88 items (Cavia porcellus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	XBP1	X-box binding protein 1. (268 aa)
	MED13	Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2123 aa)
	AMPD2	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (825 aa)
	Ces1d	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (565 aa)
	FABP4	Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	ABCG8	ATP binding cassette subfamily G member 8. (658 aa)
	RALY	RALY heterogeneous nuclear ribonucleoprotein. (314 aa)
	LIMA1	LIM domain and actin binding 1. (755 aa)
	NCOR1	Nuclear receptor corepressor 1. (2389 aa)
	SIRT1	Sirtuin 1. (717 aa)
	NPC2	NPC intracellular cholesterol transporter 2. (150 aa)
	COMMD1	Copper metabolism domain containing 1. (188 aa)
	NR1H4	Nuclear receptor subfamily 1 group H member 4. (484 aa)
	MYLIP	Myosin regulatory light chain interacting protein. (441 aa)
	TMEM97	Transmembrane protein 97; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins. (176 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (189 aa)
	CYP7A1	Cytochrome P450 family 7 subfamily A member 1; Belongs to the cytochrome P450 family. (496 aa)
	LIPC	Lipase C, hepatic type. (497 aa)
	LPL	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (495 aa)
	GPR39	G protein-coupled receptor 39; Belongs to the G-protein coupled receptor 1 family. (295 aa)
	DGAT2	Diacylglycerol O-acyltransferase 2. (388 aa)
	TTC39B	Tetratricopeptide repeat domain 39B. (618 aa)
	APOB	Apolipoprotein B. (4479 aa)
	HDAC9	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1046 aa)
	SOAT2	O-acyltransferase. (457 aa)
	ABCB11	Uncharacterized protein. (1320 aa)
	ANGPTL3	Angiopoietin like 3. (421 aa)
	NPC1	NPC intracellular cholesterol transporter 1. (1277 aa)
	ABCG4	ATP binding cassette subfamily G member 4. (646 aa)
	LOC100733616	Uncharacterized protein; Belongs to the cytochrome P450 family. (319 aa)
	HNF4A	Hepatocyte nuclear factor 4 alpha. (474 aa)
	APOE	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (298 aa)
	Mia2	Uncharacterized protein. (776 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1600 aa)
	TTC39A	Tetratricopeptide repeat domain 39A. (578 aa)
	EHD1	EH domain containing 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (534 aa)
	RORA	RAR related orphan receptor A. (467 aa)
	NR5A2	Nuclear receptor subfamily 5 group A member 2. (551 aa)
	LIPG	Lipase G, endothelial type. (498 aa)
	PLSCR3	Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (295 aa)
	ABCA1	ATP binding cassette subfamily A member 1. (2200 aa)
	COMMD9	COMM domain containing 9. (198 aa)
	LOC100730472	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (559 aa)
	NR1H2	Nuclear receptor subfamily 1 group H member 2. (463 aa)
	APOA1	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. (264 aa)
	ALMS1	ALMS1 centrosome and basal body associated protein. (3698 aa)
	NUS1	NUS1 dehydrodolichyl diphosphate synthase subunit. (285 aa)
	ABCA5	ATP binding cassette subfamily A member 5. (1593 aa)
	LOC100717473	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (561 aa)
	LAMTOR1	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa)
	TSKU	Tsukushi, small leucine rich proteoglycan. (364 aa)
	ENSCPOP00000024925	COesterase domain-containing protein. (295 aa)
	TSPO	Translocator protein. (169 aa)
	CYP7B1	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (493 aa)
	NR1H3	Nuclear receptor subfamily 1 group H member 3. (443 aa)
	GPIHBP1	Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1. (194 aa)
	SREBF2	Sterol regulatory element binding transcription factor 2. (1149 aa)
	PEX2	Peroxisomal biogenesis factor 2. (304 aa)
	MALRD1	MAM and LDL receptor class A domain containing 1. (2080 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	G6PC2	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
	EPHX2	Epoxide hydrolase 2. (469 aa)
	SLC37A4	Solute carrier family 37 member 4. (451 aa)
	NFE2L1	Nuclear factor, erythroid 2 like 1. (743 aa)
	LDLR	Low density lipoprotein receptor. (807 aa)
	ABCG5	ATP binding cassette subfamily G member 5. (480 aa)
	LCAT	Lecithin-cholesterol acyltransferase. (441 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
