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GNL3L | G protein nucleolar 3 like. (574 aa) | ||||
TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (249 aa) | ||||
DFFB | DNA fragmentation factor subunit beta. (302 aa) | ||||
RAD17 | RAD17 checkpoint clamp loader component. (696 aa) | ||||
MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1336 aa) | ||||
THOC1 | THO complex 1. (657 aa) | ||||
SHLD2 | Shieldin complex subunit 2. (905 aa) | ||||
MEN1 | Menin 1. (615 aa) | ||||
SMCHD1 | Structural maintenance of chromosomes flexible hinge domain containing 1. (1945 aa) | ||||
DCP2 | Decapping mRNA 2. (422 aa) | ||||
ACVRL1 | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa) | ||||
BLM | BLM RecQ like helicase. (1405 aa) | ||||
H0UX17_CAVPO | BRCT domain-containing protein. (722 aa) | ||||
PPARG | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (504 aa) | ||||
Rad50 | Zinc-hook domain-containing protein. (1275 aa) | ||||
TNKS2 | Poly [ADP-ribose] polymerase. (1162 aa) | ||||
UBQLN4 | Ubiquilin 4. (593 aa) | ||||
ANKRD1 | Ankyrin repeat domain 1. (319 aa) | ||||
CTC1 | CST telomere replication complex component 1. (1206 aa) | ||||
MLH1 | MutL homolog 1. (758 aa) | ||||
Dnmt3l | PHD-type domain-containing protein. (359 aa) | ||||
ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) | ||||
DONSON | Downstream neighbor of SON. (553 aa) | ||||
H0V4A5_CAVPO | Uncharacterized protein. (830 aa) | ||||
BRCA2 | BRCA2 DNA repair associated. (3151 aa) | ||||
GZMA | Granzyme A; Belongs to the peptidase S1 family. (261 aa) | ||||
Ahr | Uncharacterized protein. (832 aa) | ||||
Trim28 | Uncharacterized protein. (829 aa) | ||||
Kmt2a | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (2938 aa) | ||||
Ankle1 | Uncharacterized protein. (520 aa) | ||||
FOXP3 | Forkhead box P3. (432 aa) | ||||
ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2539 aa) | ||||
FBXO5 | F-box protein 5. (450 aa) | ||||
TRIP12 | Thyroid hormone receptor interactor 12. (1959 aa) | ||||
GMNN | Geminin DNA replication inhibitor. (209 aa) | ||||
DNAJC2 | DnaJ heat shock protein family (Hsp40) member C2. (604 aa) | ||||
PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (463 aa) | ||||
GATA3 | GATA binding protein 3. (443 aa) | ||||
OGG1 | 8-oxoguanine DNA glycosylase. (303 aa) | ||||
DFFA | DNA fragmentation factor subunit alpha. (331 aa) | ||||
NDFIP1 | Nedd4 family interacting protein 1. (209 aa) | ||||
UBR5 | Ubiquitin protein ligase E3 component n-recognin 5. (2649 aa) | ||||
TERF1 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (409 aa) | ||||
PARPBP | PARP1 binding protein. (577 aa) | ||||
H0VGS2_CAVPO | Uncharacterized protein. (611 aa) | ||||
FBH1 | F-box DNA helicase 1. (1012 aa) | ||||
Cgas | Mab-21 domain-containing protein. (387 aa) | ||||
ACD | ACD shelterin complex subunit and telomerase recruitment factor. (421 aa) | ||||
ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3031 aa) | ||||
H1-0 | H1 histone family member 0. (194 aa) | ||||
MSH3 | MutS homolog 3. (1047 aa) | ||||
KLHL15 | Kelch like family member 15. (604 aa) | ||||
KCNK2 | Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (426 aa) | ||||
ENSCPOP00000032936 | H15 domain-containing protein. (272 aa) | ||||
XRCC4 | X-ray repair cross complementing 4. (333 aa) | ||||
NMNAT1 | Nicotinamide-nucleotide adenylyltransferase. (280 aa) | ||||
HSF1 | Heat shock transcription factor 1. (555 aa) | ||||
HCRT | Hypocretin neuropeptide precursor. (110 aa) | ||||
NUDT16L1 | Nudix hydrolase 16 like 1. (211 aa) | ||||
EXOSC10 | Exosome component 10. (901 aa) | ||||
XRCC1 | X-ray repair cross complementing 1. (629 aa) | ||||
ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1473 aa) | ||||
TERF2 | Telomeric repeat binding factor 2. (542 aa) | ||||
ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (300 aa) | ||||
NAT10 | RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1030 aa) | ||||
POT1 | Protection of telomeres 1. (652 aa) | ||||
TSPYL2 | TSPY like 2; Belongs to the nucleosome assembly protein (NAP) family. (621 aa) | ||||
ENSCPOP00000030006 | H15 domain-containing protein. (273 aa) | ||||
RMI2 | RecQ mediated genome instability 2. (147 aa) | ||||
TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (423 aa) | ||||
ENSCPOP00000029646 | RRM domain-containing protein. (236 aa) | ||||
