STRINGSTRING
PYCARD PYCARD CTNNB1 CTNNB1 STAC STAC BAK1 BAK1 KCNB2 KCNB2 ABCC8 ABCC8 PACS1 PACS1 RIMS3 RIMS3 KCND3 KCND3 KCNH5 KCNH5 Hsp90aa1 Hsp90aa1 KCNAB3 KCNAB3 PPM1A PPM1A KCNAB2 KCNAB2 ACTN3 ACTN3 KCNH1 KCNH1 PKD1 PKD1 STX1A STX1A KCNC2 KCNC2 HRC HRC FMR1 FMR1 SCN4B SCN4B H0V1T2_CAVPO H0V1T2_CAVPO HSP90AB1 HSP90AB1 LOC100725052 LOC100725052 AKAP9 AKAP9 KCNAB1 KCNAB1 DPP10 DPP10 SNTA1 SNTA1 ANKDD1B ANKDD1B PACS2 PACS2 AKAP6 AKAP6 RIMS2 RIMS2 CDK5RAP2 CDK5RAP2 ATP2A3 ATP2A3 CRBN CRBN RASA1 RASA1 H0VBD1_CAVPO H0VBD1_CAVPO Cbarp Cbarp KCNQ3 KCNQ3 GRINA GRINA GOPC GOPC RIMS4 RIMS4 YWHAQ YWHAQ KCNC1 KCNC1 PPP1R9A PPP1R9A LYN LYN ITPR2 ITPR2 USP10 USP10 HERPUD2 HERPUD2 SCN10A SCN10A ACTN2 ACTN2 KCNIP1 KCNIP1 PKD2 PKD2 KCNIP3 KCNIP3 LRRC52 LRRC52 YES1 YES1 RANGRF RANGRF KCNQ1 KCNQ1 H0VXJ2_CAVPO H0VXJ2_CAVPO PRKCSH PRKCSH SLC5A3 SLC5A3 ID2 ID2 LOC100732332 LOC100732332 CHERP CHERP Ankrd60 Ankrd60 IQANK1 IQANK1 SH3GL1 SH3GL1 KCNJ11 KCNJ11 LOC100725322 LOC100725322 SCN1B SCN1B H0WDH3_CAVPO H0WDH3_CAVPO SRC SRC KCNIP2 KCNIP2 PDE4D PDE4D YWHAH YWHAH KCNE2 KCNE2 NPTN NPTN KCNE3 KCNE3 PANX1 PANX1 AP2M1 AP2M1 LOC100725824 LOC100725824 CACNA1C CACNA1C FGF13 FGF13 ENSCPOP00000023749 ENSCPOP00000023749 LOC100719969 LOC100719969 HTT HTT ANK2 ANK2 KCNG4 KCNG4 PDE4B PDE4B FYN FYN YWHAZ YWHAZ Fkbp1a Fkbp1a SCN3B SCN3B TSPO TSPO ARRB1 ARRB1 RAPGEF3 RAPGEF3 CIB1 CIB1 ACTN4 ACTN4 AGRN AGRN TRDN TRDN Rims1 Rims1 FLNA FLNA Trappc2 Trappc2 FKBP1B FKBP1B CAV1 CAV1 ENSCPOP00000028113 ENSCPOP00000028113 CABP4 CABP4 ACTN1 ACTN1 Vdac1 Vdac1 PPP1R9B PPP1R9B FGF12 FGF12 KCNB1 KCNB1 ENSCPOP00000029147 ENSCPOP00000029147 BAG2 BAG2 NEDD4L NEDD4L PIRT PIRT PHPT1 PHPT1 LRRC38 LRRC38 ATP2A2 ATP2A2 Ywhae Ywhae ANK1 ANK1 TCAF1 TCAF1 LRRC55 LRRC55 Ank3 Ank3 Cabp1 Cabp1 MPP2 MPP2 ITPR1 ITPR1 Camk2d Camk2d CAV3 CAV3 ABCC9 ABCC9 Vamp2 Vamp2 KCNE4 KCNE4 S100a10 S100a10 CDH5 CDH5 FHL1 FHL1 HOMER1 HOMER1 HERPUD1 HERPUD1 SCN5A SCN5A TCAP TCAP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PYCARDPYD and CARD domain containing. (195 aa)
CTNNB1Catenin beta 1. (781 aa)
STACSH3 and cysteine rich domain. (402 aa)
BAK1BCL2 antagonist/killer 1. (214 aa)
KCNB2Potassium voltage-gated channel subfamily B member 2; Belongs to the potassium channel family. (911 aa)
ABCC8ATP binding cassette subfamily C member 8. (1549 aa)
PACS1Phosphofurin acidic cluster sorting protein 1. (844 aa)
RIMS3Regulating synaptic membrane exocytosis 3. (308 aa)
KCND3Potassium voltage-gated channel subfamily D member 3; Belongs to the potassium channel family. (654 aa)
KCNH5Potassium voltage-gated channel subfamily H member 5. (989 aa)
Hsp90aa1Heat shock protein 90 alpha family class A member 1. (733 aa)
KCNAB3Potassium voltage-gated channel subfamily A regulatory beta subunit 3. (404 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (382 aa)
KCNAB2Potassium voltage-gated channel subfamily A regulatory beta subunit 2. (382 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (889 aa)
KCNH1Uncharacterized protein. (989 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4283 aa)
STX1ASyntaxin 1A; Belongs to the syntaxin family. (288 aa)
KCNC2Potassium voltage-gated channel subfamily C member 2; Belongs to the potassium channel family. (418 aa)
HRCHistidine rich calcium binding protein. (674 aa)
FMR1Fragile X mental retardation 1. (612 aa)
SCN4BSodium voltage-gated channel beta subunit 4. (184 aa)
