STRINGSTRING
GLRX2 GLRX2 PDGFD PDGFD APEX1 APEX1 HSF1 HSF1 SMPD3 SMPD3 BECN1 BECN1 MB MB PDCD10 PDCD10 SIGMAR1 SIGMAR1 CASP6 CASP6 ENSCPOP00000030888 ENSCPOP00000030888 PLEKHA1 PLEKHA1 ZNF277 ZNF277 PTK2B PTK2B AIFM1 AIFM1 BNIP3 BNIP3 CRYAB CRYAB ENSCPOP00000029431 ENSCPOP00000029431 APTX APTX ENSCPOP00000029129 ENSCPOP00000029129 EDN1 EDN1 Rps3 Rps3 MAP3K5 MAP3K5 LOC106027874 LOC106027874 LOC100722819 LOC100722819 CYP1B1 CYP1B1 NFE2L2 NFE2L2 NR4A3 NR4A3 FKBP1B FKBP1B ENSCPOP00000026628 ENSCPOP00000026628 ENSCPOP00000026239 ENSCPOP00000026239 PRKCD PRKCD OSER1 OSER1 HDAC6 HDAC6 STK25 STK25 ARG1 ARG1 JUN JUN AREG AREG ENSCPOP00000025613 ENSCPOP00000025613 FYN FYN SOD2 SOD2 PAX2 PAX2 MDM2 MDM2 RIPK1 RIPK1 RNF112 RNF112 MAPK8 MAPK8 IMPACT IMPACT STK24 STK24 FOSL1 FOSL1 PRDX3 PRDX3 MAP1LC3A MAP1LC3A H0V2A5_CAVPO H0V2A5_CAVPO CAPN1 CAPN1 EZH2 EZH2 COL1A1 COL1A1 STK26 STK26 LOC100718490 LOC100718490 H0UY86_CAVPO H0UY86_CAVPO LOC100725465 LOC100725465 Bad Bad UBE3A UBE3A PPP1R15B PPP1R15B PDGFRB PDGFRB H0WBB7_CAVPO H0WBB7_CAVPO TRPC6 TRPC6 MMP2 MMP2 H0UWK8_CAVPO H0UWK8_CAVPO SETX SETX SIRT1 SIRT1 ERN1 ERN1 BAK1 BAK1 PCGF2 PCGF2 Lig1 Lig1 HMOX1 HMOX1 DICER1 DICER1 SLC4A1 SLC4A1 LOC100724477 LOC100724477 H0VY83_CAVPO H0VY83_CAVPO LOC100719324 LOC100719324 ZNF580 ZNF580 CAPN2 CAPN2 TRPM2 TRPM2 ND6 ND6 ND5 ND5 H0VSI3_CAVPO H0VSI3_CAVPO MAPK13 MAPK13 ANXA1 ANXA1 NET1 NET1 HDAC2 HDAC2 SOD1 SOD1 IL18RAP IL18RAP PPIF PPIF STAT6 STAT6 CAT CAT H0VLM6_CAVPO H0VLM6_CAVPO SPHK1 SPHK1 Trpa1 Trpa1 Aqp1 Aqp1 TNFAIP3 TNFAIP3 KPNA4 KPNA4 PCNA PCNA LOC100726004 LOC100726004 H0VDE6_CAVPO H0VDE6_CAVPO AXL AXL ADAM9 ADAM9 OPTN OPTN LOC100725733 LOC100725733 CRK CRK PARK7 PARK7 PLD2 PLD2 FXN FXN KDM6B KDM6B ANKZF1 ANKZF1 ECT2 ECT2 Cdk1 Cdk1 MAPK7 MAPK7 KCNA5 KCNA5 TXNIP TXNIP RIPK3 RIPK3 HSPD1 HSPD1 BCL2 BCL2 H0W0U4_CAVPO H0W0U4_CAVPO RELA RELA PRKAA1 PRKAA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GLRX2Glutaredoxin 2. (160 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
HSF1Heat shock transcription factor 1. (555 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (656 aa)
BECN1Beclin 1. (448 aa)
MBMyoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (154 aa)
PDCD10Programmed cell death 10. (212 aa)
SIGMAR1Sigma non-opioid intracellular receptor 1; Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. [...] (223 aa)
CASP6Caspase 6; Belongs to the peptidase C14A family. (279 aa)
ENSCPOP00000030888Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (238 aa)
PLEKHA1Pleckstrin homology domain containing A1. (402 aa)
ZNF277Zinc finger protein 277. (473 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
AIFM1Apoptosis inducing factor mitochondria associated 1. (614 aa)
BNIP3BCL2 interacting protein 3. (194 aa)
CRYABAlphaB-crystallin; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
ENSCPOP00000029431Uncharacterized protein. (111 aa)
APTXAprataxin. (341 aa)
ENSCPOP00000029129Protein kinase domain-containing protein. (254 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (208 aa)
Rps3KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1344 aa)
LOC106027874Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (209 aa)
LOC100722819Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (223 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (540 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (591 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (633 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
ENSCPOP00000026628Uncharacterized protein. (100 aa)
ENSCPOP00000026239Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (223 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
OSER1Oxidative stress responsive serine rich 1. (292 aa)
HDAC6Histone deacetylase 6. (1196 aa)
STK25Serine/threonine kinase 25. (426 aa)
ARG1Arginase. (322 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (253 aa)
AREGAmphiregulin. (241 aa)
ENSCPOP00000025613Proton_antipo_M domain-containing protein. (171 aa)
FYNTyrosine-protein kinase. (537 aa)
SOD2Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
PAX2Paired box 2. (393 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (664 aa)
RNF112Ring finger protein 112. (654 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IMPACTImpact RWD domain protein. (318 aa)
