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| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (573 aa) |
| | ENSCPOP00000033122 | MPN domain-containing protein. (250 aa) |
| | CD28 | CD28 molecule. (222 aa) |
| | E2F8 | E2F transcription factor 8. (860 aa) |
| | CTNNB1 | Catenin beta 1. (781 aa) |
| | ACTL6A | Actin like 6A; Belongs to the actin family. (429 aa) |
| | ARRB2 | Arrestin beta 2. (417 aa) |
| | DTX3L | Deltex E3 ubiquitin ligase 3L. (719 aa) |
| | WT1 | WT1 transcription factor. (320 aa) |
| | RGCC | Regulator of cell cycle. (133 aa) |
| | MFSD11 | Major facilitator superfamily domain containing 11. (449 aa) |
| | LOC100722203 | BZIP domain-containing protein. (150 aa) |
| | CCT8 | Chaperonin containing TCP1 subunit 8. (553 aa) |
| | HSF1 | Heat shock transcription factor 1. (555 aa) |
| | CLCF1 | Cardiotrophin like cytokine factor 1. (223 aa) |
| | YEATS4 | YEATS domain containing 4. (227 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (192 aa) |
| | FGFR4 | Fibroblast growth factor receptor. (801 aa) |
| | CDC42 | Cell division cycle 42. (191 aa) |
| | XRCC1 | X-ray repair cross complementing 1. (629 aa) |
| | Il4 | Interleukin-4. (144 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1473 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (486 aa) |
| | TNFSF13 | TNF superfamily member 13; Belongs to the tumor necrosis factor family. (249 aa) |
| | TERF2 | Telomeric repeat binding factor 2. (542 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (300 aa) |
| | USP9X | Ubiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2558 aa) |
| | ENSCPOP00000030888 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (238 aa) |
| | ATF1 | Activating transcription factor 1. (269 aa) |
| | POT1 | Protection of telomeres 1. (652 aa) |
| | Camk2d | Protein kinase domain-containing protein. (532 aa) |
| | GREM1 | Gremlin. (184 aa) |
| | PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (334 aa) |
| | POGZ | Pogo transposable element derived with ZNF domain. (1412 aa) |
| | Morf4l1 | Mortality factor 4 like 1. (377 aa) |
| | EREG | Epiregulin. (164 aa) |
| | TNFAIP1 | TNF alpha induced protein 1. (316 aa) |
| | TNFSF4 | Tumor necrosis factor ligand 2B; Belongs to the tumor necrosis factor family. (185 aa) |
| | CST3 | Cystatin domain-containing protein; Belongs to the cystatin family. (141 aa) |
| | ENSCPOP00000029646 | RRM domain-containing protein. (236 aa) |
| | PFN1 | Profilin; Belongs to the profilin family. (140 aa) |
| | ENSCPOP00000029431 | Uncharacterized protein. (111 aa) |
| | PTGES3 | Prostaglandin E synthase 3. (160 aa) |
| | MBTD1 | Mbt domain containing 1. (627 aa) |
| | CRHR2 | Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. (436 aa) |
| | TNKS | Poly [ADP-ribose] polymerase. (1327 aa) |
| | DHX9 | DExH-box helicase 9. (1373 aa) |
| | ENSCPOP00000029129 | Protein kinase domain-containing protein. (254 aa) |
| | FAM168A | Family with sequence similarity 168 member A. (244 aa) |
| | SHLD1 | Shieldin complex subunit 1. (216 aa) |
| | ARID2 | AT-rich interaction domain 2. (1763 aa) |
| | CCT3 | T-complex protein 1 subunit gamma. (545 aa) |
| | PKIB | cAMP-dependent protein kinase inhibitor beta. (77 aa) |
| | LOC100728313 | RNase_PH domain-containing protein. (256 aa) |
| | EP400 | E1A binding protein p400. (3128 aa) |
| | BCL7B | BAF chromatin remodeling complex subunit BCL7B. (202 aa) |
| | FUS | FUS RNA binding protein. (490 aa) |
| | Rps3 | KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa) |
| | PTPRC | Protein tyrosine phosphatase receptor type C. (1307 aa) |
| | EYA1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa) |
| | HNRNPA2B1 | Heterogeneous nuclear ribonucleoprotein A2/B1. (369 aa) |
| | CYP1B1 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (540 aa) |
| | ENSCPOP00000028155 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (102 aa) |
| | HDGFL2 | HDGF like 2. (666 aa) |
| | MEAF6 | MYST/Esa1 associated factor 6. (171 aa) |
| | MMS19 | MMS19 homolog, cytosolic iron-sulfur assembly component. (1027 aa) |
| | UBE2V2 | Ubiquitin conjugating enzyme E2 V2. (145 aa) |
| | NPM2 | Nucleophosmin/nucleoplasmin 2. (183 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (358 aa) |
| | INO80C | INO80 complex subunit C. (192 aa) |
| | ENSCPOP00000027005 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (83 aa) |
