STRINGSTRING
ARL6 ARL6 ARL4A ARL4A GDF6 GDF6 H0WC94_CAVPO H0WC94_CAVPO Bbs1 Bbs1 RGS2 RGS2 Dio2 Dio2 ZBTB7A ZBTB7A DHRS7B DHRS7B TCF7L2 TCF7L2 Snai2 Snai2 FGF10 FGF10 NUDT7 NUDT7 PLCB1 PLCB1 RUNX1T1 RUNX1T1 SLC2A4 SLC2A4 PER2 PER2 SOCS7 SOCS7 WNT3A WNT3A ENSCPOP00000032922 ENSCPOP00000032922 ANGPTL8 ANGPTL8 INHBB INHBB CTBP2 CTBP2 ARID5B ARID5B FFAR2 FFAR2 FABP4 FABP4 TMEM120B TMEM120B TFAP2B TFAP2B LRRN4CL LRRN4CL C1qtnf3 C1qtnf3 ATF5 ATF5 MB MB ATF2 ATF2 PEX11A PEX11A METTL8 METTL8 MED1 MED1 BNIP3 BNIP3 SDF4 SDF4 TRIM32 TRIM32 WNT10B WNT10B OPA3 OPA3 NR4A3 NR4A3 MKKS MKKS ADIPOQ ADIPOQ FAM120B FAM120B CCND1 CCND1 ITGA6 ITGA6 EGR2 EGR2 RETN RETN LRRC8C LRRC8C ALDH6A1 ALDH6A1 TTC8 TTC8 PSMB8 PSMB8 SIRT1 SIRT1 BBS9 BBS9 OSBPL8 OSBPL8 BBS7 BBS7 FBXO9 FBXO9 EBF2 EBF2 SMAD6 SMAD6 UCP1 UCP1 PTGS2 PTGS2 PPARG PPARG FFAR4 FFAR4 RETREG1 RETREG1 SREBF1 SREBF1 SOX8 SOX8 NR4A1 NR4A1 H0V0H5_CAVPO H0V0H5_CAVPO BBS2 BBS2 LAMB3 LAMB3 GDF10 GDF10 LOC100716676 LOC100716676 METRNL METRNL EP300 EP300 TBL1XR1 TBL1XR1 OSBPL11 OSBPL11 TMEM120A TMEM120A LAMA4 LAMA4 PIAS1 PIAS1 ERO1A ERO1A GRK5 GRK5 SH2B2 SH2B2 Tbl1x Tbl1x NIPBL NIPBL NR4A2 NR4A2 GLIS1 GLIS1 NOC3L NOC3L GATA2 GATA2 DYSF DYSF RARRES2 RARRES2 STEAP4 STEAP4 PRDM16 PRDM16 CNTN2 CNTN2 PDGFRA PDGFRA CLIP3 CLIP3 H0VL09_CAVPO H0VL09_CAVPO ALOXE3 ALOXE3 H0VN16_CAVPO H0VN16_CAVPO CREB5 CREB5 EIF2AK3 EIF2AK3 GSK3B GSK3B ENPP1 ENPP1 PLAC8 PLAC8 BSCL2 BSCL2 WNT1 WNT1 NCOR2 NCOR2 PRLH PRLH Cebpa Cebpa LRG1 LRG1 PNPLA3 PNPLA3 H0W0H8_CAVPO H0W0H8_CAVPO CEBPB CEBPB CTBP1 CTBP1 ADRB1 ADRB1 ADRB2 ADRB2 ZNF516 ZNF516 AP1S2 AP1S2 SOCS1 SOCS1 BBS12 BBS12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARL6ADP ribosylation factor like GTPase 6; Belongs to the small GTPase superfamily. Arf family. (186 aa)
ARL4AADP ribosylation factor like GTPase 4A. (200 aa)
GDF6Growth differentiation factor 6. (365 aa)
H0WC94_CAVPOUncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (770 aa)
Bbs1BBS1 domain-containing protein. (593 aa)
RGS2Regulator of G protein signaling 2. (211 aa)
Dio2Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (256 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (564 aa)
DHRS7BDehydrogenase/reductase 7B; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (331 aa)
TCF7L2Transcription factor 7 like 2. (350 aa)
Snai2Uncharacterized protein. (268 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
NUDT7Nudix hydrolase 7. (256 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1217 aa)
RUNX1T1RUNX1 partner transcriptional co-repressor 1. (602 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
PER2Period circadian regulator 2. (1237 aa)
SOCS7Suppressor of cytokine signaling 7. (527 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (328 aa)
ENSCPOP00000032922Uncharacterized protein. (109 aa)
ANGPTL8Angiopoietin like 8. (198 aa)
INHBBInhibin subunit beta B. (374 aa)
CTBP2C-terminal binding protein 2. (978 aa)
ARID5BAT-rich interaction domain 5B. (1194 aa)
FFAR2Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (330 aa)
FABP4Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
TMEM120BTransmembrane protein 120B. (339 aa)
TFAP2BTranscription factor AP-2 beta. (332 aa)
LRRN4CLLRRN4 C-terminal like. (226 aa)
C1qtnf3C1q domain-containing protein. (320 aa)
ATF5Activating transcription factor 5. (279 aa)
MBMyoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (154 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
PEX11APeroxisomal biogenesis factor 11 alpha. (246 aa)
METTL8Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family. (386 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1584 aa)
BNIP3BCL2 interacting protein 3. (194 aa)
SDF4Stromal cell derived factor 4. (378 aa)
TRIM32Tripartite motif containing 32. (653 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (390 aa)
OPA3Outer mitochondrial membrane lipid metabolism regulator OPA3. (180 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (633 aa)
