STRINGSTRING
BTD BTD GRIA2 GRIA2 DRP2 DRP2 Pde11a Pde11a KCNB2 KCNB2 OPN4 OPN4 KCNK1 KCNK1 H0UVS7_CAVPO H0UVS7_CAVPO GRIK2 GRIK2 Ckmt1a Ckmt1a KLHL6 KLHL6 AIF1 AIF1 CRHBP CRHBP WDR20 WDR20 PCSK5 PCSK5 DDN DDN MAP2K1 MAP2K1 H0V006_CAVPO H0V006_CAVPO KCNH1 KCNH1 MPP5 MPP5 KCNC2 KCNC2 CNR2 CNR2 PDPK1 PDPK1 GRIA3 GRIA3 FMR1 FMR1 KCNA1 KCNA1 Ercc8 Ercc8 SYT11 SYT11 KCNAB1 KCNAB1 BRD1 BRD1 ENO2 ENO2 SEMA4F SEMA4F PCSK2 PCSK2 MAP1B MAP1B NEURL1 NEURL1 Gap43 Gap43 RUFY3 RUFY3 DBNL DBNL DHX36 DHX36 HTR5A HTR5A RACK1 RACK1 TOP1 TOP1 SLC17A8 SLC17A8 CTSV CTSV NGB NGB DRD2 DRD2 CIB3 CIB3 C9orf72 C9orf72 ITGA8 ITGA8 SEPTIN14 SEPTIN14 KLHL35 KLHL35 PCSK1 PCSK1 SHTN1 SHTN1 EPHA4 EPHA4 Ccr2 Ccr2 MCRS1 MCRS1 PAM PAM PTPN5 PTPN5 KCND2 KCND2 ASTN1 ASTN1 SERPINI1 SERPINI1 KLHL24 KLHL24 GLRA3 GLRA3 DIP2B DIP2B CACNA1H CACNA1H TH TH SLC4A10 SLC4A10 KNG1 KNG1 KIF5A KIF5A PTPRS PTPRS SLC1A1 SLC1A1 ITGA1 ITGA1 GRIP1 GRIP1 GLRA1 GLRA1 MAP2K4 MAP2K4 CACNA1E CACNA1E ADCYAP1 ADCYAP1 LOC100732110 LOC100732110 CPE CPE NCDN NCDN TRPM2 TRPM2 H0VVI0_CAVPO H0VVI0_CAVPO NPPA NPPA OPRM1 OPRM1 CDK5R1 CDK5R1 GJC2 GJC2 CTNND2 CTNND2 GRIK3 GRIK3 OLFM1 OLFM1 CAMK2B CAMK2B H0W1V8_CAVPO H0W1V8_CAVPO EFNA2 EFNA2 ESR2 ESR2 CNGA3 CNGA3 ATP7A ATP7A CACNA1F CACNA1F ROGDI ROGDI SLC5A7 SLC5A7 CNGA4 CNGA4 PNMT PNMT KCNC3 KCNC3 Asl Asl GRIK5 GRIK5 RTN4R RTN4R Nefh Nefh CACNA1A CACNA1A ENDOG ENDOG CHRNA10 CHRNA10 NEUROG1 NEUROG1 APP APP ASS1 ASS1 SCN1B SCN1B NTRK2 NTRK2 CCK CCK CKAP5 CKAP5 RNF112 RNF112 NSMF NSMF KCNE3 KCNE3 ANXA5 ANXA5 CACNA1C CACNA1C PPP1CA PPP1CA PPP5C PPP5C SIRT2 SIRT2 GIGYF2 GIGYF2 Pgr Pgr CRMP1 CRMP1 Elavl4 Elavl4 GLUL GLUL MAPK8 MAPK8 CIB1 CIB1 PCMT1 PCMT1 NPFF NPFF MAPK9 MAPK9 RTN4RL1 RTN4RL1 HDAC6 HDAC6 Septin4 Septin4 ZPR1 ZPR1 ENSCPOP00000026034 ENSCPOP00000026034 CPLX1 CPLX1 CPLX2 CPLX2 PDE10A PDE10A RGS8 RGS8 PDE9A PDE9A AMIGO2 AMIGO2 AZIN2 AZIN2 Nefm Nefm DMWD DMWD HNRNPA2B1 HNRNPA2B1 KCNA2 KCNA2 KCNB1 KCNB1 FUS FUS RBFOX3 RBFOX3 SLC8A3 SLC8A3 ENSCPOP00000029029 ENSCPOP00000029029 CRHR2 CRHR2 PRPH PRPH ARPC2 ARPC2 SYNPO SYNPO RGS7BP RGS7BP CRH CRH LOC100734633 LOC100734633 NTSR1 NTSR1 Smn1 Smn1 AMIGO1 AMIGO1 AVPR1B AVPR1B RELN RELN SYAP1 SYAP1 LOC100720587 LOC100720587 BGLAP BGLAP EPM2A EPM2A GOT2 GOT2 CDK5 CDK5 HSPB1 HSPB1 MAPK10 MAPK10 GRIK4 GRIK4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BTDBiotinidase. (548 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
DRP2Dystrophin related protein 2. (957 aa)
Pde11aPhosphodiesterase. (888 aa)
KCNB2Potassium voltage-gated channel subfamily B member 2; Belongs to the potassium channel family. (911 aa)
OPN4Opsin 4. (471 aa)
KCNK1Potassium channel subfamily K member 1; Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues. Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) at subphysiological K(+) levels and upon acidification of the extracellular medium. The homodimer has very low potassium [...] (336 aa)
H0UVS7_CAVPOUncharacterized protein. (1296 aa)
GRIK2Glutamate ionotropic receptor kainate type subunit 2. (908 aa)
Ckmt1aUncharacterized protein; Belongs to the ATP:guanido phosphotransferase family. (417 aa)
KLHL6Kelch like family member 6. (564 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
WDR20WD repeat domain 20. (508 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1856 aa)
DDNDendrin. (709 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
H0V006_CAVPOMFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (489 aa)
KCNH1Uncharacterized protein. (989 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (675 aa)
KCNC2Potassium voltage-gated channel subfamily C member 2; Belongs to the potassium channel family. (418 aa)
CNR2Cannabinoid receptor 2; Belongs to the G-protein coupled receptor 1 family. (355 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (550 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (888 aa)
FMR1Fragile X mental retardation 1. (612 aa)
KCNA1Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa)
Ercc8WD_REPEATS_REGION domain-containing protein. (396 aa)
SYT11Synaptotagmin 11. (431 aa)
