STRINGSTRING
Prkaca Prkaca ARRB2 ARRB2 LZTS1 LZTS1 BAIAP2 BAIAP2 ITGB1 ITGB1 RAB8A RAB8A HOMER1 HOMER1 CDC42 CDC42 KCND1 KCND1 ENSCPOP00000031438 ENSCPOP00000031438 MYLK2 MYLK2 RHOA RHOA OPHN1 OPHN1 PTK2B PTK2B LZTS3 LZTS3 SIPA1L1 SIPA1L1 MPP2 MPP2 RGS7BP RGS7BP SYNPO SYNPO ARFGEF2 ARFGEF2 ARPC2 ARPC2 ABHD17C ABHD17C CRIPT CRIPT ATP1A2 ATP1A2 ADORA1 ADORA1 Chrna7 Chrna7 SLC8A3 SLC8A3 FUS FUS Ppp1r2 Ppp1r2 OPRD1 OPRD1 PPP1R9B PPP1R9B ENSCPOP00000028569 ENSCPOP00000028569 CNIH2 CNIH2 TANC2 TANC2 ACTN1 ACTN1 SEPTIN11 SEPTIN11 GPM6A GPM6A DNAJB1 DNAJB1 KCNA4 KCNA4 LOC100726317 LOC100726317 ABHD17A ABHD17A SEZ6 SEZ6 NUMB NUMB NRGN NRGN PDE4B PDE4B GRIN1 GRIN1 ZMYND8 ZMYND8 ABR ABR CNN3 CNN3 MYH10 MYH10 Arf4 Arf4 FRMPD4 FRMPD4 CLSTN1 CLSTN1 SHISA7 SHISA7 MOB4 MOB4 DRD1 DRD1 APBA1 APBA1 ARRB1 ARRB1 FXR1 FXR1 CYFIP1 CYFIP1 DLGAP2 DLGAP2 LPAR1 LPAR1 Pgr Pgr GPER1 GPER1 SHISA9 SHISA9 CTNND1 CTNND1 PTPRZ1 PTPRZ1 PPP1CA PPP1CA ATP2B1 ATP2B1 NSMF NSMF MT3 MT3 ARHGAP33 ARHGAP33 RAC1 RAC1 GABBR1 GABBR1 NCOA2 NCOA2 LRRC4 LRRC4 SHISA8 SHISA8 DGKI DGKI NTRK2 NTRK2 CACNA1S CACNA1S Drd4 Drd4 ASIC2 ASIC2 APP APP DLG4 DLG4 PDLIM4 PDLIM4 DRD5 DRD5 DLGAP3 DLGAP3 ARC ARC FXR2 FXR2 GIPC1 GIPC1 DBN1 DBN1 SHANK1 SHANK1 PTEN PTEN KCNC3 KCNC3 ATP2B2 ATP2B2 GRID2IP GRID2IP NLGN1 NLGN1 CDK5R1 CDK5R1 SHANK3 SHANK3 P2RX3 P2RX3 APBB1 APBB1 SLC1A2 SLC1A2 ADGRB1 ADGRB1 MTMR2 MTMR2 Srgap2 Srgap2 PPP1R1B PPP1R1B GRM5 GRM5 DRD2 DRD2 DTNBP1 DTNBP1 LRRC7 LRRC7 H0VF00_CAVPO H0VF00_CAVPO SHANK2 SHANK2 ITGA8 ITGA8 GRK3 GRK3 PPP3CA PPP3CA SLC8A2 SLC8A2 SRI SRI TRPV1 TRPV1 ADAM10 ADAM10 Atp1a3 Atp1a3 RAPGEF4 RAPGEF4 EPHB2 EPHB2 EPHA4 EPHA4 ASAP1 ASAP1 PPP1R9A PPP1R9A GRID2 GRID2 KCND2 KCND2 EEF2K EEF2K STRN STRN FBXO2 FBXO2 DAGLA DAGLA P2RX6 P2RX6 SLC1A1 SLC1A1 GRIN2A GRIN2A GRM3 GRM3 CYP19A1 CYP19A1 CAPZB CAPZB Myo5b Myo5b ALS2 ALS2 GSK3B GSK3B PTPRO PTPRO ABI3BP ABI3BP NR1D1 NR1D1 ANKS1B ANKS1B ARHGAP44 ARHGAP44 GRM1 GRM1 FMR1 FMR1 DIP2A DIP2A GRIA1 GRIA1 RGS14 RGS14 P2rx4 P2rx4 CTTNBP2 CTTNBP2 RGS10 RGS10 COMT COMT SYT11 SYT11 SYNDIG1 SYNDIG1 H0V4H8_CAVPO H0V4H8_CAVPO ABHD17B ABHD17B PSD PSD SNX1 SNX1 GRIA2 GRIA2 CALB1 CALB1 KCNN2 KCNN2 NEDD4 NEDD4 ITSN1 ITSN1 ATP6AP2 ATP6AP2 DNM3 DNM3 PTK2 PTK2 TENM2 TENM2 STRN4 STRN4 GRIA4 GRIA4 FARP1 FARP1 CD3E CD3E PRRT2 PRRT2 KCND3 KCND3 USP8 USP8 ESPN ESPN PRKAR2B PRKAR2B BCR BCR PSMC2 PSMC2 Apba3 Apba3 PALMD PALMD IGF2BP1 IGF2BP1 STX4 STX4 RPH3A RPH3A APBA2 APBA2 ITPKA ITPKA DDN DDN CANX CANX ADD1 ADD1 PPFIA2 PPFIA2 GRIA3 GRIA3 CTTN CTTN PPP1CC PPP1CC DOCK10 DOCK10 GRIN2B GRIN2B MAP1B MAP1B NEURL1 NEURL1 CAMK2A CAMK2A DVL1 DVL1 SLC1A3 SLC1A3 ABI2 ABI2 ZNF804A ZNF804A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PrkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
ARRB2Arrestin beta 2. (417 aa)
LZTS1Leucine zipper tumor suppressor 1. (606 aa)
BAIAP2BAI1 associated protein 2. (535 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
RAB8ARAB8A, member RAS oncogene family. (207 aa)
HOMER1Homer scaffold protein 1. (329 aa)
CDC42Cell division cycle 42. (191 aa)
KCND1Potassium voltage-gated channel subfamily D member 1; Belongs to the potassium channel family. (651 aa)
ENSCPOP00000031438annotation not available (62 aa)
MYLK2Myosin light chain kinase 2. (593 aa)
RHOARas homolog family member A. (193 aa)
OPHN1Uncharacterized protein. (802 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
