosomal protein uL22 family.	0.774