STRINGSTRING
OTOG OTOG PAWR PAWR LRIG1 LRIG1 ESPN ESPN H0UXA2_CAVPO H0UXA2_CAVPO Usp53 Usp53 USH1C USH1C Pdzd7 Pdzd7 FBXO11 FBXO11 COL2A1 COL2A1 WHRN WHRN TFAP2A TFAP2A GET1 GET1 CDKN1B CDKN1B TPRN TPRN PCDH15 PCDH15 TSHZ3 TSHZ3 SPRY2 SPRY2 GJB2 GJB2 ENSCPOP00000031233 ENSCPOP00000031233 MYO3B MYO3B CDC14A CDC14A ENSCPOP00000030659 ENSCPOP00000030659 Chrnb2 Chrnb2 MYH14 MYH14 TMIE TMIE CCDC50 CCDC50 PTPRQ PTPRQ COCH COCH ENSCPOP00000029185 ENSCPOP00000029185 RAB3A RAB3A ENSCPOP00000028869 ENSCPOP00000028869 LOC100727296 LOC100727296 CDKN2D CDKN2D CLIC5 CLIC5 MKKS MKKS THRB THRB Triobp Triobp ENSCPOP00000027396 ENSCPOP00000027396 KCNMA1 KCNMA1 SIX1 SIX1 CXCR4 CXCR4 ENSCPOP00000027148 ENSCPOP00000027148 EYA4 EYA4 SLC9A3R1 SLC9A3R1 ATP6V0A4 ATP6V0A4 LHFPL4 LHFPL4 ROR1 ROR1 FYN FYN MYC MYC CLRN1 CLRN1 PKHD1L1 PKHD1L1 SERPINE2 SERPINE2 MYO6 MYO6 GRAP GRAP ENSCPOP00000024297 ENSCPOP00000024297 PHF24 PHF24 EPYC EPYC AQP4 AQP4 BIRC5 BIRC5 ASIC3 ASIC3 ALMS1 ALMS1 CXCL12 CXCL12 Snai2 Snai2 Ndufs4 Ndufs4 OTOS OTOS HOXA1 HOXA1 GJB6 GJB6 TBX18 TBX18 PJVK PJVK ASIC2 ASIC2 MYO7A MYO7A CHRNA10 CHRNA10 H0WA79_CAVPO H0WA79_CAVPO WFS1 WFS1 KCNK4 KCNK4 BARHL1 BARHL1 MAP1A MAP1A POU4F3 POU4F3 CEACAM16 CEACAM16 LOC100726021 LOC100726021 H0W3X9_CAVPO H0W3X9_CAVPO LHFPL5 LHFPL5 ATP2B2 ATP2B2 H0W2T6_CAVPO H0W2T6_CAVPO CRYM CRYM COL11A2 COL11A2 HPN HPN GRM7 GRM7 LHFPL3 LHFPL3 SLC9A3R2 SLC9A3R2 NAV2 NAV2 CABP2 CABP2 KCNQ1 KCNQ1 GRXCR1 GRXCR1 OTOGL OTOGL ITGA2 ITGA2 H0VU16_CAVPO H0VU16_CAVPO SCN8A SCN8A Fam107b Fam107b TMC2 TMC2 ENPP1 ENPP1 GABRB2 GABRB2 TLR4 TLR4 HOMER2 HOMER2 SLC12A2 SLC12A2 OTOA OTOA FZD4 FZD4 SOD1 SOD1 SPNS2 SPNS2 H0VQ66_CAVPO H0VQ66_CAVPO POU4F2 POU4F2 H0VPD8_CAVPO H0VPD8_CAVPO P2RX2 P2RX2 CHD7 CHD7 LOC100730761 LOC100730761 SCARB2 SCARB2 MYO1A MYO1A SOBP SOBP DDIT3 DDIT3 COL11A1 COL11A1 TH TH CHRNA5 CHRNA5 GJC3 GJC3 TBX1 TBX1 CDH1 CDH1 TMPRSS3 TMPRSS3 TECTA TECTA Trpa1 Trpa1 KIT KIT CNTN5 CNTN5 AXIN1 AXIN1 TJP1 TJP1 Hexa Hexa ATP6V1B1 ATP6V1B1 TRPV1 TRPV1 TMTC4 TMTC4 LOXHD1 LOXHD1 SPTBN4 SPTBN4 SLC17A8 SLC17A8 CHRNA9 CHRNA9 SERPINB6 SERPINB6 NIPBL NIPBL SLC26A5 SLC26A5 RIPOR2 RIPOR2 USH2A USH2A CFAP57 CFAP57 SLC1A3 SLC1A3 ESPNL ESPNL LRIG2 LRIG2 FGFR1 FGFR1 ATP8B1 ATP8B1 HEXB HEXB TMEM120A TMEM120A TECTB TECTB GRIN2B GRIN2B USH1G USH1G GABRB3 GABRB3 KCNQ4 KCNQ4 KCNA1 KCNA1 TSPEAR TSPEAR CEMIP CEMIP GABRA5 GABRA5 P2rx4 P2rx4 H0V266_CAVPO H0V266_CAVPO EPS8L2 EPS8L2 SLC52A3 SLC52A3 MYO15A MYO15A SRRM4 SRRM4 DCDC2 DCDC2 GRXCR2 GRXCR2 COL1A1 COL1A1 CACNB3 CACNB3 NTRK1 NTRK1 IL18 IL18 PGAP1 PGAP1 CDH23 CDH23 TMC1 TMC1 SCN1A SCN1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
OTOGOtogelin. (2777 aa)
PAWRPro-apoptotic WT1 regulator. (307 aa)
LRIG1Leucine rich repeats and immunoglobulin like domains 1. (1089 aa)
ESPNEspin. (870 aa)
H0UXA2_CAVPOUncharacterized protein. (978 aa)
Usp53Uncharacterized protein. (90 aa)
USH1CUSH1 protein network component harmonin. (909 aa)
Pdzd7Uncharacterized protein. (553 aa)
FBXO11F-box protein 11. (911 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
WHRNWhirlin. (916 aa)
TFAP2ATranscription factor AP-2 alpha. (437 aa)
GET1Guided entry of tail-anchored proteins factor 1. (174 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