	HPN	Hepsin; Belongs to the peptidase S1 family. (433 aa)
	PLA2G10	Phospholipase A(2). (152 aa)
	H0VU94_CAVPO	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (520 aa)
	PCSK9	Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (686 aa)
	PLA2G12B	Phospholipase A2 group XIIB. (195 aa)
	APOA2	Apolipoprotein A2. (101 aa)
	ABCG1	ATP binding cassette subfamily G member 1. (666 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
	LOC100721835	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (565 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1. (611 aa)
	INSIG1	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (248 aa)
	SEC24A	SEC24 homolog A, COPII coat complex component. (1050 aa)
	GRAMD1B	GRAM domain containing 1B. (857 aa)
	ABCA2	ATP binding cassette subfamily A member 2. (2427 aa)
	APOA5	Apolipoprotein A5. (429 aa)
	G6PC	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (356 aa)
	SOAT1	O-acyltransferase. (543 aa)
	LDLRAP1	Low density lipoprotein receptor adaptor protein 1. (308 aa)
	FGFR4	Fibroblast growth factor receptor. (801 aa)
	RALYL	RALY RNA binding protein like. (292 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA1	ABCB11	ENSCPOP00000008428	ENSCPOP00000005355	ATP binding cassette subfamily A member 1.	Uncharacterized protein.	0.411
ABCA1	ABCG1	ENSCPOP00000008428	ENSCPOP00000013696	ATP binding cassette subfamily A member 1.	ATP binding cassette subfamily G member 1.	0.415
ABCA1	ABCG5	ENSCPOP00000008428	ENSCPOP00000019639	ATP binding cassette subfamily A member 1.	ATP binding cassette subfamily G member 5.	0.461
ABCA1	APOA1	ENSCPOP00000008428	ENSCPOP00000032306	ATP binding cassette subfamily A member 1.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family.	0.962
ABCA1	APOA2	ENSCPOP00000008428	ENSCPOP00000013814	ATP binding cassette subfamily A member 1.	Apolipoprotein A2.	0.554
ABCA1	APOB	ENSCPOP00000008428	ENSCPOP00000004440	ATP binding cassette subfamily A member 1.	Apolipoprotein B.	0.586
ABCA1	APOE	ENSCPOP00000008428	ENSCPOP00000006519	ATP binding cassette subfamily A member 1.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.773
ABCA1	CAV1	ENSCPOP00000008428	ENSCPOP00000027566	ATP binding cassette subfamily A member 1.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.433
ABCA1	CYP7A1	ENSCPOP00000008428	ENSCPOP00000003062	ATP binding cassette subfamily A member 1.	Cytochrome P450 family 7 subfamily A member 1; Belongs to the cytochrome P450 family.	0.583
ABCA1	LCAT	ENSCPOP00000008428	ENSCPOP00000018146	ATP binding cassette subfamily A member 1.	Lecithin-cholesterol acyltransferase.	0.653
ABCA1	MYLIP	ENSCPOP00000008428	ENSCPOP00000002649	ATP binding cassette subfamily A member 1.	Myosin regulatory light chain interacting protein.	0.439
ABCA1	NPC1	ENSCPOP00000008428	ENSCPOP00000005618	ATP binding cassette subfamily A member 1.	NPC intracellular cholesterol transporter 1.	0.540
ABCA1	NR1H2	ENSCPOP00000008428	ENSCPOP00000032644	ATP binding cassette subfamily A member 1.	Nuclear receptor subfamily 1 group H member 2.	0.921
ABCA1	NR1H3	ENSCPOP00000008428	ENSCPOP00000025335	ATP binding cassette subfamily A member 1.	Nuclear receptor subfamily 1 group H member 3.	0.904
ABCA1	NR1H4	ENSCPOP00000008428	ENSCPOP00000001965	ATP binding cassette subfamily A member 1.	Nuclear receptor subfamily 1 group H member 4.	0.684
ABCA1	PCSK9	ENSCPOP00000008428	ENSCPOP00000014122	ATP binding cassette subfamily A member 1.	Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family.	0.491
ABCA1	SCARB1	ENSCPOP00000008428	ENSCPOP00000017718	ATP binding cassette subfamily A member 1.	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.630
ABCA1	SREBF2	ENSCPOP00000008428	ENSCPOP00000027507	ATP binding cassette subfamily A member 1.	Sterol regulatory element binding transcription factor 2.	0.565
ABCA2	APOA1	ENSCPOP00000013064	ENSCPOP00000032306	ATP binding cassette subfamily A member 2.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family.	0.890
ABCA2	APOE	ENSCPOP00000013064	ENSCPOP00000006519	ATP binding cassette subfamily A member 2.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.424