H0V1T2_CAVPOS_100 domain-containing protein; Belongs to the S-100 family. (91 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (723 aa)
LOC100725052Peptidase M60 domain-containing protein. (919 aa)
AKAP9A-kinase anchoring protein 9. (3887 aa)
KCNAB1Potassium voltage-gated channel subfamily A member regulatory beta subunit 1. (401 aa)
DPP10Dipeptidyl peptidase like 10; Belongs to the peptidase S9B family. (776 aa)
SNTA1Syntrophin alpha 1. (505 aa)
ANKDD1BAnkyrin repeat and death domain containing 1B. (431 aa)
PACS2Phosphofurin acidic cluster sorting protein 2. (872 aa)
AKAP6A-kinase anchoring protein 6. (2208 aa)
RIMS2Regulating synaptic membrane exocytosis 2. (1410 aa)
CDK5RAP2CDK5 regulatory subunit associated protein 2. (1868 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1028 aa)
CRBNCereblon. (442 aa)
RASA1RAS p21 protein activator 1. (1024 aa)
H0VBD1_CAVPO14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (105 aa)
CbarpUncharacterized protein. (691 aa)
KCNQ3Potassium voltage-gated channel subfamily Q member 3; Belongs to the potassium channel family. (860 aa)
GRINAGlutamate ionotropic receptor NMDA type subunit associated protein 1. (351 aa)
GOPCPDZ domain-containing protein. (461 aa)
RIMS4Regulating synaptic membrane exocytosis 4. (253 aa)
YWHAQTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (245 aa)
KCNC1Potassium voltage-gated channel subfamily C member 1; Belongs to the potassium channel family. (585 aa)
PPP1R9AProtein phosphatase 1 regulatory subunit 9A. (1288 aa)
LYNTyrosine-protein kinase. (512 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2622 aa)
USP10Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (780 aa)
HERPUD2HERPUD family member 2. (349 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1943 aa)
ACTN2Actinin alpha 2. (894 aa)
KCNIP1Potassium voltage-gated channel interacting protein 1. (227 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (839 aa)
KCNIP3Potassium voltage-gated channel interacting protein 3. (256 aa)
LRRC52Leucine rich repeat containing 52. (316 aa)
YES1Tyrosine-protein kinase. (541 aa)
RANGRFRAN guanine nucleotide release factor. (186 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1; Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity). Associates with KCNE beta subunits that modulates current kinetics (By similarity). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac r [...] (671 aa)
H0VXJ2_CAVPOUncharacterized protein. (240 aa)
PRKCSHProtein kinase C substrate 80K-H. (532 aa)
SLC5A3Solute carrier family 5 member 3; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (718 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
LOC100732332Uncharacterized protein. (142 aa)
CHERPCalcium homeostasis endoplasmic reticulum protein. (934 aa)
Ankrd60ANK_REP_REGION domain-containing protein. (195 aa)
IQANK1IQ motif and ankyrin repeat containing 1. (568 aa)
SH3GL1SH3 domain containing GRB2 like 1, endophilin A2. (359 aa)
KCNJ11ATP-sensitive inward rectifier potassium channel 11; This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Can form cardiac and smo [...] (390 aa)
LOC100725322Peptidase M60 domain-containing protein. (914 aa)
SCN1BSodium voltage-gated channel beta subunit 1. (216 aa)
H0WDH3_CAVPO14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (246 aa)
SRCTyrosine-protein kinase. (542 aa)
KCNIP2Potassium voltage-gated channel interacting protein 2. (270 aa)
PDE4DPhosphodiesterase. (782 aa)
