STRINGSTRING
EYA2 EYA2 ENSCPOP00000033122 ENSCPOP00000033122 ACTL6A ACTL6A DTX3L DTX3L MFSD11 MFSD11 LOC100722203 LOC100722203 YEATS4 YEATS4 XRCC1 XRCC1 ERCC6 ERCC6 RNF8 RNF8 RAD51AP1 RAD51AP1 POGZ POGZ Morf4l1 Morf4l1 ENSCPOP00000029431 ENSCPOP00000029431 MBTD1 MBTD1 DHX9 DHX9 FAM168A FAM168A SHLD1 SHLD1 ARID2 ARID2 EP400 EP400 BCL7B BCL7B FUS FUS Rps3 Rps3 EYA1 EYA1 ENSCPOP00000028155 ENSCPOP00000028155 HDGFL2 HDGFL2 MEAF6 MEAF6 MMS19 MMS19 UBE2V2 UBE2V2 BABAM2 BABAM2 INO80C INO80C ENSCPOP00000027005 ENSCPOP00000027005 EYA4 EYA4 RNF168 RNF168 ENSCPOP00000024875 ENSCPOP00000024875 CBX8 CBX8 BCL7A BCL7A ENSCPOP00000024582 ENSCPOP00000024582 WDR48 WDR48 SPIRE1 SPIRE1 ENSCPOP00000024428 ENSCPOP00000024428 PRKCG PRKCG TRRAP TRRAP BRCC3 BRCC3 KMT5B KMT5B TIMELESS TIMELESS ENSCPOP00000023362 ENSCPOP00000023362 FH FH FGF10 FGF10 RIF1 RIF1 ENSCPOP00000022509 ENSCPOP00000022509 KAT5 KAT5 MGMT MGMT ACTB ACTB ACTR2 ACTR2 LOC100736130 LOC100736130 MRGBP MRGBP VPS72 VPS72 RUVBL2 RUVBL2 ING3 ING3 MAD2L2 MAD2L2 Yy1 Yy1 DMAP1 DMAP1 WAS WAS H0VYM4_CAVPO H0VYM4_CAVPO APBB1 APBB1 Parp9 Parp9 Parp1 Parp1 FOXM1 FOXM1 H0VS04_CAVPO H0VS04_CAVPO PARG PARG PRKDC PRKDC PARP3 PARP3 TMEM161A TMEM161A Brca1 Brca1 LOC106026468 LOC106026468 Ino80b Ino80b EYA3 EYA3 INO80E INO80E ACTR5 ACTR5 TFPT TFPT INO80 INO80 MCRS1 MCRS1 H0VI45_CAVPO H0VI45_CAVPO UIMC1 UIMC1 TIGAR TIGAR RUVBL1 RUVBL1 PCNA PCNA HELQ HELQ KMT5C KMT5C EPC2 EPC2 BRD8 BRD8 CCDC117 CCDC117 RBBP8 RBBP8 ACTR8 ACTR8 Babam1 Babam1 KDM4D KDM4D Trim28 Trim28 PNKP PNKP SLF1 SLF1 H0V4A5_CAVPO H0V4A5_CAVPO DDX11 DDX11 WRAP53 WRAP53 EPC1 EPC1 PIAS4 PIAS4 BLM BLM SMCHD1 SMCHD1 ABRAXAS1 ABRAXAS1 SHLD2 SHLD2 SLF2 SLF2 SIRT1 SIRT1 UCHL5 UCHL5 NFRKB NFRKB SPIRE2 SPIRE2 EGFR EGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (529 aa)
ENSCPOP00000033122MPN domain-containing protein. (250 aa)
ACTL6AActin like 6A; Belongs to the actin family. (429 aa)
DTX3LDeltex E3 ubiquitin ligase 3L. (719 aa)
MFSD11Major facilitator superfamily domain containing 11. (449 aa)
LOC100722203BZIP domain-containing protein. (150 aa)
YEATS4YEATS domain containing 4. (227 aa)
XRCC1X-ray repair cross complementing 1. (629 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1473 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (486 aa)
RAD51AP1RAD51 associated protein 1. (334 aa)
POGZPogo transposable element derived with ZNF domain. (1412 aa)
Morf4l1Mortality factor 4 like 1. (377 aa)
ENSCPOP00000029431Uncharacterized protein. (111 aa)
MBTD1Mbt domain containing 1. (627 aa)
DHX9DExH-box helicase 9. (1373 aa)
FAM168AFamily with sequence similarity 168 member A. (244 aa)
SHLD1Shieldin complex subunit 1. (216 aa)
ARID2AT-rich interaction domain 2. (1763 aa)
EP400E1A binding protein p400. (3128 aa)
BCL7BBAF chromatin remodeling complex subunit BCL7B. (202 aa)
FUSFUS RNA binding protein. (490 aa)
Rps3KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
ENSCPOP00000028155UBIQUITIN_CONJUGAT_2 domain-containing protein. (102 aa)
HDGFL2HDGF like 2. (666 aa)
MEAF6MYST/Esa1 associated factor 6. (171 aa)
MMS19MMS19 homolog, cytosolic iron-sulfur assembly component. (1027 aa)
UBE2V2Ubiquitin conjugating enzyme E2 V2. (145 aa)
BABAM2BRISC and BRCA1 A complex member 2. (358 aa)
INO80CINO80 complex subunit C. (192 aa)
ENSCPOP00000027005UBIQUITIN_CONJUGAT_2 domain-containing protein. (83 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (639 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (573 aa)
ENSCPOP00000024875MRG domain-containing protein. (231 aa)
CBX8Chromobox 8. (389 aa)
BCL7ABAF chromatin remodeling complex subunit BCL7A. (188 aa)
ENSCPOP00000024582MRG domain-containing protein. (291 aa)
WDR48WD repeat domain 48. (676 aa)
SPIRE1Spire type actin nucleation factor 1. (625 aa)
