STRINGSTRING
SIX2 SIX2 EPB41L5 EPB41L5 CPS1 CPS1 CLMP CLMP VPS52 VPS52 DICER1 DICER1 HIF1A HIF1A CTNNB1 CTNNB1 Gata4 Gata4 ADA ADA HMGCS2 HMGCS2 SALL1 SALL1 HOXD13 HOXD13 COL3A1 COL3A1 BMP4 BMP4 PTK6 PTK6 CCDC40 CCDC40 TGFB2 TGFB2 NIPBL NIPBL RB1 RB1 WNT11 WNT11 TIGAR TIGAR NKX2-3 NKX2-3 VANGL2 VANGL2 RARRES2 RARRES2 DNAAF1 DNAAF1 STX2 STX2 KIT KIT PDGFRA PDGFRA CDH1 CDH1 PDGFC PDGFC DCHS1 DCHS1 OTC OTC MEGF8 MEGF8 EXT1 EXT1 SMO SMO IL6ST IL6ST SMAD2 SMAD2 CCDC103 CCDC103 PRDM1 PRDM1 MYB MYB PKDCC PKDCC CCDC39 CCDC39 RARB RARB EDNRB EDNRB TYMS TYMS Nphp3 Nphp3 NODAL NODAL STRA6 STRA6 NCKAP1 NCKAP1 KCNQ1 KCNQ1 SOX11 SOX11 ID2 ID2 CCKBR CCKBR FOXP4 FOXP4 BCL2 BCL2 TCF21 TCF21 ALX4 ALX4 ASCL1 ASCL1 SFRP5 SFRP5 ASS1 ASS1 TCF7 TCF7 HLX HLX HES1 HES1 CXCL8 CXCL8 SOX10 SOX10 TCF7L2 TCF7L2 FGF10 FGF10 ENSCPOP00000022792 ENSCPOP00000022792 Pitx2 Pitx2 WNT5A WNT5A TGFBR2 TGFBR2 COBL COBL TBX2 TBX2 FGFR3 FGFR3 LINS1 LINS1 ENSCPOP00000025708 ENSCPOP00000025708 GLI3 GLI3 SHOX2 SHOX2 NKX3-2 NKX3-2 IFT172 IFT172 GLI2 GLI2 CLDN18 CLDN18 CBFA2T2 CBFA2T2 DACT1 DACT1 HOXA5 HOXA5 SFRP2 SFRP2 SPDEF SPDEF C1galt1 C1galt1 SHH SHH SMAD3 SMAD3 IHH IHH OVOL2 OVOL2 HOXA13 HOXA13 SAV1 SAV1 OXTR OXTR TP73 TP73 CRKL CRKL TP63 TP63 FGFR2 FGFR2 GATA5 GATA5 TGFB3 TGFB3 SFRP1 SFRP1 ACVR2B ACVR2B PDGFA PDGFA AGR2 AGR2 EGFR EGFR SOX17 SOX17 FOXF1 FOXF1 EPHB3 EPHB3 HNF1B HNF1B YIPF6 YIPF6 KLF5 KLF5 TNF TNF ZIC3 ZIC3 MYOCD MYOCD CHD8 CHD8 PCSK5 PCSK5 ALDH1A2 ALDH1A2 PKD1 PKD1 FAT4 FAT4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SIX2SIX homeobox 2. (298 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (705 aa)
CPS1Carbamoyl-phosphate synthase 1. (1499 aa)
CLMPCXADR like membrane protein. (373 aa)
VPS52VPS52 subunit of GARP complex. (723 aa)
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1903 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (828 aa)
CTNNB1Catenin beta 1. (781 aa)
Gata4Uncharacterized protein. (237 aa)
ADAAdenosine deaminase. (365 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
SALL1Spalt like transcription factor 1. (1287 aa)
HOXD13Homeobox D13. (313 aa)
COL3A1Collagen type III alpha 1 chain. (1462 aa)
BMP4Bone morphogenetic protein 4. (404 aa)
PTK6Tyrosine-protein kinase. (451 aa)
CCDC40Coiled-coil domain containing 40. (1120 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (440 aa)
NIPBLNipped-B protein. (2721 aa)
RB1RB transcriptional corepressor 1. (840 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (265 aa)
NKX2-3NK2 homeobox 3. (358 aa)
VANGL2Vang-like protein. (548 aa)
RARRES2Retinoic acid receptor responder 2. (159 aa)
DNAAF1Dynein assembly factor 1, axonemal. (606 aa)
STX2Syntaxin 2; Belongs to the syntaxin family. (286 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (970 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (891 aa)
PDGFCPlatelet derived growth factor C. (295 aa)
DCHS1Dachsous cadherin-related 1. (3297 aa)
OTCOrnithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (354 aa)
MEGF8Multiple EGF like domains 8. (2787 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (789 aa)
IL6STInterleukin 6 signal transducer. (903 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
CCDC103Coiled-coil domain containing 103. (230 aa)
PRDM1PR/SET domain 1. (813 aa)
MYBMYB proto-oncogene, transcription factor. (743 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (435 aa)
CCDC39Coiled-coil domain containing 39. (678 aa)
RARBUncharacterized protein. (448 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (415 aa)
TYMSThymidylate synthetase. (314 aa)
Nphp3TPR_REGION domain-containing protein. (1281 aa)
NODALNodal growth differentiation factor. (351 aa)
STRA6Stimulated by retinoic acid 6. (661 aa)
