STRINGSTRING
NOCT NOCT ANGEL2 ANGEL2 AXIN2 AXIN2 MLH1 MLH1 DICER1 DICER1 RC3H1 RC3H1 EXOSC8 EXOSC8 TRIM71 TRIM71 CNOT2 CNOT2 EXOSC7 EXOSC7 FASTKD1 FASTKD1 TUT4 TUT4 RC3H2 RC3H2 AGO2 AGO2 APEX1 APEX1 PCID2 PCID2 CSDE1 CSDE1 CARHSP1 CARHSP1 PABPC3 PABPC3 HNRNPR HNRNPR EIF4ENIF1 EIF4ENIF1 TENT5B TENT5B PAN3 PAN3 CPEB3 CPEB3 ENSCPOP00000030783 ENSCPOP00000030783 ALKBH5 ALKBH5 LSM1 LSM1 ENSCPOP00000029900 ENSCPOP00000029900 METTL14 METTL14 TARDBP TARDBP FASTK FASTK PABPC4L PABPC4L DHX9 DHX9 EXOSC2 EXOSC2 NANOS1 NANOS1 FUS FUS RIDA RIDA ZFP36L1 ZFP36L1 CELF1 CELF1 CSDC2 CSDC2 TNRC6B TNRC6B SYNCRIP SYNCRIP GDNF GDNF HNRNPD HNRNPD E2F1 E2F1 TENT5C TENT5C EXOSC5 EXOSC5 TRAF2 TRAF2 CNOT6 CNOT6 TENT5A TENT5A ENSCPOP00000025764 ENSCPOP00000025764 PABPC4 PABPC4 ZFP36 ZFP36 EXOSC9 EXOSC9 FXR1 FXR1 Elavl4 Elavl4 CNOT3 CNOT3 TOB1 TOB1 YTHDF3 YTHDF3 GIGYF2 GIGYF2 PUM1 PUM1 ZC3H14 ZC3H14 CNOT7 CNOT7 METTL16 METTL16 AGO3 AGO3 BOLL BOLL RBM24 RBM24 CNOT8 CNOT8 PARN PARN TRAF5 TRAF5 PUM2 PUM2 HNRNPA0 HNRNPA0 PLEKHN1 PLEKHN1 FXR2 FXR2 LOC100725600 LOC100725600 MYD88 MYD88 PABPN1L PABPN1L FASTKD5 FASTKD5 ZFP36L2 ZFP36L2 H0W1V8_CAVPO H0W1V8_CAVPO YTHDF2 YTHDF2 TIRAP TIRAP H0W0H8_CAVPO H0W0H8_CAVPO MAPKAPK2 MAPKAPK2 LOC101787900 LOC101787900 UPF1 UPF1 PNLDC1 PNLDC1 NANOS3 NANOS3 MEIOC MEIOC CIRBP CIRBP IGF2BP1 IGF2BP1 THRAP3 THRAP3 CACNG7 CACNG7 IGF2BP3 IGF2BP3 NANOS2 NANOS2 PAN2 PAN2 SAMD4A SAMD4A PCBP4 PCBP4 ZC3H12D ZC3H12D MOV10 MOV10 DCPS DCPS CNOT1 CNOT1 FTO FTO TRAF3IP2 TRAF3IP2 RBM38 RBM38 ROCK2 ROCK2 SLC11A1 SLC11A1 TBRG4 TBRG4 HNRNPU HNRNPU ELAVL1 ELAVL1 TENT4B TENT4B Srsf1 Srsf1 MTOR MTOR ZC3H12A ZC3H12A PNPT1 PNPT1 YBX1 YBX1 MYEF2 MYEF2 ROCK1 ROCK1 CNOT6L CNOT6L Rbm46 Rbm46 LOC101788648 LOC101788648 YTHDF1 YTHDF1 YBX2 YBX2 LARP4B LARP4B DND1 DND1 TENT4A TENT4A IKBKE IKBKE EXOSC3 EXOSC3 DHX36 DHX36 DAZL DAZL CALCR CALCR PATL1 PATL1 FASTKD3 FASTKD3 SAMD4B SAMD4B FASTKD2 FASTKD2 IGF2BP2 IGF2BP2 DCP1B DCP1B DIS3L2 DIS3L2 KHSRP KHSRP BRF1 BRF1 DCP1A DCP1A TNRC6C TNRC6C VIM VIM PDE12 PDE12 DCP2 DCP2 TUT7 TUT7 Paip1 Paip1 METTL3 METTL3 POLR2D POLR2D PATL2 PATL2 RBM10 RBM10 LRRC27 LRRC27 LARP1 LARP1 FMR1 FMR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NOCTNocturnin. (432 aa)
ANGEL2Angel homolog 2. (544 aa)
AXIN2Axin 2. (802 aa)
MLH1MutL homolog 1. (758 aa)
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1903 aa)
RC3H1Ring finger and CCCH-type domains 1. (1116 aa)
EXOSC8Exosome component 8. (276 aa)
TRIM71Tripartite motif containing 71. (866 aa)
CNOT2CCR4-NOT transcription complex subunit 2. (544 aa)
EXOSC7Exosome component 7. (291 aa)
FASTKD1FAST kinase domains 1. (630 aa)
TUT4Terminal uridylyl transferase 4. (1584 aa)
RC3H2Ring finger and CCCH-type domains 2. (1188 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (857 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
PCID2PCI domain containing 2. (399 aa)
CSDE1Cold shock domain-containing protein E1; RNA-binding protein. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). (779 aa)
CARHSP1Calcium regulated heat stable protein 1. (149 aa)
PABPC3Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (586 aa)
HNRNPRHeterogeneous nuclear ribonucleoprotein R. (633 aa)
EIF4ENIF1Eukaryotic translation initiation factor 4E nuclear import factor 1. (991 aa)
TENT5BTerminal nucleotidyltransferase 5B. (423 aa)
PAN3PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (751 aa)
CPEB3Cytoplasmic polyadenylation element binding protein 3. (588 aa)
ENSCPOP00000030783MIF4G domain-containing protein. (390 aa)
ALKBH5AlkB homolog 5, RNA demethylase. (394 aa)