LZTS3Leucine zipper tumor suppressor family member 3. (671 aa)
SIPA1L1Signal induced proliferation associated 1 like 1. (1803 aa)
MPP2Membrane palmitoylated protein 2; Belongs to the MAGUK family. (569 aa)
RGS7BPRegulator of G protein signaling 7 binding protein. (257 aa)
SYNPOSynaptopodin. (937 aa)
ARFGEF2ADP ribosylation factor guanine nucleotide exchange factor 2. (1784 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
ABHD17CAbhydrolase domain containing 17C. (330 aa)
CRIPTCXXC repeat containing interactor of PDZ3 domain. (101 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. (326 aa)
Chrna7Uncharacterized protein. (483 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
FUSFUS RNA binding protein. (490 aa)
Ppp1r2Uncharacterized protein. (205 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
PPP1R9BProtein phosphatase 1 regulatory subunit 9B. (821 aa)
ENSCPOP00000028569ANF_receptor domain-containing protein. (260 aa)
CNIH2Cornichon family AMPA receptor auxiliary protein 2. (160 aa)
TANC2Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2. (2013 aa)
ACTN1Actinin alpha 1. (914 aa)
SEPTIN11Septin 11; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (429 aa)
GPM6AGlycoprotein M6A. (278 aa)
DNAJB1DnaJ heat shock protein family (Hsp40) member B1. (339 aa)
KCNA4Potassium voltage-gated channel subfamily A member 4; Belongs to the potassium channel family. (622 aa)
LOC100726317Uncharacterized protein. (421 aa)
ABHD17AAbhydrolase domain containing 17A. (310 aa)
SEZ6Seizure related 6 homolog. (994 aa)
NUMBNUMB endocytic adaptor protein. (648 aa)
NRGNNeurogranin. (78 aa)
PDE4BPhosphodiesterase. (736 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (943 aa)
ZMYND8Zinc finger MYND-type containing 8. (1213 aa)
ABRABR activator of RhoGEF and GTPase. (859 aa)
CNN3Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (310 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1974 aa)
Arf4Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (180 aa)
FRMPD4FERM and PDZ domain containing 4. (1325 aa)
CLSTN1Calsyntenin 1. (989 aa)
SHISA7Shisa family member 7. (377 aa)
MOB4HSPE1-MOB4 readthrough. (225 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (444 aa)
APBA1Amyloid beta precursor protein binding family A member 1. (837 aa)
ARRB1Arrestin beta 1. (430 aa)
FXR1FMR1 autosomal homolog 1. (677 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1264 aa)
DLGAP2DLG associated protein 2. (1058 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
PgrUncharacterized protein. (428 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
SHISA9Shisa family member 9. (424 aa)
CTNND1Catenin delta 1. (966 aa)
PTPRZ1Protein tyrosine phosphatase receptor type Z1. (1433 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1249 aa)
NSMFNMDA receptor synaptonuclear signaling and neuronal migration factor. (513 aa)
MT3Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (66 aa)
ARHGAP33Rho GTPase activating protein 33. (1311 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (211 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (844 aa)
NCOA2Nuclear receptor coactivator. (1462 aa)
LRRC4Leucine rich repeat containing 4. (652 aa)
SHISA8Shisa family member 8. (301 aa)
DGKIDiacylglycerol kinase. (957 aa)