TPRNTaperin. (833 aa)
PCDH15Protocadherin related 15. (1913 aa)
TSHZ3Teashirt zinc finger homeobox 3. (1081 aa)
SPRY2Sprouty RTK signaling antagonist 2. (316 aa)
GJB2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (226 aa)
ENSCPOP00000031233SH3 domain-containing protein. (173 aa)
MYO3BMyosin IIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1306 aa)
CDC14ACell division cycle 14A. (596 aa)
ENSCPOP00000030659G_PROTEIN_RECEP_F3_4 domain-containing protein. (497 aa)
Chrnb2Uncharacterized protein. (499 aa)
MYH14Myosin heavy chain 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2034 aa)
TMIETransmembrane inner ear. (149 aa)
CCDC50Coiled-coil domain containing 50. (481 aa)
PTPRQProtein tyrosine phosphatase receptor type Q. (2192 aa)
COCHCochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. (553 aa)
ENSCPOP00000029185Uncharacterized protein. (516 aa)
RAB3ARAB3A, member RAS oncogene family. (220 aa)
ENSCPOP00000028869Uncharacterized protein. (609 aa)
LOC100727296Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase. (474 aa)
CDKN2DCyclin dependent kinase inhibitor 2D. (166 aa)
CLIC5Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (252 aa)
MKKSMcKusick-Kaufman syndrome. (575 aa)
THRBThyroid hormone receptor beta. (475 aa)
TriobpPH domain-containing protein. (630 aa)
ENSCPOP00000027396Uncharacterized protein. (258 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1133 aa)
SIX1SIX homeobox 1. (284 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (346 aa)
ENSCPOP00000027148Uncharacterized protein. (278 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (639 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (358 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (834 aa)
LHFPL4LHFPL tetraspan subfamily member 4. (247 aa)
ROR1Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (931 aa)
FYNTyrosine-protein kinase. (537 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
CLRN1Clarin 1. (232 aa)
PKHD1L1PKHD1 like 1. (4269 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (397 aa)
MYO6Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1294 aa)
GRAPGRB2 related adaptor protein. (217 aa)
ENSCPOP00000024297Uncharacterized protein. (406 aa)
PHF24PHD finger protein 24. (400 aa)
EPYCEpiphycan. (319 aa)
AQP4Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (323 aa)
BIRC5Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (By simi [...] (142 aa)
ASIC3Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (532 aa)
ALMS1ALMS1 centrosome and basal body associated protein. (3698 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
Snai2Uncharacterized protein. (268 aa)
Ndufs4Uncharacterized protein. (175 aa)
OTOSOtospiralin; May be essential for the survival of the neurosensory epithelium of the inner ear. (87 aa)
HOXA1Homeobox A1. (333 aa)
GJB6Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (261 aa)
TBX18T-box transcription factor 18. (606 aa)
PJVKPejvakin. (352 aa)
ASIC2Acid sensing ion channel subunit 2; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (493 aa)
MYO7AMyosin VIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2203 aa)