ENSCPOP00000024428PARP-type domain-containing protein. (104 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa)
TRRAPTransformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. (3860 aa)
BRCC3BRCA1/BRCA2-containing complex subunit 3. (291 aa)
KMT5BLysine methyltransferase 5B. (882 aa)
TIMELESSTimeless circadian regulator. (1239 aa)
ENSCPOP00000023362UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
FHFumarate hydratase. (508 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
RIF1Replication timing regulatory factor 1. (2387 aa)
ENSCPOP00000022509Uncharacterized protein. (140 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (541 aa)
MGMTO-6-methylguanine-DNA methyltransferase. (208 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
LOC100736130Uncharacterized protein. (287 aa)
MRGBPMRG domain binding protein. (204 aa)
VPS72Vacuolar protein sorting 72 homolog. (364 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (486 aa)
ING3Inhibitor of growth protein. (418 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (211 aa)
Yy1Uncharacterized protein. (195 aa)
DMAP1DNA methyltransferase 1 associated protein 1. (445 aa)
WASWASP actin nucleation promoting factor. (505 aa)
H0VYM4_CAVPOUncharacterized protein. (503 aa)
APBB1Amyloid beta precursor protein binding family B member 1. (709 aa)
Parp9Uncharacterized protein. (703 aa)
Parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa)
FOXM1Forkhead box M1. (762 aa)
H0VS04_CAVPOHist_deacetyl domain-containing protein. (286 aa)
PARGPoly(ADP-ribose) glycohydrolase. (973 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4043 aa)
PARP3Poly [ADP-ribose] polymerase. (533 aa)
TMEM161ATransmembrane protein 161A. (474 aa)
Brca1Uncharacterized protein. (79 aa)
LOC106026468UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (174 aa)
Ino80bPAPA-1 domain-containing protein. (373 aa)
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (497 aa)
INO80EINO80 complex subunit E. (244 aa)
ACTR5Actin related protein 5; Belongs to the actin family. (602 aa)
TFPTTCF3 fusion partner. (257 aa)
INO80INO80 complex ATPase subunit. (1558 aa)
MCRS1Microspherule protein 1. (462 aa)
H0VI45_CAVPOzf-C3Hc3H domain-containing protein. (414 aa)
UIMC1Ubiquitin interaction motif containing 1. (716 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (265 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
HELQHelicase, POLQ like. (1054 aa)
KMT5CLysine methyltransferase 5C. (476 aa)
EPC2Enhancer of polycomb homolog. (803 aa)
BRD8Bromodomain containing 8. (951 aa)
CCDC117Coiled-coil domain containing 117. (278 aa)
RBBP8RB binding protein 8, endonuclease. (900 aa)
ACTR8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa)
Babam1Uncharacterized protein. (337 aa)
KDM4DLysine demethylase 4D. (512 aa)
Trim28Uncharacterized protein. (829 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (523 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1061 aa)
H0V4A5_CAVPOUncharacterized protein. (830 aa)
DDX11DEAD/H-box helicase 11. (878 aa)
WRAP53WD repeat containing antisense to TP53. (541 aa)
EPC1Enhancer of polycomb homolog 1. (763 aa)
PIAS4Protein inhibitor of activated STAT 4. (514 aa)
BLMBLM RecQ like helicase. (1405 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain containing 1. (1945 aa)
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (371 aa)
SHLD2Shieldin complex subunit 2. (905 aa)
SLF2SMC5-SMC6 complex localization factor 2. (1141 aa)
SIRT1Sirtuin 1. (717 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (324 aa)
NFRKBNuclear factor related to kappaB binding protein. (1298 aa)
SPIRE2Spire type actin nucleation factor 2. (717 aa)
EGFRReceptor protein-tyrosine kinase. (1214 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.