STRINGSTRING
GRPEL1 GRPEL1 BAK1 BAK1 Dnaja1 Dnaja1 KSR1 KSR1 DNAJA4 DNAJA4 TIMM44 TIMM44 SLC25A17 SLC25A17 St13 St13 USP13 USP13 HSPA9 HSPA9 WRAP53 WRAP53 SUGT1 SUGT1 HSPA8 HSPA8 TSC1 TSC1 AMFR AMFR Ahsa2p Ahsa2p Ahr Ahr AHSA1 AHSA1 DNAJC13 DNAJC13 PTGES3L PTGES3L Dnaja2 Dnaja2 BAG3 BAG3 GRN GRN FGB FGB FNIP2 FNIP2 TG TG Cnpy1 Cnpy1 BIRC2 BIRC2 ERP29 ERP29 DNAJB4 DNAJB4 Atp1a3 Atp1a3 DNAJB13 DNAJB13 PLG PLG PACRGL PACRGL DNAJC1 DNAJC1 BAG4 BAG4 CFTR CFTR FN1 FN1 DNAJC10 DNAJC10 SCARB2 SCARB2 Mapt Mapt PACRG PACRG HSCB HSCB GNB5 GNB5 SOD1 SOD1 SLC12A2 SLC12A2 DNAJB5 DNAJB5 CTSC CTSC PIH1D3 PIH1D3 TERT TERT DNAJC9 DNAJC9 BAG5 BAG5 HSPD1 HSPD1 H0W3X9_CAVPO H0W3X9_CAVPO ATP7A ATP7A STUB1 STUB1 DNLZ DNLZ BIN1 BIN1 Cnpy2 Cnpy2 ENSCPOP00000033036 ENSCPOP00000033036 GRPEL2 GRPEL2 CDC37 CDC37 ENSCPOP00000032931 ENSCPOP00000032931 CDKN1B CDKN1B ENSCPOP00000032487 ENSCPOP00000032487 FNIP1 FNIP1 ENSCPOP00000032121 ENSCPOP00000032121 UBL4B UBL4B BAX BAX ENSCPOP00000031634 ENSCPOP00000031634 ENSCPOP00000031515 ENSCPOP00000031515 GET4 GET4 SACS SACS TP53 TP53 TIMM9 TIMM9 HSPB6 HSPB6 PTGES3 PTGES3 BAG2 BAG2 ATP1A2 ATP1A2 LOC100715002 LOC100715002 PFDN6 PFDN6 CDC37L1 CDC37L1 UBL4A UBL4A DNAJB1 DNAJB1 Dnajb6 Dnajb6 DNAJC12 DNAJC12 ENSCPOP00000027159 ENSCPOP00000027159 TFRC TFRC SDF2L1 SDF2L1 HSPA2 HSPA2 DNAJB2 DNAJB2 ATP1A1 ATP1A1 DNAJC3 DNAJC3 FICD FICD ENSCPOP00000024297 ENSCPOP00000024297 ENSCPOP00000024193 ENSCPOP00000024193 DNAJB9 DNAJB9 STIP1 STIP1 CP CP Lbr Lbr TIMM10 TIMM10 DNAJB8 DNAJB8 Pdpn Pdpn SYVN1 SYVN1 HES1 HES1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GRPEL1GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family. (217 aa)
BAK1BCL2 antagonist/killer 1. (214 aa)
Dnaja1Uncharacterized protein. (397 aa)
KSR1Kinase suppressor of ras 1. (879 aa)
DNAJA4DnaJ heat shock protein family (Hsp40) member A4. (397 aa)
TIMM44Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family. (452 aa)
SLC25A17Solute carrier family 25 member 17; Belongs to the mitochondrial carrier (TC 2.A.29) family. (308 aa)
St13TPR_REGION domain-containing protein. (365 aa)
USP13Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (823 aa)
HSPA9Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family. (678 aa)
WRAP53WD repeat containing antisense to TP53. (541 aa)
SUGT1SGT1 homolog, MIS12 kinetochore complex assembly cochaperone. (273 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
TSC1TSC complex subunit 1. (1166 aa)
AMFRAutocrine motility factor receptor. (643 aa)
Ahsa2pAha1_N domain-containing protein. (331 aa)
AhrUncharacterized protein. (832 aa)
AHSA1Activator of HSP90 ATPase activity 1. (338 aa)
DNAJC13DnaJ heat shock protein family (Hsp40) member C13. (2223 aa)
PTGES3LProstaglandin E synthase 3 like. (149 aa)
Dnaja2Uncharacterized protein. (412 aa)
BAG3BCL2 associated athanogene 3. (572 aa)
GRNParagranulin; Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (By similarity). Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes (By similarity). Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB (By similarity). In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule str [...] (605 aa)
FGBFibrinogen beta chain. (479 aa)
FNIP2Folliculin interacting protein 2. (1079 aa)
TGThyroglobulin. (2742 aa)
Cnpy1DUF3456 domain-containing protein. (145 aa)
BIRC2Baculoviral IAP repeat containing 2. (615 aa)
ERP29Endoplasmic reticulum resident protein 29; Does not seem to be a disulfide isomerase. (261 aa)
DNAJB4DnaJ heat shock protein family (Hsp40) member B4. (337 aa)
Atp1a3Sodium/potassium-transporting ATPase subunit alpha. (1028 aa)
DNAJB13DnaJ heat shock protein family (Hsp40) member B13. (316 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (810 aa)
PACRGLParkin coregulated like. (251 aa)
DNAJC1DnaJ heat shock protein family (Hsp40) member C1. (523 aa)