KCNAB1Potassium voltage-gated channel subfamily A member regulatory beta subunit 1. (401 aa)
BRD1Bromodomain containing 1. (1189 aa)
ENO2Enolase 2. (434 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (776 aa)
PCSK2Proprotein convertase subtilisin/kexin type 2; Belongs to the peptidase S8 family. (606 aa)
MAP1BMicrotubule associated protein 1B. (2465 aa)
NEURL1Neuralized E3 ubiquitin protein ligase 1. (574 aa)
Gap43Uncharacterized protein. (211 aa)
RUFY3RUN and FYVE domain containing 3. (628 aa)
DBNLDrebrin like. (437 aa)
DHX36DEAH-box helicase 36. (916 aa)
HTR5A5-hydroxytryptamine receptor 5A. (356 aa)
RACK1Receptor for activated C kinase 1. (317 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (768 aa)
SLC17A8Solute carrier family 17 member 8. (476 aa)
CTSVCathepsin V; Belongs to the peptidase C1 family. (333 aa)
NGBNeuroglobin; Belongs to the globin family. (151 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (446 aa)
CIB3Calcium and integrin binding family member 3. (160 aa)
C9orf72C9orf72-SMCR8 complex subunit. (481 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1062 aa)
SEPTIN14Septin 14; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (346 aa)
KLHL35Kelch like family member 35. (493 aa)
PCSK1Proprotein convertase subtilisin/kexin type 1. (755 aa)
SHTN1Shootin 1. (631 aa)
EPHA4EPH receptor A4. (986 aa)
Ccr2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (371 aa)
MCRS1Microspherule protein 1. (462 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (975 aa)
PTPN5Protein tyrosine phosphatase non-receptor type 5. (541 aa)
KCND2Potassium voltage-gated channel subfamily D member 2; Belongs to the potassium channel family. (630 aa)
ASTN1Astrotactin 1. (1216 aa)
SERPINI1Serpin family I member 1; Belongs to the serpin family. (410 aa)
KLHL24Kelch like family member 24. (600 aa)
GLRA3Glycine receptor alpha 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (464 aa)
DIP2BDisco interacting protein 2 homolog B. (1486 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2337 aa)
THTyrosine hydroxylase. (498 aa)
SLC4A10Anion exchange protein. (1118 aa)
KNG1Kininogen 1. (625 aa)
KIF5AKinesin family member 5A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1032 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1805 aa)
SLC1A1Amino acid transporter. (525 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1168 aa)
GRIP1Glutamate receptor interacting protein 1. (1127 aa)
GLRA1Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (386 aa)
CACNA1EVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2313 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (180 aa)
LOC100732110MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (482 aa)
CPECarboxypeptidase E. (476 aa)
NCDNNeurochondrin. (599 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1502 aa)
H0VVI0_CAVPOUncharacterized protein. (1225 aa)
NPPACardiodilatin-related peptide; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity). (223 aa)
OPRM1Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP- bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell ty [...] (416 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
GJC2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (405 aa)
CTNND2Catenin delta 2. (1098 aa)
GRIK3Glutamate ionotropic receptor kainate type subunit 3. (884 aa)
OLFM1Olfactomedin 1. (483 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (659 aa)
H0W1V8_CAVPOUncharacterized protein. (319 aa)
EFNA2Ephrin A2; Belongs to the ephrin family. (190 aa)
ESR2Estrogen receptor 2. (568 aa)
CNGA3Cyclic nucleotide gated channel subunit alpha 3. (647 aa)
ATP7AATPase copper transporting alpha. (1433 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1774 aa)
ROGDIRogdi atypical leucine zipper. (274 aa)
SLC5A7Solute carrier family 5 member 7; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (579 aa)
CNGA4Cyclic nucleotide gated channel subunit alpha 4. (574 aa)
PNMTPhenylethanolamine N-methyltransferase. (316 aa)
KCNC3Potassium voltage-gated channel subfamily C member 3; Belongs to the potassium channel family. (729 aa)