YWHAH14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (246 aa)
KCNE2Potassium voltage-gated channel subfamily E member 2; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-t [...] (123 aa)
NPTNNeuroplastin. (397 aa)
KCNE3Potassium voltage-gated channel subfamily E regulatory subunit 3. (105 aa)
PANX1Pannexin; Structural component of the gap junctions and the hemichannels. (427 aa)
AP2M1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (435 aa)
LOC100725824HATPase_c domain-containing protein. (695 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2089 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
ENSCPOP00000023749Uncharacterized protein. (244 aa)
LOC100719969Uncharacterized protein. (144 aa)
HTTHuntingtin. (3133 aa)
ANK2Ankyrin 2. (3876 aa)
KCNG4Potassium voltage-gated channel modifier subfamily G member 4; Belongs to the potassium channel family. (509 aa)
PDE4BPhosphodiesterase. (736 aa)
FYNTyrosine-protein kinase. (537 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (245 aa)
Fkbp1aPeptidylprolyl isomerase. (108 aa)
SCN3BSodium voltage-gated channel beta subunit 3. (215 aa)
TSPOTranslocator protein. (169 aa)
ARRB1Arrestin beta 1. (430 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (926 aa)
CIB1Calcium and integrin binding 1. (191 aa)
ACTN4Actinin alpha 4. (911 aa)
AGRNAgrin. (1967 aa)
TRDNTriadin. (682 aa)
Rims1C2 domain-containing protein. (219 aa)
FLNAFilamin A. (2645 aa)
Trappc2Uncharacterized protein. (140 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
ENSCPOP0000002811314_3_3 domain-containing protein; Belongs to the 14-3-3 family. (231 aa)
CABP4Calcium binding protein 4. (271 aa)
ACTN1Actinin alpha 1. (914 aa)
Vdac1Uncharacterized protein. (283 aa)
PPP1R9BProtein phosphatase 1 regulatory subunit 9B. (821 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (855 aa)
ENSCPOP00000029147Uncharacterized protein. (272 aa)
BAG2BCL2 associated athanogene 2. (211 aa)
NEDD4LNEDD4 like E3 ubiquitin protein ligase. (992 aa)
PIRTPhosphoinositide interacting regulator of transient receptor potential channels. (135 aa)
PHPT1Phosphohistidine phosphatase 1. (125 aa)
LRRC38Leucine rich repeat containing 38. (295 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
Ywhae14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa)
ANK1Ankyrin 1. (1911 aa)
TCAF1TRPM8 channel associated factor 1. (921 aa)
LRRC55Leucine rich repeat containing 55. (328 aa)
Ank3Uncharacterized protein. (1948 aa)
Cabp1Uncharacterized protein. (227 aa)
MPP2Membrane palmitoylated protein 2; Belongs to the MAGUK family. (569 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2738 aa)
Camk2dProtein kinase domain-containing protein. (532 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
ABCC9ATP binding cassette subfamily C member 9. (1546 aa)
Vamp2V-SNARE coiled-coil homology domain-containing protein. (164 aa)
KCNE4Potassium voltage-gated channel subfamily E regulatory subunit 4. (174 aa)
S100a10S_100 domain-containing protein; Belongs to the S-100 family. (96 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (747 aa)
FHL1Four and a half LIM domains 1. (323 aa)
HOMER1Homer scaffold protein 1. (329 aa)
HERPUD1Homocysteine inducible ER protein with ubiquitin like domain 1. (389 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2015 aa)
TCAPTitin-cap. (167 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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