BAG4BCL2 associated athanogene 4. (456 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1448 aa)
FN1Fibronectin 1. (2478 aa)
DNAJC10DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. (792 aa)
SCARB2Scavenger receptor class B member 2; Belongs to the CD36 family. (439 aa)
MaptMicrotubule-associated protein. (370 aa)
PACRGParkin coregulated. (241 aa)
HSCBHscB mitochondrial iron-sulfur cluster cochaperone. (235 aa)
GNB5G protein subunit beta 5. (406 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (153 aa)
SLC12A2Solute carrier family 12 member 2. (1136 aa)
DNAJB5DnaJ heat shock protein family (Hsp40) member B5. (382 aa)
CTSCCathepsin C; Belongs to the peptidase C1 family. (463 aa)
PIH1D3PIH1 domain containing 3. (204 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1018 aa)
DNAJC9DnaJ heat shock protein family (Hsp40) member C9. (260 aa)
BAG5BCL2 associated athanogene 5. (447 aa)
HSPD1Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (574 aa)
H0W3X9_CAVPOUncharacterized protein. (2048 aa)
ATP7AATPase copper transporting alpha. (1433 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
DNLZDNL-type zinc finger. (176 aa)
BIN1Bridging integrator 1. (577 aa)
Cnpy2Saposin B-type domain-containing protein. (182 aa)
ENSCPOP00000033036Uncharacterized protein; Belongs to the GroES chaperonin family. (85 aa)
GRPEL2GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family. (225 aa)
CDC37Cell division cycle 37. (378 aa)
ENSCPOP00000032931CR-type domain-containing protein. (379 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
ENSCPOP00000032487HipN domain-containing protein. (121 aa)
FNIP1Folliculin interacting protein 1. (1164 aa)
ENSCPOP00000032121Uncharacterized protein. (213 aa)
UBL4BUbiquitin like 4B. (177 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
ENSCPOP00000031634J domain-containing protein. (69 aa)
ENSCPOP00000031515Uncharacterized protein. (406 aa)
GET4Guided entry of tail-anchored proteins factor 4. (331 aa)
SACSSacsin molecular chaperone. (4542 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (423 aa)
TIMM9Translocase of inner mitochondrial membrane 9. (89 aa)
HSPB6Heat shock protein family B (small) member 6; Belongs to the small heat shock protein (HSP20) family. (162 aa)
PTGES3Prostaglandin E synthase 3. (160 aa)
BAG2BCL2 associated athanogene 2. (211 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
LOC100715002Uncharacterized protein; Belongs to the GroES chaperonin family. (102 aa)
PFDN6Prefoldin subunit 6. (131 aa)
CDC37L1Cell division cycle 37 like 1. (339 aa)
UBL4AUbiquitin like 4A. (157 aa)
DNAJB1DnaJ heat shock protein family (Hsp40) member B1. (339 aa)
Dnajb6J domain-containing protein. (333 aa)
DNAJC12DnaJ heat shock protein family (Hsp40) member C12. (198 aa)
ENSCPOP00000027159TPR_REGION domain-containing protein. (226 aa)
TFRCTransferrin receptor protein 1. (765 aa)
SDF2L1Stromal cell derived factor 2 like 1. (221 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (620 aa)
DNAJB2DnaJ heat shock protein family (Hsp40) member B2. (278 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1048 aa)
DNAJC3DnaJ heat shock protein family (Hsp40) member C3. (492 aa)
FICDFIC domain containing. (458 aa)
ENSCPOP00000024297Uncharacterized protein. (406 aa)
ENSCPOP00000024193Uncharacterized protein. (355 aa)
DNAJB9DnaJ heat shock protein family (Hsp40) member B9. (222 aa)
STIP1Stress induced phosphoprotein 1. (543 aa)
CPCeruloplasmin; Belongs to the multicopper oxidase family. (1097 aa)
LbrTudor domain-containing protein. (133 aa)
TIMM10Translocase of inner mitochondrial membrane 10. (90 aa)
DNAJB8DnaJ heat shock protein family (Hsp40) member B8. (228 aa)
PdpnUncharacterized protein. (158 aa)
SYVN1Synoviolin 1. (605 aa)
HES1Hes family bHLH transcription factor 1. (279 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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