| | TFRC | Transferrin receptor protein 1. (765 aa) |
| | PRKCQ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (705 aa) |
| | Cacybp | Uncharacterized protein. (230 aa) |
| | HNRNPD | Heterogeneous nuclear ribonucleoprotein D. (313 aa) |
| | EYA4 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (639 aa) |
| | ENSCPOP00000026288 | Uncharacterized protein. (201 aa) |
| | NOX4 | NADPH oxidase 4. (551 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | PRKCD | Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa) |
| | ENSCPOP00000026024 | T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (453 aa) |
| | STN1 | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (375 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa) |
| | MAS1 | MAS1 proto-oncogene, G protein-coupled receptor; Belongs to the G-protein coupled receptor 1 family. (322 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1214 aa) |
| | OGA | O-GlcNAcase. (878 aa) |
| | GINS1 | GINS complex subunit 1. (196 aa) |
| | GNL3 | G protein nucleolar 3. (518 aa) |
| | SPIRE2 | Spire type actin nucleation factor 2. (717 aa) |
| | NFRKB | Nuclear factor related to kappaB binding protein. (1298 aa) |
| | HGF | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa) |
| | PMS2 | PMS1 homolog 2, mismatch repair system component. (890 aa) |
| | UCHL5 | Ubiquitin carboxyl-terminal hydrolase. (324 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1194 aa) |
| | SIRT1 | Sirtuin 1. (717 aa) |
| | SLF2 | SMC5-SMC6 complex localization factor 2. (1141 aa) |
| | SHLD2 | Shieldin complex subunit 2. (905 aa) |
| | FAF1 | Fas associated factor 1. (555 aa) |
| | TGFB1 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa) |
| | PML | Promyelocytic leukemia. (849 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (371 aa) |
| | PAGR1 | PAXIP1 associated glutamate rich protein 1. (254 aa) |
| | SMCHD1 | Structural maintenance of chromosomes flexible hinge domain containing 1. (1945 aa) |
| | BLM | BLM RecQ like helicase. (1405 aa) |
| | H0UX17_CAVPO | BRCT domain-containing protein. (722 aa) |
| | KAT7 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (612 aa) |
| | Hsp90aa1 | Heat shock protein 90 alpha family class A member 1. (733 aa) |
| | CCT5 | Chaperonin containing TCP1 subunit 5. (541 aa) |
| | CCT4 | T-complex protein 1 subunit delta. (539 aa) |
| | Rad50 | Zinc-hook domain-containing protein. (1275 aa) |
| | TNKS2 | Poly [ADP-ribose] polymerase. (1162 aa) |
| | SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1051 aa) |
| | DDX39B | DExD-box helicase 39B. (428 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (514 aa) |
| | EPC1 | Enhancer of polycomb homolog 1. (763 aa) |
| | WRAP53 | WD repeat containing antisense to TP53. (541 aa) |
| | WRN | WRN RecQ like helicase. (1462 aa) |
| | USP7 | Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1101 aa) |
| | CTC1 | CST telomere replication complex component 1. (1206 aa) |
| | PRKD2 | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (865 aa) |
| | SSBP1 | Single stranded DNA binding protein 1. (137 aa) |
| | APLF | Aprataxin and PNKP like factor. (498 aa) |
| | DDX11 | DEAD/H-box helicase 11. (878 aa) |
| | HSP90AB1 | Heat shock protein 90 alpha family class B member 1. (723 aa) |
| | PRIM2 | DNA primase subunit 2. (432 aa) |
| | MLH1 | MutL homolog 1. (758 aa) |
| | Dnmt3l | PHD-type domain-containing protein. (359 aa) |
| | H0V4A5_CAVPO | Uncharacterized protein. (830 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1061 aa) |
| | PNKP | Polynucleotide kinase 3'-phosphatase. (523 aa) |
| | FGF2 | Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (114 aa) |
| | PDGFB | Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa) |
| | IGF1R | Tyrosine-protein kinase receptor. (1367 aa) |
| | Cdk1 | Protein kinase domain-containing protein. (240 aa) |
| | GLI1 | GLI family zinc finger 1. (1104 aa) |
| | GRHL2 | Grainyhead like transcription factor 2. (620 aa) |
| | Trim28 | Uncharacterized protein. (829 aa) |
| | PDGFRB | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1102 aa) |
| | KDM4D | Lysine demethylase 4D. (512 aa) |
| | FGFR1 | Fibroblast growth factor receptor. (822 aa) |
| | CIZ1 | CDKN1A interacting zinc finger protein 1. (867 aa) |
| | Babam1 | Uncharacterized protein. (337 aa) |