ENSCPOP00000029431 | Uncharacterized protein. (111 aa) | ||||
TNKS | Poly [ADP-ribose] polymerase. (1327 aa) | ||||
BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1035 aa) | ||||
SHLD1 | Shieldin complex subunit 1. (216 aa) | ||||
Rps3 | KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa) | ||||
LOC100712757 | TINF2_N domain-containing protein. (397 aa) | ||||
BCL6 | BCL6 transcription repressor. (705 aa) | ||||
Ten1 | Uncharacterized protein. (122 aa) | ||||
ZNF830 | Zinc finger protein 830. (363 aa) | ||||
PINX1 | PIN2 (TERF1) interacting telomerase inhibitor 1. (325 aa) | ||||
ADIPOQ | Adiponectin, C1Q and collagen domain containing. (247 aa) | ||||
DACH1 | Dachshund family transcription factor 1. (750 aa) | ||||
DUSP1 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (368 aa) | ||||
INPPL1 | Inositol polyphosphate phosphatase like 1. (1267 aa) | ||||
CDKN1A | Cyclin dependent kinase inhibitor 1A. (169 aa) | ||||
STN1 | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (375 aa) | ||||
ENSCPOP00000025455 | Protein kinase domain-containing protein. (360 aa) | ||||
XRCC5 | X-ray repair cross complementing 5. (739 aa) | ||||
Gdf1 | TGF_BETA_2 domain-containing protein. (367 aa) | ||||
ENSCPOP00000024428 | PARP-type domain-containing protein. (104 aa) | ||||
TIMELESS | Timeless circadian regulator. (1239 aa) | ||||
ATG7 | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (699 aa) | ||||
SLX4 | SLX4 structure-specific endonuclease subunit. (1738 aa) | ||||
SUB1 | SUB1 regulator of transcription. (127 aa) | ||||
WAPL | WAPL cohesin release factor. (1210 aa) | ||||
RIF1 | Replication timing regulatory factor 1. (2387 aa) | ||||
RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (989 aa) | ||||
OTUB2 | OTU deubiquitinase, ubiquitin aldehyde binding 2. (234 aa) | ||||
GMNC | Geminin coiled-coil domain containing. (341 aa) | ||||
H1-10 | H1 histone family member X. (185 aa) | ||||
AUNIP | Aurora kinase A and ninein interacting protein. (351 aa) | ||||
LOC101788961 | H15 domain-containing protein. (278 aa) | ||||
H1-2 | Histone cluster 1 H1 family member c. (213 aa) | ||||
NIBAN2 | Niban apoptosis regulator 2. (737 aa) | ||||
OTUB1 | Ubiquitin thioesterase. (271 aa) | ||||
NRM | Nurim. (203 aa) | ||||
LOC100732533 | Uncharacterized protein. (311 aa) | ||||
H0W7U6_CAVPO | H15 domain-containing protein. (269 aa) | ||||
CDT1 | Chromatin licensing and DNA replication factor 1. (549 aa) | ||||
CYREN | Cell cycle regulator of NHEJ. (180 aa) | ||||
H1-1 | Histone cluster 1 H1 family member a. (215 aa) | ||||
NPPC | Natriuretic peptide C. (126 aa) | ||||
MAD2L2 | Mitotic arrest deficient 2 like 2. (211 aa) | ||||
TERF2IP | TERF2 interacting protein. (371 aa) | ||||
LOC106027455 | H15 domain-containing protein. (211 aa) | ||||
MCIDAS | Multiciliate differentiation and DNA synthesis associated cell cycle protein. (389 aa) | ||||
H0VYV4_CAVPO | Uncharacterized protein. (260 aa) | ||||
Hnrnpa1 | RRM domain-containing protein. (324 aa) | ||||
Chek1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (439 aa) | ||||
RNF169 | Ring finger protein 169. (699 aa) | ||||
Parp1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa) | ||||
SMG6 | SMG6 nonsense mediated mRNA decay factor. (1420 aa) | ||||
LOC100735848 | TINF2_N domain-containing protein. (416 aa) | ||||
Rtel1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1246 aa) | ||||
MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa) | ||||
RAD18 | RAD18 E3 ubiquitin protein ligase. (493 aa) | ||||
PARP3 | Poly [ADP-ribose] polymerase. (533 aa) | ||||
RGN | Regucalcin. (299 aa) | ||||
GTPBP4 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (634 aa) | ||||
NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (751 aa) | ||||
HELB | DNA helicase B. (1063 aa) | ||||
MAPK15 | Mitogen-activated protein kinase. (539 aa) | ||||
CDAN1 | Codanin 1. (1147 aa) | ||||
H0VN16_CAVPO | Uncharacterized protein. (71 aa) | ||||
LIG3 | DNA ligase. (1012 aa) | ||||
FLCN | Folliculin. (579 aa) | ||||
SMARCAL1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (938 aa) | ||||
GDF2 | Growth differentiation factor 2. (411 aa) | ||||
HNRNPU | Heterogeneous nuclear ribonucleoprotein U. (822 aa) | ||||
TENT4B | Terminal nucleotidyltransferase 4B. (673 aa) | ||||
PDS5A | PDS5 cohesin associated factor A. (1337 aa) |