STRINGSTRING
Sdha Sdha GOT1 GOT1 IDH2 IDH2 GCLC GCLC TAT TAT PHYH PHYH MTRR MTRR PCK1 PCK1 ALDH1L1 ALDH1L1 MDH1B MDH1B Glud1 Glud1 ME3 ME3 SHMT1 SHMT1 HOGA1 HOGA1 GAD1 GAD1 OGDH OGDH SUCLG1 SUCLG1 ME1 ME1 NAGS NAGS GLS2 GLS2 ADSS2 ADSS2 AMDHD1 AMDHD1 ALDH18A1 ALDH18A1 D2HGDH D2HGDH NIT2 NIT2 ACOT4 ACOT4 ME2 ME2 UROC1 UROC1 AASDHPPT AASDHPPT GOT2 GOT2 ENSCPOP00000032995 ENSCPOP00000032995 ACOT8 ACOT8 SHMT2 SHMT2 ACSF3 ACSF3 HAL HAL MTHFD1 MTHFD1 IDH1 IDH1 GPT2 GPT2 GAD2 GAD2 KMO KMO SDHAF3 SDHAF3 SLC25A12 SLC25A12 SUCLA2 SUCLA2 IDH3B IDH3B ATIC ATIC FPGS FPGS QPRT QPRT FTCD FTCD LOC100732617 LOC100732617 SDHB SDHB Asl Asl GOT1L1 GOT1L1 OGDHL OGDHL HAAO HAAO ASS1 ASS1 IDH3G IDH3G FH FH HTT HTT GLUL GLUL ENSCPOP00000024451 ENSCPOP00000024451 PC PC Adhfe1 Adhfe1 ALDH4A1 ALDH4A1 Ggt1 Ggt1 DDO DDO ALDH5A1 ALDH5A1 ACLY ACLY AADAT AADAT MRPS36 MRPS36 Prodh2 Prodh2 GRHPR GRHPR GLS GLS FOLR1 FOLR1 KYNU KYNU PCK2 PCK2 MDH1 MDH1 ALDH1L2 ALDH1L2 OAT OAT DGLUCY DGLUCY MDH2 MDH2 MTHFD1L MTHFD1L KYAT3 KYAT3 ADSS1 ADSS1 Dlst Dlst
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SdhaSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (652 aa)
GOT1Aspartate aminotransferase. (413 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (639 aa)
TATTyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (449 aa)
PHYHPhytanoyl-CoA 2-hydroxylase. (336 aa)
MTRR5-methyltetrahydrofolate-homocysteine methyltransferase reductase. (748 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
ALDH1L110-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (902 aa)
MDH1BMalate dehydrogenase 1B. (515 aa)
Glud1Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (540 aa)
ME3Malic enzyme. (604 aa)
SHMT1Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (484 aa)
HOGA14-hydroxy-2-oxoglutarate aldolase 1; Belongs to the DapA family. (321 aa)
GAD1Glutamate decarboxylase 1. (594 aa)
OGDHOxoglutarate dehydrogenase. (1038 aa)
SUCLG1Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (346 aa)
ME1Malic enzyme. (501 aa)
NAGSN-acetylglutamate synthase. (469 aa)
GLS2Glutaminase 2. (558 aa)
ADSS2Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (453 aa)
AMDHD1Amidohydrolase domain containing 1. (426 aa)
ALDH18A1Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. (795 aa)
D2HGDHD-2-hydroxyglutarate dehydrogenase. (538 aa)
NIT2Nitrilase family member 2. (277 aa)
ACOT4Acyl-CoA thioesterase 4. (421 aa)
ME2Malic enzyme. (584 aa)
UROC1Urocanate hydratase 1. (701 aa)
AASDHPPTAminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase. (309 aa)
GOT2Aspartate aminotransferase. (430 aa)
ENSCPOP00000032995Lipoyl-binding domain-containing protein. (440 aa)
ACOT8Acyl-CoA thioesterase 8. (324 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (504 aa)
ACSF3Acyl-CoA synthetase family member 3. (598 aa)
HALHistidine ammonia-lyase; Belongs to the PAL/histidase family. (657 aa)
MTHFD1Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (928 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
GPT2Glutamic--pyruvic transaminase 2. (496 aa)
GAD2Glutamate decarboxylase 2. (585 aa)
KMOKynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (487 aa)
SDHAF3Succinate dehydrogenase complex assembly factor 3. (126 aa)
SLC25A12Solute carrier family 25 member 12; Belongs to the mitochondrial carrier (TC 2.A.29) family. (678 aa)
SUCLA2Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (457 aa)
IDH3BIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (383 aa)
ATIC5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. (561 aa)
FPGSFolylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (582 aa)
QPRTNicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (295 aa)
FTCDFormimidoyltransferase cyclodeaminase. (540 aa)
LOC100732617Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (600 aa)
SDHBSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (280 aa)
AslUncharacterized protein. (465 aa)
GOT1L1Glutamic-oxaloacetic transaminase 1 like 1. (387 aa)
OGDHLOxoglutarate dehydrogenase like. (1022 aa)
HAAO3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. (286 aa)
ASS1Argininosuccinate synthase 1. (415 aa)
IDH3GIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (393 aa)
FHFumarate hydratase. (508 aa)
HTTHuntingtin. (3133 aa)
GLULGlutamine synthetase. (373 aa)
ENSCPOP00000024451Uncharacterized protein. (153 aa)
PCPyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1219 aa)
Adhfe1Fe-ADH domain-containing protein. (466 aa)
ALDH4A1Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (589 aa)
Ggt1Uncharacterized protein. (569 aa)
DDOD-aspartate oxidase. (341 aa)
ALDH5A1Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (472 aa)
ACLYATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1101 aa)
AADATAminoadipate aminotransferase. (425 aa)
MRPS36Mitochondrial ribosomal protein S36. (100 aa)
Prodh2Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (260 aa)
GRHPRGlyoxylate and hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (328 aa)
GLSGlutaminase. (649 aa)
FOLR1Folate receptor alpha. (160 aa)
KYNUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (466 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (652 aa)
MDH1Malate dehydrogenase. (335 aa)
ALDH1L210-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (923 aa)
OATOrnithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (439 aa)
DGLUCYD-glutamate cyclase. (554 aa)
MDH2Malate dehydrogenase. (338 aa)
MTHFD1LMethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (901 aa)
KYAT3Kynurenine aminotransferase 3. (451 aa)
ADSS1Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (457 aa)
DlstLipoyl-binding domain-containing protein. (440 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.