| | CCT6A | Chaperonin containing TCP1 subunit 6A. (531 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2539 aa) |
| | POLG2 | DNA polymerase gamma 2, accessory subunit. (482 aa) |
| | ACTR8 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa) |
| | OTUD4 | OTU deubiquitinase 4. (1076 aa) |
| | E2F7 | E2F transcription factor 7. (904 aa) |
| | NSD2 | Nuclear receptor binding SET domain protein 2. (1366 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (900 aa) |
| | DHX36 | DEAH-box helicase 36. (916 aa) |
| | CCDC117 | Coiled-coil domain containing 117. (278 aa) |
| | ATRX | ATRX chromatin remodeler. (2481 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (152 aa) |
| | DBF4 | DBF4 zinc finger. (675 aa) |
| | BRD8 | Bromodomain containing 8. (951 aa) |
| | EPC2 | Enhancer of polycomb homolog. (803 aa) |
| | EXOSC3 | Exosome component 3. (275 aa) |
| | RFC3 | Replication factor C subunit 3. (220 aa) |
| | DKC1 | Dyskerin pseudouridine synthase 1. (513 aa) |
| | KMT5C | Lysine methyltransferase 5C. (476 aa) |
| | HELQ | Helicase, POLQ like. (1054 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | MAPKAPK5 | MAPK activated protein kinase 5. (474 aa) |
| | RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa) |
| | TIGAR | TP53 induced glycolysis regulatory phosphatase. (265 aa) |
| | WIZ | WIZ zinc finger. (918 aa) |
| | CHTF18 | Chromosome transmission fidelity factor 18. (988 aa) |
| | BRPF3 | Bromodomain and PHD finger containing 3. (1208 aa) |
| | NAF1 | Nuclear assembly factor 1 ribonucleoprotein. (491 aa) |
| | UIMC1 | Ubiquitin interaction motif containing 1. (716 aa) |
| | ACD | ACD shelterin complex subunit and telomerase recruitment factor. (421 aa) |
| | TOX | Thymocyte selection associated high mobility group box. (526 aa) |
| | H0VI45_CAVPO | zf-C3Hc3H domain-containing protein. (414 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3031 aa) |
| | MCRS1 | Microspherule protein 1. (462 aa) |
| | RFC4 | Replication factor C subunit 4. (363 aa) |
| | NEK2 | NIMA related kinase 2. (442 aa) |
| | INO80 | INO80 complex ATPase subunit. (1558 aa) |
| | TFPT | TCF3 fusion partner. (257 aa) |
| | ACTR5 | Actin related protein 5; Belongs to the actin family. (602 aa) |
| | GFER | Sulfhydryl oxidase. (200 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1831 aa) |
| | BAZ1A | Bromodomain adjacent to zinc finger domain 1A. (1523 aa) |
| | INO80E | INO80 complex subunit E. (244 aa) |
| | STOML2 | Stomatin like 2. (356 aa) |
| | RFC2 | Replication factor C subunit 2. (352 aa) |
| | EYA3 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (497 aa) |
| | MECP2 | Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (504 aa) |
| | Ino80b | PAPA-1 domain-containing protein. (373 aa) |
| | CDC7 | Cell division cycle 7. (560 aa) |
| | ANXA3 | Annexin. (323 aa) |
| | STAT6 | Signal transducer and activator of transcription. (838 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (325 aa) |
| | LOC106026468 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (174 aa) |
| | MAPK15 | Mitogen-activated protein kinase. (539 aa) |
| | EYA2 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (529 aa) |
| | MAP3K4 | Mitogen-activated protein kinase kinase kinase 4. (1601 aa) |
| | MET | MET proto-oncogene, receptor tyrosine kinase. (1380 aa) |
| | LPIN1 | Lipin 1. (899 aa) |
| | Brca1 | Uncharacterized protein. (79 aa) |
| | TMEM161A | Transmembrane protein 161A. (474 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (751 aa) |
| | KCTD13 | Potassium channel tetramerization domain containing 13. (303 aa) |
| | PARP3 | Poly [ADP-ribose] polymerase. (533 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4043 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa) |
| | PARG | Poly(ADP-ribose) glycohydrolase. (973 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (423 aa) |
| | Rtel1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1246 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (386 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (706 aa) |
| | H0VS04_CAVPO | Hist_deacetyl domain-containing protein. (286 aa) |
| | NABP2 | Nucleic acid binding protein 2. (227 aa) |
| | FOXM1 | Forkhead box M1. (762 aa) |
| | PPP1R10 | Protein phosphatase 1 regulatory subunit 10. (883 aa) |
| | Parp1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa) |