NCKAP1NCK associated protein 1. (1140 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1; Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity). Associates with KCNE beta subunits that modulates current kinetics (By similarity). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac r [...] (671 aa)
SOX11Transcription factor SOX. (377 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
CCKBRCholecystokinin B receptor; Belongs to the G-protein coupled receptor 1 family. (426 aa)
FOXP4Forkhead box P4. (677 aa)
BCL2BCL2 apoptosis regulator. (183 aa)
TCF21Transcription factor 21. (179 aa)
ALX4ALX homeobox 4. (398 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (215 aa)
SFRP5Secreted frizzled related protein 5. (296 aa)
ASS1Argininosuccinate synthase 1. (415 aa)
TCF7Transcription factor 7. (262 aa)
HLXH2.0 like homeobox. (442 aa)
HES1Hes family bHLH transcription factor 1. (279 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity). (101 aa)
SOX10SRY-box transcription factor 10. (469 aa)
TCF7L2Transcription factor 7 like 2. (350 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
ENSCPOP00000022792Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal- beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins; Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily. (330 aa)
Pitx2Homeobox protein. (325 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
COBLCordon-bleu WH2 repeat protein. (1253 aa)
TBX2T-box transcription factor 2. (686 aa)
FGFR3Fibroblast growth factor receptor. (801 aa)
LINS1Lines homolog 1. (754 aa)
ENSCPOP00000025708SH3 domain-containing protein. (146 aa)
GLI3GLI family zinc finger 3. (1580 aa)
SHOX2Short stature homeobox 2. (320 aa)
NKX3-2NK3 homeobox 2. (336 aa)
IFT172Intraflagellar transport 172. (1749 aa)
GLI2GLI family zinc finger 2. (1570 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
CBFA2T2CBFA2/RUNX1 partner transcriptional co-repressor 2. (595 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (551 aa)
HOXA5Homeobox A5. (270 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
SPDEFSAM pointed domain containing ETS transcription factor. (331 aa)
C1galt1Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal- beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins; Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily. (371 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (447 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (409 aa)
OVOL2Ovo like zinc finger 2. (269 aa)
HOXA13Homeobox A13. (203 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
OXTROxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (390 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (641 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
FGFR2Fibroblast growth factor receptor. (801 aa)
GATA5GATA binding protein 5. (292 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
SFRP1Secreted frizzled related protein 1. (307 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (190 aa)
AGR2Anterior gradient 2, protein disulphide isomerase family member. (172 aa)
EGFRReceptor protein-tyrosine kinase. (1214 aa)
SOX17SRY-box transcription factor 17. (400 aa)
FOXF1Forkhead box F1. (376 aa)
EPHB3EPH receptor B3. (1011 aa)
HNF1BHNF1 homeobox B. (558 aa)
YIPF6Protein YIPF. (236 aa)
KLF5Kruppel like factor 5. (374 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
ZIC3Zic family member 3. (246 aa)
MYOCDMyocardin. (976 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2583 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1856 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (512 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4283 aa)
FAT4FAT atypical cadherin 4. (4796 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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