STRINGSTRING
HCRT HCRT XRCC5 XRCC5 NUDT16L1 NUDT16L1 EXOSC10 EXOSC10 XRCC1 XRCC1 ERCC6 ERCC6 TERF2 TERF2 ERCC1 ERCC1 NAT10 NAT10 POT1 POT1 TSPYL2 TSPYL2 ENSCPOP00000030006 ENSCPOP00000030006 Rtel1 Rtel1 MSH2 MSH2 RAD18 RAD18 PARP3 PARP3 RMI2 RMI2 TP53 TP53 ENSCPOP00000029646 ENSCPOP00000029646 ENSCPOP00000029431 ENSCPOP00000029431 TNKS TNKS BMPR2 BMPR2 SHLD1 SHLD1 Rps3 Rps3 RGN RGN GTPBP4 GTPBP4 NBN NBN HELB HELB MAPK15 MAPK15 CDAN1 CDAN1 H0VN16_CAVPO H0VN16_CAVPO LIG3 LIG3 FLCN FLCN SMARCAL1 SMARCAL1 GDF2 GDF2 HNRNPU HNRNPU TENT4B TENT4B PDS5A PDS5A H1-0 H1-0 MSH3 MSH3 ATM ATM ACD ACD Cgas Cgas FBH1 FBH1 H0VGS2_CAVPO H0VGS2_CAVPO PARPBP PARPBP TERF1 TERF1 UBR5 UBR5 NDFIP1 NDFIP1 DFFA DFFA OGG1 OGG1 GATA3 GATA3 PIF1 PIF1 DNAJC2 DNAJC2 GMNN GMNN TRIP12 TRIP12 FBXO5 FBXO5 ATR ATR FOXP3 FOXP3 Ankle1 Ankle1 Kmt2a Kmt2a Trim28 Trim28 Ahr Ahr GZMA GZMA BRCA2 BRCA2 H0V4A5_CAVPO H0V4A5_CAVPO DONSON DONSON ERCC4 ERCC4 Dnmt3l Dnmt3l MLH1 MLH1 CTC1 CTC1 ANKRD1 ANKRD1 DFFB DFFB TIPIN TIPIN UBQLN4 UBQLN4 TNKS2 TNKS2 Rad50 Rad50 PPARG PPARG H0UX17_CAVPO H0UX17_CAVPO BLM BLM ACVRL1 ACVRL1 DCP2 DCP2 SMCHD1 SMCHD1 MEN1 MEN1 SHLD2 SHLD2 THOC1 THOC1 MSH6 MSH6 RAD17 RAD17 LOC100712757 LOC100712757 BCL6 BCL6 Ten1 Ten1 ZNF830 ZNF830 PINX1 PINX1 ADIPOQ ADIPOQ DACH1 DACH1 DUSP1 DUSP1 INPPL1 INPPL1 KLHL15 KLHL15 KCNK2 KCNK2 ENSCPOP00000032936 ENSCPOP00000032936 XRCC4 XRCC4 Gdf1 Gdf1 ENSCPOP00000024428 ENSCPOP00000024428 TIMELESS TIMELESS ATG7 ATG7 SLX4 SLX4 SUB1 SUB1 WAPL WAPL RIF1 RIF1 RECQL5 RECQL5 OTUB2 OTUB2 GMNC GMNC H1-10 H1-10 AUNIP AUNIP LOC101788961 LOC101788961 H1-2 H1-2 NIBAN2 NIBAN2 OTUB1 OTUB1 NRM NRM LOC100732533 LOC100732533 H0W7U6_CAVPO H0W7U6_CAVPO CDT1 CDT1 CYREN CYREN H1-1 H1-1 NPPC NPPC MAD2L2 MAD2L2 TERF2IP TERF2IP LOC106027455 LOC106027455 MCIDAS MCIDAS H0VYV4_CAVPO H0VYV4_CAVPO Hnrnpa1 Hnrnpa1 Chek1 Chek1 RNF169 RNF169 Parp1 Parp1 GNL3L GNL3L STN1 STN1 ENSCPOP00000025455 ENSCPOP00000025455 NMNAT1 NMNAT1 SMG6 SMG6 LOC100735848 LOC100735848 HSF1 HSF1 CDKN1A CDKN1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HCRTHypocretin neuropeptide precursor. (110 aa)
XRCC5X-ray repair cross complementing 5. (739 aa)
NUDT16L1Nudix hydrolase 16 like 1. (211 aa)
EXOSC10Exosome component 10. (901 aa)
XRCC1X-ray repair cross complementing 1. (629 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1473 aa)
TERF2Telomeric repeat binding factor 2. (542 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (300 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1030 aa)
POT1Protection of telomeres 1. (652 aa)
TSPYL2TSPY like 2; Belongs to the nucleosome assembly protein (NAP) family. (621 aa)
ENSCPOP00000030006H15 domain-containing protein. (273 aa)
Rtel1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1246 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
RAD18RAD18 E3 ubiquitin protein ligase. (493 aa)
PARP3Poly [ADP-ribose] polymerase. (533 aa)
RMI2RecQ mediated genome instability 2. (147 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (423 aa)
ENSCPOP00000029646RRM domain-containing protein. (236 aa)
ENSCPOP00000029431Uncharacterized protein. (111 aa)
TNKSPoly [ADP-ribose] polymerase. (1327 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1035 aa)
SHLD1Shieldin complex subunit 1. (216 aa)
Rps3KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
RGNRegucalcin. (299 aa)
GTPBP4Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (634 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (751 aa)
HELBDNA helicase B. (1063 aa)
MAPK15Mitogen-activated protein kinase. (539 aa)
CDAN1Codanin 1. (1147 aa)
H0VN16_CAVPOUncharacterized protein. (71 aa)
LIG3DNA ligase. (1012 aa)
FLCNFolliculin. (579 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (938 aa)
GDF2Growth differentiation factor 2. (411 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (822 aa)
TENT4BTerminal nucleotidyltransferase 4B. (673 aa)
PDS5APDS5 cohesin associated factor A. (1337 aa)
H1-0H1 histone family member 0. (194 aa)
MSH3MutS homolog 3. (1047 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3031 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (421 aa)
CgasMab-21 domain-containing protein. (387 aa)
FBH1F-box DNA helicase 1. (1012 aa)
H0VGS2_CAVPOUncharacterized protein. (611 aa)
PARPBPPARP1 binding protein. (577 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (409 aa)
UBR5Ubiquitin protein ligase E3 component n-recognin 5. (2649 aa)
NDFIP1Nedd4 family interacting protein 1. (209 aa)
DFFADNA fragmentation factor subunit alpha. (331 aa)
OGG18-oxoguanine DNA glycosylase. (303 aa)
GATA3GATA binding protein 3. (443 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (463 aa)