NTRK2Tyrosine-protein kinase receptor. (816 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1867 aa)
Drd4G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (341 aa)
ASIC2Acid sensing ion channel subunit 2; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (493 aa)
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (770 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (754 aa)
PDLIM4PDZ and LIM domain 4. (290 aa)
DRD5Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. (474 aa)
DLGAP3DLG associated protein 3. (979 aa)
ARCActivity regulated cytoskeleton associated protein. (395 aa)
FXR2FMR1 autosomal homolog 2. (672 aa)
GIPC1GIPC PDZ domain containing family member 1. (332 aa)
DBN1Drebrin 1. (677 aa)
SHANK1SH3 and multiple ankyrin repeat domains 1. (1749 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (355 aa)
KCNC3Potassium voltage-gated channel subfamily C member 3; Belongs to the potassium channel family. (729 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1296 aa)
GRID2IPGrid2 interacting protein. (1204 aa)
NLGN1Neuroligin 1. (843 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1694 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (391 aa)
APBB1Amyloid beta precursor protein binding family B member 1. (709 aa)
SLC1A2Amino acid transporter. (573 aa)
ADGRB1Adhesion G protein-coupled receptor B1; Belongs to the G-protein coupled receptor 2 family. (1578 aa)
MTMR2Myotubularin related protein 2. (643 aa)
Srgap2Uncharacterized protein. (1063 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (184 aa)
GRM5Glutamate metabotropic receptor 5. (873 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (446 aa)
DTNBP1Dystrobrevin binding protein 1. (354 aa)
LRRC7Leucine rich repeat containing 7. (1504 aa)
H0VF00_CAVPOUncharacterized protein. (323 aa)
SHANK2SH3 and multiple ankyrin repeat domains 2. (1839 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1062 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (673 aa)
PPP3CASerine/threonine-protein phosphatase. (518 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (840 aa)
SRISorcin. (198 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits [...] (839 aa)
ADAM10ADAM metallopeptidase domain 10. (679 aa)
Atp1a3Sodium/potassium-transporting ATPase subunit alpha. (1028 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (989 aa)
EPHB2EPH receptor B2. (949 aa)
EPHA4EPH receptor A4. (986 aa)
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 1. (1147 aa)
PPP1R9AProtein phosphatase 1 regulatory subunit 9A. (1288 aa)
GRID2Glutamate ionotropic receptor delta type subunit 2. (1007 aa)
KCND2Potassium voltage-gated channel subfamily D member 2; Belongs to the potassium channel family. (630 aa)
EEF2KEukaryotic elongation factor 2 kinase. (724 aa)
STRNStriatin. (780 aa)
FBXO2F-box protein OCP1. (300 aa)
DAGLADiacylglycerol lipase alpha. (1037 aa)
P2RX6P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (381 aa)
SLC1A1Amino acid transporter. (525 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1462 aa)
GRM3Glutamate metabotropic receptor 3. (877 aa)
CYP19A1Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
CAPZBF-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (301 aa)
Myo5bUncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1803 aa)
