STRINGSTRING
IPMK IPMK PIK3C2A PIK3C2A PDGFRB PDGFRB PGAP2 PGAP2 PIK3CA PIK3CA PIGX PIGX INPP5K INPP5K Pigp Pigp MTMR6 MTMR6 PIK3R4 PIK3R4 PIP4K2A PIP4K2A LOC101788042 LOC101788042 LOC100734206 LOC100734206 SYNJ2 SYNJ2 CISH CISH PIGQ PIGQ Pigy Pigy ENSCPOP00000030554 ENSCPOP00000030554 DPM2 DPM2 ENSCPOP00000031025 ENSCPOP00000031025 PIP5KL1 PIP5KL1 BECN1 BECN1 PIK3C2B PIK3C2B MTM1 MTM1 CDIPT CDIPT FAM102A FAM102A PITPNM3 PITPNM3 FAM126B FAM126B EFR3B EFR3B IP6K3 IP6K3 PIK3CD PIK3CD PIGU PIGU MBOAT7 MBOAT7 SMG1 SMG1 PLA2G3 PLA2G3 INPP5J INPP5J PIGO PIGO PIGK PIGK PIGB PIGB MTMR7 MTMR7 SLA2 SLA2 PITPNC1 PITPNC1 LPGAT1 LPGAT1 ATM ATM ITPKA ITPKA MTMR12 MTMR12 MTMR3 MTMR3 TTC7B TTC7B PLCG2 PLCG2 PIP5K1A PIP5K1A GPLD1 GPLD1 PIP5K1C PIP5K1C VAC14 VAC14 IMPA2 IMPA2 ATG14 ATG14 PIK3CB PIK3CB PLCD1 PLCD1 OCRL OCRL ITPKB ITPKB MTMR10 MTMR10 PIK3R6 PIK3R6 PGAP1 PGAP1 PIGH PIGH MTMR4 MTMR4 SOCS4 SOCS4 PLEK PLEK PIGA PIGA PIGW PIGW PIK3R1 PIK3R1 IP6K2 IP6K2 H0VB67_CAVPO H0VB67_CAVPO SOCS2 SOCS2 MTMR11 MTMR11 SACM1L SACM1L MTMR2 MTMR2 INPP5B INPP5B INPP5F INPP5F ITPKC ITPKC RGSL1 RGSL1 INPP5E INPP5E SLC27A1 SLC27A1 UVRAG UVRAG PI4KB PI4KB PIP5K1B PIP5K1B PIK3C3 PIK3C3 PI4K2A PI4K2A FGF2 FGF2 INPP5D INPP5D PLCB2 PLCB2 PIGG PIGG LOC100725517 LOC100725517 PIP4K2B PIP4K2B PIGN PIGN SOCS5 SOCS5 P3R3URF P3R3URF BPNT1 BPNT1 PGAP3 PGAP3 PIK3CG PIK3CG TTC7A TTC7A DGKE DGKE PIGL PIGL INPP1 INPP1 PLCH2 PLCH2 GPAA1 GPAA1 PYURF PYURF TMEM150A TMEM150A INPPL1 INPPL1 INPP4B INPP4B INPP4A INPP4A IP6K1 IP6K1 LCLAT1 LCLAT1 PIGT PIGT CDS1 CDS1 SOCS7 SOCS7 LOC100718345 LOC100718345 FAM126A FAM126A PIGF PIGF PIKFYVE PIKFYVE PIP4P2 PIP4P2 PLCB1 PLCB1 PSORS1C2 PSORS1C2 Pigv Pigv MTMR9 MTMR9 PIP4P1 PIP4P1 DPM1 DPM1 MPPE1 MPPE1 PI4K2B PI4K2B FAM102B FAM102B SYNJ1 SYNJ1 PLCB3 PLCB3 SOCS6 SOCS6 IMPAD1 IMPAD1 IMPA1 IMPA1 SOCS1 SOCS1 PIGM PIGM PTEN PTEN PI4KA PI4KA SOCS3 SOCS3 SH3YL1 SH3YL1 H0W3F4_CAVPO H0W3F4_CAVPO Pigz Pigz LOC100721187 LOC100721187 PIGC PIGC H0W027_CAVPO H0W027_CAVPO DPM3 DPM3 PLCG1 PLCG1 CSF1R CSF1R PIP4K2C PIP4K2C PIGS PIGS PLCD4 PLCD4 INPP5A INPP5A CWH43 CWH43
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IPMKKinase; Belongs to the inositol phosphokinase (IPK) family. (377 aa)
PIK3C2APhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1404 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1102 aa)
PGAP2Post-GPI attachment to proteins 2. (255 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1044 aa)
PIGXPhosphatidylinositol glycan anchor biosynthesis class X. (254 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (461 aa)
PigpPIG-P domain-containing protein. (185 aa)
MTMR6Myotubularin related protein 6. (620 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1354 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (398 aa)
LOC101788042C2 domain-containing protein. (110 aa)
LOC100734206Uncharacterized protein. (461 aa)
SYNJ2Synaptojanin 2. (1489 aa)
CISHCytokine inducible SH2 containing protein. (253 aa)
PIGQPhosphatidylinositol glycan anchor biosynthesis class Q. (581 aa)
PigyUncharacterized protein. (64 aa)
ENSCPOP00000030554Phosphatidylinositol N-acetylglucosaminyltransferase subunit P; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. (136 aa)
DPM2Dolichol phosphate-mannose biosynthesis regulatory protein; Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. Belongs to the DPM2 family. (84 aa)
ENSCPOP00000031025SAC domain-containing protein. (814 aa)
PIP5KL1Phosphatidylinositol-4-phosphate 5-kinase like 1. (423 aa)
BECN1Beclin 1. (448 aa)
PIK3C2BPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1633 aa)
MTM1Myotubularin 1. (599 aa)
CDIPTCDP-diacylglycerol--inositol 3-phosphatidyltransferase. (213 aa)
FAM102AFamily with sequence similarity 102 member A. (385 aa)
PITPNM3PITPNM family member 3. (1015 aa)
FAM126BFamily with sequence similarity 126 member B. (586 aa)