LSM1U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. (133 aa)
ENSCPOP00000029900Uncharacterized protein. (195 aa)
METTL14Methyltransferase like 14; Belongs to the MT-A70-like family. (456 aa)
TARDBPTAR DNA binding protein. (413 aa)
FASTKFas activated serine/threonine kinase. (514 aa)
PABPC4LPoly(A) binding protein cytoplasmic 4 like. (359 aa)
DHX9DExH-box helicase 9. (1373 aa)
EXOSC2Exosome component 2. (293 aa)
NANOS1Nanos C2HC-type zinc finger 1; Belongs to the nanos family. (269 aa)
FUSFUS RNA binding protein. (490 aa)
RIDAReactive intermediate imine deaminase A homolog. (137 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
CELF1CUGBP Elav-like family member 1. (487 aa)
CSDC2Cold shock domain containing C2. (153 aa)
TNRC6BTrinucleotide repeat containing adaptor 6B. (1812 aa)
SYNCRIPSynaptotagmin binding cytoplasmic RNA interacting protein. (562 aa)
GDNFGlial cell derived neurotrophic factor. (210 aa)
HNRNPDHeterogeneous nuclear ribonucleoprotein D. (313 aa)
E2F1E2F transcription factor 1. (389 aa)
TENT5CTerminal nucleotidyltransferase 5C. (391 aa)
EXOSC5Exosome component 5. (240 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
CNOT6CCR4-NOT transcription complex subunit 6. (534 aa)
TENT5ATerminal nucleotidyltransferase 5A. (432 aa)
ENSCPOP00000025764MIF4G domain-containing protein. (404 aa)
PABPC4Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (660 aa)
ZFP36ZFP36 ring finger protein. (313 aa)
EXOSC9Exosome component 9. (439 aa)
FXR1FMR1 autosomal homolog 1. (677 aa)
Elavl4ELAV-like protein; Belongs to the RRM elav family. (385 aa)
CNOT3CCR4-NOT transcription complex subunit 3. (751 aa)
TOB1Transducer of ERBB2, 1. (364 aa)
YTHDF3YTH N6-methyladenosine RNA binding protein 3. (585 aa)
GIGYF2GRB10 interacting GYF protein 2. (1292 aa)
PUM1Pumilio RNA binding family member 1. (1189 aa)
ZC3H14Zinc finger CCCH-type containing 14. (734 aa)
CNOT7CCR4-NOT transcription complex subunit 7. (285 aa)
METTL16U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that methylates adenosine residues of a subset of RNAs and plays a key role in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6- methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. In presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifical [...] (552 aa)
AGO3Argonaute RISC catalytic component 3; Belongs to the argonaute family. (827 aa)
BOLLBoule homolog, RNA binding protein. (322 aa)
RBM24RNA binding motif protein 24. (236 aa)
CNOT8CCR4-NOT transcription complex subunit 8. (292 aa)
PARNPoly(A)-specific ribonuclease. (637 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (565 aa)
PUM2Pumilio RNA binding family member 2. (1068 aa)
HNRNPA0Heterogeneous nuclear ribonucleoprotein A0. (301 aa)
PLEKHN1Pleckstrin homology domain containing N1. (597 aa)
FXR2FMR1 autosomal homolog 2. (672 aa)
LOC100725600Uncharacterized protein. (536 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (294 aa)
PABPN1LPoly(A) binding protein nuclear 1 like, cytoplasmic. (273 aa)
FASTKD5FAST kinase domains 5. (795 aa)
ZFP36L2ZFP36 ring finger protein like 2. (403 aa)
H0W1V8_CAVPOUncharacterized protein. (319 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (549 aa)
TIRAPTIR domain containing adaptor protein. (221 aa)
H0W0H8_CAVPOUncharacterized protein. (336 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (383 aa)
LOC101787900Uncharacterized protein. (501 aa)
UPF1UPF1 RNA helicase and ATPase. (1109 aa)
PNLDC1PARN like, ribonuclease domain containing 1. (518 aa)