CHRNA10Cholinergic receptor nicotinic alpha 10 subunit. (447 aa)
H0WA79_CAVPOANF_receptor domain-containing protein. (187 aa)
WFS1Wolframin ER transmembrane glycoprotein. (888 aa)
KCNK4Potassium two pore domain channel subfamily K member 4; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (392 aa)
BARHL1BarH like homeobox 1. (327 aa)
MAP1AMicrotubule associated protein 1A. (2915 aa)
POU4F3POU domain protein. (338 aa)
CEACAM16Carcinoembryonic antigen related cell adhesion molecule 16. (424 aa)
LOC100726021Uncharacterized protein. (1725 aa)
H0W3X9_CAVPOUncharacterized protein. (2048 aa)
LHFPL5LHFPL tetraspan subfamily member 5. (219 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1296 aa)
H0W2T6_CAVPOUncharacterized protein. (189 aa)
CRYMCrystallin mu. (314 aa)
COL11A2Collagen type XI alpha 2 chain. (1689 aa)
HPNHepsin; Belongs to the peptidase S1 family. (433 aa)
GRM7Glutamate metabotropic receptor 7. (922 aa)
LHFPL3LHFPL tetraspan subfamily member 3. (226 aa)
SLC9A3R2Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (337 aa)
NAV2Neuron navigator 2. (2385 aa)
CABP2Calcium binding protein 2. (221 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1; Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity). Associates with KCNE beta subunits that modulates current kinetics (By similarity). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac r [...] (671 aa)
GRXCR1Glutaredoxin and cysteine rich domain containing 1. (290 aa)
OTOGLOtogelin like. (2177 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1156 aa)
H0VU16_CAVPOOccludin_ELL domain-containing protein. (144 aa)
SCN8ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1876 aa)
Fam107bUncharacterized protein. (153 aa)
TMC2Transmembrane channel-like protein. (868 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (900 aa)
GABRB2Gamma-aminobutyric acid type A receptor beta2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (512 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (837 aa)
HOMER2Homer scaffold protein 2. (357 aa)
SLC12A2Solute carrier family 12 member 2. (1136 aa)
OTOAOtoancorin. (1143 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (538 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (153 aa)
SPNS2Sphingolipid transporter 2. (549 aa)
H0VQ66_CAVPOUncharacterized protein. (336 aa)
POU4F2POU domain protein. (408 aa)
H0VPD8_CAVPOUncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (749 aa)
P2RX2P2X purinoceptor 2; Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle (By similarity); Belongs to the P2X receptor family. (411 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2996 aa)
LOC100730761Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (418 aa)
SCARB2Scavenger receptor class B member 2; Belongs to the CD36 family. (439 aa)
MYO1AMyosin IA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1043 aa)
SOBPSine oculis binding protein homolog. (707 aa)
DDIT3DNA damage inducible transcript 3. (167 aa)
COL11A1Collagen type XI alpha 1 chain. (1712 aa)
THTyrosine hydroxylase. (498 aa)
CHRNA5Cholinergic receptor nicotinic alpha 5 subunit. (438 aa)
GJC3Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (256 aa)
