45 items (Cavia porcellus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Trpa1	ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (991 aa)
	WHRN	Whirlin. (916 aa)
	Pdzd7	Uncharacterized protein. (553 aa)
	PAWR	Pro-apoptotic WT1 regulator. (307 aa)
	SCN1A	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1997 aa)
	TMC1	Transmembrane channel-like protein. (761 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (189 aa)
	NTRK1	Tyrosine-protein kinase receptor. (798 aa)
	CACNB3	Calcium voltage-gated channel auxiliary subunit beta 3. (484 aa)
	H0V266_CAVPO	Uncharacterized protein. (2204 aa)
	KCNA1	Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa)
	GRIN2B	Glutamate ionotropic receptor NMDA type subunit 2B. (1381 aa)
	TMEM120A	Transmembrane protein 120A. (343 aa)
	CHRNA9	Cholinergic receptor nicotinic alpha 9 subunit. (465 aa)
	KIT	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (970 aa)
	CHRNA5	Cholinergic receptor nicotinic alpha 5 subunit. (438 aa)
	COL11A1	Collagen type XI alpha 1 chain. (1712 aa)
	H0VQ66_CAVPO	Uncharacterized protein. (336 aa)
	SLC12A2	Solute carrier family 12 member 2. (1136 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (837 aa)
	TMC2	Transmembrane channel-like protein. (868 aa)
	ITGA2	Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1156 aa)
	KCNQ1	Potassium voltage-gated channel subfamily KQT member 1; Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity). Associates with KCNE beta subunits that modulates current kinetics (By similarity). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac r [...] (671 aa)
	HPN	Hepsin; Belongs to the peptidase S1 family. (433 aa)
	ATP2B2	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1296 aa)
	LHFPL5	LHFPL tetraspan subfamily member 5. (219 aa)
	LOC100726021	Uncharacterized protein. (1725 aa)
	KCNK4	Potassium two pore domain channel subfamily K member 4; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (392 aa)
	H0WA79_CAVPO	ANF_receptor domain-containing protein. (187 aa)
	CHRNA10	Cholinergic receptor nicotinic alpha 10 subunit. (447 aa)
	ASIC2	Acid sensing ion channel subunit 2; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (493 aa)
	PJVK	Pejvakin. (352 aa)
	CXCL12	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
	ASIC3	Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (532 aa)
	PHF24	PHD finger protein 24. (400 aa)
	SERPINE2	Serpin family E member 2; Belongs to the serpin family. (397 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	ENSCPOP00000027148	Uncharacterized protein. (278 aa)
	CXCR4	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (346 aa)
	MKKS	McKusick-Kaufman syndrome. (575 aa)
	ENSCPOP00000028869	Uncharacterized protein. (609 aa)
	PTPRQ	Protein tyrosine phosphatase receptor type Q. (2192 aa)
	ENSCPOP00000030659	G_PROTEIN_RECEP_F3_4 domain-containing protein. (497 aa)
	PCDH15	Protocadherin related 15. (1913 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASIC2	ASIC3	ENSCPOP00000020959	ENSCPOP00000023267	Acid sensing ion channel subunit 2; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	0.934
ASIC3	ASIC2	ENSCPOP00000023267	ENSCPOP00000020959	Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	Acid sensing ion channel subunit 2; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	0.934
ASIC3	Trpa1	ENSCPOP00000023267	ENSCPOP00000010361	Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family.	0.514
CACNB3	SCN1A	ENSCPOP00000002962	ENSCPOP00000002422	Calcium voltage-gated channel auxiliary subunit beta 3.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.768
CHRNA10	CHRNA5	ENSCPOP00000020255	ENSCPOP00000011309	Cholinergic receptor nicotinic alpha 10 subunit.	Cholinergic receptor nicotinic alpha 5 subunit.	0.524
CHRNA10	CHRNA9	ENSCPOP00000020255	ENSCPOP00000007501	Cholinergic receptor nicotinic alpha 10 subunit.	Cholinergic receptor nicotinic alpha 9 subunit.	0.683
CHRNA10	LOC100726021	ENSCPOP00000020255	ENSCPOP00000018111	Cholinergic receptor nicotinic alpha 10 subunit.	Uncharacterized protein.	0.586
CHRNA5	CHRNA10	ENSCPOP00000011309	ENSCPOP00000020255	Cholinergic receptor nicotinic alpha 5 subunit.	Cholinergic receptor nicotinic alpha 10 subunit.	0.524
CHRNA5	CHRNA9	ENSCPOP00000011309	ENSCPOP00000007501	Cholinergic receptor nicotinic alpha 5 subunit.	Cholinergic receptor nicotinic alpha 9 subunit.	0.683
CHRNA9	CHRNA10	ENSCPOP00000007501	ENSCPOP00000020255	Cholinergic receptor nicotinic alpha 9 subunit.	Cholinergic receptor nicotinic alpha 10 subunit.	0.683
CHRNA9	CHRNA5	ENSCPOP00000007501	ENSCPOP00000011309	Cholinergic receptor nicotinic alpha 9 subunit.	Cholinergic receptor nicotinic alpha 5 subunit.	0.683
CHRNA9	LOC100726021	ENSCPOP00000007501	ENSCPOP00000018111	Cholinergic receptor nicotinic alpha 9 subunit.	Uncharacterized protein.	0.460
COL11A1	CXCL12	ENSCPOP00000011361	ENSCPOP00000022617	Collagen type XI alpha 1 chain.	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family.	0.426
COL11A1	ITGA2	ENSCPOP00000011361	ENSCPOP00000014204	Collagen type XI alpha 1 chain.	Integrin subunit alpha 2; Belongs to the integrin alpha chain family.	0.507
CXCL12	COL11A1	ENSCPOP00000022617	ENSCPOP00000011361	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family.	Collagen type XI alpha 1 chain.	0.426
CXCL12	CXCR4	ENSCPOP00000022617	ENSCPOP00000027222	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family.	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.998
CXCL12	KIT	ENSCPOP00000022617	ENSCPOP00000010258	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family.	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.585
CXCL12	TLR4	ENSCPOP00000022617	ENSCPOP00000013667	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.512
CXCR4	CXCL12	ENSCPOP00000027222	ENSCPOP00000022617	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family.	0.998
CXCR4	FYN	ENSCPOP00000027222	ENSCPOP00000025358	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	Tyrosine-protein kinase.	0.448