AslUncharacterized protein. (465 aa)
GRIK5Glutamate ionotropic receptor kainate type subunit 5. (892 aa)
RTN4RReticulon 4 receptor. (434 aa)
NefhIF rod domain-containing protein; Belongs to the intermediate filament family. (1064 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2105 aa)
ENDOGEndonuclease. (299 aa)
CHRNA10Cholinergic receptor nicotinic alpha 10 subunit. (447 aa)
NEUROG1Neurogenin 1. (241 aa)
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (770 aa)
ASS1Argininosuccinate synthase 1. (415 aa)
SCN1BSodium voltage-gated channel beta subunit 1. (216 aa)
NTRK2Tyrosine-protein kinase receptor. (816 aa)
CCKCholecystokinin. (115 aa)
CKAP5Cytoskeleton associated protein 5. (2032 aa)
RNF112Ring finger protein 112. (654 aa)
NSMFNMDA receptor synaptonuclear signaling and neuronal migration factor. (513 aa)
KCNE3Potassium voltage-gated channel subfamily E regulatory subunit 3. (105 aa)
ANXA5Annexin. (318 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2089 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
PPP5CSerine/threonine-protein phosphatase. (533 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (352 aa)
GIGYF2GRB10 interacting GYF protein 2. (1292 aa)
PgrUncharacterized protein. (428 aa)
CRMP1Collapsin response mediator protein 1. (686 aa)
Elavl4ELAV-like protein; Belongs to the RRM elav family. (385 aa)
GLULGlutamine synthetase. (373 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CIB1Calcium and integrin binding 1. (191 aa)
PCMT1Protein-L-isoaspartate O-methyltransferase. (285 aa)
NPFFNeuropeptide FF-amide peptide precursor. (109 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
RTN4RL1Reticulon 4 receptor like 1. (446 aa)
HDAC6Histone deacetylase 6. (1196 aa)
Septin4Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (477 aa)
ZPR1ZPR1 zinc finger. (459 aa)
ENSCPOP00000026034Tudor domain-containing protein. (290 aa)
CPLX1Complexin 1. (134 aa)
CPLX2Complexin 2. (134 aa)
PDE10APhosphodiesterase. (773 aa)
RGS8Regulator of G protein signaling 8. (180 aa)
PDE9APhosphodiesterase. (534 aa)
AMIGO2Adhesion molecule with Ig like domain 2. (521 aa)
AZIN2Uncharacterized protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (460 aa)
NefmIF rod domain-containing protein; Belongs to the intermediate filament family. (866 aa)
DMWDDM1 locus, WD repeat containing. (664 aa)
HNRNPA2B1Heterogeneous nuclear ribonucleoprotein A2/B1. (369 aa)
KCNA2Potassium voltage-gated channel subfamily A member 2; Belongs to the potassium channel family. (499 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (855 aa)
FUSFUS RNA binding protein. (490 aa)
RBFOX3RNA binding protein fox-1 homolog 3; RNA-binding protein that regulates alternative splicing events. (376 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
ENSCPOP00000029029Uncharacterized protein. (69 aa)
CRHR2Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. (436 aa)
PRPHPeripherin; Belongs to the intermediate filament family. (598 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
SYNPOSynaptopodin. (937 aa)
RGS7BPRegulator of G protein signaling 7 binding protein. (257 aa)
CRHCorticotropin releasing hormone. (193 aa)
LOC100734633MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (496 aa)
NTSR1Neurotensin receptor 1; Belongs to the G-protein coupled receptor 1 family. (412 aa)
Smn1Tudor domain-containing protein. (302 aa)
AMIGO1Adhesion molecule with Ig like domain 1. (492 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (422 aa)
RELNReelin. (3423 aa)
SYAP1Synapse associated protein 1. (349 aa)
LOC100720587Transmembrane protease serine; Belongs to the peptidase S1 family. (423 aa)
BGLAPOsteocalcin; Binds strongly to apatite and calcium. (100 aa)
EPM2AEPM2A glucan phosphatase, laforin. (193 aa)
GOT2Aspartate aminotransferase. (430 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (200 aa)
MAPK10Mitogen-activated protein kinase 10. (434 aa)
GRIK4Glutamate ionotropic receptor kainate type subunit 4. (956 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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