ALS2Alsin Rho guanine nucleotide exchange factor ALS2. (1580 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (423 aa)
PTPROProtein tyrosine phosphatase receptor type O. (1216 aa)
ABI3BPABI family member 3 binding protein. (1070 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (611 aa)
ANKS1BAnkyrin repeat and sterile alpha motif domain containing 1B. (1260 aa)
ARHGAP44Rho GTPase activating protein 44. (751 aa)
GRM1Glutamate metabotropic receptor 1. (1195 aa)
FMR1Fragile X mental retardation 1. (612 aa)
DIP2ADisco interacting protein 2 homolog A. (1549 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (861 aa)
RGS14Regulator of G protein signaling 14. (570 aa)
P2rx4Uncharacterized protein. (343 aa)
CTTNBP2Cortactin binding protein 2. (1650 aa)
RGS10Regulator of G protein signaling 10. (182 aa)
COMTCatechol-O-methyltransferase. (292 aa)
SYT11Synaptotagmin 11. (431 aa)
SYNDIG1Synapse differentiation inducing 1. (250 aa)
H0V4H8_CAVPOKH domain-containing protein. (145 aa)
ABHD17BAbhydrolase domain containing 17B. (288 aa)
PSDPleckstrin and Sec7 domain containing. (1025 aa)
SNX1Sorting nexin 1. (521 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
CALB1Calbindin 1. (275 aa)
KCNN2Potassium calcium-activated channel subfamily N member 2. (842 aa)
NEDD4E3 ubiquitin-protein ligase. (896 aa)
ITSN1Intersectin 1. (1657 aa)
ATP6AP2ATPase H+ transporting accessory protein 2. (350 aa)
DNM3Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (811 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1084 aa)
TENM2Teneurin transmembrane protein 2. (2765 aa)
STRN4Striatin 4. (777 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (819 aa)
FARP1FERM, ARH/RhoGEF and pleckstrin domain protein 1. (1048 aa)
CD3ECD3e molecule. (194 aa)
PRRT2Proline rich transmembrane protein 2. (340 aa)
KCND3Potassium voltage-gated channel subfamily D member 3; Belongs to the potassium channel family. (654 aa)
USP8Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1081 aa)
ESPNEspin. (870 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (350 aa)
BCRBCR activator of RhoGEF and GTPase. (1227 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (458 aa)
Apba3PID domain-containing protein. (351 aa)
PALMDPalmdelphin. (551 aa)
IGF2BP1Insulin like growth factor 2 mRNA binding protein 1. (547 aa)
STX4Syntaxin 4; Belongs to the syntaxin family. (298 aa)
RPH3ARabphilin 3A. (667 aa)
APBA2Amyloid beta precursor protein binding family A member 2. (750 aa)
ITPKAKinase; Belongs to the inositol phosphokinase (IPK) family. (434 aa)
DDNDendrin. (709 aa)
CANXCalnexin. (593 aa)
ADD1Adducin 1. (733 aa)
PPFIA2PTPRF interacting protein alpha 2. (1165 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (888 aa)
CTTNCortactin. (550 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
DOCK10Dedicator of cytokinesis 10; Belongs to the DOCK family. (2198 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1381 aa)
MAP1BMicrotubule associated protein 1B. (2465 aa)
NEURL1Neuralized E3 ubiquitin protein ligase 1. (574 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
DVL1Dishevelled segment polarity protein 1. (698 aa)
SLC1A3Amino acid transporter. (542 aa)
ABI2Abl interactor 2. (479 aa)
ZNF804AZinc finger protein 804A. (1209 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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