TBX1T-box transcription factor 1. (360 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (891 aa)
TMPRSS3Transmembrane serine protease 3; Belongs to the peptidase S1 family. (475 aa)
TECTATectorin alpha. (2151 aa)
Trpa1ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (991 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (970 aa)
CNTN5Contactin 5. (1099 aa)
AXIN1Axin 1. (863 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1754 aa)
HexaBeta-hexosaminidase. (527 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits [...] (839 aa)
TMTC4Transmembrane O-mannosyltransferase targeting cadherins 4. (742 aa)
LOXHD1Lipoxygenase homology domains 1. (2070 aa)
SPTBN4Spectrin beta chain; Belongs to the spectrin family. (2530 aa)
SLC17A8Solute carrier family 17 member 8. (476 aa)
CHRNA9Cholinergic receptor nicotinic alpha 9 subunit. (465 aa)
SERPINB6Serpin B6; Belongs to the serpin family. (378 aa)
NIPBLNipped-B protein. (2721 aa)
SLC26A5Prestin; Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (744 aa)
RIPOR2RHO family interacting cell polarization regulator 2. (1062 aa)
USH2AUsherin. (5190 aa)
CFAP57Cilia and flagella associated protein 57. (1249 aa)
SLC1A3Amino acid transporter. (542 aa)
ESPNLEspin like. (905 aa)
LRIG2Leucine rich repeats and immunoglobulin like domains 2. (1063 aa)
FGFR1Fibroblast growth factor receptor. (822 aa)
ATP8B1Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1146 aa)
HEXBHexosaminidase subunit beta. (442 aa)
TMEM120ATransmembrane protein 120A. (343 aa)
TECTBTectorin beta. (329 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1381 aa)
USH1GUSH1 protein network component sans. (462 aa)
GABRB3Gamma-aminobutyric acid type A receptor beta3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (441 aa)
KCNQ4Potassium voltage-gated channel subfamily Q member 4; Belongs to the potassium channel family. (699 aa)
KCNA1Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa)
TSPEARThrombospondin type laminin G domain and EAR repeats. (652 aa)
CEMIPCell migration inducing hyaluronidase 1. (1363 aa)
GABRA5Gamma-aminobutyric acid type A receptor alpha5 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (462 aa)
P2rx4Uncharacterized protein. (343 aa)
H0V266_CAVPOUncharacterized protein. (2204 aa)
EPS8L2EPS8 like 2. (717 aa)
SLC52A3Solute carrier family 52 member 3. (463 aa)
MYO15AMyosin XVA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (3221 aa)
SRRM4Serine/arginine repetitive matrix 4. (608 aa)
DCDC2Doublecortin domain containing 2. (469 aa)
GRXCR2Glutaredoxin and cysteine rich domain containing 2. (246 aa)
COL1A1Collagen type I alpha 1 chain. (1454 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (484 aa)
NTRK1Tyrosine-protein kinase receptor. (798 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (189 aa)
PGAP1GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI- anchored proteins from the endoplasmic reticulum to the Golgi. (872 aa)
CDH23Cadherin related 23. (3350 aa)
TMC1Transmembrane channel-like protein. (761 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1997 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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