NANOS3Nanos C2HC-type zinc finger 3; Belongs to the nanos family. (178 aa)
MEIOCMeiosis specific with coiled-coil domain. (919 aa)
CIRBPCold inducible RNA binding protein. (173 aa)
IGF2BP1Insulin like growth factor 2 mRNA binding protein 1. (547 aa)
THRAP3Thyroid hormone receptor associated protein 3. (953 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
IGF2BP3Insulin like growth factor 2 mRNA binding protein 3. (519 aa)
NANOS2Nanos C2HC-type zinc finger 2; Belongs to the nanos family. (130 aa)
PAN2PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1204 aa)
SAMD4ASterile alpha motif domain containing 4A. (714 aa)
PCBP4Poly(rC) binding protein 4. (403 aa)
ZC3H12DZinc finger CCCH-type containing 12D. (464 aa)
MOV10Mov10 RISC complex RNA helicase. (1063 aa)
DCPSDecapping enzyme, scavenger. (337 aa)
CNOT1CCR4-NOT transcription complex subunit 1. (2294 aa)
FTOFTO alpha-ketoglutarate dependent dioxygenase. (499 aa)
TRAF3IP2TRAF3 interacting protein 2. (561 aa)
RBM38RNA binding motif protein 38. (247 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1371 aa)
SLC11A1Solute carrier family 11 member 1. (541 aa)
TBRG4Transforming growth factor beta regulator 4. (631 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (822 aa)
ELAVL1ELAV like RNA binding protein 1. (295 aa)
TENT4BTerminal nucleotidyltransferase 4B. (673 aa)
Srsf1Uncharacterized protein. (253 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (550 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1. (783 aa)
YBX1YB1. (324 aa)
MYEF2Myelin expression factor 2. (574 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
CNOT6LCCR4-NOT transcription complex subunit 6 like. (462 aa)
Rbm46Uncharacterized protein. (534 aa)
LOC101788648Uncharacterized protein. (485 aa)
YTHDF1YTH N6-methyladenosine RNA binding protein 1. (559 aa)
YBX2Y-box binding protein 2. (359 aa)
LARP4BLa ribonucleoprotein domain family member 4B. (738 aa)
DND1DND microRNA-mediated repression inhibitor 1. (353 aa)
TENT4ATerminal nucleotidyltransferase 4A. (657 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
EXOSC3Exosome component 3. (275 aa)
DHX36DEAH-box helicase 36. (916 aa)
DAZLDeleted in azoospermia like. (295 aa)
CALCRCalcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. (474 aa)
PATL1PAT1 homolog 1, processing body mRNA decay factor. (790 aa)
FASTKD3FAST kinase domains 3. (688 aa)
SAMD4BSterile alpha motif domain containing 4B. (692 aa)
FASTKD2FAST kinase domains 2. (673 aa)
IGF2BP2Insulin like growth factor 2 mRNA binding protein 2. (539 aa)
DCP1BDecapping mRNA 1B. (592 aa)
DIS3L2DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] (877 aa)
KHSRPKH-type splicing regulatory protein. (726 aa)
BRF1BRF1 RNA polymerase III transcription initiation factor subunit. (677 aa)
DCP1ADecapping mRNA 1A. (601 aa)
TNRC6CTrinucleotide repeat containing adaptor 6C. (1892 aa)
VIMIF rod domain-containing protein; Belongs to the intermediate filament family. (445 aa)
PDE12Phosphodiesterase 12. (608 aa)
DCP2Decapping mRNA 2. (422 aa)
TUT7Terminal uridylyl transferase 7. (1514 aa)
Paip1MIF4G domain-containing protein. (399 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (553 aa)
POLR2DRNA polymerase II subunit D. (142 aa)
PATL2PAT1 homolog 2. (517 aa)
RBM10RNA binding motif protein 10. (931 aa)
LRRC27Leucine rich repeat containing 27. (508 aa)
LARP1La ribonucleoprotein domain family member 1. (954 aa)
FMR1Fragile X mental retardation 1. (612 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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