DNAJC2DnaJ heat shock protein family (Hsp40) member C2. (604 aa)
GMNNGeminin DNA replication inhibitor. (209 aa)
TRIP12Thyroid hormone receptor interactor 12. (1959 aa)
FBXO5F-box protein 5. (450 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2539 aa)
FOXP3Forkhead box P3. (432 aa)
Ankle1Uncharacterized protein. (520 aa)
Kmt2aHistone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (2938 aa)
Trim28Uncharacterized protein. (829 aa)
AhrUncharacterized protein. (832 aa)
GZMAGranzyme A; Belongs to the peptidase S1 family. (261 aa)
BRCA2BRCA2 DNA repair associated. (3151 aa)
H0V4A5_CAVPOUncharacterized protein. (830 aa)
DONSONDownstream neighbor of SON. (553 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
Dnmt3lPHD-type domain-containing protein. (359 aa)
MLH1MutL homolog 1. (758 aa)
CTC1CST telomere replication complex component 1. (1206 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
DFFBDNA fragmentation factor subunit beta. (302 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (249 aa)
UBQLN4Ubiquilin 4. (593 aa)
TNKS2Poly [ADP-ribose] polymerase. (1162 aa)
Rad50Zinc-hook domain-containing protein. (1275 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (504 aa)
H0UX17_CAVPOBRCT domain-containing protein. (722 aa)
BLMBLM RecQ like helicase. (1405 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
DCP2Decapping mRNA 2. (422 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain containing 1. (1945 aa)
MEN1Menin 1. (615 aa)
SHLD2Shieldin complex subunit 2. (905 aa)
THOC1THO complex 1. (657 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1336 aa)
RAD17RAD17 checkpoint clamp loader component. (696 aa)
LOC100712757TINF2_N domain-containing protein. (397 aa)
BCL6BCL6 transcription repressor. (705 aa)
Ten1Uncharacterized protein. (122 aa)
ZNF830Zinc finger protein 830. (363 aa)
PINX1PIN2 (TERF1) interacting telomerase inhibitor 1. (325 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (247 aa)
DACH1Dachshund family transcription factor 1. (750 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (368 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1267 aa)
KLHL15Kelch like family member 15. (604 aa)
KCNK2Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (426 aa)
ENSCPOP00000032936H15 domain-containing protein. (272 aa)
XRCC4X-ray repair cross complementing 4. (333 aa)
Gdf1TGF_BETA_2 domain-containing protein. (367 aa)
ENSCPOP00000024428PARP-type domain-containing protein. (104 aa)
TIMELESSTimeless circadian regulator. (1239 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (699 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1738 aa)
SUB1SUB1 regulator of transcription. (127 aa)
WAPLWAPL cohesin release factor. (1210 aa)
RIF1Replication timing regulatory factor 1. (2387 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (989 aa)
OTUB2OTU deubiquitinase, ubiquitin aldehyde binding 2. (234 aa)
GMNCGeminin coiled-coil domain containing. (341 aa)
H1-10H1 histone family member X. (185 aa)
AUNIPAurora kinase A and ninein interacting protein. (351 aa)
LOC101788961H15 domain-containing protein. (278 aa)
H1-2Histone cluster 1 H1 family member c. (213 aa)
NIBAN2Niban apoptosis regulator 2. (737 aa)
OTUB1Ubiquitin thioesterase. (271 aa)
NRMNurim. (203 aa)
LOC100732533Uncharacterized protein. (311 aa)
H0W7U6_CAVPOH15 domain-containing protein. (269 aa)
CDT1Chromatin licensing and DNA replication factor 1. (549 aa)
CYRENCell cycle regulator of NHEJ. (180 aa)
H1-1Histone cluster 1 H1 family member a. (215 aa)
NPPCNatriuretic peptide C. (126 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (211 aa)
TERF2IPTERF2 interacting protein. (371 aa)
LOC106027455H15 domain-containing protein. (211 aa)
MCIDASMulticiliate differentiation and DNA synthesis associated cell cycle protein. (389 aa)
H0VYV4_CAVPOUncharacterized protein. (260 aa)
Hnrnpa1RRM domain-containing protein. (324 aa)
Chek1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (439 aa)
RNF169Ring finger protein 169. (699 aa)
Parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa)
GNL3LG protein nucleolar 3 like. (574 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (375 aa)
ENSCPOP00000025455Protein kinase domain-containing protein. (360 aa)
NMNAT1Nicotinamide-nucleotide adenylyltransferase. (280 aa)
SMG6SMG6 nonsense mediated mRNA decay factor. (1420 aa)
LOC100735848TINF2_N domain-containing protein. (416 aa)
HSF1Heat shock transcription factor 1. (555 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (169 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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