STK24Serine/threonine kinase 24. (470 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (275 aa)
PRDX3Peroxiredoxin 3. (257 aa)
MAP1LC3AMicrotubule associated protein 1 light chain 3 alpha. (121 aa)
H0V2A5_CAVPOLipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (237 aa)
CAPN1Calpain 1; Belongs to the peptidase C2 family. (714 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (747 aa)
COL1A1Collagen type I alpha 1 chain. (1454 aa)
STK26Serine/threonine kinase 26. (410 aa)
LOC100718490Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (198 aa)
H0UY86_CAVPOLipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (213 aa)
LOC100725465FABP domain-containing protein. (127 aa)
BadUncharacterized protein. (166 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (874 aa)
PPP1R15BProtein phosphatase 1 regulatory subunit 15B. (702 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1102 aa)
H0WBB7_CAVPOLipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (199 aa)
TRPC6Uncharacterized protein; Belongs to the transient receptor (TC 1.A.4) family. (934 aa)
MMP2Matrix metallopeptidase 2. (662 aa)
H0UWK8_CAVPOLipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (250 aa)
SETXSenataxin. (2661 aa)
SIRT1Sirtuin 1. (717 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (974 aa)
BAK1BCL2 antagonist/killer 1. (214 aa)
PCGF2Polycomb group ring finger 2. (342 aa)
Lig1DNA ligase. (909 aa)
HMOX1Heme oxygenase 1. (297 aa)
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1903 aa)
SLC4A1Anion exchange protein. (901 aa)
LOC100724477Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (187 aa)
H0VY83_CAVPOLipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (200 aa)
LOC100719324Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (212 aa)
ZNF580Zinc finger protein 580. (211 aa)
CAPN2Calpain 2; Belongs to the peptidase C2 family. (700 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1502 aa)
ND6NADH-ubiquinone oxidoreductase chain 6; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (176 aa)
ND5NADH-ubiquinone oxidoreductase chain 5; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (603 aa)
H0VSI3_CAVPODNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. (677 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
ANXA1Annexin. (346 aa)
NET1Neuroepithelial cell transforming 1. (597 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (153 aa)
IL18RAPInterleukin 18 receptor accessory protein. (564 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (210 aa)
STAT6Signal transducer and activator of transcription. (838 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells; Belongs to the catalase family. (527 aa)
H0VLM6_CAVPOLipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (199 aa)
SPHK1Sphingosine kinase 1. (386 aa)
Trpa1ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (991 aa)
Aqp1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
TNFAIP3TNF alpha induced protein 3. (789 aa)
KPNA4Importin subunit alpha; Functions in nuclear protein import. (558 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
LOC100726004FABP domain-containing protein. (127 aa)
H0VDE6_CAVPOLipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (196 aa)
AXLAXL receptor tyrosine kinase. (888 aa)
ADAM9ADAM metallopeptidase domain 9. (853 aa)
OPTNOptineurin. (576 aa)
LOC100725733FABP domain-containing protein. (127 aa)
CRKCRK proto-oncogene, adaptor protein. (281 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
PLD2Phospholipase. (936 aa)
FXNFrataxin. (211 aa)
KDM6BLysine demethylase 6B. (1467 aa)
ANKZF1Ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1. (722 aa)
ECT2Epithelial cell transforming 2. (913 aa)
Cdk1Protein kinase domain-containing protein. (240 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (797 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (609 aa)
TXNIPThioredoxin interacting protein. (392 aa)
RIPK3Receptor interacting serine/threonine kinase 3; Belongs to the protein kinase superfamily. (482 aa)
HSPD1Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (574 aa)
BCL2BCL2 apoptosis regulator. (183 aa)
H0W0U4_CAVPOCalpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (420 aa)
RELARELA proto-oncogene, NF-kB subunit. (549 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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