| | Parp9 | Uncharacterized protein. (703 aa) |
| | APBB1 | Amyloid beta precursor protein binding family B member 1. (709 aa) |
| | Hnrnpa1 | RRM domain-containing protein. (324 aa) |
| | H0VYM4_CAVPO | Uncharacterized protein. (503 aa) |
| | H0VYV4_CAVPO | Uncharacterized protein. (260 aa) |
| | MAP2K7 | Mitogen-activated protein kinase kinase 7. (459 aa) |
| | WAS | WASP actin nucleation promoting factor. (505 aa) |
| | RFC5 | Replication factor C subunit 5. (340 aa) |
| | DMAP1 | DNA methyltransferase 1 associated protein 1. (445 aa) |
| | Yy1 | Uncharacterized protein. (195 aa) |
| | H0W392_CAVPO | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (341 aa) |
| | MAD2L2 | Mitotic arrest deficient 2 like 2. (211 aa) |
| | TBX21 | T-box transcription factor 21. (388 aa) |
| | ING3 | Inhibitor of growth protein. (418 aa) |
| | DERPC | DERPC proline and glycine rich nuclear protein. (531 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa) |
| | CDT1 | Chromatin licensing and DNA replication factor 1. (549 aa) |
| | NEK7 | NIMA related kinase 7; Belongs to the protein kinase superfamily. (270 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (486 aa) |
| | LOC100732533 | Uncharacterized protein. (311 aa) |
| | VPS72 | Vacuolar protein sorting 72 homolog. (364 aa) |
| | STPG4 | Sperm-tail PG-rich repeat containing 4. (241 aa) |
| | ENDOG | Endonuclease. (299 aa) |
| | H0WAZ8_CAVPO | Uncharacterized protein. (275 aa) |
| | NRM | Nurim. (203 aa) |
| | Slx1a | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (266 aa) |
| | H0WCZ5_CAVPO | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (316 aa) |
| | MRGBP | MRG domain binding protein. (204 aa) |
| | JUN | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (253 aa) |
| | LOC100736130 | Uncharacterized protein. (287 aa) |
| | IGFBP3 | Insulin like growth factor binding protein 3. (293 aa) |
| | PPARGC1A | PPARG coactivator 1 alpha. (796 aa) |
| | ACTR2 | Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa) |
| | ACTB | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa) |
| | PARN | Poly(A)-specific ribonuclease. (637 aa) |
| | RAC1 | Ras-related C3 botulinum toxin substrate 1. (211 aa) |
| | MGMT | O-6-methylguanine-DNA methyltransferase. (208 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (541 aa) |
| | ENSCPOP00000022509 | Uncharacterized protein. (140 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa) |
| | RIF1 | Replication timing regulatory factor 1. (2387 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa) |
| | FH | Fumarate hydratase. (508 aa) |
| | FBXO4 | F-box protein 4. (324 aa) |
| | NVL | Nuclear VCP like. (849 aa) |
| | BCAR3 | BCAR3 adaptor protein, NSP family member. (826 aa) |
| | LOC100725824 | HATPase_c domain-containing protein. (695 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1021 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1738 aa) |
| | ENSCPOP00000023362 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) |
| | Cct7 | T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (543 aa) |
| | TIMELESS | Timeless circadian regulator. (1239 aa) |
| | Exosc6 | RNase_PH domain-containing protein. (246 aa) |
| | PAK3 | Non-specific serine/threonine protein kinase. (559 aa) |
| | KMT5B | Lysine methyltransferase 5B. (882 aa) |
| | BRCC3 | BRCA1/BRCA2-containing complex subunit 3. (291 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa) |
| | TRRAP | Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. (3860 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | ENSCPOP00000024428 | PARP-type domain-containing protein. (104 aa) |
| | SPIRE1 | Spire type actin nucleation factor 1. (625 aa) |
| | GLI2 | GLI family zinc finger 2. (1570 aa) |
| | WDR48 | WD repeat domain 48. (676 aa) |
| | ENSCPOP00000024582 | MRG domain-containing protein. (291 aa) |
| | BCL7A | BAF chromatin remodeling complex subunit BCL7A. (188 aa) |
| | CBX8 | Chromobox 8. (389 aa) |
| | ENSCPOP00000024875 | MRG domain-containing protein. (231 aa) |
| | TCP1 | T-complex 1. (556 aa) |
| | GINS3 | GINS complex subunit 3. (216 aa) |
| | CD40 | CD40 molecule. (285 aa) |
| | XRCC5 | X-ray repair cross complementing 5. (739 aa) |
| | SMOC2 | SPARC related modular calcium binding 2. (447 aa) |
| | ERCC2 | ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa) |
