STRINGSTRING
PTK2 PTK2 TRPC3 TRPC3 TWF1 TWF1 PPARG PPARG AIF1 AIF1 DDX39B DDX39B CTDP1 CTDP1 Glrx3 Glrx3 ACTN3 ACTN3 TNNC1 TNNC1 NFATC1 NFATC1 P2rx4 P2rx4 NOS3 NOS3 ADK ADK NOL3 NOL3 SLC25A4 SLC25A4 SMAD4 SMAD4 AKAP6 AKAP6 PDE5A PDE5A H0VDT0_CAVPO H0VDT0_CAVPO DMD DMD PPP3CA PPP3CA FBXO32 FBXO32 MTPN MTPN ATP2B4 ATP2B4 CCN4 CCN4 Foxp1 Foxp1 CMYA5 CMYA5 ATP2A2 ATP2A2 ENSCPOP00000024428 ENSCPOP00000024428 SGCA SGCA HAMP HAMP GTF2IRD1 GTF2IRD1 ENSCPOP00000025546 ENSCPOP00000025546 PIN1 PIN1 IGFBP5 IGFBP5 DAG1 DAG1 RGS4 RGS4 PDE9A PDE9A GATA5 GATA5 SLC9A1 SLC9A1 NR4A3 NR4A3 LMCD1 LMCD1 EDN1 EDN1 TNFRSF1A TNFRSF1A Mlip Mlip Camk2d Camk2d CAV3 CAV3 SMAD3 SMAD3 ADRA1A ADRA1A BECN1 BECN1 MEF2A MEF2A IGF1 IGF1 ERRFI1 ERRFI1 CASQ1 CASQ1 SCN5A SCN5A HAND2 HAND2 Cdk9 Cdk9 ROCK1 ROCK1 TOMM70 TOMM70 MTOR MTOR SRL SRL ROCK2 ROCK2 HDAC4 HDAC4 JARID2 JARID2 AKAP1 AKAP1 GSK3B GSK3B TRIP10 TRIP10 RPS6KB1 RPS6KB1 FDPS FDPS Parp1 Parp1 TNNT1 TNNT1 LMNA LMNA PRKAG3 PRKAG3 H0W2T6_CAVPO H0W2T6_CAVPO LOC100725780 LOC100725780 Yy1 Yy1 ADRB1 ADRB1 Foxo3 Foxo3 TRIM63 TRIM63 PARP2 PARP2 P2rx7 P2rx7 PI16 PI16 TNFRSF1B TNFRSF1B MYMK MYMK G6PD G6PD MYOG MYOG GSK3A GSK3A BMP10 BMP10 AGT AGT RGS2 RGS2 TNNI1 TNNI1 SELENON SELENON MEF2C MEF2C Ndufs4 Ndufs4 PAK1 PAK1 OGA OGA SIRT1 SIRT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1084 aa)
TRPC3ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (849 aa)
TWF1Twinfilin actin binding protein 1. (337 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (504 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
DDX39BDExD-box helicase 39B. (428 aa)
CTDP1RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (956 aa)
Glrx3Uncharacterized protein. (171 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (889 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (161 aa)
NFATC1Nuclear factor of activated T cells 1. (928 aa)
P2rx4Uncharacterized protein. (343 aa)
NOS3Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity); Belongs to the NOS family. (1206 aa)
ADKAdenosine kinase. (362 aa)
NOL3Nucleolar protein 3. (207 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
AKAP6A-kinase anchoring protein 6. (2208 aa)
PDE5APhosphodiesterase. (863 aa)
H0VDT0_CAVPOProtein kinase domain-containing protein. (337 aa)
DMDDystrophin. (3613 aa)
PPP3CASerine/threonine-protein phosphatase. (518 aa)
FBXO32F-box protein 32. (355 aa)
MTPNMyotrophin. (118 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1207 aa)
CCN4Cellular communication network factor 4. (367 aa)
Foxp1Fork-head domain-containing protein. (687 aa)
CMYA5Cardiomyopathy associated 5. (3757 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
ENSCPOP00000024428PARP-type domain-containing protein. (104 aa)
SGCASarcoglycan alpha. (387 aa)
HAMPHepcidin antimicrobial peptide. (84 aa)
GTF2IRD1GTF2I repeat domain containing 1. (1004 aa)
ENSCPOP00000025546Uncharacterized protein. (58 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (166 aa)
IGFBP5Insulin like growth factor binding protein 5. (271 aa)
DAG1Dystroglycan 1. (891 aa)
RGS4Regulator of G protein signaling 4. (205 aa)
PDE9APhosphodiesterase. (534 aa)
GATA5GATA binding protein 5. (292 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (810 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (633 aa)
LMCD1LIM and cysteine rich domains 1. (365 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (208 aa)
TNFRSF1ATNF receptor superfamily member 1A. (469 aa)
MlipUncharacterized protein. (298 aa)
Camk2dProtein kinase domain-containing protein. (532 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
ADRA1AAlpha-1A adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity). (466 aa)
BECN1Beclin 1. (448 aa)
MEF2AMyocyte enhancer factor 2A. (517 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (153 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (462 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (399 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2015 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
Cdk9Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (372 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
TOMM70Translocase of outer mitochondrial membrane 70. (609 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
SRLSarcalumenin; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (472 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1371 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1078 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1247 aa)
AKAP1A-kinase anchoring protein 1. (860 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (423 aa)
TRIP10Thyroid hormone receptor interactor 10. (546 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (503 aa)
FDPSFarnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (352 aa)
Parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa)
TNNT1Troponin T1, slow skeletal type. (253 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (624 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (465 aa)
H0W2T6_CAVPOUncharacterized protein. (189 aa)
LOC100725780Uncharacterized protein. (997 aa)
Yy1Uncharacterized protein. (195 aa)
ADRB1G_PROTEIN_RECEP_F1_2 domain-containing protein. (470 aa)
Foxo3Forkhead box O3. (660 aa)
TRIM63Tripartite motif containing 63. (329 aa)
PARP2Poly [ADP-ribose] polymerase. (536 aa)
P2rx7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (594 aa)
PI16Peptidase inhibitor 16; Belongs to the CRISP family. (508 aa)
TNFRSF1BTNF receptor superfamily member 1B. (482 aa)
MYMKMyomaker, myoblast fusion factor. (221 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (515 aa)
MYOGMyogenin. (249 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (470 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
RGS2Regulator of G protein signaling 2. (211 aa)
TNNI1Troponin I1, slow skeletal type. (189 aa)
SELENONSelenoprotein N. (573 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
Ndufs4Uncharacterized protein. (175 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
OGAO-GlcNAcase. (878 aa)
SIRT1Sirtuin 1. (717 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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