MKKSMcKusick-Kaufman syndrome. (575 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (247 aa)
FAM120BFamily with sequence similarity 120B. (833 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1158 aa)
EGR2Early growth response 2. (473 aa)
RETNResistin. (112 aa)
LRRC8CLeucine rich repeat containing 8 VRAC subunit C. (803 aa)
ALDH6A1Aldehyde dehydrogenase 6 family member A1. (533 aa)
TTC8Tetratricopeptide repeat domain 8. (515 aa)
PSMB8Proteasome subunit beta. (273 aa)
SIRT1Sirtuin 1. (717 aa)
BBS9Bardet-Biedl syndrome 9. (887 aa)
OSBPL8Oxysterol-binding protein; Belongs to the OSBP family. (889 aa)
BBS7Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa)
FBXO9F-box protein 9. (438 aa)
EBF2EBF transcription factor 2. (575 aa)
SMAD6Mothers against decapentaplegic homolog. (508 aa)
UCP1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
PTGS2Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (604 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (504 aa)
FFAR4Free fatty acid receptor 4. (363 aa)
RETREG1Reticulophagy regulator 1. (413 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1155 aa)
SOX8SRY-box transcription factor 8. (462 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (598 aa)
H0V0H5_CAVPOANK_REP_REGION domain-containing protein. (1480 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (721 aa)
LAMB3Laminin subunit beta 3. (1174 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (472 aa)
LOC100716676TPR_REGION domain-containing protein. (567 aa)
METRNLMeteorin like, glial cell differentiation regulator. (280 aa)
EP300E1A binding protein p300. (2425 aa)
TBL1XR1Transducin beta like 1 X-linked receptor 1. (504 aa)
OSBPL11Oxysterol-binding protein; Belongs to the OSBP family. (667 aa)
TMEM120ATransmembrane protein 120A. (343 aa)
LAMA4Laminin subunit alpha 4. (1810 aa)
PIAS1Protein inhibitor of activated STAT 1. (651 aa)
ERO1AEndoplasmic reticulum oxidoreductase 1 alpha. (425 aa)
GRK5G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (590 aa)
SH2B2SH2B adaptor protein 2. (634 aa)
Tbl1xUncharacterized protein. (526 aa)
NIPBLNipped-B protein. (2721 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
GLIS1GLIS family zinc finger 1. (788 aa)
NOC3LNucleolar complex protein 3 homolog. (800 aa)
GATA2GATA binding protein 2. (374 aa)
DYSFDysferlin. (2103 aa)
RARRES2Retinoic acid receptor responder 2. (159 aa)
STEAP4STEAP4 metalloreductase. (482 aa)
PRDM16PR/SET domain 16. (1265 aa)
CNTN2Contactin 2. (1041 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
CLIP3CAP-Gly domain containing linker protein 3. (547 aa)
H0VL09_CAVPOUncharacterized protein. (114 aa)
ALOXE3Arachidonate lipoxygenase 3. (711 aa)
H0VN16_CAVPOUncharacterized protein. (71 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (461 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1112 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (423 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (900 aa)
PLAC8Placenta associated 8. (113 aa)
BSCL2BSCL2 lipid droplet biogenesis associated, seipin. (366 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
NCOR2Nuclear receptor corepressor 2. (2467 aa)
PRLHProlactin releasing hormone. (87 aa)
CebpaUncharacterized protein. (158 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (352 aa)
PNPLA3Patatin like phospholipase domain containing 3. (405 aa)
H0W0H8_CAVPOUncharacterized protein. (336 aa)
CEBPBCCAAT enhancer binding protein beta. (216 aa)
CTBP1C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (346 aa)
ADRB1G_PROTEIN_RECEP_F1_2 domain-containing protein. (470 aa)
ADRB2Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. (418 aa)
ZNF516Zinc finger protein 516. (1157 aa)
AP1S2AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (160 aa)
SOCS1Suppressor of cytokine signaling 1. (217 aa)
BBS12Bardet-Biedl syndrome 12. (704 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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