EFR3BEFR3 homolog B. (842 aa)
IP6K3Kinase; Belongs to the inositol phosphokinase (IPK) family. (401 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
PIGUPhosphatidylinositol glycan anchor biosynthesis class U. (435 aa)
MBOAT7Membrane bound O-acyltransferase domain containing 7; Belongs to the membrane-bound acyltransferase family. (472 aa)
SMG1SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3632 aa)
PLA2G3Phospholipase A2 group III. (645 aa)
INPP5JInositol polyphosphate-5-phosphatase J. (1015 aa)
PIGOPhosphatidylinositol glycan anchor biosynthesis class O. (1098 aa)
PIGKGPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family. (395 aa)
PIGBMannosyltransferase. (535 aa)
MTMR7Myotubularin related protein 7. (640 aa)
SLA2Src like adaptor 2. (276 aa)
PITPNC1Phosphatidylinositol transfer protein cytoplasmic 1. (308 aa)
LPGAT1Lysophosphatidylglycerol acyltransferase 1. (370 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3031 aa)
ITPKAKinase; Belongs to the inositol phosphokinase (IPK) family. (434 aa)
MTMR12Myotubularin related protein 12. (747 aa)
MTMR3Myotubularin related protein 3. (1221 aa)
TTC7BTetratricopeptide repeat domain 7B. (827 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1270 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (536 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (839 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (689 aa)
VAC14VAC14 component of PIKFYVE complex. (770 aa)
IMPA2Inositol-1-monophosphatase. (283 aa)
ATG14Autophagy related 14. (492 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1018 aa)
PLCD1Phosphoinositide phospholipase C. (755 aa)
OCRLOCRL inositol polyphosphate-5-phosphatase. (900 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (890 aa)
MTMR10Myotubularin related protein 10. (753 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (763 aa)
PGAP1GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI- anchored proteins from the endoplasmic reticulum to the Golgi. (872 aa)
PIGHPhosphatidylinositol glycan anchor biosynthesis class H. (188 aa)
MTMR4Myotubularin related protein 4. (1189 aa)
SOCS4Suppressor of cytokine signaling 4. (435 aa)
PLEKPleckstrin. (350 aa)
PIGAPhosphatidylinositol glycan anchor biosynthesis class A. (484 aa)
PIGWPhosphatidylinositol-glycan biosynthesis class W protein; Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. (518 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
IP6K2Kinase; Belongs to the inositol phosphokinase (IPK) family. (449 aa)
H0VB67_CAVPOPhosphatidylinositol 3-kinase catalytic subunit type 3. (651 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
MTMR11Myotubularin related protein 11. (692 aa)
SACM1LSAC1 like phosphatidylinositide phosphatase. (587 aa)
MTMR2Myotubularin related protein 2. (643 aa)
INPP5BInositol polyphosphate-5-phosphatase B. (983 aa)
INPP5FInositol polyphosphate-5-phosphatase F. (1107 aa)
ITPKCKinase; Belongs to the inositol phosphokinase (IPK) family. (679 aa)
RGSL1Regulator of G protein signaling like 1. (1037 aa)
INPP5EInositol polyphosphate-5-phosphatase E. (646 aa)
SLC27A1Solute carrier family 27 member 1. (590 aa)
UVRAGUV radiation resistance associated. (698 aa)
PI4KBPhosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family. (828 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (488 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
PI4K2API3K/PI4K domain-containing protein. (479 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (114 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1220 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
PIGGPhosphatidylinositol glycan anchor biosynthesis class G. (991 aa)
LOC100725517Myotubularin phosphatase domain-containing protein. (355 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (362 aa)
PIGNPhosphatidylinositol glycan anchor biosynthesis class N. (912 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
P3R3URFPIK3R3 upstream reading frame. (91 aa)
BPNT13'(2'), 5'-bisphosphate nucleotidase 1. (331 aa)
PGAP3Post-GPI attachment to proteins factor 3; Involved in the lipid remodeling steps of GPI-anchor maturation; Belongs to the PGAP3 family. (320 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1092 aa)
TTC7ATetratricopeptide repeat domain 7A. (853 aa)
DGKEDiacylglycerol kinase. (575 aa)
PIGLPhosphatidylinositol glycan anchor biosynthesis class L. (299 aa)
INPP1Inositol polyphosphate-1-phosphatase. (526 aa)
PLCH2Phosphoinositide phospholipase C. (1461 aa)
GPAA1Glycosylphosphatidylinositol anchor attachment 1. (621 aa)
PYURFPIGY upstream reading frame. (114 aa)
TMEM150ATransmembrane protein 150A. (271 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1267 aa)
INPP4BInositol polyphosphate-4-phosphatase type II B. (939 aa)
INPP4AInositol polyphosphate-4-phosphatase type I A. (972 aa)
IP6K1Kinase; Belongs to the inositol phosphokinase (IPK) family. (433 aa)
LCLAT1Lysocardiolipin acyltransferase 1. (376 aa)
PIGTPhosphatidylinositol glycan anchor biosynthesis class T. (578 aa)
CDS1Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (422 aa)
SOCS7Suppressor of cytokine signaling 7. (527 aa)
LOC100718345Uncharacterized protein. (71 aa)
FAM126AFamily with sequence similarity 126 member A. (521 aa)
PIGFPhosphatidylinositol glycan anchor biosynthesis class F. (219 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2079 aa)
PIP4P2Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (257 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1217 aa)
PSORS1C2Psoriasis susceptibility 1 candidate 2. (138 aa)
PigvGPI mannosyltransferase 2; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. (265 aa)
MTMR9Myotubularin related protein 9. (549 aa)
PIP4P1Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (284 aa)
DPM1Dolichol-phosphate mannosyltransferase subunit 1; Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins. (260 aa)
MPPE1Metallophosphoesterase 1. (393 aa)
PI4K2BPhosphatidylinositol 4-kinase type 2 beta. (469 aa)
FAM102BFamily with sequence similarity 102 member B. (360 aa)
SYNJ1Synaptojanin 1. (1607 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1227 aa)
SOCS6Suppressor of cytokine signaling 6. (535 aa)
IMPAD1Inositol monophosphatase domain containing 1. (355 aa)
IMPA1Inositol-1-monophosphatase. (277 aa)
SOCS1Suppressor of cytokine signaling 1. (217 aa)
PIGMGPI mannosyltransferase 1; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN- acyl-PI during GPI precursor assembly. (422 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (355 aa)
PI4KAPhosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family. (2064 aa)
SOCS3Suppressor of cytokine signaling 3. (228 aa)
SH3YL1SH3 and SYLF domain containing 1. (340 aa)
H0W3F4_CAVPOMyotubularin phosphatase domain-containing protein. (121 aa)
PigzMannosyltransferase. (575 aa)
LOC100721187Uncharacterized protein. (489 aa)
PIGCPhosphatidylinositol glycan anchor biosynthesis class C. (297 aa)
H0W027_CAVPOUncharacterized protein. (722 aa)
DPM3Dolichol-phosphate mannosyltransferase subunit 3; Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER. Belongs to the DPM3 family. (92 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1235 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (979 aa)
PIP4K2CPhosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (419 aa)
PIGSPhosphatidylinositol glycan anchor biosynthesis class S. (555 aa)
PLCD4Phosphoinositide phospholipase C. (762 aa)
INPP5AInositol polyphosphate-5-phosphatase A. (390 aa)
CWH43Cell wall biogenesis 43 C-terminal homolog. (683 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
Server load: low (22%) [HD]